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effectivehealthcare.ahrq.gov/sites/default/files/pdf/celiac-disease_research-protocol.pdf
June 12, 2014 - PICOTs Each study must address a population, intervention, comparator, and
outcome listed under PICOTs … Low We have limited confidence that the estimate of effect lies close to the true effect for
this outcome … such as diagnostic accuracy, then
the reviewer does not need to automatically
“downgrade” this outcome … (i.e., for
each outcome separately). … OR outcomes OR treatment outcome OR treatment
outcomes
NOT
case report* OR case reports[pt])
==
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/gastric-cancers-protocol-amendment.pdf
May 02, 2025 - data
• Bias in measurement of the outcome
• Bias in selection of the reported result
Each domain … data
• Bias in measurement of the outcome
• Bias in selection of the reported result
Each domain … This rating is made separately for each outcome of each comparison of each KQ. … We will assign a rating of Insufficient when the evidence does not permit a conclusion for the
outcome … Precision is the degree of certainty surrounding an effect estimate with respect
to a given outcome,
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/selecting-evidence.ppt
January 01, 2010 - When RCTs report only an intermediate outcome, for example, larger, longer, well-designed observational … studies—reporting a main health outcome of interest—may be better suited to answer some questions. … OS = observational study; PICOTS = population, intervention, comparator, outcome, timing, and setting … (I)
In addition to using PICOTS (population, intervention, comparator, outcome, timing, and setting) … The potential for publication bias and selective outcome reporting bias should be considered.
-
effectivehealthcare.ahrq.gov/sites/default/files/selecting-evidence.ppt
January 01, 2010 - When RCTs report only an intermediate outcome, for example, larger, longer, well-designed observational … studies—reporting a main health outcome of interest—may be better suited to answer some questions. … OS = observational study; PICOTS = population, intervention, comparator, outcome, timing, and setting … (I)
In addition to using PICOTS (population, intervention, comparator, outcome, timing, and setting) … The potential for publication bias and selective outcome reporting bias should be considered.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-artery-disease-treatment_executive.pdf
May 01, 2013 - We considered meta-analysis for comparisons where at
least three studies reported the same outcome at … Meta-analyses were based on the nature of the outcome
variable, but random-effects models were used … Continuous outcome measures comparing two
treatments that used a similar scale were combined
6 … Studies reporting dichotomous outcome measures were
combined using a random-effects, multiple logistic … and not a direct clinical outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_executive.pdf
September 01, 2014 - outcome of interest across studies. … Our assessment of
the strength of evidence for this outcome is summarized in
Table G.
Table G. … Strength of evidence for underestimation rates in women at average risk of cancer
Outcome
Comparison … Harms were
reported inconsistently, raising concerns about selective
outcome and analysis reporting … Random effects meta-analysis
of event outcome in the framework of the generalized linear mixed
model
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ankyloglossia_research-protocol.pdf
June 30, 2014 - Studies included
one RCT, and all used different outcome measures to assess effects of frenotomy. … The
intermediate outcome is tongue mobility and final health outcomes include articulation disorder, … Within each KQ, we will organize results by study design and
outcome, with a focus on those designs … We will record strength of
evidence assessments in tables, summarizing results for each outcome. … / or treatment outcome*.tw. or outcome*.tw. or oral surgery/ or oral
surger*.tw. or surgical.tw. or
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/grading.ppt
January 01, 2010 - Are rated separately for each important outcome or comparison, including for any summary estimate of … EPC reviewers are not expected to grade every possible comparison for every outcome. … Second, a grade of insufficient is also appropriate when evidence on the outcome is too weak, sparse, … For each outcome of interest, the tables give the numbers of studies and subjects (left column), the … The row identifying the outcome as a whole (e.g., severe diarrhea) also gives the overall rating (e.g
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-strength_methods.pdf
July 01, 2009 - In this way, readers can better understand the available evidence for any
given outcome or comparison … However, evidence of an association between a
richer nutritional milieu and the ultimate outcome of … This domain should be rated as precise or imprecise separately for each
important outcome. … EPCs are not expected to grade every possible
comparison for every outcome. … (i.e.,
for each outcome separately).
