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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan23/hepatitis-b-virus-infection-screening-may-2014
March 15, 2013 - with no evidence of HBV immunity at screening, how effective is HBV vaccination in improving clinical outcomes … and adults with chronic HBV infection, how effective is antiviral treatment in improving intermediate outcomes … effective is education or behavioral change counseling in reducing transmission and improving health outcomes … Do improvements in intermediate outcomes improve final health outcomes? … Gold standard diagnostic test
KQ 8
No treatment
Outcomes
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/vitamin-d-calcium-combined-supplementation-primary-prevention-falls-fractures-communitydwelling-adults
April 06, 2023 - KQ 2: Incident cancer or cardiovascular disease or events; asymptomatic renal outcomes (soft-tissue … In response to comments, the USPSTF added specificity to the fall outcomes eligible for inclusion, removed … Reviewers suggested the addition of intermediate health outcomes such as bone mineral density, muscle … Reviewers also suggested that incident cancer and cardiovascular events should be eligible outcomes; … these are not included in this update because these outcomes are comprehensively addressed in the recent
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www.uspreventiveservicestaskforce.org/uspstf/methods-and-processes/uspstf-analytic-framework-child-and-adolescent-health-topics
October 01, 2017 - The influences of family and other caregivers on child and adolescent health decisions and outcomes. … Intermediate and health outcomes are depicted by rectangles. … Key Questions:
Is screening for X associated with improved health outcomes? … Are effective treatments available that make a difference in intermediate outcomes when the disease is … How strong is the association between the intermediate outcomes and final health outcomes?
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan21/chlamydia-and-gonorrhea-screening
June 15, 2013 - to reduced complications of the gonococcal or chlamydial infection and to reduced adverse pregnancy outcomes … to reduced tramsmission of the infection to the newborn, and it may lead to reduced adverse infant outcomes … 1: Reduction in:
Disease transmission
Preterm birth
Neonatal clinical outcomes … or false-positive results)
Intermediate outcomes (outcomes that are not health outcomes, such … Other comments addressed outcomes and interventions that are considered outside the scope of the USPSTF's
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan21/chlamydia-and-gonorrhea-screening-september-2014
June 15, 2013 - to reduced complications of the gonococcal or chlamydial infection and to reduced adverse pregnancy outcomes … to reduced tramsmission of the infection to the newborn, and it may lead to reduced adverse infant outcomes … 1: Reduction in:
Disease transmission
Preterm birth
Neonatal clinical outcomes … or false-positive results)
Intermediate outcomes (outcomes that are not health outcomes, such … Other comments addressed outcomes and interventions that are considered outside the scope of the USPSTF's
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/skin-cancer-counseling
June 30, 2016 - the following questions: whether counseling patients in skin cancer prevention improves intermediate outcomes … (sunburn or precursor lesions) or skin cancer outcomes (melanoma, squamous or basal cell carcinoma incidence … What is the association between skin self-examination and skin cancer outcomes (melanoma, squamous cell … , or mortality; intermediate outcomes: sunburn, nevi, and actinic keratosis
KQ 2: Behavioral outcomes … In the analytic framework, the USPSTF added “avoidance of indoor tanning” to the behavioral outcomes
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/speech-language-delay-disorders-children-age-5-years-younger-screening
January 20, 2022 - speech and language delay or disorders in children age 5 years or younger improve speech and language outcomes … , school performance, function, or quality-of-life outcomes? … speech and language delay or disorders in children age 6 years or younger improve speech and language outcomes … disorders in children age 6 years or younger improve school performance, function, or quality-of-life outcomes … No comparator, studies comparing two active interventions (i.e., comparative effectiveness)
Outcomes
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/4_pXjq7Egjwb_vjZZT-NGB
May 01, 2021 - MAIN OUTCOMES AND MEASURES Morbidity or mortality, measures of health-related
quality of life. … The questions are
depicted by linkages that relate to
interventions and outcomes. … Outcomes: Study did not have relevant outcomes or had incomplete outcomes. … Racial
disparities in adverse pregnancy outcomes and
psychosocial stress. … Preeclampsia outcomes at delivery and race.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan16/screening-for-abnormal-blood-glucose-and-type-2-diabetes
August 15, 2013 - type 2 diabetes, impaired glucose tolerance, and impaired fasting glucose for improving future health outcomes … An overarching arrow connects screening to clinical health outcomes on the far right side of the framework … Arrows lead from each of these groups to clinical health outcomes. … A dotted line represents the association between type 2 diabetes and clinical health outcomes.
… data are available on clinical health outcomes.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan16/screening-for-abnormal-blood-glucose-and-type-2-diabetes-october-2015
August 15, 2013 - type 2 diabetes, impaired glucose tolerance, and impaired fasting glucose for improving future health outcomes … An overarching arrow connects screening to clinical health outcomes on the far right side of the framework … Arrows lead from each of these groups to clinical health outcomes. … A dotted line represents the association between type 2 diabetes and clinical health outcomes.
