-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_surveillance.pdf
December 01, 2012 - ) what patient, surgical or postsurgical characteristics predict or differentiate patient risk
of venous … Safety surveillance alerts: No safety alert was identified. … Safety surveillance alerts: No safety alert was identified. … Safety surveillance alerts: No safety alert was identified. … Safety surveillance alerts: No safety alert was identified.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/off-label-use-research-priorities_research.pdf
May 01, 2009 - The DEcIDE
network assists health care providers, patients, and policymakers seeking unbiased information … Notably, while raising some concerns about off-label use, the studies
also identify disease- and patient-specific … Three prior studies have examined off-label use among broader, more representative
patient populations … insure that the most common
drugs dispensed through pharmacies matched those reported by physicians at patient … Regulatory and
reimbursement issues in treating patients
with immune-mediated neuropathies.
-
effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1512.pdf
December 01, 2015 - According to the Cystic Fibrosis Foundation’s 2014 patient registry, almost 47%
of CF patients in the … One phase III trial is
ongoing, evaluating pirfenidone’s long-term safety and efficacy in patients … However, experts thought
that patients are likely to accept lumacaftor/ivacaftor if long-term safety … Safety
and efficacy of treatment with lumacaftor in
combination with ivacaftor in patients with CF … Safety and
tolerability of nintedanib in patients with Ipf:
interim analysis from an open-label extension
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/anxiety-children_research-protocol.pdf
September 12, 2016 - There is a great deal of uncertainty regarding comparative effectiveness and safety of all
treatments … that are widely
available and validated; which are:(patients/parent reported and clinician assessed … What are the treatment burdens (for patients, providers, and health systems) and
contextual factors … specific phobias, generalized
• Animals
• Adults (age >= 18 years)
• Infants (age < 3 years)
• Patients … Key Informants
Key Informants are the end users of research, including patients and caregivers,
practicing
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0365_10-28-2010.pdf
January 01, 2010 - of trauma experienced (including acute vs. chronic types of PTSD), timing of
treatment initiation, patient … What patient characteristics (including those listed below) are associated with
variations in treatment … Is there sufficient evidence to support
treatment matching based on patient characteristics or resources … Indirect/media (location at time of exposure—degree of
safety)
3. … Does this vary by age, sex, or other patient characteristics?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout_executive.pdf
March 01, 2016 - Safety of allopurinol
compared with other urate-lowering drugs in patients with gout:
a systematic … Diabetes and gout:
efficacy and safety of febuxostat and allopurinol. … The efficacy and safety of
febuxostat for urate lowering in gout patients >/=65 years of age. … African American
patients with gout: efficacy and safety of febuxostat vs
allopurinol. … Patient
compliance in rheumatoid arthritis, polymyalgia rheumatica,
and gout.
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_6-user-guide-to-ocer_130129.pdf
October 30, 2012 - thrombosis (ST)], and two relating to both safety
and effectiveness [composite of death, MI, ST, … The safety-only definition of MACE
yielded a hazard ratio of 1.75 (p<0.05), indicating
that patients … definitions
also yielded different results; while the safety-
only composite endpoint demonstrated … This construct
comprises outcomes from the patient perspective
and are measured by asking the patient … using clozapine may appear to have a worse safety
profile with respect to this outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/healthcare-infections_research-protocol.pdf
January 01, 2014 - What criteria (clinical effectiveness, safety, adherence to FDA regulations, market value,
others) … of patients (family/guests)? … Centers for Disease Control
and Prevention (CDC), Environmental Protection Agency (EPA), Occupational
Safety … searched to identify clinical practice guidelines,
white papers or position statements, regulatory or safety … OR "patient rooms" OR "patients rooms" OR "health care setting" OR
"health care settings" OR ward OR
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hip-fracture-pain.ppt
May 01, 2011 - effectiveness and safety? … Evidence about the patient subpopulation characteristics that influence effectiveness and safety was … It is important to note that no studies examined the effectiveness or safety of the most commonly used … The evidence may support continued research to test effectiveness and safety. … Influence of Subpopulation Characteristics on Effectiveness and Safety (2)
Abou-Setta AM, Beaupre LA,
-
effectivehealthcare.ahrq.gov/sites/default/files/hip-fracture-pain.ppt
May 01, 2011 - effectiveness and safety? … Evidence about the patient subpopulation characteristics that influence effectiveness and safety was … It is important to note that no studies examined the effectiveness or safety of the most commonly used … The evidence may support continued research to test effectiveness and safety. … Influence of Subpopulation Characteristics on Effectiveness and Safety (2)
Abou-Setta AM, Beaupre LA,
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gerd-disposition-120104.pdf
April 01, 2011 - Summary of available data on patient
characteristics and response to prior medical
treatment have been … The subjective
parameters should also include Patient Reported Outcomes (PROs)
as appropriate instruments … At
baseline and Week 4 (Final Visit), 3 patient-reported outcome
questionnaires were completed to assess … comprising 11% of patients in the
trials.1 No overall differences were seen in the safety or effectiveness … The safety of
Thank you for your comments.
