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effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-child-interventions_disposition-comments.pdf
February 11, 2013 - N/A
TEP #4 General Title of the review: Given the age range of participants included in the studies … various studies are
considered as isolated independent studies, the numbers obtained in
characterizing participants … based on
symptoms” to indicate whether the inclusion
criteria of each particular study required
participants … rating criteria the review does not give sufficient weight nor
highlight sufficiently the number of participants … RCTs in this field because conducting a large
number of very expensive RCTs with sufficient number of participants
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-protocol.pdf
June 05, 2024 - % of participants <50
years (if reported)
Text
% Female
Note … Text
Age range of included population (if
reported)
Text
% of participants ≥65 years (if … Radio Yes
No
Other
Length of followup (in years) used to
consider participants cancer free … with cancer identified
through clinical presentation (if reported
Text
N (%) of participants … N True Negatives(participants without cancer and
negative test)
N False Positives (participants
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-report-creating-efficiencies-extraction-data.pdf
August 01, 2021 - 3
abstracts to identify the first 75 randomized trials that reported on outcomes for participants … ExaCT’s extraction:
Sentence Ranking Sentence
1 Participants were randomly assigned to an experimental … cartridge”
ExaCT’s extraction:
Sentence Ranking Sentence
1 After a 7-day washout period when participants … received Peptamen 1.5 with their usual
dose of PERT products but without digestive cartridge, participants … received Peptamen 1.5 with their usual
dose of PERT products but without digestive cartridge, participants
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/management-adhd-adults-protocol-amendment.pdf
January 08, 2025 - e.g., use of a scale or checklist) and whether adverse event data were collected actively
(e.g., all participants … were asked about the occurrence of specific harms) or passively (e.g.,
participants might have reported … population included in the study to identify those with
narrow eligibility criteria, that excluded participants … with comorbidities, that had more complex
participants than typically seen in the community, and those … that had run-in periods where
adherence was tested and participants were excluded for non-adherence
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hyperactivity-disorder-protocol-amendment.pdf
January 08, 2025 - ADHD
Individuals 17 years of age or younger
unless findings are reported separately
for older participants … We will obtain all published reports providing data on a study (a study is defined
by the included participants … We will document the targeted population, abstract reported
characteristics for all participants (participants … included in the study to
identify studies with narrow eligibility criteria, studies that excluded participants … with
comorbidities, or that had more complex participants than typically seen in the community.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hyperactivity-disorder-protocol.pdf
November 10, 2024 - ADHD
Individuals 17 years of age or younger
unless findings are reported separately
for older participants … We will obtain all published reports providing data on a study (a study is defined
by the included participants … We will document the targeted population, abstract reported
characteristics for all participants (participants … included in the study to
identify studies with narrow eligibility criteria, studies that excluded participants … with
comorbidities, or that had more complex participants than typically seen in the community.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/management-adhd-adults-protocol.pdf
June 10, 2024 - e.g., use of a scale or checklist) and whether adverse event data were collected actively
(e.g., all participants … were asked about the occurrence of specific harms) or passively (e.g.,
participants might have reported … population included in the study to identify those with
narrow eligibility criteria, that excluded participants … with comorbidities, that had more complex
participants than typically seen in the community, and those … that had run-in periods where
adherence was tested and participants were excluded for non-adherence
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/white-paper-outcome-measure-harmonization-depression.pdf
November 01, 2020 - Recruitment
The American Psychiatric Association (APA) focused on recruiting sites that are existing
participants
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0365_10-28-2010.pdf
January 01, 2010 - general or specific pharmacotherapies or
psychotherapies, in addition to wait list or placebo group participants
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/registry-of-patient-registries-development_research_0.pdf
February 01, 2012 - of
the study results is necessary from an ethical standpoint to fulfill this promise to the study
participants … benefit from and impose some burdens (e.g., time to
complete surveys, risk of loss of privacy) on their participants … participating sites
Patient enrollment target
Status of enrollment (i.e., actively recruiting
participants … The project began following the Ministerial Summit on Health
Research in 2004, during which participants
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-207-ptsd-disposition-comments.pdf
May 17, 2018 - All studies included a majority of
participants with clinical PTSD and the portion who did
not had … the 2013 SR reports, for the same study, “At 6-
month follow-up, more than twice the percentage of
participants … No participants
achieved this level of relief in the fluoxetine or placebo
group.” … Participants were randomized to a multi-
component collaborative care intervention and not to
psychotherapy … None of the participants in the RCTs of
psychological interventions were blinded while all of the
participants
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout_executive-2016.pdf
January 01, 2016 - be
identified for a diagnostic test of interest, studies were also
included if some or all of the participants … Studies were excluded if participants had already been
definitively diagnosed with gout prior to enrollment … Applicability
Applicability is a measure of the extent to which the
participants, interventions, and … We reviewed 255 full-text articles, of which 234 were
excluded for the following reasons: participants … Relatively
few studies enrolled only participants with an inflamed
joint or even with suspected gout
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-cancer_research-protocol.pdf
April 20, 2015 - Performance bias
Blinding of participants and
personnel Assessments should be
made for each main … Performance bias due to knowledge of the allocated interventions by
participants and personnel during … Were participants analyzed according to their initial intervention group throughout
follow up? … Risk of bias judgment
Bias in
selection of
participants
into the study
2.1. … 6.2 Were outcome assessors unaware of the intervention received by study participants?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-harms_methods.pdf
November 01, 2008 - Data are often insufficient to assess the methods used to
select participants.
