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Total Results: 1,161 records

Showing results for "patient safety".

301. PROPOSALS FOR A PHASED EVALUATION OF (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medical-tests-proposals_research.pdf
     January 01, 2009 - In Phase I, the safety, tolerability and toxicity, pharmacodynamics, and pharmacokinetics of the new … limited numbers of human subjects to gather preliminary evidence regarding effectiveness and additional safety … Phase III refers to controlled clinical studies intended to provide a reasonable assurance of safety … studies performed once a technology has gained marketing approval; these studies address long-term safety … Trials in volunteers usually go before trials in patients.

302. PROPOSALS FOR A PHASED EVALUATION OF (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/whitepaper3-lijmer02262010-2.pdf
     January 01, 2009 - In Phase I, the safety, tolerability and toxicity, pharmacodynamics, and pharmacokinetics of the new … limited numbers of human subjects to gather preliminary evidence regarding effectiveness and additional safety … Phase III refers to controlled clinical studies intended to provide a reasonable assurance of safety … studies performed once a technology has gained marketing approval; these studies address long-term safety … Trials in volunteers usually go before trials in patients.

303. A Framework for Conceptualizing Evidence Needs of Health Systems (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-framework-for-conceptualizing-evidence-needs_0.pdf
     December 01, 2017 - information, i.e., in the context of available resources and circumstances presented by individual patients … safety and quality of care. … 15 percent of the content of these protocols is routinely adapted to meet the needs of individual patients … outcome data) and external (published research) evidence for patients and clinicians.66 Our work … and value of patient care.

304. Research Protocol: Breast Reconstruction After Mastectomy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-reconstruction-mastectomy-protocol.pdf
     April 09, 2020 - U.S. were estimated for 2019.2 Surgery is a component of the standard treatment strategy for most patients … satisfaction and fewer complications in patients undergoing postmastectomy radiation therapy.26 But … FDA Update on the Safety of Silicone Gel-Filled Breast Implants. 2011. https://www.fda.gov/media/80685 … : FDA Safety Communication.; 2019. https://www.fda.gov/medical-devices/safety-communications/fda- requests-allergan-voluntarily-recall-natrelle-biocell-textured-breast-implants-and-tissue … your-rights-after-a-mastectomy.pdf https://www.fda.gov/media/80685/download https://www.fda.gov/medical-devices/safety-communications

305. Attention Deficit Hyperactivity Disorder: Diagnosis and Treatment in Children and Adolescents - Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/deficit-hyperactivity-protocol.pdf
     November 01, 2021 - selection: The domain patient selection addresses whether the selection of patients could have introduced … Patient-centered outcomes are considered direct. … Long-Term Effects of Stimulant Treatment for ADHD: What Can We Tell Our Patients? … Safety of Vaccines Used for Routine Immunization in the United States: An Update. … Safety of probiotics used to reduce risk and prevent or treat disease.

306. Disposition of Comments for Progestogens for Prevention of Preterm Birth (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/progestogens-preterm-birth-disposition-121205.pdf
     September 07, 2012 - The safety signal uncovered by the FDA was an excess of fetal death in patients exposed to 17P. … , of note each of these is mediated by the care provider as part of the process of care; none are patient … A it must work for patient B" clearly does not apply for 17OH. … Given that this document could be used to provide guidelines for patient care and change reimbursement … Physicians need to inform patients that there is a potential safety signal with the administration of

307. Crosscutting-Horizon-Scan-High-Impact-1406 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1406.pdf
     June 01, 2014 - Although propofol may be preferred for these reasons, its use is complicated by safety concerns. … of the controversy among clinical specialties (gastroenterology versus anesthesiology) about its safety … Patient acceptance of the technology might be low, although one expert thought that elderly patients … Clinicians can access objective, accurate, and timely data about patient adherence, to monitor patients … It may be solely age-based (i.e., patients 65 years and older) or also based on patient complaint and

308. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-2007_executive.pdf
     January 01, 2007 - The second-generation sulfonylureas, which are used today, were Comparative Effectiveness and Safety … Do oral diabetes medications for the treatment of adults with type 2 diabetes differ in their safety … similar between metformin and other oral diabetes medications or placebo (8.4 vs. 9 cases per 100,000 patient-years … additional limitations that influenced their conclusions was their decision to include studies with diverse patient … similar between metformin and other oral diabetes medications or placebo (8.4 vs. 9 cases per 100,000 patient-years

309. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: Surveillance Report 2 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-apps-a-e-surveillance-report-2-final_0_0.pdf
     March 01, 2022 - The pharmacokinetics, efficacy, and safety of a novel selective-dose cannabis inhaler in patients with … Efficacy, tolerability and safety of cannabinoids for management of pain in adult patients with multiple … Off- label use of cannabinoids efficacy and safety. … Safety and Efficacy of Medical Cannabis in Fibromyalgia. … Care of the Patient Using Cannabis.

