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effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/assessing-the-risk-of-bias-in-systematic-reviews-of-health-care-interventions-01.pdf
May 01, 2005 - o Allow for separate risk-of-bias ratings for each outcome to account for outcome-
specific variations … Yes (potential for outcome Yes (applicability of Yes (directness of outcome
measures measurement bias … Choice of Outcome Measures
The use of valid and reliable outcome measures reduces the likelihood of … data are
related to both exposure and outcome. … kBlinding of outcome assessors is especially important with subjective outcome assessments.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research.pdf
March 01, 2018 - • Identification of the primary outcome. … description
of outcome (i.e. different “primary outcome” reported), different domain used, different … None of the studies changed a primary outcome to a
secondary outcome. … All five of the studies listed
quality of life as an outcome measure. … This new study did not list quality of life as an outcome in ClincalTrials.gov.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/pelvic-pain_research-protocol.pdf
February 16, 2011 - Therefore, we will not restrict this review
to validated outcome measures. … measure(s) as one factor when assessing the outcome reporting bias. … Validated Outcome Measures:
a. … Other Outcome Measures:
a. … Core outcome measures for chronic pain clinical trials:
IMMPACT recommendations.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-238-cervical-ripening-evidence-summary.pdf
March 01, 2021 - If a prespecified, primary outcome is not listed in a table below that
• Low-strength evidence suggested … The highest strength of evidence found for any outcome was low
strength. … Primary birth outcome: cesarean delivery
Key
Question Intervention Findingsa Studies Incidence
Relative … Primary fetal harms outcomes
Key
Question Intervention Outcome Findingsa Studies Incidence
Relative … There was variation in outcome definition and reporting
across the studies, with many reporting outcomes
-
effectivehealthcare.ahrq.gov/products/library-afib
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effectivehealthcare.ahrq.gov/sites/default/files/s158.pdf
October 01, 2007 - Availability of information on disease outcome will affect
choice of analytic strategies. … Using an external validation study
without data on disease outcome to adjust for unmeasured confound- … PSC uses validation data without information on
disease outcome under a strong assumption. … †Internal validation studies contain information on disease outcome of interest by design. … Using the outcome for
imputation of missing predictor values was preferred.
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effectivehealthcare.ahrq.gov/sites/default/files/ch_11-user-guide-to-ocer_130129.pdf
January 03, 2012 - Sensitivity Analysis
Outcome Definitions
The association between exposure and outcome
can also be … assessed under different definitions of
the outcome. … on the how well the original outcome
definition truly reflects the condition of interest. … Alternately, effect estimates may vary with changes
in the outcome definition. … effect estimate than
an outcome definition including only myocardial
infarction.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/polyunsaturated-fatty-protocol.pdf
January 01, 2024 - Study eligibility criteria based on Population, Intervention, Comparator, Outcome (PICO),
and other … In all instances, if a study meets eligibility criteria for any outcome, we will extract all outcomes … even though the study might
not have met study size criteria for that specific outcome. … assessor blinding are
all unclear (with the recognition that the participant may be the outcome assessor … Grading the Strength of Evidence for Each Outcome
Following AHRQ Methods guidance,11 the review team
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/saturated-fat-replacement-protocol.pdf
January 01, 2024 - Study eligibility criteria based on Population, Intervention, Comparator, Outcome (PICO),
and other … In all instances, if a study meets eligibility criteria for any outcome, we will extract all outcomes … even though the study might
not have met study size criteria for that specific outcome. … assessor blinding are
all unclear (with the recognition that the participant may be the outcome assessor … Grading the Strength of Evidence for Each Outcome
Following AHRQ Methods guidance,14 the review team
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/patient-monitoring-systems-rapid-review.pdf
December 01, 2024 - .
