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effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-pain-opioid-treatment_research-protocol.pdf
December 19, 2013 - the comparative effectiveness of short- plus
long-acting opioids vs. long-acting opioids alone on outcomes … In patients with chronic pain, what is the effectiveness of use of risk prediction
instruments on outcomes … related to trauma, injury, or overdose: any duration
• For other outcomes: >1 year
• Settings: … Meta-analyses will be conducted to summarize data and obtain more precise
estimates on outcomes for … Results will be presented as structured by the key questions, and any
prioritized outcomes will be
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-behavior-programs_research-protocol.pdf
June 05, 2014 - of life) and
objective outcomes (e.g., HbA1C). … Outcomes of interest were finalized with input from the TEP and are listed in the PICOTS. … We will analyze outcomes at different post-intervention
time points. … ; normal for continuous outcomes), link function
(e.g., logit for binomial outcomes; identify for continuous … Association of health literacy with diabetes
outcomes. JAMA. 2002;288(4):475-82.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/hypertension-pulmonary-arterial_research-protocol.pdf
January 30, 2013 - • Does use of echocardiography and biomarkers affect decisionmaking and clinical
outcomes? … Patient outcome efficacy:
Intermediate-term outcomes
Hemodynamic parameters such as pulmonary … • KQ 1: Test-associated outcomes: Diagnostic
accuracy efficacy (sensitivity, specificity,
positive … of
interest are reported
Outcomes
(safety)
• KQs 1 and 2: Adverse effects of
echocardiography … (intermediate outcomes, health outcomes, and safety outcomes).
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/acs-pci-adjunctive-devices_research-protocol.pdf
July 01, 2010 - 39 percent.1,2
Numerous adjunctive devices have been developed in an attempt to improve clinical
outcomes … It is a logic chain that supports the link from the
intervention to the outcomes of interest. … For dichotomous
outcomes, weighted averages will be reported as relative risks and risk differences … Intermediate end points, brief followup
periods, improper definitions for
outcomes, composite end … points
Outcomes (benefits and harms)
and how they were defined
Settings Settings where standards
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-topic-refinement_methods.pdf
January 01, 2013 - , and final health outcomes). … o Outcomes (benefits and harms). … Outcomes
• Specify by KQ if relevant.
Intermediate outcomes
1. … -KQ: See refined KQ 1
(patient-centered outcomes)
and KQ 2 (intermediate
outcomes). … KQ3: Is improvement with other outcomes associated with improvement in health outcomes?
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/labor-dystocia_research-protocol.pdf
July 28, 2016 - The final KQs are:
KQ 1: Do delivery outcomes for management of abnormal labor differ based on the … PICOTS (population, interventions, comparators, outcomes, timing, and settings) for each
KQ are listed … (intermediate, final, and
adverse events outcomes). … Defining an abnormal first stage of
labor based on maternal and neonatal outcomes. … Contemporary patterns of spontaneous
labor with normal neonatal outcomes.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-bias_methods.pdf
February 01, 2013 - Outcome
Described as
effectiveness
outcomes
Reviewers determine whether
specific outcomes are … outcomes, thus making the
intervention seem more effective than
if clinical outcomes are considered … Without prespecifying that long term
outcomes are essential and only
reporting short term outcomes, … Outcomes
Regardless of the topic, SRs should focus on assessing a range of patient-centered outcomes … , while under-reporting the effect on long term outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/grading.ppt
January 01, 2013 - the CER process include developing stating key questions, analytic frameworks, identifying critical outcomes … bodies of evidence are needed to link the intervention to health outcomes. … /proxy outcomes
Better strength of evidence
Indirect (e.g., A vs. … Thus, strength of evidence should relate to those important outcomes. … For some treatments, data may be lacking about one or more of the outcomes.
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effectivehealthcare.ahrq.gov/sites/default/files/tympanostomy-tubes-disposition.pdf
May 05, 2017 - of
these outcomes was not performed. … Short term outcomes, if
reported, were not excluded. … Short term outcomes, if reported, were not
excluded. … We do not
distinguish primary and secondary outcomes. … We do not
distinguish primary and secondary outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tympanostomy-tubes-disposition.pdf
May 05, 2017 - of
these outcomes was not performed. … Short term outcomes, if
reported, were not excluded. … Short term outcomes, if reported, were not
excluded. … We do not
distinguish primary and secondary outcomes. … We do not
distinguish primary and secondary outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/methodsguidenorris_060420101.pdf
June 01, 2010 - Association between unreported outcomes and
effect size estimates in Cochrane meta-analyses. … Directness Whether the RCT evidence links the
interventions directly to health outcomes. … The important outcomes are usually health
outcomes such as coronary events or mortality,
but the available … data are often surrogate,
intermediate, or physiologic outcomes. … Are long-term outcomes similar to short-term outcomes?
