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www.uspreventiveservicestaskforce.org/uspstf/procedure-manual/procedure-manual-appendix-xii-summary-evidence-table-evidence-reviews
July 01, 2017 - stratification, most likely for large bodies of evidence with pooled data available for different types of outcomes … of the strength of evidence for the key question should be outcome-specific when multiple critical outcomes … Outcome-specific threats to validity may be reported when there are sufficient data and outcomes are … vulnerable subpopulations, lack of replication of interventions, or nonreporting of patient-important outcomes
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www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/procedure-manual/procedure-manual-appendix-xii-summary-evidence-table-evidence-reviews
July 01, 2017 - stratification, most likely for large bodies of evidence with pooled data available for different types of outcomes … of the strength of evidence for the key question should be outcome-specific when multiple critical outcomes … Outcome-specific threats to validity may be reported when there are sufficient data and outcomes are … vulnerable subpopulations, lack of replication of interventions, or nonreporting of patient-important outcomes
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/SJbAXUAQTv2GWemMuBab6W
April 08, 2025 - MAIN OUTCOMES AND MEASURES Child and maternal health outcomes, prevalence, and
duration of any and exclusive … Benefits on Health Outcomes
Key Question 1. … Benefits on Breastfeeding Outcomes
Key Question 2. … :
Study did not report relevant
outcomes. … 19 RCTs (n = 11 175) Good: 5
Fair: 14
Infant health outcomes variably
reported
Most outcomes based on
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/7K93Ldpe86aLuGS65CPKYp
July 01, 2005 - We do not know the best
way to identify children who are at risk for future adverse health outcomes … Once we identify children at increased risk for adverse health outcomes related to excess
weight, we … What we don’t know overwhelms what we do know about prevention of
the adverse outcomes associated with … Arrow 4: Do interventions lead to improved intermediate outcomes, including behavioral, physiologic or … Arrow 4: Do interventions lead to improved intermediate outcomes, including behavioral, physiologic or
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/cardiovascular-disease-risk-screening-with-electrocardiography
July 14, 2016 - ) of whether screening with resting or exercise ECG in asymptomatic adults leads to improved health outcomes … Health outcomes include all-cause mortality, cardiovascular mortality, and cardiovascular events. … of CVD may receive preventive medications or lifestyle counseling, which may lead to improved health outcomes … Does the addition of screening with resting or exercise electrocardiography (ECG) improve health outcomes … Does improvement in health outcomes vary for subgroups defined by baseline CVD risk (e.g., low, intermediate
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary23/iron-deficiency-anemia-in-young-children-screening
March 30, 2015 - Five of 6 trials sparsely reporting various growth outcomes found no clear benefit of supplementation … However, these studies had methodologic flaws; 4 for example, the outcomes examined were varied and … outcomes; and diagnosis of developmental delay), mortality, and quality of life. … Although not clearly clinical outcomes, developmental test scores after follow-up periods of 3 to 12 … were included for developmental test score outcomes, and 10 trials were included for hematological outcomes
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/depression-screening-2002
May 07, 2002 - Many trials lacked power to detect clinically important differences in outcomes. … Is treatment of depression in primary care patients effective in improving outcomes? … Neither Moore and colleagues nor Linn and Yager reported clinical outcomes. … Clinical outcomes were not measured. … Recognition, management, and outcomes of depression in primary care.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/hepatitis-c-screening
March 02, 2020 - Main Outcomes and Measures: Mortality, morbidity, quality of life, screening and treatment harms, and … SVR and Health Outcomes
Key Question 9. … Direct evidence on the effects of antiviral therapy on clinical outcomes is limited. … link between SVR and clinical outcomes with current DAA therapies. … The questions are depicted by linkages that relate interventions and outcomes.
