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effectivehealthcare.ahrq.gov/sites/default/files/pdf/research-protocol-osteoporosis_2.pdf
October 05, 2018 - Intervention Comparator Health
Outcomes &
Harms
Timing Setting Study Design
KQ 1:
Long-term … for efficacy, but
will only look at
predictors for
incident fracture
outcomes … )
>3 yr Any KQ 1 & 2:
RCT, CCT
6
KQ Population Intervention Comparator Health
Outcomes … for efficacy, but
will only look at
predictors for
incident fracture
outcomes … outcomes.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-update_research-protocol.pdf
December 23, 2014 - Outcomes Sensitivity
Specificity
Predictive values
Time-to-results
Patient outcomes
Health system … outcomes
Timing Time to test results
For patient or health system outcomes: no
specific time … We will emphasize patient-centered outcomes in the evidence synthesis. … Were outcomes
assessors blinded?
Yes Who assessed outcomes? … Yes
No Not all prespecified outcomes
reported, subscales not prespecified
reported, outcomes
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-principles_methods.pdf
August 01, 2009 - clear
what surrogate outcomes may represent them and what bodies of evidence link the surrogate
outcomes … to health outcomes. … • Focus on intermediate or surrogate outcomes. … but do not compare the outcomes among different treatments … Formularies,
therapeutics, and outcomes: new opportunities.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-fracture-pain_research-protocol.pdf
December 09, 2009 - Other outcomes
include:
a. Mortality (30 day and up to 1-year postfracture)
b. … • Outcomes for each question:
For KQ1, the measurement of pain will be measured using a validated … Primary outcomes:
• Acute pain
• Chronic pain
Secondary outcomes:
• Mortality
• Functional status … Clinical outcomes and treatment of hip fractures. Am J Med 1997;103:51S-
63S.
9. … Pain management after total joint replacement and its impact on
patient outcomes.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/mrsa-screening-2010_executive.pdf
January 01, 2010 - Three studies reported outcomes that addressed Key
Question 1, 2 studies reported outcomes that addressed … Key Question 2, 14 studies reported outcomes that
addressed Key Question 3A, 18 studies reported outcomes … studies reported outcomes that addressed Key Question 4. … Healthcare-associated outcomes are the primary outcomes
of interest because screening for MRSA carriage … are the outcomes of interest.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-loss-surgery_disposition-comments.pdf
June 05, 2013 - ES-6: Please clarify outcomes and time frame for the following
statement:
• Short-term outcomes: There … We agree
that such outcomes are not as useful as outcomes that
have a precise definition, and so state … Still, we can
only discuss the outcomes that the studies provide. … This affects both reported weight loss
and health outcomes, as well as complication/side-effect
outcomes … These peptide outcomes were not a focus of this review.
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effectivehealthcare.ahrq.gov/sites/default/files/pregnancy_hi_impact.pdf
January 01, 2012 - Director Director, Center for Outcomes and Evidence
Agency for Healthcare Research and Quality Agency … Task Order Officer
Center for Outcomes and Evidence
Agency for Healthcare Research and Quality … Overall High Impact Potential: Cell-phone-based educational program to
improve outcomes for pregnant … One health
systems expert commented: “Receiving text messages will unlikely change outcomes. … Donor human milk and
neurodevelopmental outcomes in very low
birthweight (VLBW) infants.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_research-protocol.pdf
March 13, 2012 - Predictive outcomes reflect the rate of response
to adjuvant chemotherapy. … Clinical utility should reflect patient outcomes such as
improved survival. … did those assessing outcomes know the results of GEP
testing? … predicted outcomes in patients with stage II colon cancer? … Impact of Gene Expresion
Profiling Tests on Breast Cancer Outcomes.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-3.pdf
February 01, 2018 - random effects models are generally recommended,
with some special considerations (e.g., rare binary outcomes … PMID: 11252006. http://dx.doi.org/10.1002/sim.650
Rare binary outcomes
• For rare binary events ( … Rare binary outcomes
9. Fleiss J. The statistical basis of meta-analysis. … attractive properties for meta-analyses
of rare binary outcome data.11
► This model assumes that outcomes … Rare binary outcomes
Rare binary outcomes
Rare binary outcomes
Bayesian methods
Summary of objective
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/insomnia_research-protocol.pdf
April 03, 2014 - Treatments can potentially improve secondary patient-centered outcomes such as
mood and well-being, … Outcomes
KQ1
Primary patient-centered outcomes
• Patient-reported sleep and/or distress/dysfunction … We will summarize included study characteristics and outcomes in evidence tables. … Grading the Strength of Evidence (SOE) for Individual Comparisons and
Outcomes. … Measuring outcomes in
randomized clinical trials of insomnia
treatments.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/insomnia_protocol-140716.pdf