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stones-draft-appendices.pdf
January 01, 2025 - No Intervention
Outcome
Strength of Evidence
Grade
No. … Combined Diet and Dietary Supplement
Outcome
Strength of Evidence
Grade
No. … Empiric Preventive Pharmacologic Treatment
Outcome
Strength of Evidence
Grade
No. … Placebo
Outcome
Strength of
Evidence Grade
No. … Results
B-31
Outcome
Strength of
Evidence Grade
No.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin_research-protocol.pdf
September 08, 2011 - Assessment:
o Identified primary outcome
o Identified secondary outcomes
o Response criteria … o Were outcome assessors blinded?
o Was the length of follow-up adequate? … Generally,
lack of masked
outcome
assessment is
considered a fatal
flaw, but due to the
nature … Nor
would masked outcome assessors be
relevant to mortality outcomes. … Nor would masked
outcome assessors
be relevant to
mortality outcomes.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prosthesis_research-protocol.pdf
March 16, 2017 - Lower Limb Prosthetic Outcome Measures: A Review
of the Literature 1995-2005. J. … Outcome measures in amputation
rehabilitation: ICF body functions. … Selection of outcome measures in lower
extremity amputation rehabilitation: ICF activities. … Outcome Instruments for
Prosthetics: Clinical Applications. … measures an assessment of an outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_disposition-comments.pdf
March 01, 2012 - Peer Reviewer #3 Executive
Summary
How consistent was the definition of this composite outcome of … The definition of MACE was collected from
each included trial and study that reported this
outcome … MACE being a composite outcome, is difficult to
value as much as discrete health outcomes. … Peer Reviewer #3 Abstract Appears to disagree a bit with line 43-44 The results for this outcome have … Side branch occlusion was not an a priori outcome…was never
part of the analytic framework.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/atypical-antipsychotics-off-label-update_research-protocol.pdf
May 19, 2010 - response rates, laboratory data, and time to disease recurrence; for effectiveness, we will
report outcome … Outcome
measures for harms, or adverse events, are the same as in KQ4 below. … , and duration), any
co-interventions, other allowed medication, comparisons, and results for each outcome … For each
treatment or placebo arm within a trial, the sample size, mean outcome, and standard deviation … Since most of the scales used as outcome measures in the pooled analyses
are scored so that more severely
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-updates_methods.pdf
July 01, 2011 - The identification of evidence on the
same intervention, comparator, and outcome as specified in a … Modify KQ with respect to a new PICO
element (population, intervention,
comparator, or outcome) … Outcome (binary)
and population
N
studies
Summary
result
N new
studies
Summary
Result … ‘No Tx’
(RCTs)
Outcome-1 (e.g.,
efficacy)
Sub-population-1
(e.g., males)
5
1.5 (1.1, 1.7)£ … ‘B’ (Non-
RCTs) µ
Outcome-1 (e.g.,
efficacy)
Sub-population-1
(e.g., males)
2
2.3 (1.5, 3.4
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-210-breastfeeding-evidence-summary.pdf
January 01, 2020 - Summary of key findings and strength of evidence: Community-based interventions
Breastfeeding Outcome … Summary of key findings and strength of evidence: Maternal health outcomes
Maternal
Health
Outcome … N Studies; N
Subjects Study
Limitations Outcome and Resultsa
Strength of
Evidence
Breast cancer … ; N
Subjects Study
Limitations Outcome and Resultsa
Strength of
Evidence
CVD 3 cohort studies;4, … Magnitude of postpartum weight change varies by BF exposure
and outcome measure.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-3-app-G.xlsx
January 01, 2022 - Outcome Assessors Masked? Intention-To-Treat Analysis? … Were Outcome Assessors and/or Data Analysts Blinded to the Exposure Being Studied?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-tables-f1-f2-2022-update_0.xlsx
January 01, 2022 - Outcome Assessors Masked? Intention-To-Treat Analysis? … Were Outcome Assessors and/or Data Analysts Blinded to the Exposure Being Studied?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-update-surv-rep-1-apps-G1-2.xlsx
January 01, 2022 - Outcome Assessors Masked? Intention-to-Treat Analysis? … Were Outcome Assessors and/or Data Analysts Blinded to the Exposure Being Studied?
-
effectivehealthcare.ahrq.gov/sites/default/files/grading.ppt
January 01, 2013 - Four Required Domains: Precision Scores
Are rated separately for each important outcome or comparison … Assess separately:
Each required domain (or each optional domain, as relevant)
Each major outcome, … EPC reviewers are not expected to grade every possible comparison for every outcome. … Second, a grade of insufficient is also appropriate when evidence on the outcome is too weak, sparse, … For each outcome of interest, the tables give the numbers of studies and subjects (left column), the