-
effectivehealthcare.ahrq.gov/sites/default/files/arthritis_hi_impact.pdf
January 01, 2014 - IL-1 may be a problematic target with respect to safety in the gout patient
population, however, and … and tolerability due to safety concerns over infections
reported in trials thus far. … These safety concerns may present barriers to approval or barriers
to diffusion if approved. … These safety concerns may
present significant barriers to approval and diffusion if approved. … SLE: belimumab safety, efficacy
sustained over 6 years. [internet].
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_1-user-guide-to-ocer_130129.pdf
August 13, 2012 - end-users and facilitates appropriate
translation of the results into health care practice
and use by patient … If the FDA
approves, human testing for safety and efficacy
can begin. … These endpoints may be
categorized as clinical endpoints, patient-reported
outcomes and quality of … On the other hand, a patient who has
a health condition where there are few treatments
may be willing … Likewise, some patient groups were
reported to be concerned by the decision since it
presumably would
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1406.pdf
September 26, 2014 - Patients and
their diabetes care teams work to adjust patient insulin dosages using feedback from a … health
outcomes, citing safety concerns and limited efficacy data. … Summary of safety and effectiveness data
(SSED). MiniMed 530G system. P120010. … Efficacy and safety of insulin degludec in a
flexible dosing regimen vs insulin glargine in
patients … A study of the safety and efficacy of a
new treatment for diabetic macular edema.
-
effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1406.pdf
June 01, 2014 - Preliminary data for these interventions
are promising, and ongoing trials are clarifying the safety … Results and Discussion of Comments
Seven experts, with clinical, research, patient safety, and health … widespread, if data support its efficacy and safety, the experts thought. … Investigators reported high
patient adherence (81% and 94%; adherence defined as patients completing … that SPARX could positively affect patient health outcomes
by providing an alternative for patients
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/epc-health-care-practice-delivery.pdf
November 01, 2022 - models of care (e.g., impact of telehealth on health outcomes, mobile health
technology for diabetes, patient … safety in ambulatory settings).
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy-2010_research-protocol.pdf
January 01, 2010 - With continued administration, it is expected that the treatment regimen will make the patient tolerant … KQ 2
What is the evidence for safety of SIT in patients with allergic rhinoconjunctivitis and/or … Safety of long-acting beta2-agonists in the treatment of asthma. … Not all patients with asthma are allergic. … The activity domain contains 5 ‘patient-specific’ questions.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/urinary-incontinence-treatment_surveillance.pdf
October 29, 2012 - • There are no safety concerns
Summary Decision:
This CER’s priority for updating is Low … UUI in 40% patients on 150 U; p=0.022
• >75% improvement versus baseline in UUI in 40% patients on 100 … UUI in 40%
patients on 150 U; p=0.022
>75% improvement versus
baseline in UUI in 40%
patients on … The
efficacy
and
safety
of
solifenacin
in
patients
with
overactive
bladder … in 40% patients
on 150 U; p=0.022
>75% improvement versus baseline in UUI in 40% patients
on 100
-
effectivehealthcare.ahrq.gov/sites/default/files/10_obesity_potential_high_impact_june_2012.pdf
January 01, 2012 - significantly increased the regulatory bar for gaining approval—specifically
regarding preapproval safety … data and postmarket safety evaluation—set forth by the U.S. … Kushner and colleagues announced results from a phase III clinical trial (SEQUEL)
evaluating the safety … However, potential increase in per-
patient costs might serve as barriers to acceptance by some patients … Safety and efficacy study of
EndoBarrier in subjects with type II diabetes and
obesity.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_disposition-comments.pdf
November 27, 2012 - For this reason, it is also
important to capture long-term safety to
obtain a global aspect of how … these
therapies impact patient care, both benefits
and harms. … For KQ 1, what does this patient population look like? … Efficacy and safety of infliximab vs. … One patient was reported to have hypertension in patients who
switched from methotrexate to infliximab