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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-1-app-G.xlsx
January 01, 2023 - Outcome Assessors Masked? Intention-To-Treat Analysis? … Were Outcome Assessors and/or Data Analysts Blinded to the Exposure Being Studied?
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-4-tables-G1-2.xlsx
January 01, 2022 - Outcome Assessors Masked? Intention-To-Treat Analysis? … Were Outcome Assessors and/or Data Analysts Blinded to the Exposure Being Studied?
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-4-tables-F1-F-2.xlsx
January 01, 2023 - Outcome Assessors Masked? Intention-To-Treat Analysis? … Were Outcome Assessors and/or Data Analysts Blinded to the Exposure Being Studied?
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/hepatitis-c_surveillance.pdf
December 01, 2015 - Any clinical outcome
SOE: Insufficient
No evidence. … Dual therapy with
Pegylated Interferon Alfa-2a plus Ribavirin
Outcome: Sustained viroligic response … Dual therapy with
Pegylated Interferon Alfa-2a plus Ribavirin
Outcome: Sustained viroligic response … Dual
therapy with Pegylated Interferon Alfa-2b plus Ribavirin
Outcome: Sustained viroligic response … Dual
therapy with Pegylated Interferon Alfa-2b plus Ribavirin
Outcome: Harms
SOE: Moderate
Triple
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/hepatitis-c_surveillance.pdf
December 01, 2015 - Any clinical outcome
SOE: Insufficient
No evidence. … Dual therapy with
Pegylated Interferon Alfa-2a plus Ribavirin
Outcome: Sustained viroligic response … Dual therapy with
Pegylated Interferon Alfa-2a plus Ribavirin
Outcome: Sustained viroligic response … Dual
therapy with Pegylated Interferon Alfa-2b plus Ribavirin
Outcome: Sustained viroligic response … Dual
therapy with Pegylated Interferon Alfa-2b plus Ribavirin
Outcome: Harms
SOE: Moderate
Triple
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/angina-heart-attack-treatments_executive.pdf
January 01, 2014 - Meta-analyses were based on the nature of the outcome
variable, but random-effects models were used … Dichotomous outcome measures comparing two
treatments were combined using odds ratios and a random- … Strength of the Body of Evidence
We graded the SOE (SOE) for each outcome assessed
because a given … The SOE
for each KQ and outcome was assessed using the approach
described in the Methods Guide.16,19 … SOE)
and the individual outcome of revascularization at
6 months (moderate SOE), but an increase in
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/grading-quiz.ppt
September 02, 2013 - required domains are risk of bias (i.e., quality ratings for individual studies with respect to a specific outcome … similarity in the effect sizes of different studies within an evidence base with respect to a specific outcome … evidence reflects a single, direct link between the interventions of interest and the ultimate health outcome … studies), and precision (i.e., degree of certainty for estimate of effect with respect to a specific outcome
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/grading-quiz.ppt
September 02, 2013 - required domains are risk of bias (i.e., quality ratings for individual studies with respect to a specific outcome … similarity in the effect sizes of different studies within an evidence base with respect to a specific outcome … evidence reflects a single, direct link between the interventions of interest and the ultimate health outcome … studies), and precision (i.e., degree of certainty for estimate of effect with respect to a specific outcome
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-210-breastfeeding-evidence-summary.pdf
January 01, 2020 - Summary of key findings and strength of evidence: Community-based interventions
Breastfeeding Outcome … Summary of key findings and strength of evidence: Maternal health outcomes
Maternal
Health
Outcome … N Studies; N
Subjects Study
Limitations Outcome and Resultsa
Strength of
Evidence
Breast cancer … ; N
Subjects Study
Limitations Outcome and Resultsa
Strength of
Evidence
CVD 3 cohort studies;4, … Magnitude of postpartum weight change varies by BF exposure
and outcome measure.
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effectivehealthcare-admin.ahrq.gov/products/radiation-therapy-bone-metastases/research
December 01, 2023 - HDMF Outcome Time Period Effect Findings SOE Pain, Overall Response Post-RT to 4 weeks None 6 RCTs, … MF SBRT Outcome Time Period Effect Findings SOE Pain, Overall Response 8 weeks No evidence Pain … MF EBRT Outcome Time Period Effect Findings SOE Pain, Overall Response 8 weeks None 2 RCTs (N=995) … Bisphosphonates Outcome Time Period Effect Findings SOE Pain, WHO Response Rate 4 and 12 weeks None … EBRT Outcome Time Period Effect Findings SOE Pain, Overall Response >4 to 12 weeks No evidence
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/Evidence%20Summary_0_0.pdf
April 01, 2020 - Two reviewers assessed each domain
for each key outcome with differences resolved
by consensus. … No
comparison exceeded low SOE for any outcome. … Comparative effective
studies did not exceed low SOE for any outcome. … Outcome of
adolescent depression: 6 months after treatment. … Suicidality and
its relationship to treatment outcome in depressed
adolescents.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/executive-summary-2017-schizophrenia-adult.pdf
January 01, 2017 - � Rehospitalization was not included as an
outcome because: (1) there is important
variation in … Overall, no drug intervention had
high-strength evidence for any outcome of interest, but we
found … Improvement in core illness symptoms is a continuous
outcome measured as the mean change in symptoms … determine whether the
intervention is useful or not in a broader sense, since the
ratings are made on an outcome-by-outcome … No evidence
found a newer SGA superior to older SGAs on any
outcome.
