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www.uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/update-methods-insufficient-evidence
March 04, 2021 - Acknowledging the Contribution of Non-RCT Evidence and Persisting Issues A New Approach: Process and Outcome … A New Approach: Process and Outcome In response to the concerns about the frequency of I statements, … Unlike the USPSTF system, the GRADE recommendation grades also take into account the importance of the outcome
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/nMb54adBfgajp8dG87kPcw
April 17, 2018 - Trials
measuring self-reported falls, with a recall of 6 months or less as
a primary or secondary outcome … One reviewer
abstracted descriptive and outcome data from each included
study into standardized evidence … for a given intervention type and outcome. … in
medical care, or any fall-related outcome the author categorized
as injurious was accepted. … A randomised
controlled trial of the outcome of health assessment
of people aged 75 years and over.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/827CwGYMVawpVoVg_syJpF
October 01, 2015 - However, given the relatively low fre-
quency of this outcome, studies were likely underpow-
ered to … detect a change and none reported power
calculations for this outcome. … Of the 8
studies (14–18, 21–23) reporting this outcome, 3 (15,
21, 22) found that women receiving iron … of prophy-
lactic iron supplementation in healthy pregnant women on maternal
iron status and birth outcome … randomised
placebo-controlled trial to determine the effect of iron supplemen-
tation on pregnancy outcome
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/85-VHmWWogLhD8mvajT6gq
April 01, 2015 - timing and dosing), pa-
tient populations, and other factors, meta-analysis was
not attempted for all outcome … articles (n = 1148)
Articles excluded (n = 269)
Wrong population: 61
Wrong intervention: 21
Wrong outcome … However, it is typically consid-
ered a measurable clinical outcome in pregnancy and
was reported in … Apgar scores, preterm
birth, or infant mortality; however, infant mortality was
not a prespecified outcome … The
relationship between maternal hematocrit and pregnancy outcome.
Obstet Gynecol. 1991;77:190-4.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan109/preeclampsia-screening-april-2017
August 14, 2014 - not applicable to U.S. clinical settings or populations
Study designs
Screening health outcome
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/autism-spectrum-disorder-young-children-1
June 10, 2021 - The USPSTF also added age of diagnosis as an outcome for KQ 1a.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/L5UwXoftg4JHw4buVDhjUT
October 01, 2010 - questions (n = 111)
Total articles excluded (n = 107)
Wrong population: 49
Wrong intervention: 18
Wrong outcome … Comparison of bladder cancer outcome in men undergoing hematuria
home screening versus those with standard … Long-term outcome of hematuria home screening for bladder cancer in
men. Cancer. 2006;107:2173-9. … follow-up or overall high loss to follow-up
Measurements: equal, reliable, and valid (includes masking of outcome … measurement instruments are used or not applied at all equally among groups (including not masking outcome
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/exVc75LHoUdnqjY6wYxzGV
June 01, 2003 - Outcome measure: new
skin cancers. … Outcome
measure: ratio of numbers of solar
keratoses at end of study and beginning
of study. … Outcome measures:
25-hydroxyvitamin D3 levels and 1,25-
dihydroxyvitamin D3.
86 of 87 completed one … Outcome measures: cumulative
sun exposure, sunburn episodes. … Outcome
measures: use of protective clothing,
sunscreen, shade, hats with brim.
