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81. Comparative Effectiveness Review No. 241_Physical Activity and the Health of Wheelchair Users: A Systematic Review in Multiple Sclerosis, Cerebral Palsy, and Spinal Cord Injury (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-241-physical-activity-wheelchair-evidence-summary-updated.pdf
    October 01, 2021 - More studies enrolled participants with multiple sclerosis (44%) than other conditions, followed by … measure with VO2 peak, female sexual function (e.g., desire, lubrication, pain), and depression in participants … Physical activity improved balance, function, and VO2 peak in trials that enrolled participants with … Physical activity improved activities of daily living, function, and VO2 peak in participants with spinal

82. Appendix-Table-B-1-Observational-Studies (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendix-table-B-1-observational-studies.xlsx
    March 20, 2021 - healthcare records & testing data) Healthcare workers or social care workers over the age of 16 yrs Participants … could provide written informed consent and anticipated remaining engaged in followup for 12 months Participants … Participants with negative PCR test but no Ab data were excluded. … 1,881 20–34: 4,789 35–50: 4,358 50–64: 3,925 65–79: 1,255 80+: 611 NR Second surge retest positive participants … Note: all participants had 2 or more PCR- tests between baseline Ab test and PCR+ test (and most participants

83. Weight-Gain-Prevention Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-gain-prevention_executive.pdf
    January 01, 2020 - For KQ1-5 inclusion, the participants measured at the first time point must have been the same participants … Thirty-eight trials included 150,081 participants at baseline. … Thirteen observational studies included 420,986 participants at baseline. … 12 prospective cohorts (418,520 participants) were identified. … based on a cancer registry (1,966 participants) were identified.

84. Pharmacologic and Nonpharmacologic Treatments for Posttraumatic Stress Disorder: An Update of the PTSD Repository Evidence Base (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/ptsd-3-draft-report.pdf
    January 12, 2022 - Approximately half of studies enrolled community participants (53 percent) and most were conducted in … Studies typically enrolled participants with a mix of trauma types (51 percent). … studies of participants with combat-related trauma (17 percent). … Most studies (66 percent) had sample sizes between 25 and 99 participants (Figure 17). … There were two studies with over 200 participants.

85. Whole-Body Vibration Therapy for Osteoporosis (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-vibration-therapy_technical-brief.pdf
    January 01, 2020 - vibration platform.27,32,57,71 A number of studies instructed participants to flex their knees while … ,27,47,52 while another two studies advised participants on their calcium intake.31,57 Table 3. … Studies also varied in other aspects of the treatment protocol, such as whether participants flexed … Studies that installed whole-body vibration platforms in the participants’ home required them to use … Studies might also assess the actual vibration intensity transmitted to the study participants.

86. Ptsd-5-Draft-Report-Appendix-G-1 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-5-draft-report-appendix-g-1.xlsx
    March 20, 2024 - 1.2 Was the allocation sequence concealed until participants were enrolled and assigned to interventions … 2.2 Were carers and people delivering the interventions aware of participants' assigned intervention … previous question) Was there potential for a substantial impact (on the result) of the failure to analyse participants … 3.1 Were data for this outcome available for all, or nearly all, participants randomized? … PN/NI to both previous questions) Were outcome assessors aware of the intervention received by study participants

87. Effects of Dietary Sodium and Potassium Intake on Chronic Disease (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/sodium-potassium_research-protocol.pdf
    April 18, 2017 - , incident hypertension, percent participants at blood pressure goal, and change in blood pressure) … • Setting o Studies in community-dwelling participants will be eligible. … • Setting o Studies in community-dwelling participants will be eligible. … • Setting o Studies in community-dwelling participants will be eligible. … • Setting o Studies in community-dwelling participants will be eligible.

88. Major-Depressive-Disorder Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/major-depressive-disorder_executive.pdf
    December 01, 2015 - dNonrandomized studies must have a minimum sample size of 500 participants. … Two trials (237 participants) examined the effect of adding acupuncture to the SGA treatment regimen … Second-Generation Antidepressants Versus Omega-3 Fatty Acids One trial (40 participants) compared an … Two trials (72 participants) examined the effect of adding omega-3 fatty acids to the SGA regimen. … John’s Wort We identified 12 trials (1,806 participants) comparing SGAs with St.

89. Executive Summary: Pain Management Interventions for Hip Fracture (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer30_hip-fracture-pain-executive-summary_20110517.pdf
    May 01, 2011 - The mean age of study participants ranged from 59.2 to 86.3 years. … The mean age was not reported; most participants were female. … The mean age was 67.1; all participants were female. … All participants were female. … The mean age ranged from 74.0 to 81.0; most participants were female.