310. S3 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s3.pdf
     October 01, 2007 - EDITORIAL The Comparative Effectiveness and Safety Emerging Methods Symposium A Tribute to Harry A. … knowledge about the development and application of methods pertaining to comparative effectiveness and safety … core material of standard clinical textbooks verbatim and could recite that material in the care of patients … mastered, but also had an ability to analyze and apply original research articles in the care of the patients … was the first person I encountered who masterfully demonstrated the application of these methods to patient

311. Ced-Appendix-3 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced-appendix-3.xlsx
     June 24, 2022 - NEST_data • Patient-centeredness: Patients are engaged in the RWD/RWE process and provide consent when … NAM 2018 Safety monitoring in real-world trials NAM 2018 Results more generalizable and relevant NAM … NAM2019 Questions to consider regarding participant safety and investigator control of treatments in … NAM2019 How much would the effectiveness or safety of the study treatment(s) vary among providers or … NAM2019 Is there some minimal or floor level of treatment quality necessary to assure participant safety

312. Disposition of Comments_Technical Brief No. 40: Interventions To Decrease Hospital Length of Stay (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hospital-length-of-stay-disposition-comments_0.pdf
     September 20, 2021 - In addition, ICU LOS is often seen as an important measure (from a quality of care and safety standpoint … coaching), healthcare delivery processes, managed care and risk management, and hospital quality and safety … Ideally there would be more patient or family stakeholder KIs. … coaching), healthcare delivery processes, managed care and risk management, and hospital quality and safety … Presumably the patient level factors that drive prolonged length of hospital stay in patients with multi

313. Systematic Review on Treatments for Acute Pain: Surveillance Report 3 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/main-apps-surv-report-3-acute-pain.pdf
     June 01, 2022 - How do harms vary depending on: (1) patient demographics (e.g., age, gender); (2) patient medical or … How do harms vary depending on: (1) patient demographics (e.g., age, gender); (2) patient medical comorbidities … How do harms vary depending on: (1) patient demographics (e.g., age, gender); (2) patient medical and … safety and pain management: a systematic review and meta-analysis. … Effect of intensive patient education vs placebo patient education on outcomes in patients with acute

314. Methods Research Report: Testing a Machine Learning Tool for Facilitating Living Systematic Reviews of Chronic Pain Treatments (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-report-testing-machine-learning-tool-chronic-pain.pdf
     November 01, 2020 - A 1-year safety and efficacy study of duloxetine in patients with fibromyalgia. … Evaluation of efficacy and safety of gabapentin, duloxetine, and pregabalin in patients with painful … Comparative safety and tolerability of duloxetine vs. … in patients with moderate-to-severe chronic low back pain. … Safety and efficacy of tapentadol ER in patients with painful diabetic peripheral neuropathy: results

315. CER 215 Executive Summary: Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-215-depression-older-adults-executive-summary.pdf
     March 01, 2019 - Further characterization of the comparative safety of antidepressants is difficult because few studies … Comparative efficacy and safety of sertraline versus nortriptyline in major depression in patients … Safety and tolerability of duloxetine at 60 mg once daily in elderly patients with major depressive … double- blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety … Are old-old patients with major depression more likely to relapse than young-old patients during continuation

316. Suicidal-Thoughts-Young-People-Amendement-May-2025 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-amendement-may-2025.pdf
     January 01, 2025 - regulation and management, behavioral planning, family engagement and communication training, and practical safety … intervals), directness of the evidence to the KQs (focusing on whether the outcomes were important to patients … Intervention research with persons at high risk for suicidality: safety and ethical considerations. … The SAFETY program: a treatment-development trial of a cognitive-behavioral family treatment for adolescent … Key Informants Key Informants are the end-users of research; they can include patients and caregivers

317. Topic 0318 Psychiatric Hospital Discharge NSD FINAL (2)_SJ_Clean-2 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0376-140408.pdf
     November 06, 2013 - Key Questions from Nominator:  Patient … factors prompting the admission  Individual and family felt the stay was sufficient to address safety … hospitalizations for persons with SMI and the circumstances surrounding hospitalization that promote positive patient

318. Methods White Paper: Improving the Utility of Evidence Synthesis for Decision Makers in the Face of Insufficient Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/improving-utility-evidence-synthesis-white-paper.pdf
     April 01, 2021 - Patient safety in ambulatory settings. … VA National Center for Patient Safety . … Veterans Affairs (VA) managers and policymakers VA National Center for Patient Safety "improve … with STEMI Few trials followed patients long-term and lack of data regarding safety C-10 … Patient safety in ambulatory settings.

319. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-anemia-update_research-protocol.pdf
     June 16, 2010 - The 2006 CER revealed safety concerns for the erythropoietic stimulants as a class. … In an individual patient data meta-analysis of 13,933 patients in 53 trials treated with epoetin alfa … analyzed individual patient data from 2,122 patients in 6 trials receiving darbepoetin alpha finding … Study and Independent Patient Level Meta-Analysis Selection: Results from study- and patient-level meta-analysis … Erythropoietin or Darbepoetin for patients with cancer--meta-analysis based on individual patient data

320. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/treatment-resistant-depression_research-protocol.pdf
     December 09, 2009 - when the patient is treatment resistant. … For adults with treatment-resistant depression, do non-pharmacologic interventions differ in safety, … Comparators: ECT, rTMS, VNS, demonstrated effective psychotherapy • Outcomes for each question • Safety … KQ4 focuses on safety issues (adverse effects, adherence) with each of the interventions. … While the patient is ultimately the one to make the decision about whether to receive the non- pharmacologic