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effectivehealthcare.ahrq.gov/sites/default/files/cer30_hip-fracture-pain-executive-summary_20110517.pdf
May 01, 2011 - KQ 2: Other outcomes. … KQ 2: Other outcomes. … KQ 2: Other outcomes. … KQ 2: Other outcomes. No other outcomes were
reported.
KQ3: Adverse effects. … Outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-observational-studies_methods.pdf
June 01, 2010 - Association between unreported outcomes and
effect size estimates in Cochrane meta-analyses. … Directness Whether the RCT evidence links the
interventions directly to health outcomes. … The important outcomes are usually health
outcomes such as coronary events or mortality,
but the available … data are often surrogate,
intermediate, or physiologic outcomes. … Are long-term outcomes similar to short-term outcomes?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_research-protocol.pdf
November 30, 2011 - The issue of adherence to antiviral treatment and outcomes was considered and discussed by
AHRQ. … Intermediate outcomes,
such as viremia and histologic changes, and ultimate health outcomes, such as … How does the comparative effectiveness of antiviral treatment for health outcomes vary
according to … the risk or rates of adverse health outcomes from HCV infection? … We will use a fixed effects model
to combining rare binary outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/acs-depression-research-protocol-amended.pdf
February 15, 2017 - outcomes and specifying the types of
emergency room visits of interest. … :
o Clinical outcomes
§ Total mortality
§ Depression-related outcomes
• Response or remission … • Total mortality
• Depression-related outcomes
• Response or remission
• Cardiac-related outcomes … (intermediate, final,
and adverse events outcomes). … The aim will be to identify and grade those
outcomes that are critical for decisionmaking.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_disposition-comments.pdf
July 08, 2014 - The exposures, the outcomes and the biological and
environmental mechanisms related to the outcomes … Evidence for other health outcomes in pregnant women is missing.” … Evidence for other health outcomes in pregnant women is missing.” … Evidence for other health outcomes in pregnant women is missing.” … We have enough trouble being able to do studies
to assess outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/lung-cancer-nonsurgical-therapies_executive.pdf
June 01, 2013 - : OS, CSS, performance
status, pulmonary QOL
• Intermediate outcomes: LCT
• Adverse outcomes: Radiotherapy-associated … )
• Final health outcomes: OS, performance status,
pulmonary QOL
• Intermediate outcomes: LCT, lung … The impact of these factors on health outcomes
remains unclear. … Outcomes • The major beneficial health outcomes in this CER are OS, CSS, and LCT, typically reported … Outcomes • The major outcomes of interest were symptom relief, OS, disease-specific survival, QOL, and
-
effectivehealthcare.ahrq.gov/sites/default/files/interventions-horizon-scan-high-impact-1306.pdf
June 01, 2013 - Finally, patient outcomes are
monitored through a centralized database. … availability
of more published evidence on outcomes … , although
some experts noted the lack of published outcomes data. … appeared optimistic about its potential to improve health outcomes in seniors. … Medication
adherence: its importance in cardiovascular
outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-transition-care_research-protocol.pdf
June 10, 2013 - (KQ 2), rather than asking about the same outcomes in a separate question
devoted to harms. … These particular outcomes may
be less likely to be reported in randomized controlled trials. … health care utilization and
health outcomes. … Update on publicly reported outcomes measures based on the 2010 release. … Circ Cardiovasc Qual Outcomes. 2010 Sep;3(5):459-67. PMID: 20736442.
4.
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effectivehealthcare.ahrq.gov/sites/default/files/cer-238-cervical-ripening-appendix-e-2.xlsx
January 01, 2017 - Effectiveness Outcomes Secondary Effectiveness Outcomes Primary Fetal Harms Outcomes Secondary Fetal … Harms Outcomes Primary Maternal Harms Outcomes Secondary Maternal Harms Outcomes Comments
Biem, 2003 … Secondary Fetal Harms Outcomes Primary Maternal Harms Outcomes Secondary Maternal Harms Outcomes Comments … Effectiveness Outcomes Secondary Effectiveness Outcomes Primary Fetal Harms Outcomes Secondary Fetal … Harms Outcomes Primary Maternal Harms Outcomes Secondary Maternal Harms Outcomes Comments
Beckmann,