90. PKU Surveillance Assessment_CER 56_Low (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/phenylketonuria_surveillance.pdf
    January 15, 2013 - Overall, participants who were using a Phe-free medical food for their nutritional needs did not … Of the 10 studies examining the effectiveness of BH4 in participants with PKU, 4 studies reported … In the RCT, at a dosage of 20 mg/kg/day over 10 weeks, participants in the treatment group increased … Do Not Know participants tolerating lower levels of supplementary Phe. … Overall, participants who were using a Phe- free medical food for their nutritional needs New

91. Methods Guide for Comparative Effectiveness Reviews_Inclusion of Nonrandomized Studies of Interventions in Systematic Reviews of Intervention Effectiveness: An Update (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/methods-guide-inclusion-nonrandomized-studies.pdf
    September 01, 2022 - , minimizes selection bias.14 Prospective assignment of participants to study arms prior to outcomes … As another example, a comparative study in which investigators nonrandomly assigned participants to … or clusters of participants are allocated to the intervention or the comparator in a nonrandom … Cross-sectional studies are non-experimental and may allow the comparison of groups of participants … Depending on knowledge or expectations of the outcome, participants or study personnel may overstate

92. Methods Guide for Comparative Effectiveness Reviews_Inclusion of Nonrandomized Studies of Interventions in Systematic Reviews of Intervention Effectiveness: An Update (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/methods-guide-inclusion-nonrandomized-studies.pdf
    September 01, 2022 - , minimizes selection bias.14 Prospective assignment of participants to study arms prior to outcomes … As another example, a comparative study in which investigators nonrandomly assigned participants to … or clusters of participants are allocated to the intervention or the comparator in a nonrandom … Cross-sectional studies are non-experimental and may allow the comparison of groups of participants … Depending on knowledge or expectations of the outcome, participants or study personnel may overstate

93. Meeting Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/stakeholders-engagement-others_slides-2011.pdf
    January 01, 2011 - At a minimum, though, all participants should fully disclose their interests in advance. … of the experience needed and request résumés from AHRQ Community Forum Page | 4 potential participants … , providing an opportunity for participants to connect outside of the research setting, providing patient … Developing transparent processes for all participants engaged in an activity creates mutual understanding … Evaluation results should be provided to participants, as well as an indication of how the results

94. CER 222: Evidence Summary: Achieving Health Equity in Preventive Services (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-222-evidence-summary-health-equity.pdf
    January 01, 2020 - populations Preventive Service Impediments and Barriers Number of Studies; Study Design; Participants … Low; low 7 Preventive Service Impediments and Barriers Number of Studies; Study Design; Participants … aSecondary data analysis of participants who did not undergo screening. … sustained weight loss. 10 Preventive Service Intervention Number of Studies; Study Design; Participants … Preventive Service Intervention Number of Studies; Study Design; Participants (n) Overall Effect

95. CER 222: Evidence Summary: Achieving Health Equity in Preventive Services (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-222-evidence-summary-health-equity.pdf
    January 01, 2020 - populations Preventive Service Impediments and Barriers Number of Studies; Study Design; Participants … Low; low 7 Preventive Service Impediments and Barriers Number of Studies; Study Design; Participants … aSecondary data analysis of participants who did not undergo screening. … sustained weight loss. 10 Preventive Service Intervention Number of Studies; Study Design; Participants … Preventive Service Intervention Number of Studies; Study Design; Participants (n) Overall Effect

96. A Framework for "Best Evidence" Approaches in Systematic Reviews (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-approaches_research.pdf
    June 01, 2011 - The relevance criteria involve whether the study participants, interventions, and settings are relevant … Conduct and reporting criteria Relevance criteria (study participants, interventions, settings) 9. … Blinding of study participants to which intervention they received • Number of studies that did this … • How difficult it is to blind study participants or maintain blinding • Whether study participant … , define the “best evidence” set as those that reported data on at least 80 percent of study participants

97. Comparative Effectiveness of Treatment for Open-Angle Glaucoma | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/glaucoma-treatment/research-protocol
    November 16, 2010 - Outcomes Outcomes for Key Question 1: Primary outcome: The proportion of participants with moderate … The proportion of participants with progression of visual field loss as defined by the Early Manifest … Outcomes for Key Question 6: The proportion of participants experiencing the following adverse events … Narrative summaries of case reports and case series (including more than 100 participants) will also … Masking of investigators and participants might not be possible with some of the interventions being

98. Glaucoma-Treatment Research-Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/glaucoma-treatment_research-protocol.pdf
    November 16, 2010 - Primary outcome: The proportion of participants with moderate, severe, and profound visual impairment … Outcomes for Key Question 3: The proportion of participants with intraocular pressure measurements … The proportion of participants with progressive optic nerve damage as defined by included studies and … The proportion of participants with progression of visual field loss as defined by the Early Manifest … Narrative summaries of case reports and case series (including more than 100 participants) will also

99. Impact of Employment Interventions for Persons with Serious Mental Illnesses (SMI) on Non-Employment Patient-Centered Outcomes | Effective Health Care Program
    effectivehealthcare.ahrq.gov/products/mental-illness-employment/abstract
    December 20, 2011 - At least 2,000 participants will be studied, with 750 in each of the IPS groups and 500 TVS participants

100. Disposition of Comments_CER 241: Physical Activity and the Health of Wheelchair Users: A Systematic Review in Multiple Sclerosis, Cerebral Palsy, and Spinal Cord Injury (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-241-wheelchair-users-disposition-comments.pdf
     October 18, 2022 - I imagine there is not a lot of evidence or reporting of the specific mobility device used by participants … Further discussion is warranted regarding the lack of ability to blind participants when using a usual … We added lack of ability to blind participants as a limitation. … We agree that more research needs to be conducted in participants with EDSS scores 6 and higher (greater … We agree that more research needs to be conducted in participants with EDSS scores 6 and higher (greater