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effectivehealthcare-admin.ahrq.gov/products/phenylketonuria/research-protocol
December 01, 2019 - One comment suggested that "cognitive decline" may not be the most accurate outcome description, so we … changed the phrase to "cognitive impairment," which is a more targeted and measureable outcome. … We will capture all validated outcome measures available within these constructs and report on their … Each key outcome on each comparison of interest will be given an overall evidence grade based on the … We will record strength of evidence assessments in tables, summarizing for each outcome.
G.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND__0250_05-20-2010.pdf
January 01, 2010 - surgical, ablation)
Comparator(s): Different drug and/or device and/or procedure (must have comparator)
Outcome … : Different anticoagulant and antiplatelet regimens, LAA occlusive
devices (must have comparator)
Outcome … and/or statins
Comparator(s): Placebo, different ACEIs, ARBs, and/or statins (must have comparator)
Outcome
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/care-adults-down-syndrome-protocol-amendment.pdf
February 05, 2025 - Population, intervention, comparator, outcome, timing, setting (PICOTS)
PICOTS KQ1 KQ2
Population Adults … Outcome Benefits: accurate diagnosis, time to
diagnosis or intervention/treatment
Health and quality … Timing KQ1: There are no restrictions on timing of the intervention,
the timing of the outcome or the … Overall risk of bias assessments for each
study-outcome will be classified as low, medium, high, or … Based on these factors, the overall strength of evidence for each intervention/comparison/
outcome will
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/bimp-protocol.pdf
September 27, 2022 - and Quality (AHRQ) is collaborating with the American
Headache Society (AHS) and Patient-Centered Outcome … evaluate each to-be-graded outcome reported by each study
and assign a risk of bias rating of “high … Although we will assess selective outcome reporting, we will
not incorporate it in the overall risk … This rating is
made separately for each outcome of each comparison of each KQ. … Precision is the degree of certainty surrounding an effect estimate with respect to a
given outcome,
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/structured-handoff-rapid-research.pdf
January 01, 2025 - Does not measure clinical safety
outcome
12. Benjamin MF, Hargrave S, Nether K. … Does not measure clinical safety
outcome
32. Fryman C, Hamo C, Raghavan S, et al. … Does not measure clinical safety
outcome
33. Hada A, Coyer F. … Does not
measure clinical safety outcome
56. Odone A, Bossi E, Scardoni A, et al. … Does not measure clinical safety
outcome
67. Sadri A, Dacombe P, Ieong E, et al.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0620_131115.pdf
March 13, 2013 - and management of MIBC
Comparator(s): Various new and existing therapies and diagnostic approaches
Outcome … socioeconomic strata) predict oncologic outcome
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/chronic-cough_research-protocol.pdf
October 22, 2012 - necessary to begin the process of describing,
implementing, and/or developing cough-related health outcome … The grading will be outcome specific such that a given study that analyzes its primary
outcome well … but did an incomplete analysis of a secondary outcome would be assigned a
different quality grade for … Grading the Evidence for Each Key Question
We will grade the strength of evidence for each outcome … Chronic persistent cough in the adult: the spectrum and
frequency of causes and successful outcome of
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_executive.pdf
January 01, 2012 - compared with usual protein diets; risk for
a composite renal outcome was significantly reduced
in … • ACEI significantly reduced risk of composite renal outcome in one of three trials. … • In one trial, ACEI significantly reduced risk of composite renal outcome. … , or composite renal outcome … but not a composite renal outcome
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_surveillance.pdf
June 01, 2012 - CI= 0.069, 1.668, and p=0.183. 13 1 Signal
Quality of life:
No new evidence was found on this outcome … study was reported to be
adequately powered to detect a
difference between interventions for
this outcome … “In a per-protocol analysis, there
Not assessed None 3 experts stated that
the result for this
outcome … the
ASTRAL trial that is
included in this report.
