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effectivehealthcare.ahrq.gov/sites/default/files/related_files/allergy-seasonal_disposition-comments.pdf
July 17, 2013 - Blinding of outcome assessors seems more important
when interpreting patient-reported outcomes. … Lack of blinding
may not introduce important bias and this should be assessed on
an outcome level ( … We agree that “[b]linding of outcome assessors seems
more important when interpreting patient-reported … TEP #10 Results, page
32
Was a TNSS minus congestion outcome where the analysis failed
to find a … No, this outcome was defined a priori.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemorrhage-postpartum_executive.pdf
April 01, 2015 - of the Body of Evidence
Two senior investigators graded the body of evidence for
key intervention/outcome … We present findings by intervention and outcome area
where possible under each KQ. … Applicability
Studies differed in terms of study population and outcome
measures. … For example, transfusion could be an adverse
outcome if treatment was not sufficient and timely to halt … Therefore, it is sometimes
hard to know whether to classify transfusion as an adverse
outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_research-protocol.pdf
December 23, 2014 - In many cases of IH, early referral and intervention is crucial to a satisfactory outcome, such
as ocular … Presentation of results
Within each KQ, we will organize results by study design and outcome, with … When no studies are available for
an outcome or comparison of interest, we will grade the evidence as … We will record strength of
evidence assessments in tables, summarizing results for each outcome. … [mh] OR therapy[tiab] OR
therapies[tiab] OR therapeutic[tiab] OR therapeutics[tiab] OR outcome[tiab]
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
September 01, 2013 - There was also substantial risk of selective
outcome reporting for outcomes other than MACE. … Intermediate Outcome: Platelet Reactivity
The intermediate outcome of platelet reactivity was
reported … For platelet
reactivity as a continuous outcome, the mean or median
reactivity was generally higher … For platelet reactivity as a
categorical outcome, studies generally showed that platelet
reactivity … Studies did not report significant effect
modification by genotype for this outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/autism-update_executive.pdf
August 01, 2014 - KQ 2: Among children ages 2–12, what are the modifiers
of outcome for different behavioral treatments … in the
treatment setting
Functional outcome outside
the treatment setting
3 4
1
2
5
Individual … Then we assessed the number of studies and
range of study designs for a given intervention-outcome … measure, but a lack of consistency
in the interventions studied and outcome measures used
makes it … In addition, although more studies are reporting primary
and secondary outcome measures determined a
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-liver-metastases-therapies_research-protocol.pdf
September 27, 2012 - by Briss and colleagues.26
Studies will be included for KQs 1 and 2 if they:
• Report on an outcome … Assessment
o Identified primary outcome
o Identified secondary outcomes
o Followup frequency … o Were outcome measures clearly valid, reliable, and equally applied to treatment
groups? … o Were outcome assessors blinded?
o Was the length of followup adequate? … o Did the analysis of outcome data incorporate a method for handling confounders such
as statistical
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/obesity-child_research-protocol.pdf
March 31, 2010 - management of study heterogeneity, lack of randomized, controlled interventions;
lack of objective outcome … □ Outcome assessment must be at least 1-year after the baseline assessment for
key questions 2 through … □ Outcome assessment must be at least 6 months after the baseline assessment
for key question 1 … sufficiently homogenous with respect to the population characteristics, intervention,
comparison, outcome … The time points of interest for outcome changes
are: 1 year, 2 years, 3 years and more than 3 years
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-treatment-ssri_research-protocol.pdf
June 15, 2010 - Contacting Authors for missing data:
Study authors will be contacted via email for missing outcome … Characteristics of the outcomes will include the type of
instrument or scale, primary or secondary outcome … that include evaluation of the domains
of randomization, blinding, co-intervention, and selective outcome … These will be explicitly detailed for each outcome evaluated. … If a particular outcome is shown to have a high risk of publication bias, then the analyses
will be
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-medical-executive-170505.pdf
May 01, 2017 - KQ2: Among children ages 2-12 with ASD, what are the
modifiers of outcome for different medical treatments … Evidence
Two senior investigators graded the strength of the
evidence (SOE) for key intervention/outcome … Effectiveness Across Environments or
Contexts
Seven studies reported teacher ratings of outcome
measures … Four studies reported teacher ratings
of outcome measures that provide some information to
address … In addition, much of the medical intervention literature
relies on baseline and outcome measures that
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guide-editorial_methods.pdf
July 01, 2012 - For example, the principal
