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effectivehealthcare-admin.ahrq.gov/products/n-1-trials/research-2014-3
August 01, 2019 - example, in research, the goal is to produce a generalizable result; any benefit gained by individual participants … Five models of n-of-1 trials
Abbreviations: IRB = Institutional Review Board, P = patients/participants … Participants will be required to mark their pain on a 10-point visual analog scale daily for 6 weeks. … At the end of each 6-week trial, participants will receive their individual results. … Informed consent of patients/participants is needed in all models of n-of-1 trials.
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effectivehealthcare-admin.ahrq.gov/products/hip-fracture-pain/research-protocol
December 01, 2019 - Even though there is a consensus that the average age of participants will be over 60 to 65 years old … nonrandomized controlled trials, cohort studies (prospective or retrospective), case-control studies
Participants … Observational study designs with no comparison group (case reports, case series, cross sectional studies)
Participants … Majority (>80%) of participants <50 years, as stated by the study investigators or evident from the … trial characteristics (e.g., mean/SD of patient population); participants with underlying pathological
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-future_research.pdf
April 01, 2013 - The Webinar participants also gave feedback on the list of gaps identified in the original
CER. … Hepatitis C virus genotypes and viral
concentratiosn in participants of a general
population survey … SVR 12
Proportion of participants with SVR 24
Number of participants with HCV RNA level >1000 IU/ … mL
Number of participants with viral breakthrough
Number of participants with viral relapse
Number … of participants with normalized alanine
aminotransferase levels
Number of participants with on-treatment
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/rotator-cuff-tear-surveillance-140925.pdf
February 01, 2014 - Males
comprised an
average of 64.6
percent of study
participants. … Males
comprised an
average of 58.9
percent of study
participants. … Males comprised an average of 64.6 percent of study
participants. … Males comprised
an average of 50 percent of participants. … Males represented 55 percent of study participants.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/osteoarthritis-knee-update-executive-170505.pdf
May 01, 2017 - If
studies reported whether their outcomes met a MCID or
reported on the percent of participants who … Many RCTs
of physical interventions reported that participants were
not or could not be blinded. … Second, published MCIDs depend on the disease
severity of the participants; the included studies often … did not report or varied widely in the disease severity of
participants. … Reported outcomes need to include the
percent of participants who experience improvement as
well as
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-1.pdf
July 01, 2019 - standard
• It is recommended to explore variability:
► Clinical intervention
► Control condition
► Participants … ► Study design
► Outcome
► Follow-up time
Heterogeneity
• Clinical heterogeneity relates to participants
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effectivehealthcare-admin.ahrq.gov/sites/default/files/assessing-the-risk-of-bias_draft-report.pdf
June 02, 2011 - matching in case-control
studies
Performance Bias Systematic differences in the care provided to participants … x x
Did the strategy for recruiting participants into the study differ across study
groups? … Participants
also recognized that many of the tools being used were not based on empirical evidence … Was the NUMBER of participants that withdrew or were lost to follow-up specified for each study group … Was the TOTAL NUMBER of participants affected by harms specified for each study arm?