April 03, 2014 - Treatments can potentially improve secondary patient-centered outcomes such as
mood and well-being, … Outcomes
KQ1
Primary patient-centered outcomes
• Patient-reported sleep and/or distress/dysfunction … We will summarize included study characteristics and outcomes in evidence tables. … Grading the Strength of Evidence (SOE) for Individual Comparisons and
Outcomes. … Measuring outcomes in included studies.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/field-triage-glascow_research-protocol.pdf
February 25, 2016 - Outcomes also
could be influenced by time of assessment, as an accurate earlier assessment could lead … However, information on clinical outcomes is often lacking and
decisions about their use must often … How do effects on clinical outcomes vary according to patient age or other
patient characteristics ( … Key Question 3 addresses
the impact of the tGCS compared with the mCGS on clinical outcomes. … mGCS
KQ1
Final health
outcomes
Mortality
Morbidity
Quality of life
KQ 3
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/crohns-disease_research-protocol.pdf
September 01, 2010 - The patient-reported outcomes will also help patients and caregivers to take into
consideration the … Patient-reported outcomes by remission and medication status will be measured by
standard quality of … , adverse events, and patient-reported outcomes. … □ For two outcomes will include all levels of evidence (including case reports). … Outcomes □ We will exclude studies that do not apply to the key questions.
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effectivehealthcare.ahrq.gov/sites/default/files/calcineurin-inhibitor_disposition-comments.pdf
March 15, 2016 - CNI withdrawal studies in general
have shown the same outcomes regardless of agent,
i.e. increased … The outcomes measurements were appropriate. … The key
outcomes to each question are well developed, clear
and concise. … only a subset
of all the important clinical
outcomes that should ideally
be measured. … real world outcomes data remains to be seen.
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effectivehealthcare.ahrq.gov/sites/default/files/s149.pdf
October 01, 2007 - longi-
tudinal treatments that uses subclassification on a longitudinal pro-
pensity score to compare outcomes … Incomplete adherence complicates the ability to
study outcomes, as outcomes are generally related to … Potential Outcomes and Goal
The times where a treatment can change are denoted by
t � 1, 2, . . . … We wish to
compare outcomes among such possible longitudinal treat-
ments, for example, with z � 1, 1 … Estimate expected outcomes in observed longitudinal
treatment groups of interest.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_executive.pdf
September 01, 2011 - Health-related 22 Low 1 fair trial: There were no differences
ECT + rTMS outcomes between groups in … Instead, we determined mean average outcomes for
pharmacologic treatments. … Health-Related Outcomes of
Nonpharmacologic Treatments (KQ 6)
Direct evidence. … Measured outcomes on the whole reflected the most
important clinical outcomes for depression measures … in TRD, and
ECT produced better outcomes than pharmacotherapy.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/catd-protocol-draft_0.pdf
November 02, 2018 - such as changes in BPSD, patient quality of life,
and caregiver outcomes. … : >24 weeks
KQ 4-6: BPSD and harms outcomes: >2 weeks for outcomes of agitation/aggression,
psychosis … Table 1 All harms
outcomes were in
one list. … This change to categorize harms outcomes was made for clarification. … All these were eliminated
as possible behavioral
outcomes.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_overview.pdf
June 24, 2014 - antilipid treatment)
compared to renal artery angioplasty with stent placement on long-term clinical
outcomes … clinical, imaging, laboratory, and anatomic characteristics are associated with
improved or worse outcomes … What treatment variables are associated with improved or worse outcomes of renal
artery angioplasty … renal-artery stenting, when added to protocol-
driven contemporary medical therapy, improves clinical outcomes
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-loss-surgery_executive.pdf
June 01, 2013 - The evidence for both short- and
long-term outcomes was assessed. … Short-Term Outcomes
Based primarily on glucose control outcomes, there is
moderate strength evidence … Strength of evidence for cholesterol and blood
pressure outcomes is low. … Outcomes for such patients may not
reflect the outcomes achieved in the wider community. … The study we identified
reported outcomes at 6 to 12 months.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-adherence_research-protocol.pdf
September 13, 2011 - We
hypothesize that the treatment adherence interventions improve these outcomes.
2. … We will also explore the association between differential adherence levels and health
outcomes. … We will undertake meta-analyses of studies where appropriate for the outcomes listed below. … Antiplatelet therapy in diabetic ischemic stroke
patients: associated factors and outcomes. … Outcomes of treatment for hepatitis C virus infection
by primary care providers.