-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/trauma-child-interventions_executive.pdf
February 01, 2013 - Population, intervention, comparator, outcome, timing, and setting (continued)
Domain Description
Outcome … Summary of Findings by Outcome
Table E presents detailed findings by outcome for
interventions with … Our outcome criteria also limited our review. … Another limitation of the evidence base results from
outcome assessment methods. … Outcome of
psychotherapy among early adolescents after trauma.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/abnormal-uterine-bleeding_research-protocol.pdf
November 21, 2011 - a clinically important difference (i.e.,
effect size) if such a difference exists for the primary outcome … measure for an outcome
listed in the PICOTS
Relevant outcomes must be extractable from data presented … Each key outcome on each comparison of
interest will be given an overall evidence grade based on the … We will record strength of evidence assessments in tables,
summarizing for each outcome.
G. … Clinical outcome of levonorgestrel intra-uterine
system in idiopathic menorrhagia.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cancer-ovarian-contraceptives_research-protocol.pdf
March 13, 2012 - Grading the Evidence for Each Key Question
The strength of evidence for each key question and outcome … For each outcome, we will use currently available estimates of lifetime
risk, prevalence of OC use, … and relative risk (or relative risk reduction) for that
outcome in OC users to generate estimates of … We will tentatively exclude any outcome from grading if the potential impact
of OC use was less than … The reference to
neurological conditions
(an outcome no longer
under consideration for
the systematic
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_executive.pdf
September 01, 2011 - comparative efficacy of nonpharmacologic treatments (continued)
Number of Strength of
Comparison Outcome … (TRD) for KQ 2,
comparative efficacy for maintaining remission
Number of Strength of
Comparison Outcome … for KQ 3,
comparative efficacy for particular symptom subtypes
Number of Strength of
Comparison Outcome … Subjects Evidencea Findingsb
rTMS vs. sham Changes in 34 Low 1 fair trial: rTMS produced better outcome … rTMS vs. sham Changes in 20 Low 1 fair trial: rTMS produced better outcome
depressive severity than
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/measuring-blood-pressure_disposition-comments.pdf
January 01, 2012 - The outcome measures chosen were largely those previously
specified by included studies. … This problem stems from the plots depicting two different
BP outcome measures. … We considered to switch the orientation for the
categorical outcome but decided against it since we … This is an important intermediate outcome for
primary care providers. … Cost was not an outcome of interest for this report.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antidepressants-update_disposition-comments.pdf
December 01, 2011 - Peer Reviewer #5 Methods Pg 33, line 16 -17 “…outcome of interest.” … 'Drug Interactions' is not really
an outcome measure. … All studies used
physician-rated scales to assess the main outcome measures. … Quality of life, however, was rarely assessed
as a primary outcome measure. … Statistical heterogeneity also depends on the
outcome measure of choice.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/aggression_executive.pdf
October 01, 2016 - Our two primary comparative outcome benefits (KQ
1), which are intermediate outcomes, are a decrease … of Interest
Outcome
N of Patients
Analyzed
Strength
of
Evidence
Supporting
Judgment
Findings … of Interest
Outcome
N of Patients
Analyzed
Strength
of
Evidence
Supporting
Judgment
Findings … of Interest
Outcome
N of
Patients
Analyzed
Strength of
Evidence
Supporting
Judgment
Findings … of
Interest
Outcome
N of Patients
Analyzed
Strength
of
Evidence
Supporting
Judgment
Findings
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/preterm-birth-terbutaline-pump_disposition-comments.pdf
September 01, 2011 - to autism spectrum disorder and determined
that this outcome was more appropriately
related to terbutaline … As we had few studies per
outcome, publication bias was not statistically
investigated. … Peer Reviewer 4 I do not see why the studies on surrogate outcome are rated as “low”
on strength of … We evaluated the outcome of maternal
hyperglycemia for all studies irrespective of
comparators. … Only two studies both
employing oral terbutaline as comparator
reported this outcome.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/antipsychotics-children-update_executive.pdf
January 01, 2018 - The main contributor to ROB was incomplete outcome
data. … Outcome (N Studies,
N Patients)
Findings,a Measurement Tool
With Possible Range of Values, if … Outcome (N Studies,
N Patients)
Findings,a Measurement Tool
With Possible Range of Values, if … f Downgraded for ROB and imprecision due to small samples for this rare outcome.
g Downgraded for ROB … Summary of findings for general adverse effects: Short-term durations of FGAs
versus SGAs
Outcome N
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/tinnitus_research-protocol.pdf
February 22, 2012 - Study authors will be contacted via e-mail for missing outcome or design data. … Outcome measurement
- A clear definition of outcome measurement is provided including
duration of … ☐ ☐ ☐
Outcome Measurements
4. … Were those measuring the main outcome unaware of the exposure status? … Were those measuring the exposure unaware of outcome status?