14.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/diabetes-behavior-programs_disposition-comments.pdf
September 28, 2015 - from the authors’ explicit statements
for study inclusion or the clinical characteristics of
the participants … We defined usual care as the clinical management
received by all study participants, regardless of their … , study
personnel, and outcome assessors, need to add a
statement that blinding participants and study … Participants are aware of the treatment they are
receiving and it is not possible to blind the treatment … While we agree that blinding of
participants and providers is difficult, the risk of bias
still remains
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-260-improved-cancer-outcomes-disposition-comments.pdf
May 22, 2023 - We cannot recruit adequate
numbers of participants for dietary/lifestyle
interventions while requiring … biopsies, as
supposed to industry drug trials, where
participants are motivated by high monetary … given limited
resources, we focused only on randomized
controlled trials randomizing at least
50 participants … stakeholders, we chose
to focus the review on randomized controlled
trials randomizing at least 50 participants
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cerebral-palsy-feeding_research-protocol.pdf
June 12, 2012 - We anticipate that participants in studies of surgical interventions likely have
more severe feeding … and personnel)
Described all measures used, if any, to blind study
participants and personnel from … Reviewer Comments:
Performance bias due
to knowledge of the
allocated interventions
by participants … Not described in
sufficient detail
Judgment: Blinding
(participants and
personnel)
□ High … Detection
bias
Were the outcome assessors blinded to the intervention or exposure
status of participants
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/registries-forums_research_0.pdf
May 01, 2014 - Meeting participants by stakeholder group (N=73)..................................................... … Meeting participants by stakeholder group (N=73)
The in-person meeting combined presentations … Peripheral participants are those who have a sustained connection to the
community, but are less engaged … Transactional participants are individuals who occasionally interact
with the community to provide or … An in-person kickoff
meeting was held in June 2012, and participants pledged to meet again to generate
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effectivehealthcare-admin.ahrq.gov/products/deliberative-methods/presentation-2012
November 01, 2017 - Recruiting/Selecting Participants by Susan Dorr Goold in slide presentation (PDF, 116 kB) and text … Educating Session Participants by Susan Dorr Goold in slide presentation (PDF, 130 kB) or text (
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-273-anal-cancer-executive-summary.pdf
August 01, 2024 - and strength of evidence
Intervention
Comparison
Outcome Number of
Studies;
Study Design;
Participants … Low
4
Intervention
Comparison
Outcome Number of
Studies;
Study Design;
Participants
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/mhs-IV-rapid-response-patient-family-engagement.pdf
October 01, 2023 - used specific items in the
ROBINS-I tool that assess bias due to confounding, bias in selection of participants … of the included original studies
Intervention Author, Year
Study
Design
Setting Number of
Participants … IV – Patient and Family Engagement
Intervention Author, Year
Study
Design
Setting Number of
Participants … fall prevention plan.21 The Partnering
With the Patient falls program involves patients as active participants … One study that implemented an electronic patient safety dashboard noted as a
barrier that some participants
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/fiber-intake-draft-report-appendix-d.pdf
January 01, 2024 - Blind, Partic: = Blinding of participants and personnel. … XO, Equal = Was the number of participants analyzed in each crossover sequence equal or near equal?
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/arthritis-knee-physical-therapy_executive.pdf
November 01, 2012 - More than 70 percent of the participants
were female. … Body mass index (BMI) of participants
averaged 29 kg/m2. … Evidence from three RCTs with 167 participants
contributed to the pooled analyses at the longest time … Adverse events were not severe enough to deter
participants from continuing treatment. … Adverse events
were not severe enough to deter participants from
continuing treatment.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
February 01, 2012 - The CPR would be applied to participants upon their entry to the cohort,
and they would be followed … All participants were contacted 5 days before the online discussion board
was made available. … Ideally,
the study should follow participants longitudinally with multiple time points for outcome … The CPR would be applied to participants upon their entry to the cohort,
and they would be followed … When the discussion period was announced, few participants
logged onto the Web site within the first
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/pelvic-pain-therapies-future_research.pdf
January 01, 2015 - One of the strengths of our process included the constituents of the stakeholder participants. … In particular, few trials adequately concealed
treatment assignments from participants, investigators … The drop-out rate exceeded 10
percent in eight studies and more than 20 percent of participants were … The CER recommended that future studies outline and report the
diagnostic process for participants. … One of the strengths of our process included the constituents of the stakeholder
participants.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/14_substance_abuse_potential_high_impact_2012-12-11.pdf
January 01, 2012 - Participants are
required to respond to all parameters. … Combined, the portals
allow participants to update their profiles and monitor their progress before … program can be accessed and
used through the text interface alone.
3
Combined, the portals allow participants … the United States in June 2011.
2
In results of a 4-week
pilot test of the intervention with 23 participants … who were smokers, the study authors reported that
14.3% of the participants quit smoking at 4 weeks
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/rapid-review-masks-prevention-covid-version-1.pdf
December 01, 2021 - The number of participants ranged from 164 to 7,687. … Blinding of participants to the mask and other interventions (e.g., hand hygiene) was
not possible. … Participants in the trials generally
received education on preventing respiratory infection and hand … used for research purposes, but should not be considered current.
18
PICOTS
Participants … units
Interventions
N95 respirator
Medical mask
Condition
COVID-19
Outcomes
Number of participants