… data are available on clinical health outcomes.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/tpsQcTR2sDok_YELXgBHFb
February 22, 2024 - reliable and valid
measures from youth self-report and the development and
validation of composite outcomes … proxies impede an accurate understanding of the
benefits of the intervention.”1
What types of outcomes … Using these outcomes, how effective are
interventions in preventing child maltreatment?
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www.uspreventiveservicestaskforce.org/uspstf/procedure-manual/procedure-manual-section-6-methods-arriving-recommendation
July 06, 2017 - Similarly, the Task Force examines composite (aggregate) outcomes carefully. … It generally asks three questions of these outcomes: 1) Are the component outcomes of similar importance … 2) Did the more or less important outcomes occur with similar frequency? … to health-related outcomes, 2) infer long-term health outcomes based on shorter-term outcomes, and 3 … Lack of evidence on important health outcomes.
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www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/procedure-manual/procedure-manual-section-6-methods-arriving-recommendation
July 06, 2017 - Similarly, the Task Force examines composite (aggregate) outcomes carefully. … It generally asks three questions of these outcomes: 1) Are the component outcomes of similar importance … 2) Did the more or less important outcomes occur with similar frequency? … to health-related outcomes, 2) infer long-term health outcomes based on shorter-term outcomes, and 3 … Lack of evidence on important health outcomes.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/prediabetes-and-type-2-diabetes-mellitus-screening
November 15, 2018 - † Other intermediate outcomes include blood pressure, lipid levels, body mass index, weight, and … Do interventions for screen-detected type 2 diabetes and prediabetes improve health outcomes compared … After interventions for prediabetes are provided, what is the magnitude of change in health outcomes … Do interventions for prediabetes improve other intermediate outcomes (blood pressure, lipid levels, BMI … Which of these screening tests * best predicts future adverse health outcomes associated with type 2
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/prediabetes-and-type-2-diabetes-screening
November 15, 2018 - † Other intermediate outcomes include blood pressure, lipid levels, body mass index, weight, and … Do interventions for screen-detected type 2 diabetes and prediabetes improve health outcomes compared … After interventions for prediabetes are provided, what is the magnitude of change in health outcomes … Do interventions for prediabetes improve other intermediate outcomes (blood pressure, lipid levels, BMI … Which of these screening tests * best predicts future adverse health outcomes associated with type 2
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/screening-for-prediabetes-and-type-2-diabetes
November 15, 2018 - † Other intermediate outcomes include blood pressure, lipid levels, body mass index, weight, and … Do interventions for screen-detected type 2 diabetes and prediabetes improve health outcomes compared … After interventions for prediabetes are provided, what is the magnitude of change in health outcomes … Do interventions for prediabetes improve other intermediate outcomes (blood pressure, lipid levels, BMI … Which of these screening tests * best predicts future adverse health outcomes associated with type 2
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/aspirin-use-to-prevent-preeclampsia-and-related-morbidity-and-mortality-preventive-medication1
June 20, 2019 - Systematically Reviewed
Does aspirin reduce adverse maternal, perinatal, child, or combined health outcomes … Does the effectiveness of aspirin for reducing adverse health outcomes vary by subpopulations defined … (e.g., nonaspirin medication, dietary supplements, dietary change, bed rest, or weight loss)
Outcomes … Maternal outcomes:
Preeclampsia
Hemolysis, elevated liver enzymes, and low platelet count (HELLP … Postpartum hemorrhage
Gastrointestinal complications (e.g., bleeding ulcer)
Fetal/neonatal/child outcomes
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan23/hepatitis-b-virus-infection-screening-nonpregnant-adolescents-adults-may-2014
March 15, 2013 - with no evidence of HBV immunity at screening, how effective is HBV vaccination in improving clinical outcomes … and adults with chronic HBV infection, how effective is antiviral treatment in improving intermediate outcomes … effective is education or behavioral change counseling in reducing transmission and improving health outcomes … Do improvements in intermediate outcomes improve final health outcomes? … Gold standard diagnostic test
KQ 8
No treatment
Outcomes
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/perinatal-depression-interventions-to-prevent
June 01, 2023 - limited to no more than 15 minutes of information)
Placebo required for medication trials
Outcomes … KQ 1:
Maternal health outcomes:
Depression incidence or symptoms (required)
Suicide deaths … including psychiatric hospital admissions
Marital discord and family function
Infant/child health outcomes … due to adverse events in trials of treatment benefit
KQ 1: Maternal behavioral intermediate outcomes … comment, the Research Plan was revised to clarify the list of included and excluded maternal health outcomes
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary29/hepatitis-b-virus-infection-screening-may-2014
May 27, 2014 - outcomes? … outcomes? … No studies with evidence on long-term clinical outcomes
No evidence on long-term clinical outcomes … in health outcomes? … outcomes?