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/osteoporosis-bone-fracture_research-protocol.pdf
May 14, 2010 - • Outcomes
- The primary outcome is change in fracture incidence (vertebral, non-vertebral,
wrist … • Outcomes
- We propose using fracture incidence as the outcome. … , 6)
2º Outcome: Adverse
effects of treatment
Factors that affect
Adherence/persistence
with … In the report, evidence tables will be used to present this information, as well
as outcome data. … The data relevant to each outcome will be presented in individual tables.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/labor-nitrous-oxide_research-protocol.pdf
August 24, 2011 - measure of
an outcome listed in the PICOTS
Relevant outcomes must be extractable from data
presented … of interest, comparability of cohorts,
assessment of outcome, adequate duration of follow-up, and … Each key outcome on each comparison of interest will be given an overall
evidence grade based on the … When no studies are available for an outcome or comparison of
interest, the evidence will be graded … We will record strength of evidence
assessments in tables, summarizing for each outcome.
G.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/osteoarthritis-knee-future_research.pdf
February 01, 2013 - All topical research needs addressed the PICOTS (population, intervention,
comparison, outcome, timing … Variation in outcome measures in hip and
knee arthroplasty clinical trials: a proposed
approach to … Recommendations for a core set of outcome
measures for future phase III clinical trials
in knee, … Variation in outcome measures in hip and
knee arthroplasty clinical trials: a proposed
approach to … Which patient-centered outcome measurement instruments should be used consistently
by all relevant
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/nonpharma-treatment-pain_research-protocol-amended.pdf
September 20, 2017 - In determining the strength of a body of evidence for each prioritized primary or
safety outcome, the … The aggregate risk of bias
across individual studies reporting an outcome is considered; graded as … • Precision: describes the level of certainty of the estimate of effect for a
particular outcome … Publication bias, selective
outcome reporting, and selective analysis reporting are types of reporting … • High—We are very confident that the estimate of effect lies close to the
true effect for this outcome
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_executive.pdf
March 01, 2012 - RCTs and observational studies included in KQ 10 and
KQ 11 needed to report on a prespecified outcome … Specific patient, intervention, comparator,
outcome, and setting factors that limit applicability were … KQ 3: Pulmonary embolism was the only final health
outcome with data depicting the relationship to the … intermediate outcome DVT. … Helps determine the
degree of importance of each variable for a given outcome.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/omega-3-maternity_disposition-comments.pdf
October 12, 2016 - In
some cases different biomarkers were assessed in
different studies evaluating the same outcome; … Outcome measures and statistical methods
appropriate. … TEP Reviewer
#4
Methods Pediatric Outcome measures--cognitive
development:
The ones listed are … Prenatal DHA status and
neurological outcome in children at age 5.5 years are
positively associated … In the column labeled "Results," we
provided the name of the test (outcome
measure) as reported in
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/fatty-acids-cardiovascular-disease_disposition-comments.pdf
August 12, 2016 - The definitions of the outcome measures could
be improved. … We have two
separate outcome sections
for these, MACE and CVD
death. … Otherwise, CVD,
per se, is not an outcome.
There is no standard
definition of MACE. … But
diabetes is not a CVD
outcome, nor was it
considered to be a standard
CVD intermediate outcome … BP was not a newly added
outcome.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_research-protocol.pdf
April 01, 2013 - Outcomes
• The primary outcome is overall mortality or survival. … Was the outcome measure of interest objective and
was it objectively measured? … o If outcome assessors were not blinded (item 3) or blinding of outcome assessors
was not reported, … then the outcome must have been objective (item 4). … o Not a blinded outcome assessor (item 3) and a subjective outcome (item 4)
• To be considered as having
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/dietary-supplements_research-protocol.pdf
December 15, 2010 - dietary supplement constituents, quality, and
dosage makes it difficult to compare and predict the outcome … O: Outcome categories (please see below for details):
• Clinical outcomes (KQ 1)
• Intermediate … In addition to quantitative data for each outcome,
definitions, methods used to assess outcomes, and … timing of outcome measurement (such as
time from randomization) within each study will be extracted … eDefinition and methods used to assess outcome including timing, and comparability of assessment
across
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/tonsillectomy_research-protocol.pdf
February 10, 2016 - We revised the KQs and population, intervention, comparator, outcome, timing, and
setting … Population, intervention, comparator, outcome characteristics*
KQ Population Intervention … "[mh] OR therapy[tiab] OR
therapies[tiab] OR therapeutic[tiab] OR therapeutics[tiab] OR outcome … Intervention-outcome pairs will be given an overall evidence grade based on the ratings … When no studies are available for an outcome or comparison of interest, we
will grade