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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/aspirin-use-to-prevent-preeclampsia-and-related-morbidity-and-mortality-preventive-medication1
June 20, 2019 - Systematically Reviewed
Does aspirin reduce adverse maternal, perinatal, child, or combined health outcomes … Does the effectiveness of aspirin for reducing adverse health outcomes vary by subpopulations defined … (e.g., nonaspirin medication, dietary supplements, dietary change, bed rest, or weight loss)
Outcomes … Maternal outcomes:
Preeclampsia
Hemolysis, elevated liver enzymes, and low platelet count (HELLP … Postpartum hemorrhage
Gastrointestinal complications (e.g., bleeding ulcer)
Fetal/neonatal/child outcomes
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/4_pXjq7Egjwb_vjZZT-NGB
May 01, 2021 - MAIN OUTCOMES AND MEASURES Morbidity or mortality, measures of health-related
quality of life. … The questions are
depicted by linkages that relate to
interventions and outcomes. … Outcomes: Study did not have relevant outcomes or had incomplete outcomes. … Racial
disparities in adverse pregnancy outcomes and
psychosocial stress. … Preeclampsia outcomes at delivery and race.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan99/celiac-disease-screening
November 03, 2014 - on clinical health outcomes. … Clinical health outcomes include mortality and morbidity, such as cancer incidence, gastrointestinal … outcomes, mood and anxiety disorders, child growth outcomes, health outcomes resulting from nutritional … or severe anemia [i.e., requiring treatment]), gastrointestinal outcomes (e.g., diarrhea, cramping, … bloating), cancer incidence, mood and anxiety disorders, child growth outcomes, infection rates, and
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/prediabetes-and-type-2-diabetes-mellitus-screening
November 15, 2018 - † Other intermediate outcomes include blood pressure, lipid levels, body mass index, weight, and … Do interventions for screen-detected type 2 diabetes and prediabetes improve health outcomes compared … After interventions for prediabetes are provided, what is the magnitude of change in health outcomes … Do interventions for prediabetes improve other intermediate outcomes (blood pressure, lipid levels, BMI … Which of these screening tests * best predicts future adverse health outcomes associated with type 2
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/prediabetes-and-type-2-diabetes-screening
November 15, 2018 - † Other intermediate outcomes include blood pressure, lipid levels, body mass index, weight, and … Do interventions for screen-detected type 2 diabetes and prediabetes improve health outcomes compared … After interventions for prediabetes are provided, what is the magnitude of change in health outcomes … Do interventions for prediabetes improve other intermediate outcomes (blood pressure, lipid levels, BMI … Which of these screening tests * best predicts future adverse health outcomes associated with type 2
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/screening-for-prediabetes-and-type-2-diabetes
November 15, 2018 - † Other intermediate outcomes include blood pressure, lipid levels, body mass index, weight, and … Do interventions for screen-detected type 2 diabetes and prediabetes improve health outcomes compared … After interventions for prediabetes are provided, what is the magnitude of change in health outcomes … Do interventions for prediabetes improve other intermediate outcomes (blood pressure, lipid levels, BMI … Which of these screening tests * best predicts future adverse health outcomes associated with type 2
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/kHT3WGUaG2wTz2pF_ke7bn
January 14, 2025 - Direct/
Indirect
Pathway† Type of Gap Study Characteristics Population
Intervention/
Comparison Outcomes … Direct/
Indirect
Pathway† Type of Gap Study Characteristics Population
Intervention/
Comparison Outcomes … Direct/
Indirect
Pathway† Type of Gap Study Characteristics Population
Intervention/
Comparison Outcomes … the femoral neck (T-
scores based on
NHANES III reference
range) or lumbar spine
Discrimination outcomes … Direct/
Indirect
Pathway† Type of Gap Study Characteristics Population
Intervention/
Comparison Outcomes
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/UXw277rnvJ8e_Dfsh4V3K3
July 26, 2022 - For intermediate health outcomes (KQ2) and behavioral
outcomes (KQ3), random-effects meta-analyses were … Benefits on Intermediate CVD Outcomes
Key Question 2. … : Study did not report relevant outcomes. … 15 (13)
2: Intermediate outcomes 43 (38)
3: Behavioral outcomes 109 (97)
4: Harms 23 (20)
Study … Third, given that behavioral outcomes were the
primary outcomes in almost all the included studies, there
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/rQBBkz9CrHh4vp7ZnEkF-t
July 18, 2023 - MAIN OUTCOMES AND MEASURES Health outcomes, diagnostic yield, intermediate outcomes,
behavioral outcomes … Outcomes for treatment ben-
efits included health outcomes (myocardial infarction, ischemic
stroke, cardiovascular … Outcomes: Study did not have relevant outcomes or had incomplete outcomes. … No treatment trials reported long-term
health outcomes. … outcomes, and mixed results for dietary outcomes (eTable 7 in the
Supplement).73
Multifactorial Dyslipidemia
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/gestational-diabetes-screening
August 10, 2021 - Main Outcomes and Measures: Pregnancy, fetal/neonatal, and long-term health outcomes; harms of screening … Findings are sparse for long-term health outcomes from treatment and for all outcomes from early treatment … : No data
Pregnancy outcomes: Consistency unknown; some imprecision
Fetal/neonatal outcomes: Consistency … unknown; some imprecision
Long-term outcomes: No data
No concerns
Pregnancy outcomes: Low association … /neonatal outcomes: Low for no significant association for all outcomes
Long-term outcomes: No data
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/tpsQcTR2sDok_YELXgBHFb
July 23, 2024 - reliable and valid
measures from youth self-report and the development and
validation of composite outcomes … proxies impede an accurate understanding of the
benefits of the intervention.”1
What types of outcomes … Using these outcomes, how effective are
interventions in preventing child maltreatment?