7
3 experts stated that
the result for this
outcome … Clinical and kidney morphologic predictors of
outcome for renal artery stenting: data to inform patient
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/measuring-blood-pressure_research-protocol.pdf
April 11, 2011 - Quality of life was added as outcome of
interest for KQs 1–4 if measured by validated instruments. … o Not just as a device to measure the outcome BP. … of BP control and
the health outcomes, in addition to the surrogate outcome cardiac measures. … The grading will be outcome-specific such that a given study that reports its primary
outcome well but … did an incomplete analysis of a secondary outcome would be graded of
different quality for the two
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effectivehealthcare-admin.ahrq.gov/products/maternal-morbidity-mortality/research
May 01, 2024 - For outcome domains, depression/other mental health outcomes represented a large proportion of the health … related to social and structural determinants of health and at least one health or healthcare-related outcome … Outcome domains included maternal mortality, severe maternal morbidity, hypertensive disorders, gestational
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/app-e-surv-report-2-noninvasive-nonpharma.xlsx
January 01, 2021 - Allocation Intention to Treat Analysis Baseline Group Similarity Patient Blinded Care Provider Blinded Outcome … Acceptable in All Groups Attrition Reported Attrition Acceptable Attrition B/w Groups Acceptable Timing of Outcome
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/app-e-surv-report-1-noninvasive-nonpharma_0.xlsx
January 01, 2021 - Allocation Intention to Treat Analysis Baseline Group Similarity Patient Blinded Care Provider Blinded Outcome … Acceptable in All Groups Attrition Reported Attrition Acceptable Attrition B/w Groups Acceptable Timing of Outcome
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effectivehealthcare-admin.ahrq.gov/products/cardiac-defibrillators/abstract
December 01, 2019 - firings will be analyzed by an expert clinical panel to determine if the firing was appropriate and the outcome … The primary outcome will be the time to first appropriate device therapy.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/dietary-supplements_executive.pdf
April 01, 2012 - • No relevant outcome was reported in the study or the
outcome data were not received from the authors … (Authors were contacted for data clarification
and additional outcome data when data were recognized … to have been recorded but not reported in the published
study—for example, outcome data without a … of interest (e.g., a surrogate outcome rather
than a clinical health outcome), or imprecision in effect … When inconclusive results were
associated with a gradable outcome, strength of evidence
was deemed
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/head-neck-cancer-update_research-protocol.pdf
February 04, 2014 - We will only report outcome data in strata
according to prognostic or other patient- related factors … The EPC should specify the comparison
and outcome for which the SOE grade
applies. … It includes:
• Study publication bias (i.e.,
nonreporting of the full study)
• Selective outcome … The overall SOE grade for each outcome will be specifically reported
in this table.
Table 2. … – Measurements: equal, reliable, and valid (includes masking of outcome
assessment).
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/heart-failure-transition-care_executive.pdf
May 01, 2014 - Two reviewers assessed
each domain for each key outcome and determined an
overall SOE grade based on … of interest); or (3) no included trials
that reported an outcome (NR). … Summary of key findings and strength of evidence, by outcome and intervention category
Intervention … at this timepoint).
10
Intervention
Category Outcome
Outcome
Timing
N Trials;
N Subjects … Limitations also included inadequate sample size
and heterogeneity of outcome measures across trials
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effectivehealthcare-admin.ahrq.gov/products/schizophrenia-adult/research-protocol
September 01, 2019 - nonpharmacological treatments for schizophrenia can result in meaningful improvements in a variety of outcome … Ideally, improvements in symptoms translate to long-term clinically relevant positive changes in other outcome … Neurocognitive testing is an intermediate outcome, rather than a patient-centered health outcome, and … If the body of evidence for each intervention and outcome group based on insufficient quality and or … will be initially assessed by one researcher for each key clinical outcome (see PICOTS) by using the
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ems-blood-transfusion-protocol.pdf
September 24, 2024 - Scale, Glasgow Outcome
Scale Extended, Modified Rankin Scale, Cerebral
Performance Category
• Length … • Moderate—Confident that the effect estimate lies close to the true effect for this outcome. … • Low—Limited confidence that the estimate of effect lies close to the true effect for this
outcome … We will assign a rating of Insufficient
when the evidence does not permit a conclusion for the outcome … Precision is the degree of certainty surrounding an effect estimate concerning a given
outcome, based
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antipsychotics-children_executive.pdf
February 01, 2012 - Studies were required to
report at least one outcome of interest including
symptom improvement, other … Common
weaknesses included lack of independent and blind
outcome assessment and failure to adequately … Summary of the strength of evidence for symptoms (Key Question 1)
Outcome Comparison (# studies) SOE … Summary of the strength of evidence for symptoms
(Key Question 1) (continued)
Outcome Comparison (# … Summary of the strength of evidence for other short- and long-term
outcomes (Key Question 3)
Outcome