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effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-frameworks.ppt
June 01, 2012 - , and improved clinical outcomes
Identification of intermediate outcomes
Limitations of the scientific … link a medical test to improved clinical outcomes. … and clinical outcomes. … Impact of management on health outcomes?
Impact of management on intermediate outcomes? … Impact of intermediate outcomes on health outcomes?
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/infertility_research-protocol.pdf
October 12, 2015 - Outcomes: (Note that these outcomes are ordered in approximate relative importance to
patients, based … Neonatal outcomes
!! Death
!! … Quality-of-life outcomes
•! Outcomes (men):
o! Quality-of-life outcomes
o! … outcomes!
•! Men:!
o! Quality0of0life!outcomes!
o! Short0!and!long0term!health!outcomes!
! … (intermediate, final, and adverse events
outcomes).
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-201-indoor-allergen-reduction-asthma-evidence-summary.pdf
February 01, 2018 - the systematic review
is to assess the effectiveness of allergen
reduction interventions on asthma
outcomes … Messages
• Evidence for single interventions
designed to reduce indoor allergen
exposure on asthma outcomes … • Multicomponent interventions that
bundle more than one strategy may
improve some asthma outcomes, … Overall strength of evidence (SOE)
for most comparisons and outcomes was either low,
inconclusive, … Patient-Oriented Outcomes
• Asthma control
• Exacerbations
• Health care utilization
and cost
•
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/radiation-therapy-brain-metases-protocol.pdf
October 10, 2019 - The inclusion criteria for outcomes include several categories of patient outcomes—
including health, … Key informant input consistently
emphasized the importance of patient-relevant outcomes. … The report will include evidence statements for outcomes outlined in the box
below. … Outcomes were
ranked and checked for conceptual overlap. … Box 1: Key Outcomes
Outcomes for Key Question 4 (adverse events)
1.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/cognitive-decline_research-protocol.pdf
March 22, 2016 - Evidence synthesis with intermediate outcomes introduces two important, related
challenges. … One is understanding the relationship between the intermediate outcomes and
the clinical outcomes of … The KQs are further specified by the populations, interventions, comparators,
outcomes, timing, and … The search strategy for KQ3 will first
identify intermediate outcomes in KQ1 and KQ2. … to the final outcomes.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_executive.pdf
December 01, 2011 - The outcomes are
separated into adverse events, intermediate outcomes,
and final health outcomes. … Those outcomes
with insufficient strength of evidence rating are listed in
Table C. … No other final health outcomes were evaluated
in this trial and study. … All outcomes
devices versus control
Note: ”All outcomes” includes all 15 final, intermediate, and … It was difficult to assess
the impact of these devices on final health outcomes
and intermediate outcomes
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/quantitative-synthesis-expanded-methods_methods.pdf
March 01, 2013 - Binary Outcomes
Three effect measures could be used for binary outcomes in meta-analyses including risk … or the way outcomes were
measured differed among studies. … Specify whether surrogate
outcomes or composite endpoints were used. … secondary
outcomes
Specify whether outcomes were primary or secondary outcomes
in the original studies … Specify benefit and harm outcomes clearly.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_executive.pdf
November 01, 2012 - , and
reporting of prespecified outcomes. … No other intermediate outcomes were reported. … , and no other final health
outcomes were reported. … adequately evaluate
such outcomes, with exception of HRQoL. … Alternatively,
for intermediate outcomes, studies were sufficient in length
to evaluate such outcomes
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cultural-competence_research-protocol.pdf
July 09, 2014 - What outcomes are considered high priority and final patient-centered outcomes
differ by priority population … outcomes, such as depression, substance use
o Improved medical health outcomes, such as reduction in … Intermediate outcomes
• Provider training and
motivation outcomes
(competencies, knowledge,
changes … § Patient medical
care outcomes
§ Patient mental
health
outcomes
Models of
cultural … Intermediate Patient Outcomes
Intermediate organizational
outcomes- structural changes
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-supplements_executive.pdf
April 01, 2012 - Benefits and harms are measured as outcomes that
may be clinical outcomes, their proxy surrogates, or … (i.e., clinical and surrogate outcomes
of efficacy and harms, and pharmacokinetic outcomes)
with their … A priori outcomes for grading the strength of evidence
Key
Question Outcomes
1
Mortality (all-cause … For
pharmacokinetic outcomes, we followed the U.S. … Three notable trials reported outcomes that were not
a priori gradable outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/executive-summary-2017-schizophrenia-adult.pdf
January 01, 2017 - Outcomes for each question (see also outcomes in
Figure A):