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/prevention-human-immunodeficiency-virus-hiv-infection-prep
November 04, 2021 - *Harms also include renal dysfunction, adverse effects on bone, pregnancy-related outcomes … and what is the effect of infection with PrEP-related, antiretroviral drug–resistant HIV on treatment outcomes … , 5: TDF-FTC (for TAF-FTC or cabotegravir)
KQ 3: Reference standard for HIV infection
Outcomes … transmitted infections, risk of hepatitis C virus, renal insufficiency, fracture, and pregnancy-related outcomes … ; for KQ 2, lipid parameters and weight gain
KQ 3: Diagnostic accuracy measures
Outcomes not listed
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/perinatal-depression-interventions-to-prevent
February 23, 2023 - Do interventions to prevent perinatal depression improve health outcomes … limited to no more than 15 minutes of information)
Placebo required for medication trials
Outcomes … KQ 1:
Maternal health outcomes:
Depression incidence or symptoms (required)
Suicide deaths … functioning
Psychiatric hospital admissions
Marital discord and family function
Infant/child health outcomes …
Withdrawals due to adverse events in trials of treatment benefit
KQ 1: Maternal behavioral outcomes
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/sexually-transmitted-infections
January 16, 2025 - States contribute to inequities in STI risk, and how can they be addressed to improve sexual health outcomes … promotion, or nutrition education)
Active intervention (i.e., comparative effectiveness)
Outcomes … KQ 1 (Health outcomes) :
STI incidence (based on testing/biologic confirmation)
Mortality and … quality of life
STI-related health outcomes, including cancers, reproductive complications, perinatal … or neonatal morbidity/mortality, and mental health
KQ 2 (Behavioral outcomes):
Changes in
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/WGyw9FcXJDcAM_Uj_uwPBW
January 01, 2001 - Indirect
Pathway†
Type of
Gap‡
Study
Characteristics Population
Intervention/
Comparison
Outcomes … effectiveness and
harms of primary
care–based oral
health screening
strategies on oral
health outcomes … Indirect
Pathway†
Type of
Gap‡
Study
Characteristics Population
Intervention/
Comparison
Outcomes … ) of
oral health
examinations
and risk
Overall test
performance
in identifying
adults with
outcomes … Indirect
Pathway†
Type of
Gap‡
Study
Characteristics Population
Intervention/
Comparison
Outcomes
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/syphilis-infection-nonpregnant-adults-adolescents-1
November 19, 2020 - or diagnosis of infection)
KQs 1, 3: No comparator or alternate screening test/algorithm
Outcomes … identification of infection
KQ 3: Harms from screening (e.g., stigma, sequelae of test inaccuracy)
KQ 1: Outcomes … that are not directly related to health outcomes (e.g., laboratory studies); cost-effectiveness or cost-related … outcomes
Setting
Primary care and primary care–relevant settings (e.g., school-based clinics
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/healthful-diet-and-physical-activity-for-cardiovascular-disease-prevention-in-adults-without-known-risk-factors-behavioral-counseling
July 11, 2017 - Main Outcomes and Measures: Cardiometabolic health and intermediate outcomes, behavioral outcomes, and … For intermediate health outcomes (KQ2) and behavioral outcomes (KQ3), random-effects meta-analyses using … test 19 (for dichotomous outcomes) were used. … Circ Cardiovasc Qual Outcomes. 2008;1(2):98-106. … Outcomes: Study did not have relevant outcomes or had incomplete outcomes.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/healthful-diet-and-physical-activity-for-cardiovascular-disease-prevention-in-adults-without-known-risk-factors-behavioral-counseling-july-2017
July 11, 2017 - Main Outcomes and Measures: Cardiometabolic health and intermediate outcomes, behavioral outcomes, and … For intermediate health outcomes (KQ2) and behavioral outcomes (KQ3), random-effects meta-analyses using … test 19 (for dichotomous outcomes) were used. … Circ Cardiovasc Qual Outcomes. 2008;1(2):98-106. … Outcomes: Study did not have relevant outcomes or had incomplete outcomes.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/bMkXJkhy-AKqc4QYxvvYH8
January 01, 2001 - that screening and treatment of BV in
asymptomatic women who are not at high risk does not improve
outcomes … Be-
cause BV may be a marker for adverse pregnancy
outcomes, rather than a causative factor, controlled … trials have been conducted to determine whether treat-
ing BV will also improve pregnancy outcomes. … (The USPSTF found at least
fair evidence that [the service] can improve health outcomes but concludes … Poor: Evidence is insufficient to assess the effects on health outcomes because of limited number or
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/primary-open-angle-glaucoma-screening
May 24, 2022 - leads to improvements in health outcomes. … (such as changes in the optic nerve or IOP) result in improved health outcomes. … tangible health outcomes for patients. … (visual impairment, vision-related function, quality of life, and other patient-reported outcomes). … Limited evidence that improvement in intermediate outcomes leads to improvements in health outcomes
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/type2-diabetes-children-adolescents-screening
July 30, 2020 - 2 diabetes mellitus (T2DM) and prediabetes in asymptomatic children and adolescents improves health outcomes … Do interventions for screen-detected T2DM and prediabetes provide an incremental benefit in health outcomes … Do interventions for recently diagnosed T2DM improve health outcomes compared with no intervention, usual … After interventions for prediabetes are provided, what is the magnitude of change in health outcomes … Does screening for prediabetes or T2DM change the intermediate outcomes of hemoglobin A1c, fasting plasma
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/prediabetes-type2-diabetes-children-adolescents-screening
July 30, 2020 - 2 diabetes mellitus (T2DM) and prediabetes in asymptomatic children and adolescents improves health outcomes … Do interventions for screen-detected T2DM and prediabetes provide an incremental benefit in health outcomes … Do interventions for recently diagnosed T2DM improve health outcomes compared with no intervention, usual … After interventions for prediabetes are provided, what is the magnitude of change in health outcomes … Does screening for prediabetes or T2DM change the intermediate outcomes of hemoglobin A1c, fasting plasma
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/peripheral-artery-disease-in-adults-screening-with-the-ankle-brachial-index
June 16, 2016 - when used in addition to traditional CVD risk factors, 2) CVD risk reclassification, and 3) CVD health outcomes … screen-detected or generally asymptomatic adults with PAD or abnormal ABI improves the patient health outcomes … or generally asymptomatic adults * with PAD or an abnormal ABI † lead to improved patient health outcomes … (for screening and treatment)
Intermediate cardiovascular outcomes (e.g., blood pressure, cholesterol … Second, all of the PAD morbidity outcomes (e.g., impaired ambulation or amputation) and CVD outcomes