-
effectivehealthcare-admin.ahrq.gov/health-topics/metabolic-disorders?page=3
April 05, 2010 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … Intensive Control in Type 2 Diabetes
Research Report November 9, 2009
Additional Patient … Report
Systematic Review Archived September 15, 2008
Comparative Effectiveness, Safety … 2005
Addressing Knowledge Gaps in Type 2 Diabetes Therapeutics: Comparative Effectiveness and Safety … Study to Assess Association of Variations in OCT Genes with Effectiveness of Metformin in Diabetic Patients
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/vaccine-safety_research-protocol.pdf
September 18, 2012 - System
(VAERS),11 the Vaccine Safety Datalink,12 and the Clinical Immunization Safety Assessment
Network … Both
patient factors (i.e., age and race) and vaccine factors (i.e., formulation, dosage, and timing … AEs) or passive (participants are not specifically asked about or tested for the
occurrence of AEs; patient … Multiple publications are defined by the investigated patients.
F. … The Vaccine Safety Datalink: a model for monitoring
immunization safety.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-214-afib-disposition-comments.pdf
October 30, 2019 - Efficacy and safety of dabigatran
compared to warfarin in patients with paroxysmal,
persistent, and … Recommendation: Based on the evidence, all
DOACS have shown safety and efficacy in patients
who are … The safety population is used, which is the same
population used in other DOAC trials to assess
safety … Efficacy and safety
of rivaroxaban compared with warfarin in patients
with peripheral artery disease … Efficacy and safety of
rivaroxaban compared with warfarin in patients with
carotid artery disease and
-
effectivehealthcare-admin.ahrq.gov/health-topics/hormones?page=1
December 20, 2011 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … October 4, 2010
Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients … Research Report December 4, 2009
Mortality Risk in Chronic Obstructive Pulmonary Disease Patients … December 4, 2009
Outcomes Associated With Tiotropium use in Chronic Obstructive Pulmonary Disease Patients … Systematic Review Archived September 15, 2008
Comparative Effectiveness, Safety
-
effectivehealthcare-admin.ahrq.gov/products/peripheral-artery-disease-treatment/research-protocol
December 01, 2019 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … with aortoiliac disease, supervised exercise therapy improved peak walking time and patient-reported … including patient characteristics, severity of symptoms, anatomic considerations, and patient and physician … with CLI. 38 Amputation-free survival is generally considered the best limb and patient outcome for … , patients with atypical leg pain, IC, or CLI), as well as demographic and other data (patient characteristics
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/atypical-antipsychotics-seniors-death_research.pdf
August 01, 2007 - Microsoft Word - ehcrr#2toCSI.doc
Effective Health Care
Number 2
Research Reports
Comparative Safety … Patients. … Older Patients. … The older patient: the ongoing challenge of
efficacy and tolerability. … The efficacy,
safety, and tolerability of antipsychotics in the
elderly.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/registries-guide-2nd-edition_disposition-comments.pdf
March 03, 2010 - who get entered into
registry vs. (2) universe of patients with condition of interest to provide an … General
The use of registries for product safety assessment should augment all of
the other safety … safety assessments. … and patient complexity. … used to examine safety for medical devices.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1512.pdf
December 01, 2015 - at increased risk of
esophageal cancer and that its potential safety relative to endoscopy would be … reprocessing
of endoscopes have been recognized for several years, and FDA has published several safety … Treatments are aimed at symptomatic relief, but questions of safety and efficacy
remain. … However, other experts thought the
availability of a new IBS therapy with a seemingly good safety profile … Persistent contamination on colonoscopes and
gastroscopes detected by biologic cultures and
rapid indicators
-
effectivehealthcare-admin.ahrq.gov/products/weight-loss-surgery/research-protocol
December 01, 2019 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … The benefits-to-risks ratio in the long term is also a concern: effectiveness and safety data are very … Benefits and harms for specific subpopulations (by gender, age, and race/ethnicity) and other patient … studies will be excluded: 1) studies that did not report any outcomes of efficacy, effectiveness, or safety … Provisional analytic framework for evaluating the effectiveness and safety of alternative approaches
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/weight-loss-surgery_research-protocol.pdf
December 14, 2010 - The benefits/risks ratio in the long term is also a concern:
effectiveness and safety data are very … studies will be excluded: 1) studies that did not report any
outcomes of efficacy, effectiveness, or safety … Provisional analytic framework for evaluating the effectiveness and safety of
alternative approaches … to treatment of metabolic conditions in the patient population with BMI
below 35. … Provisional analytic framework for evaluating the effectiveness and safety of
alternative approaches
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/crohns-disease_disposition-comments.pdf
February 25, 2014 - centered outcomes, and observational studies along with RCT
for safety. … All patients in global safety summary
were Crohn’s Disease patients. … Please consider inclusion of this safety data. … According to our analytic
framework, patient-reported
outcomes are relevant. … questions
in terms of final patient important outcomes.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_disposition-comments.pdf
November 27, 2012 - For this reason, it is also
important to capture long-term safety to
obtain a global aspect of how … these
therapies impact patient care, both benefits
and harms. … For KQ 1, what does this patient population look like? … Efficacy and safety of infliximab vs. … One patient was reported to have hypertension in patients who
switched from methotrexate to infliximab
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/stem-cell-children_surveillance.pdf
October 29, 2012 - , 4, 5 and 6 up to date
• Expert opinion: conclusions still valid
• There are no new significant safety … using searches through August, 2011 and
addressed six key questions to evaluate effectiveness and safety … Administration (FDA), Health Canada, and Medicines and Healthcare Products Regulatory
Agency (MHRA) safety … Taken
into consideration the totality of evidence (i.e., updating signals, expert opinion, and safety … Experts: Still valid
Safety surveillance alerts: No
Conclusion: Up to date
7
Table 1.
