-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_appendixes.pdf
January 01, 2006 - Peds: safety and efficacy
not established in pediatric
patients
sulindac Elimination half-life: … Patient
masked? … Patient
masked? … Trials of etoricoxib and lumiracoxib (Safety only)
Author
Year
Patient
masked? … Patient global
response pooled data indicated that patients taking 25mg rofecoxib v celecoxib had good-excellent
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cancer-anemia-update_disposition-comments.pdf
April 25, 2013 - or specific patient populations since
there is evidence that certain groups of patients may not
necessarily … However, that group was part of
the patient population defined for the review. … more in this manuscript because it is relevant to clinical practice and
it is the reason for ongoing safety … measures in accordance
with the AHRQ Methods Guide, these data are clinically important to consider for
safety … Since the 2008 ODAC meeting,
there have been no new safety signals that would warrant the conclusion
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/antipsychotics-children_research-protocol.pdf
June 04, 2010 - • The following outcomes were added: patient or parent/caregiver preferences, work-related
functional … outcomes, patient insight into illness. … followup), patient baseline characteristics (diagnosis and age at diagnosis, age, sex, race,
weight … in each group, and the number of patients affected. … Adults
Pediatric use: safety & effectiveness not
established in patients <18 yr
1. agranulocytosis
-
effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-outcomes/methods
October 01, 2019 - consequences if the tested individual is in a profession that requires disclosure of health threats for the safety … one of their key questions: whether prediction of prognosis with spirometry, with or without clinical indicators … , is more accurate than prediction based on clinical indicators alone. … Spirometry is a noninvasive test that most patients tolerate well. … Challenges in and Principles for Conducting Systematic Reviews of Genetic Tests Used as Predictive Indicators
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_executive.pdf
May 01, 2010 - This report evaluates the level of evidence
currently available to support the
effectiveness and safety … The FDA drug approval process
mandates randomized clinical trials that demonstrate
efficacy and safety … Use of rFVIIa for selected
indications in patient with/undergoing cardiac
surgery
Key Question 4c. … • Are there patient subpopulations more likely to
benefit from rFVIIa use? … • Are there patient subpopulations where harms are
more likely?
-
effectivehealthcare-admin.ahrq.gov/products/cystic-fibrosis-hgh/research-protocol
December 01, 2019 - in secondary costs per year per patient [6 ]. … However, issues arise in its clinical interpretation because of its basis on height; a CF patient with … KQ 6: In patients with CF, how is efficacy, effectiveness, safety or adverse events impacted by rhGH … KQ 7: In patients with CF, how do the efficacy, effectiveness, safety or adverse events of treatment … Patient Registry Annual Report 2006 . Bethesda, Maryland; 2008.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cancer-radiation_executive.pdf
November 01, 2009 - Each of four reviewers
extracted study, patient, and treatment
characteristics; clinical outcomes;
and … CS=cancer-specific survival; GI=gastrointestinal; OvS=overall survival.
3
Most studies reported patient … This Technical Brief did not intend to assess outcomes
or evaluate the validity of claims on the safety … focused systematic reviews will not be
able to provide a definitive answer on the effectiveness
and safety … studies (preferably randomized) are likely
necessary to provide meaningful answers on the relative
safety
-
effectivehealthcare-admin.ahrq.gov/products/weight-gain-prevention/research-protocol
December 01, 2019 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … help provide an evidence base for future practice guidelines to influence individual decision making, patient … Objectives
We aim to compare the effectiveness, safety and impact on quality of life of individual … Health Indicators Warehouse. Healthy Weight in Adults. … http://www.healthindicators.gov/Indicators/Healthyweightinadults_1207/Profile/Data .
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1306.pdf
January 01, 2016 - for calibrating the
CGM (as applicable) and checking sensor performance as needed plus associated
reagents … But the experts called for
longer safety and efficacy studies to determine whether this system would … Genentech has a patient assistance program to help defray costs for
qualified patients.135
Several … Efficacy and safety of exenatide once weekly
versus sitagliptin or pioglitazone as an adjunct to … Efficacy,
safety, and tolerability of exenatide once weekly
in patients with type 2 diabetes mellitus
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/diabetes-update-2015_research-protocol.pdf
January 01, 2015 - patients who cannot initiate or who cannot tolerate
metformin remains unclear. … outcomes will be especially
useful to clinicians, patients, investigators, guideline developers, and … Patients and patient advocates also will find the information valuable when making decisions
about treatment … • We will exclude studies of patients with
type 1 diabetes, impaired glucose
tolerance, metabolic … using a co-morbidity scale or index; by including other medical
conditions or medications used by the patient
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/unpublished-drug-trials-white-paper.pdf
December 01, 2024 - The information in this report is intended to help healthcare decision makers—patients and
clinicians … information, i.e., in the context of available resources
and circumstances presented by individual patients … Most AHRQ documents are publicly
available to use for noncommercial purposes (research, clinical or patient … Efficacy and safety of paroxetine treatment
for chronic PTSD: a fixed-dose, placebo-
controlled study … Efficacy
and safety of mifepristone in the treatment
of male US veterans with posttraumatic
stress
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/crohns-disease-future_research.pdf
July 01, 2016 - Patient Stakeholder
Thomas Ullman, M.D.