45
In addition, because … Participants are asked in structured questionnaires or interviews about the occurrence of
specific adverse … Passive surveillance of
harms
Participants are not specifically asked about or tested for the occurrence … Was the NUMBER of participants that withdrew or were lost to follow-up specified for each study group … Was the TOTAL NUMBER of participants affected by harms specified for each study arm?
14.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tympanostomy-tubes-executive-170523.pdf
May 01, 2017 - n/N (%)
Odds ratio
(95% CI)
Goldstein 2005 15689760
7/1996-6/1999
U.S.
1 year Ear plugs All Participants … 42/90 (46.7) 0.68 (0.37 – 1.25)
No precautions All Participants 46/82 (56.1) [reference]
Ear plugs … 18/30 (60.0) 0.71 (0.29 – 1.76)
Ear plugs† All Participants 13/15 (86.7) 3.10 (0.64 – 15.04)
No precautions … All Participants 42/62 (67.7) [reference]
†Randomized to the nonswimming group, but self-selected to … Across RCTs relative to KQs 1 and 2, there was universal
lack of blinding of participants and, in many
-
effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_chou_assessing_harms_when_comparing.pdf
November 01, 2008 - Data are often insufficient to assess the methods used to
select participants.
45
In addition, because … Participants are asked in structured questionnaires or interviews about the occurrence of
specific adverse … Passive surveillance of
harms
Participants are not specifically asked about or tested for the occurrence … Was the NUMBER of participants that withdrew or were lost to follow-up specified for each study group … Was the TOTAL NUMBER of participants affected by harms specified for each study arm?
14.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-cancer-risk-reduction_research.pdf
October 25, 2010 - led to differences
in the numbers reported for allocation of participants. … Participants were contacted no more than three times. … Participants were asked to
complete the questionnaire by July 16. … (Figure 3) and the numbers of participants by stakeholder
category (Table 1). … Participants were not
substantially different from non-participants.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_appendixes.pdf
March 01, 2009 - >3 months
>100
participants
Primary or
secondary breast
cancer outcomes;
other benefits … >3 months
>100
participants
Any health
outcome defined
by key question 2. … RCTS: >3
months and
>100
participants
Any measure of
treatment
adherence,
persistence, or … **Cohen, 2000, Johnston, 2000, and Jolly, 2003 include some of the same study participants. … ††Lufkin, 1998 and Nickelson, 1999 include some of the same study participants.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-reporting-bias_methods.pdf
November 01, 2013 - has halted prematurely but potentially will
resume
# Terminated: recruiting or enrolling participants … has halted prematurely and will not resume;
participants are no longer being examined or treated
# … Gender Physical gender of individuals who may participate in the protocol
Age Groups Age of participants … Countries of
Recruitment
The countries from which participants will be, are intended to be, or have … are not yet being recruited or enrolled at any site
• Recruiting: participants are currently being
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ems-blood-transfusion-draft-report-app-f.xlsx
August 18, 2025 - Did analyses include all eligible trial participants post-randomization (i.e., were not excluded)?