3.2.1.1.4 Hospital Mortality
Both studies examined this outcome. … For the outcome of cardiorespiratory arrest, a score had little impact. … PMID: 29870923. - No outcome of
interest
15. Durden L, Wilford BN. … PMID: 36692798. - No outcome of
interest
53. Petersen JA. … PMID: 31002971. - No outcome of
interest
Pub.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/pharma-nonpharma-ptsd-2022-update-app-g2-3.xlsx
January 01, 2022 - Outcome Data (Cochrane) or Attrition Bias (AHRQ); Attrition Bias Due to Missing Outcome Data (Cochrane … Measurement Risk of Bias in Measurement of the Outcome (Cochrane) or Detection Bias (AHRQ); Outcome … Risk of Bias in Measurement of the Outcome (Cochrane) or Detection Bias (AHRQ); Outcome Measurement … Risk of Bias in Measurement of the Outcome (Cochrane) or Detection Bias (AHRQ); Outcome Measurement Risk … of Bias in Measurement of the Outcome (Cochrane) or Detection Bias (AHRQ); Outcome Measurement: RoB
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/instrumental-variable-methods_research.pdf
April 01, 2010 - between the actual
treatment taken by the patient and the outcome will be confounded. … Assumption 3 states that the
instrument should affect the outcome only via treatment. … Preference must only affect the outcome
through its influence on the treatment under study. … could affect the outcome were different over the weekend. … Below, let outcome be the outcome, exp be the exposure, iv be the instrument, age be a
continuous age
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-informed-care-protocol.pdf
April 19, 2023 - Population, intervention, comparator, outcome, timing, setting (PICOTS)
PICOTS KQ1 KQ2
Population … blinding (performance and detection
bias), completeness of follow-up (attrition bias), analyses and outcome … Overall risk of bias assessments for each
study-outcome will be classified as low, high, or unclear … Based on these factors, the overall strength of evidence for each intervention/comparator/
outcome will … Childhood maltreatment predicts unfavorable course of illness
and treatment outcome in depression: a
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-238-cervical-ripening-appendix-g.xlsx
May 29, 2025 - Outcome Assessor Masked? Groups Similar at Baseline? Intention-to-Treat Analysis? … Avoidance of Selective Outcome Reporting? … Outcome assessor/data analyst blind?
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_4-user-guide-to-ocer_130129.pdf
January 01, 2010 - First, it is helpful
to lay out a theoretical link between the exposure and the event/outcome of interest … because all of the exposure necessary to
cause the event or outcome has been completed. … The latent period is the time from when the
outcome starts to when the outcome is identified. … In other words, it is the period between when the
disease or outcome begins and when the outcome
is … of Outcome
interest complete Identi�ed/Diagnosed
Start of outcome
x x x xx x xxx xxx
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/cesarean-birth-2010_research-protocol.pdf
January 01, 2010 - in two and as a
secondary outcome in four others. … Additional nonrandomized controlled trials
that had cesarean rate as a primary or secondary outcome … Abbreviations: PICOTS = population, intervention, comparator, outcome, timing, and setting. … of
interest, comparability of cohorts, assessment of outcome, adequate duration of followup, and … We will record strength of
evidence assessments in tables, summarizing for each outcome.
G.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-reconstruction-mastectomy-protocol.pdf
April 09, 2020 - assessors, and subjective outcome assessors; incomplete outcome data;
selective outcome reporting; … assessors, and subjective outcome assessors;
incomplete outcome data; selective outcome reporting; … data, selective outcome reporting,
and other issues that could be related bias. … Development of a core outcome set for research and audit
studies in reconstructive breast surgery. … Developing core outcome sets for clinical trials:
issues to consider.
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_9-user-guide-to-ocer_130129.pdf
September 21, 2012 - Most importantly, investigators must specify a
primary study outcome and a minimum treatment
effect … of interest for that outcome. … In trials with a continuous outcome (e.g.,
LDL cholesterol), investigators must make
assumptions about … the standard deviation of the
outcome in each trial arm; when the outcome
is the occurrence of an … Describe:
- The primary outcome on which the study size
or power estimate is based.
-
effectivehealthcare.ahrq.gov/sites/default/files/assessing-the-risk-of-bias_draft-report.pdf
June 02, 2011 - Blinding of outcome
assessors, especially with
subjective outcome
assessments, bias in
inferential … reporting for another outcome. … Alternatively, with no evidence of selective outcome reporting for an individual outcome, EPCs
may … still judge that selective outcome reporting exists for the body of evidence for that outcome
alone … of the outcome data in studies reporting that outcome.
9
This overall risk-of-bias is
dictated by
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/quantitative-synthesis-expanded-methods_methods.pdf
March 01, 2013 - If a composite
outcome is time-to-event, it takes the value of the time until the first event. … Although the use of a
composite outcome as the primary outcome in a clinical trial can reduce sample … • Interpretation of composite outcome results is fraught. … Criteria for selecting
outcomes for
combining
Outcome
definitions
Specify whether outcome definitions … This should be done
for each outcome considered.