-
effectivehealthcare-admin.ahrq.gov/products/asthma-immunotherapy-2010/research-protocol
December 01, 2020 - KQ 2
What is the evidence for safety of SIT in patients with allergic rhinoconjunctivitis and/or asthma … CBER provides two US standard reagents to manufacturers for their determination of Amb a 1 content, a … but only "change in skin test reactivity" (in-vivo) and "change in antibody" (in-vitro) are accepted indicators … Not all patients with asthma are allergic. … The activity domain contains 5 ‘patient-specific’ questions.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/depression_hi_impact.pdf
October 01, 2014 - For example, TMS is contraindicated in patients with implanted DBS devices, and the
safety of ECT in … the stimulation parameters, and how to recognize safety concerns. … Government has approved clinical trials assessing the safety and efficacy of MDMA for
the treatment … In published results in one safety trial
investigating MDMA-assisted psychotherapy in women with PTSD … The safety and efficacy of {+/-}3,4-
methylenedioxymethamphetamine-assisted
psychotherapy in subjects
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cancer-anemia_executive.pdf
May 01, 2006 - What are the comparative efficacy and safety of
epoetin (alfa or beta) and darbepoetin?
2. … Are any patient characteristics at baseline or early
hematologic changes useful to select patients or … empirically evaluated to determine whether the
degree of change is perceptible and meaningful to
the patient … treated with epoetin; this prompted an FDA safety
review in May 2004 and revised product labeling to … Neither higher than recommended
target Hb nor any other single patient- or treatment-
related factor
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1412.pdf
December 01, 2014 - Experts wanted to see additional clinical trial data assessing
baclofen’s long-term safety and efficacy … solution to a reference
product; a user experience study with adult and juvenile volunteers; and a safety … All adult volunteers, and 15 of 19 adolescent volunteers,
successfully used Evzio, removing the safety … to patients’ families that it be available for emergency use at home. … ,
and patients’ families, the experts concluded.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-205-predictors-trauma-care-disposition-comments.pdf
April 01, 2018 - These sites also need some type of triage scheme to
determine if a patient needs to go to a higher level … We have expanded the
explanation that we used several
indicators for serious injury in this
review … Very different from triage of daily occurring injuries where focus is on
a single patient. … We agree that using different
indicators of serious injury effects
the performance and we included … Doing so increases costs and risks
to personal safety.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_disposition-comments.pdf
May 01, 2013 - Disposition of Comments for Efficacy and Safety of Screening for Postpartum Depression
Comparative … Effectiveness Research Review Disposition of Comments Report
Research Review Title: Efficacy and Safety … Efficacy
and Safety of Screening for Postpartum Depression. Comparative Effectiveness Review 106. … What are community patients? … It can be considered unethical to screen
women without a safety net and protocol in place.
-
effectivehealthcare-admin.ahrq.gov/products/vaccine-safety/research-protocol
December 01, 2020 - EHC
The Evidence-based Practice Centers
The Scientific Resource Center
Registry of Patient … Reporting System (VAERS), 11 the Vaccine Safety Datalink, 12 and the Clinical Immunization Safety Assessment … Both patient factors (i.e., age and race) and vaccine factors (i.e., formulation, dosage, and timing) … Multiple publications are defined by the investigated patients.
F. … The Vaccine Safety Datalink: a model for monitoring immunization safety.