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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-272-genitourinary-syndrome-executive-summary.pdf
July 01, 2024 - Among 19 high RoB randomized controlled trials , the most common source of bias was
missing outcome … above, the evidence was very uncertain
(very low COE) for all other studied intervention-comparator-outcome … Despite the breadth of studies, findings were limited by heterogeneity in intervention-
comparator-outcome … interventions or direct
comparisons were few, small, short, and often lacked methodologic rigor in outcome … A core
outcome set for genitourinary symptoms
associated with menopause: the COMMA (Core
Outcomes in
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/ocd-protocol.pdf
August 15, 2023 - Questions related to outcome assessor blinding, missing data, outcome measurement
reporting adequacy … , and analytic adequacy will be assessed for each outcome. … measurement, analysis plan).27 The questions
will be assessed for each outcome (e.g., whether each … outcome was adjusted for potential
confounders). … data, and
selective outcome reporting, and items from the National Heart, Lung, and Blood Institute
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/bereaved-persons-research-executive-summ.pdf
March 01, 2025 - Summary of findings and strength of evidence for Key Question 3
Intervention Key Outcome Findings … systematic effect (SMD -0.07; -0.78,
0.65)
Insufficient
5
Intervention Key Outcome … Self-help
intervention
Suicide outcomes N/A Insufficient
7
Intervention Key Outcome … systematic effects, but
analyses were limited
Insufficient
8
Intervention Key Outcome … with more complicated grief benefit more
from interventions, but analyses were
limited (continuous outcome
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/disparities-quality-improvement_research-protocol.pdf
February 23, 2012 - Outcomes measures for each question:
The outcome measures of interest include: health outcome … Included studies should capture health outcome measures and/or
process measures. … of interest,
comparability of cohorts, assessment of outcome, adequate duration of followup, and … We will record
strength of evidence assessments in tables, summarizing for each outcome.
g. … is situated between the intervention box and the outcome box.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research-2012.pdf
January 01, 2012 - The NNT/NNH
ratio is an example of an approach where a single benefit outcome and a single harm outcome … the harm outcome. … While in some areas benefit and harm outcome measurement
is harmonized (e.g., outcome measures in rheumatology … Combining all the
benefit outcomes into a single outcome (e.g., a composite outcome) and only reporting … this
composite outcome is not information-preserving.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research-protocol.pdf
September 02, 2016 - Background
Information biases, including publication bias, time-lag bias, selective outcome reporting … At the level of
the evidence-base, and for each pertinent exposure-outcome relationship, we will assess … For outcome
instantiations that are reported in both, we will record whether the quantitative results … Outcome reporting in industry-sponsored
trials of gabapentin for off-label use. … Outcome reporting bias in randomized
trials funded by the Canadian Institutes of Health Research.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/ischemic-stroke-treatment_research-protocol.pdf
February 19, 2010 - The intermediate outcome is
recanalization. … (e.g.,
recanalization, mortality, mRS, or outcome score including NIHSS, Barthel Index or GOS) or … , ≥3=poor outcome), NIHSS score [including a
NIHSS decrease ≥ 4 points deemed significant by the FDA … For prospective and retrospective studies enrolling
consecutive patients, we will assess if outcome … Food and Drug Administration
GOS Glascow Outcome Scale
IA Intraarterial
ICH Intracerebral
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-1-year-final-report-updated-title_0.pdf
May 01, 2024 - Use of Report Cards and Outcome Measurements To Improve the Safety of
Surgical Care ............... … o For adults, SOE was insufficient in the pre-hospital setting across outcome categories
owing to the … Use of Report Cards and Outcome Measurements To
Improve the Safety of Surgical Care
10a. … Panel’s post-discussion ratings of patient safety practices related to use of report
cards and outcome … Use of Report Cards and Outcome Measurements To Improve the Safety of Surgical Care
10a.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-update_research-protocol.pdf
December 04, 2015 - Rather than distinguishing between benefit outcomes primarily
by type of outcome (symptom vs. other … There has been the addition of
an outcome for global impressions, which captures symptoms and overall … outcome!data!for!extraction!in!the!comparative!effectiveness!review!
Adverse!event!categories! … outcome!data!extracted!
Mortality! ND!
Cerebrovascular!events! ND!
Weight!and!body!composition! … outcome!measurement!tools!from!
original!CER!
$$
Outcome!measurement!tool*!