We limited the outcomes to those that are … patient centered
health outcomes (rather than intermediate outcomes),
which were arranged according … Benefits Outcomes
Although functional outcomes were prioritized as most
important, few studies of SGA … other
17
than symptoms (e.g., functional outcomes), even when
those outcomes were not the focus … Outcomes
The evidence is applicable only to a select group of
outcomes that vary by intervention.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/joint-replacement-evidence%20-summary.pdf
November 01, 2021 - arthroplasty (TKA), may reduce length of hospital stays and increase in
strength but may lead to comparable outcomes … exceptions, studies reported a unique
(p)rehabilitation intervention and a wide range of disparate outcomes … More intensive rehabilitation led to similar outcomes of strength
among rehabilitation programs delivered … Several prioritized outcomes, including strength, ROM, satisfaction
with care, and QoL, were infrequently … However, there was some evidence of improved outcomes in specific
(p)rehabilitation programs, and a
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-ovarian-contraceptives_research-protocol.pdf
March 13, 2012 - for each question:
KQs 1, 2, 3, 6:
• Intermediate outcomes: none
• Final outcomes: diagnosis of … (intermediate
outcomes, health outcomes, and safety outcomes). … The safety outcomes will be
framed to help identify adverse events as described in KQ 5. … • Outcomes: Data on all the relevant outcomes is unlikely to be available for all
potentially … The final outcomes of the model are death from ovarian cancer and death
from other causes.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
November 22, 2011 - Furthermore, existing reviews have not assessed comparative test performance for
predicting outcomes … does not necessarily mean that changing treatment on the basis of these tests will
improve outcomes … Therefore the evidence of test impact on treatment
decisions and subsequent patient outcomes must be … Do the following factors modify the association between genetic test
results and clinical outcomes? … (biomarkers of outcomes), or measuring
past toxic or preventive exposures.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/phenylketonuria_executive.pdf
February 01, 2012 - Outcomes
Our outcomes of interest for Key Question 1 included
Phe levels and cognitive impairment, … most clinically important: cognitive
outcomes including IQ and executive function, nutritional
outcomes … No study evaluated quality-of-life
outcomes. … Long-term efficacy outcomes beyond 22 weeks and safety
outcomes beyond 3 years are currently unavailable … Outcomes beyond
phenylalanine: an international perspective.
-
effectivehealthcare.ahrq.gov/sites/default/files/s1.pdf
October 01, 2007 - Nevertheless, expanded
access and use of drug therapies also holds the potential for poor outcomes resulting … generally not designed to evaluate multiple endpoints, detect rare adverse effects,
evaluate health outcomes … for hospital and medical
care through Medicare, a new national focus has emerged on understanding the outcomes … The need of patients, health care providers, and policy makers for objective
information about the outcomes … Smith, MSPH, PhD, Director, Pharmaceutical Outcomes Research, Center for Outcomes and Evidence, Agency
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/white-paper-standardized-library.pdf
February 01, 2019 - This work was supported by
the Office of the Secretary Patient-Centered Outcomes Research Trust Fund … Registries for Evaluating Patient Outcomes:
A User’s Guide. Third edition. Two
volumes. … and Patient-Centered
Outcomes Research (PCOR): Challenges
and Opportunities. … Asthma outcomes workshop: overview. J
Allergy Clin Immunol. 2012;129(3
Suppl):S1-8. … International Consortium for
Health Outcomes Measurement (ICHOM)
Standard Sets.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-254-rural-telehealth-app-e.xlsx
January 01, 2021 - Outcomes Prespecified and Reported? Financial Conflicts of Interest? … Outcomes Prespecified and Reported? Financial Conflicts of Interest? … Outcomes Prespecified and Reported? Financial Conflicts of Interest? … Are All Outcomes Measured Appropriately? Are All Outcomes Valued Appropriately? … Are All Future Costs and Outcomes Discounted Appropriately?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/labor-nitrous-oxide_research-protocol.pdf
August 24, 2011 - Outcomes
Primary outcomes:
1. Pain reduction.
2. Satisfaction with pain management.
3. … Other outcomes:
Labor and intermediate outcomes
o Pain.
o Coping.
o Labor progress. … Timing
Intermediate outcomes will include associated labor outcomes. … Long-term outcomes will include associated birth outcomes. … Determine Outcomes to Extract. Outcomes to extract have been identified a priori.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/telehealth-acute-chronic_research-protocol.pdf
February 15, 2017 - Intermediate outcomes include both outcomes that precede the ultimate outcomes of
interest and secondary … outcomes. … Do clinical, economic, intermediate, or negative outcomes (i.e., the outcomes in Key
Questions 1, 2, … for Each Key Question
• Key Question 1: Clinical and economic outcomes
o Clinical outcomes such … However, if the difference in outcomes is uncertain or there is an expectation of differences
outcomes