Mt. … KQ 3 What is the comparative safety of therapies alone or in combination used in adults and children … Given that patient-
reported outcomes may be even more relevant to patients who are not currently experiencing … Study Design
Observational studies may be too short in duration to observe some safety outcomes. … outcomes
• Studies in non-white
populations
Children
• Trials and safety
studies in
children
Patient
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/copd-anticholinergic-medicines_research.pdf
December 01, 2009 - Therefore, each patient was given a 30 day immortal period following the switch. … homogeneous patient population. … Thus, there is still
need to evaluate tiotropium safety in patient populations who are treatment naïve … Methodologic challenges to
studying patient safety and comparative
effectiveness. … Methodologic challenges to
studying patient safety and comparative
effectiveness.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-4.pdf
January 01, 2023 - Cannabis for
chronic pain: cardiovascular safety in a nationwide
Danish study. … Pharmacokinetics and pharmacodynamics of cannabis-
based medicine in a patient population included in … Medicinal cannabis for Australian patients with chronic
refractory pain including arthritis.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/s16.pdf
October 01, 2007 - evidence is centered on the protocol-driven ran-
domized trials, which the FDA requires to establish safety … information from
industry-funded trials may remain unpublished, limiting the
ability to examine potential safety … carefully studied in trials (especially rare or
slow emerging harms); explore sources of heterogeneity in
safety … may depend on severity of
strokes, patient preferences. … patients; audits could examine the rates at which
women and patients over age 80 are undergoing surgery
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/health-careassociated-infections_executive.pdf
November 01, 2012 - safety practices:8
• Theory behind patient safety practice
• Existing patient safety infrastructure … patient safety culture and teamwork at the unit level. … Safety Practice 9 3 4 0 16
Existing Patient Safety Infrastructure 8 6 2 4 20
External Factors 9 7 … Assessing the Evidence
for Context-Sensitive Effectiveness and Safety of Patient
Safety Practices: … Advancing
the science of patient safety. Ann Intern Med. 2011 May
17;154(10):693-6.
-
effectivehealthcare-admin.ahrq.gov/health-topics/diabetes-type-2?page=2
July 28, 2009 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … Report
Systematic Review Archived September 15, 2008
Comparative Effectiveness, Safety … Hypertension
Systematic Review Archived July 16, 2007
Comparative Effectiveness and Safety … 2005
Addressing Knowledge Gaps in Type 2 Diabetes Therapeutics: Comparative Effectiveness and Safety … Study to Assess Association of Variations in OCT Genes with Effectiveness of Metformin in Diabetic Patients
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/weight-gain-prevention_research-protocol.pdf
January 01, 2020 - help provide an evidence base
for future practice guidelines to influence individual decision making, patient … The safety issues to be addressed will also help individuals and clinicians to
take into consideration … Objectives
We aim to compare the effectiveness, safety and impact on quality of life of individual … Health Indicators Warehouse. Healthy Weight in Adults. … http://www.healthindicators.gov/Indicators/Healthyweightinadults_1207/Profile/Data
.
3.
-
effectivehealthcare-admin.ahrq.gov/products/telehealth-women/research
January 01, 2023 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … , depression, fear of partner, coercive control, self-efficacy, post-traumatic stress disorder, and safety … s preventive services for reproductive healthcare and interpersonal violence (IPV), and to evaluate patient … , depression, post-traumatic stress disorder, fear of partner, coercive control, self-efficacy, and safety … Telehealth use was facilitated by strategies to ensure safety of individuals who receive IPV services
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/10_obesity_potential_high_impact_2012-12-11.pdf
January 01, 2012 - data and postmarket safety evaluation—set
forth by the U.S. … Kushner and colleagues announced results from a phase III clinical trial (SEQUEL)
evaluating the safety … However, a
potential increase in per-patient cost might serve as a barrier to acceptance by some patients … While
preliminary results are promising, further studies evaluating efficacy and safety are needed, … Safety and efficacy study of
EndoBarrier in subjects with type II diabetes and
obesity.