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effectivehealthcare.ahrq.gov/sites/default/files/ijzerman_ahrq-webinar-mcda.pdf
January 01, 2011 - Integration of preferences in quantitative framework
2
I want the best treatment:
Clinical Outcome … to determine
the relative preference for the alternatives:
I want the best treatment:
Clinical Outcome … Response Remission Relaps
patients
experts
effectiveness Quality of life Adverse events
Rank 1 Outcome … measure for psychiatrists
Rank 1 Outcome measure for patients
Danner, Hummel et al.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-app-g-table-surveillance-report-2_0.xlsx
May 29, 2025 - Outcome Assessors Masked? Intention-To-Treat Analysis? … Were Outcome Assessors and/or Data Analysts Blinded to the Exposure Being Studied?
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND__0399_01-07-2011.pdf
January 01, 2011 - Outcome(s): Survival, quality of life, palliation, and safety/adverse events.
2. … Outcome(s): Survival, tumor recurrence post-transplantation, prevention of tumor
progression while on … Outcome(s): Survival, quality of life, palliation, and safety/adverse events.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_disposition-comments.pdf
July 26, 2012 - The definitions and
diagnostic outcome measures are explicitly stated. … Definitions for outcome measures
appear appropriate. … The definitions and
diagnostic outcome measures are explicitly stated. … and
reported it as an important clinical outcome. … . control, and symptomatic
recurrence outcome for allopurinol vs.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/meditation_executive.pdf
January 01, 2014 - baseline
in an outcome measure in the treatment group minus
the change from baseline in the outcome … Footnote c: Total number—This is the number of trials that measured the outcome: primary outcome (PO) … , the number of trials
for which this outcome was a primary outcome; primary analysis (PA), the number … that outcome. … Two
mindfulness trials evaluated weight as an outcome, and it
was a primary outcome for both.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_technical-brief.pdf
December 01, 2012 - That
is, no studies showed the impact on net health outcome. … How does use impact net outcome, such as survival or recurrence-free survival? … How strongly is the GEP assay result correlated with the outcome of
interest? … Molecular profiles and clinical outcome of
stage UICC II colon cancer patients. … (recur$ or relaps$).tw.
21. exp treatment outcome/
22.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/study-design-framework_research.pdf
March 01, 2012 - The
size of a study depends on a variety of factors, including the expected number of outcome events … of the outcome when it is a scale, the anticipated dropout rate, and the difference in the study … outcome between the intervention and comparator groups that is needed to be of clinical or
policy … This means a composite outcome. … and those who do not have the outcome of interest (controls).
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-3.pdf
February 01, 2018 - a model
• Factors affecting model choice include:
► Number and size of included studies
► Type of outcome … A refined method for the meta‐analysis of controlled clinical trials with binary outcome. … binary outcomes
• Beta-binomial models have attractive properties for meta-analyses
of rare binary outcome … • Factors affecting model choice include the number and size of included
studies, and type of outcome … A refined method for the meta‐analysis of controlled clinical trials with binary outcome.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-216-telehealth-evidence-summary.pdf
April 01, 2019 - Strength of evidence was assessed for each outcome
and Key Question as described in the Methods
Guide … Inpatient telehealth consultations: strength of evidence
Topic Outcome (KQ)
Number of
Studies (N) … Emergency care telehealth consultations: strength of evidence
Topic Outcome (KQ)
Number
of Studies … All
of these studies addressed at least one intermediate
outcome, and we organized these into three … For 10 topics there were improvements in at
least one intermediate outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/malnutrition-hospitalized-adults-protocol.pdf
October 19, 2020 - was not provided by the
largest report or reports longer followup data for an outcome.
4. … The study must report data pertaining to one of the clinical outcomes of interest (see
outcome list … A rating of insufficient will be given when the evidence does not
permit a conclusion for the outcome … Precision is the degree of certainty surrounding an effect estimate with respect to a
given outcome, … A refined method for the
meta-analysis of controlled clinical trials with
binary outcome.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/care-adults-down-syndrome-protocol.pdf
July 09, 2024 - Population, intervention, comparator, outcome, timing, setting (PICOTS)
PICOTS KQ1 KQ2
Population Adults … Outcome Benefits: accurate diagnosis, time to
diagnosis or intervention/treatment
Health and quality … Timing KQ1: There are no restrictions on timing of the intervention,
the timing of the outcome or the … Overall risk of bias assessments for each
study-outcome will be classified as low, medium, high, or … Based on these factors, the overall strength of evidence for each intervention/comparison/
outcome will