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/low-dose-aspirin-use-for-the-prevention-of-morbidity-and-mortality-from-preeclampsia-preventive-medication
September 26, 2019 - Does the effectiveness of aspirin for reducing adverse health outcomes vary by subpopulations defined … (e.g., nonaspirin medication, dietary supplements, dietary change, bed rest, or weight loss)
Outcomes … Maternal outcomes:
Preeclampsia; preeclampsia with severe features
Hemolysis, elevated liver … Postpartum hemorrhage
Gastrointestinal complications (e.g., bleeding ulcer)
Fetal/neonatal/child outcomes … clinically important categories to define preeclampsia and preterm birth to more fully represent health outcomes
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www.uspreventiveservicestaskforce.org/uspstf/sites/default/files/inline-files/prevmethods.pdf
December 01, 2010 - focuses on specific diseases, well-defined preventive interventions,
and evidence of improved health outcomes … ; older adults are not often rep-
resented in clinical trials; and important outcomes may not be
measured … Often, these are discrete and well-understood
outcomes, such as all-cause or cause-specific mortality … , including im-
provements of global health outcomes, such as quality of
life. … Analytic framework for USPSTF review on interventions to reduce falls and fall-related outcomes.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/healthy-lifestyle-and-physical-activity-for-cvd-prevention-adults-without-known-risk-factors-behavioral-counseling
July 26, 2022 - For intermediate health outcomes (KQ2) and behavioral outcomes (KQ3), random-effects meta-analyses were … Benefits on Intermediate CVD Outcomes
Key Question 2. … Third, given that behavioral outcomes were the primary outcomes in almost all the included studies, there … : Study did not report relevant outcomes. … 15 (13)
2: Intermediate outcomes
43 (38)
3: Behavioral outcomes
109 (97)
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/gestational-diabetes-screening
August 10, 2021 - Few trials examined longer-term maternal or childhood outcomes. … More studies that report on maternal health outcomes, especially hypertension and preeclampsia. … Hyperglycemia and adverse pregnancy outcomes. N Engl J Med . 2008;358(19):1991-2002. … Hyperglycaemia and risk of adverse perinatal outcomes: systematic review and meta-analysis. … Effect of treatment of gestational diabetes mellitus on pregnancy outcomes.
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/weight-management-children-adolescents-interventions
February 10, 2022 - management interventions for children and adolescents with higher body mass index (BMI) improve health outcomes … combined weight management interventions for children and adolescents with higher BMI affect weight outcomes … or cardiometabolic outcomes? … focused on healthy lifestyle, as this is too similar to intervention programs for weight loss
Outcomes … Health outcomes:
Control groups with no intervention (e.g., wait-list control, usual care), minimal
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/high-body-mass-index-children-adolescents-interventions
February 10, 2022 - management interventions for children and adolescents with higher body mass index (BMI) improve health outcomes … combined weight management interventions for children and adolescents with higher BMI affect weight outcomes … or cardiometabolic outcomes? … focused on healthy lifestyle, as this is too similar to intervention programs for weight loss
Outcomes … Health outcomes:
Control groups with no intervention (e.g., wait-list control, usual care), minimal
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan37/vitamin-d-deficiency-screening
March 24, 2014 - What is the association between serum 25-hydroxyvitamin D levels and health outcomes? … What is the effect of vitamin D (with or without calcium) on intermediate outcomes (e.g., blood pressure … KQs 1, 3: Health outcomes include:
Decreased morbidity from osteoporosis/fractures, falls, … include:
Mortality
Renal outcomes (e.g., stones)
Soft tissue calcification
Adverse events … )
Intermediate physiological outcomes (examined as contextual question)
Behavioral changes (e.g.,
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan37/vitamin-d-deficiency-screening-november-2014
March 24, 2014 - What is the association between serum 25-hydroxyvitamin D levels and health outcomes? … What is the effect of vitamin D (with or without calcium) on intermediate outcomes (e.g., blood pressure … KQs 1, 3: Health outcomes include:
Decreased morbidity from osteoporosis/fractures, falls, … include:
Mortality
Renal outcomes (e.g., stones)
Soft tissue calcification
Adverse events … )
Intermediate physiological outcomes (examined as contextual question)
Behavioral changes (e.g.,
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www.uspreventiveservicestaskforce.org/apps/gradedef.jsp
July 01, 2012 - These studies assess the effects of the
preventive service on health outcomes. … More information may allow estimation of effects on health outcomes … The USPSTF found at least fair
evidence that [the service] improves important health outcomes … Fair: Evidence is sufficient to determine effects on health outcomes, but the strength of the evidence … Poor: Evidence is insufficient to assess the effects on health outcomes because of limited number or