86 clinicians, including
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/skin-cancer-counseling-2003
October 06, 2003 - Outcome measure: new skin cancers. Analysis: intention-to-treat. … Outcome measure: ratio of numbers of solar keratoses at end of study and beginning of study. … Outcome measures: 25-hydroxyvitamin D3 levels and 1,25-dihydroxyvitamin D3. … Outcome measures: cumulative sun exposure, sunburn episodes. … Outcome measures: use of protective clothing, sunscreen, shade, hats with brim.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/m_E9nFrmxuS5-surqVHK2u
November 13, 2018 - A dashed line depicts a health
outcome that follows an
intermediate outcome. … Additionally, for the outcome drinks per week, which was the most
commonly reported outcome, meta-regression … The most commonly reported health outcome was alcohol-
related problems or consequences, measured using … Trials
were not powered for this outcome and many had very few events,
resulting in imprecise results … Moderators of outcome in a
technology-based intervention to prevent and
reduce problem drinking among
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/gestational-diabetes-screening
August 10, 2021 - explored with sensitivity analyses using predefined variables (eg, study quality, setting, differing outcome … The aggregate strength of evidence was assessed for each outcome, using the Agency for Healthcare Research … (only an isolated fasting glucose level ≥ 95 mg/dL), but the authors’ sensitivity analysis for the outcome … participants but was not significantly associated with differences in any pregnancy or fetal/neonatal outcome … data, and some possible selective outcome reporting)
Group 1: 32.4 (5.1)
Group 2: 34.3 (5.2)
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/prevention-of-human-immunodeficiency-virus-hiv-infection-pre-exposure-prophylaxis-june-2019
June 11, 2019 - and the FEM-PrEP trial (n = 2120) found no significant difference in risk of any adverse pregnancy outcome … A dashed line indicates a health outcome that immediately follows an intermediate outcome. … Placebo/No PrEP
Outcome … reporting bias detected
Good
Small number of serious adverse events in most trials
Composite outcome … 95% CI, 0.48%-3.43%)
Some inconsistency; precise
No reporting bias detected
Good
Composite outcome
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary9/alcohol-misuse-screening-and-behavioral-counseling-interventions-in-primary-care-2013
September 25, 2012 - For the outcome of alcohol consumption, the effect measure was mean difference between the intervention … Two reviewers assessed each domain for each key outcome, and differences were resolved by consensus. … We summarize the main findings by population and outcome and report the SOE for each.
… If complete abstinence is used as an outcome, 15% to 35% of patients have been reported to achieve 1 … Alcohol counselling of 85 pregnant problem drinkers: effect on drinking and fetal outcome.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/tobacco-use-intervention-prevention-cessation-children-adolescents
June 27, 2024 - The inclusion/exclusion criteria were revised to reflect the population of interest for each outcome
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan-aspirin-to-prevent-cardiovascular-diseas/aspirin-to-prevent-cardiovascular-disease-and-cancer-april-2016
October 07, 2013 - , case studies, or case series
Setting
Outpatient
Exclusively inpatient
Timing of outcome
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan93/impaired-visual-acuity-in-older-adults-screening-2016
September 27, 2014 - response to public comments, the inclusion and exclusion criteria were revised to include cognition as an outcome
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-harms-of-screening-for-breast-cancer/breast-cancer-screening-january-2016
January 11, 2016 - Studies of anxiety and pain used different outcome measures. … Although overdiagnosis is an important outcome of screening, it is difficult to evaluate in individual … of randomized trials, uncertainty about the comparability of comparison groups, and differences in outcome … patients from 11 health centers in an HMO
40–69
NR
Study Years
Comparison
Outcome … Design
Population
Age, y
Study
Period
Comparison
(Number of
Participants)
Outcome
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/VpT-c4bnmvHFRPyKgPwb2Z
December 01, 2010 - care–relevant interventions among community-
dwelling older adults that reported falls or fallers as an outcome … overall high loss to follow-
up; a clear definition of the intervention; equal, reliable,
and valid outcome … Fi-
nally, we report here the proportion of fallers as our pri-
mary outcome, but in the full report, … A randomised controlled trial of the
outcome of health assessment of people aged 75 years and over. … Preventing falls in older
people: outcome evaluation of a randomized controlled trial.
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www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary-false-positive-and-false-negative-rates-of-/breast-cancer-screening-january-2016
January 11, 2016 - Outcome and Risk Factor Measures
Outcome measures included rates of false-positive and false-negative … that used intervals ranging from 12 to 33 months. 13
Our goal was to provide overall rates of the outcome … Follow-up and outcome monitoring. … Variable
Women With Missing Data
Number
Percentage
Outcome
Invasive … Mammography Examination*
Outcome
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/hepatitis-b-virus-infection-screening-nonpregnant-adolescents-adults-may-2014
June 18, 2014 - median duration of 32.4 months because it reached a prespecified stopping threshold for a composite outcome … composite intermediate outcomes) and clinical (death, hepatocellular carcinoma, or a composite clinical outcome … Methodological issues included unclear blinding status of outcome assessors and failure to report loss … concludes with moderate certainty that antiviral treatment results in an important improved clinical outcome … Efficacy of a heat inactivated hepatitis B vaccine in male homosexuals: outcome of a placebo controlled