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effectivehealthcare-admin.ahrq.gov/products/atrial-fibrillation/research-protocol
December 01, 2019 - KQ 6: What are the comparative diagnostic accuracy, diagnostic thinking, therapeutic, and patient outcome … The grading will be outcome-specific such that a given study that analyzes its primary outcome well but … did an incomplete analysis of a secondary outcome would be assigned a different quality grade for each … Grading the Evidence for Each Key Question
We will grade the strength of evidence for each outcome … thinking efficacy, therapeutic efficacy, and patient outcome efficacy of echocardiographic studies (
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effectivehealthcare-admin.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-pain-management-grand-rounds-slides.pptx
March 01, 2022 - some nonpharmacological interventions and other methodological limitations
Variability in timing of outcome … Comparison: Placebo, another opioid therapy/nonopioid pharmacologic therapy/nonpharmacologic therapy
Outcome … Improved pain and function (moderate to high SOE)
Ergotamine + caffeine versus placebo Improved pain outcome … (moderate SOE)
Antiemetics versus placebo Improved pain outcome (low SOE)
New treatments CGRP versus … placebo Improved pain outcome (moderate to high SOE)
Lasmiditan versus placebo Improved pain and function
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effectivehealthcare-admin.ahrq.gov/sites/default/files/wysiwyg/pdf/mhs-IV-epc-grand-rounds-slides.pptx
January 01, 2023 - (2018–2023)
4 reviews, 19 primary studies
43
RRS Versus no RRS: Mortality
44
Study Study Type Outcome … this resistant problem.
46
Afferent Arm Modification: Mortality
47
Study Study Type Modifications Outcome … Children
Afferent Arm Modification: Cardiorespiratory Arrest
48
Study Study Type Modifications Outcome … Pre-post)
Insufficient
Adverse Events k = 1 (Pre-post)
Insufficient
ICU Care Transitions
k = 3
Outcome … Patient satisfaction k=1 (Pre-post)
Insufficient
Residential Treatment Facility Discharge
k = 1
Outcome
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/lung-cancer-staging_research-protocol.pdf
December 08, 2014 - • Add tumor response as an effectiveness outcome. … For each outcome, studies will be rated as “Low,” “Medium,” or “High” risk of bias. … This grade is provided separately for each outcome of each comparison of
each Key Question. … Was the outcome measure of interest objective and was it objectively measured?
18. … Was a standard instrument used to measure the outcome?
19.
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effectivehealthcare-admin.ahrq.gov/products/acs-pci-adjunctive-devices/research-protocol
December 01, 2019 - criteria: comparable study groups at baseline, detailed description of study outcomes, blinding of outcome … For each outcome, we will conduct separate analyses of studies and compare each individual adjunctive … Risk of Bias
Risk of bias is the degree to which the included studies for any given outcome or comparison … Precision refers to the degree of certainty surrounding an effect estimate with respect to a given outcome … of the body of evidence will then be determined and reported separately and qualitatively for each outcome
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cannabis-2024-update-appendix-f.xlsx
January 01, 2024 - Outcome Assessors Masked? Intention-To-Treat Analysis? … Were Outcome Assessors and/or Data Analysts Blinded to the Exposure Being Studied?
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-tables-f1-2.xlsx
January 01, 2024 - Outcome Assessors Masked? Intention-To-Treat Analysis? … Were Outcome Assessors and/or Data Analysts Blinded to the Exposure Being Studied?
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effectivehealthcare-admin.ahrq.gov/sites/default/files/methodsguidenorris_060420101.pdf
June 01, 2010 - Selective outcome reporting can occur in a number of ways, including selective omission of
outcomes … For
example, high-quality observational studies that focus on outcome measures such as persistency … Bias in meta-analysis
due to outcome variable selection within studies. … Outcome reporting bias in randomized trials
funded by the Canadian Institutes of Health
Research. … Precision The degree of certainty surrounding an effect
estimate for a given outcome.