“outcome” of a study of a medical test is commonly a proxy or intermediate … outcome. … The most common outcome in
an evaluation of this test is the accuracy of the test in identifying clinically … Clinicians, while interested in this proxy outcome, would find more value in the
ability of the test
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mental-illness-adults-prisons_disposition-comments.pdf
August 21, 2013 - For
use of between-group comparisons of outcome
data as problematic. … Regarding all-cause mortality, we did not
assess that outcome. … None of the included trials,
however, reported that outcome. … Both modified therapeutic community trials
reported substance use as an outcome. … Where is the outcome data for these programs
that our courts continue to utilize?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/binge-eating_research-protocol.pdf
July 21, 2014 - first-line treatment, the formulation of the comprehensive
treatment plan and ultimately, treatment outcome … Timing of Treatment studies: end of treatment or Treatment studies: Outcome measurement prior
outcome … We will consider the risk of bias for each relevant outcome of a study. … Binge eating and its relationship to
outcome after laparoscopic adjustable gastric banding. … Pretreatment and process predictors of
outcome in interpersonal and cognitive behavioral psychotherapy
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/psoriasis-chronic_research-protocol.pdf
January 10, 2012 - The Psoriasis Area and Severity Index (PASI)
score will be considered not only as a binary outcome … but as a continuous outcome as suggested. … Risk of bias is the degree to which the included studies, for a given outcome or comparison,
have a … We will rate the outcome as either direct or indirect. … We will rate the outcome as either precise or
imprecise.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/choice-of-mean_white-paper.pdf
April 01, 2015 - The distribution of the baseline outcome scores is similar for adequately randomized RCTs. … The distribution of the baseline outcome scores could become imbalanced in inadequately
randomized trials … concealment.5 In addition, even for trials without
baseline imbalance, systematic attrition linked to outcome … For each review, we abstracted data
on whether continuous outcome and meta-analysis were used, the effect … We avoided including more
than one CER that evaluated the same continuous outcome (duplicate outcome
-
effectivehealthcare.ahrq.gov/sites/default/files/han.pdf
December 26, 2012 - falling short of
certainty to an almost complete lack of conviction or knowledge especially about an
outcome … cancer treatment
• Probability: 20% probability of benefit from treatment (Indeterminacy of
future
outcome … related
to the
patient, the
disease, or treatment)
to predict
a diagnostic or therapeutic outcome
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
February 01, 2012 - If a convincing argument can be made that a
continuous outcome could be an adequate proxy outcome for … However, it is currently unclear than any continuous outcome would be a convincing proxy. … outcome like respiratory complications. … If a convincing argument
can be made that a continuous outcome could be an adequate proxy outcome for … The proper outcome
measure is quality-adjusted life-years (QALYs) gained.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nonpharmacologic-treatment_research-protocol.pdf
October 04, 2016 - PICOTS (Population, Intervention, Comparator, Outcome, Timing, Setting)
• Populations
Source … was not provided by the
largest report or reports longer followup data for an outcome.
3. … This rating is made separately for each outcome of
each comparison of each KQ. … Precision is the degree of certainty surrounding an effect estimate with respect to a
given outcome, … A refined method for the meta-analysis of controlled clinical trials with binary outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy-disposition-170415.pdf
January 17, 2017 - Peer reviewer #1 General Clarity and Usability: There is a dichotomous outcome
in the usability- the … The multitude of outcome measures are
defined. … We also assessed whether studies used blinded
outcome assessors. … normal diet" make this a quantitative outcome so
readers can judge the clinical importance. … We also assessed whether studies used blinded
outcome assessors.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/dementia-nursing-home-characteristics_disposition-comments.pdf
October 23, 2012 - We did include quality of life as an outcome within the
larger grouping of psychosocial outcomes for … While we recognize that depressive symptoms could be
considered as either a psychosocial outcome or … a health
outcome, we have categorized it within the health
outcomes. … We have changed depression to depressive symptoms
throughout the report as our outcome of interest was … We have changed depression to depressive symptoms
throughout the report as our outcome of interest was
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/infertility_research-protocol.pdf
October 12, 2015 - Outcomes of Interest: There has been ongoing debate about the most appropriate outcome for
evaluation … adverse outcomes, and in some cases preferences for process as well as outcome. … outcome!of!
interest!(e.g.,!live!
birth!or!
complications!of!
treatment).!
Pregnancy!rates! … The grading will be outcome-specific such that a given study that analyzes its primary
outcome well … Live birth is the correct outcome for clinical trials evaluating therapy for
the infertile couple.