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effectivehealthcare-admin.ahrq.gov/products/obesity-research-methods/research-protocol
January 01, 2019 - Most reported the behavioral outcome of change in caloric intake during a single meal, which was the … outcome used in the meta-analysis. 17
As demonstrated in the review, 16 few studies included BMI or … weight as a primary outcome. … Outcome(s)
Outcomes of interest (need one or more of these: See Appendix B, list of outcome measures … Co-outcomes to be considered ONLY if at least one required outcome is also reported: Food-environment
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effectivehealthcare-admin.ahrq.gov/sites/default/files/upenn-final-report-2005-certs-ce-supplement.pdf
January 01, 2005 - Measure the positive predictive value of a specific outcome that might be employed in studies of comparative … In particular, we validated hospitalization for the composite outcome of sudden
cardiac death and ventricular … VF and VT), some authors prefer the term “presumed
arrhythmic death” to SCD.14 Validation of this outcome … This potentially argues that studies of utilizing this outcome should
include only those SCD/VA events … Conclusion: Overall, our outpatient-occurring composite SCD/VA outcome validated poorly (PPV= 18%).
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/administrative-data-validity_research.pdf
January 01, 2007 - Measure the positive predictive value of a specific outcome that might be employed in studies of comparative … In particular, we validated hospitalization for the composite outcome of sudden
cardiac death and ventricular … VF and VT), some authors prefer the term “presumed
arrhythmic death” to SCD.14 Validation of this outcome … This potentially argues that studies of utilizing this outcome should
include only those SCD/VA events … Conclusion: Overall, our outpatient-occurring composite SCD/VA outcome validated poorly (PPV= 18%).
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/carbohydrate-intake-protocol.pdf
April 08, 2024 - Inclusion and Exclusion Criteria by Population, Intervention, Comparator,
Outcome, Timing, Setting/Study … Outcome KQ1:
Newborn size and body
composition
• Birth weight, weight-
for-age and percentile … The aggregate risk of bias across
individual studies reporting an outcome is considered. … • Directness (direct or indirect)
o This is the degree to which the outcome is directly or indirectly … Low Limited confidence that the estimate of effect lies close to the true effect
for this outcome.
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effectivehealthcare-admin.ahrq.gov/products/summary-findings
December 01, 2024 - service Reducing adverse drug events related to anticoagulant use in adults Use of report cards and outcome … The TEP recommended more research with stronger study designs and better outcome measures to demonstrate … Use of Report Cards and Outcome Measurements To Improve the Safety of Surgical Care 10a. … The final report is available at: Use of Report Cards and Outcome Measurements To Improve the Safety … Use of Report Cards and Outcome Measurements to Improve the Safety of Surgical Care The TEP encouraged
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effectivehealthcare-admin.ahrq.gov/products/carbohydrate-intake/protocol
May 01, 2024 - Inclusion and Exclusion Criteria by Population, Intervention, Comparator, Outcome, Timing, Setting/Study … Outcome
KQ1:
Newborn size and body composition
Birth weight, weight-for-age and percentile … The aggregate risk of bias across individual studies reporting an outcome is considered. … Directness (direct or indirect)
This is the degree to which the outcome is directly or indirectly … Low
Limited confidence that the estimate of effect lies close to the true effect for this outcome
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/carbohydrate-intake-appendixes-a-f.pdf
April 29, 2024 - Exclusion reason: Ineligible
outcome
42. Chen Y, Qin Y, Zhang Z, et al. … Exclusion reason: Ineligible
outcome
71. Fan Y, Vinjamuri A, Tu D, et al. … Exclusion reason: Ineligible
outcome
73. Fikawati S, Wahyuni D, Syafiq A. … Exclusion reason: Ineligible
outcome
154. Lin Q, Zhang Z, Meng Q, et al. … Exclusion reason: Ineligible
outcome
286. Watson PE, McDonald BW.
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effectivehealthcare-admin.ahrq.gov/products/thromboembolism-update/research-2017
January 01, 2021 - interventions (such as aspirin and mechanical devices); most reported on total deep vein thrombosis (DVT), an outcome … Longer duration LMWH has lower risk of various VTE outcome risks (low to high SoE). … Importantly, though, most studies evaluate “total DVT” (an outcome of unclear clinical significance since … This limitation yields a high likelihood of selective outcome reporting bias.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_executive.pdf
March 01, 2011 - We noted
that one medication or class may have favorable effects
on one lipid outcome and unfavorable … effects on
another lipid outcome. … We
did not identify any studies for the outcome of
retinopathy. … Insufficient No studies addressed the outcome of retinopathy. … Cancer Insufficient Few studies addressed the outcome of cancer.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-201-indoor-allergen-reduction-asthma-evidence-summary.pdf
February 01, 2018 - • Qualitative comparative analysis affirmed the general
lack of robust findings of improved outcome … heterogeneity (e.g., patient age and asthma
severity), infrequent reporting of validated asthma
outcome … We also found that few studies
reported critical, discrete, validated outcome measures,
which have … paucity of studies using current, standardized
measures limited our interpretation of the primary outcome … The evidence base could also
be evaluated with greater precision if outcome reporting
were improved
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/peripheral-nerve-block-protocol.pdf
November 18, 2023 - We agree this likely will be rarely reported, but we will attempt to identify
outcome correlations … ● Outcome: Comments on outcomes highlighted a need for defining efficacy and
narrowing the scope … Overall risk of bias assessments for each study outcome will be classified as low, moderate,
or high … Data Synthesis
Results will be organized by intervention comparison, targeted outcome, and outcome … For each comparison, one review author will rate the certainty of evidence
for each outcome as high
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effectivehealthcare-admin.ahrq.gov/products/fiber-intake/protocol
March 01, 2024 - Study eligibility criteria based on Population, Intervention, Comparator, Outcome (PICO), and other elements … Particularly since several outcome measures (e.g., fecal frequency) may be commonly measured over a period … (i.e., requiring a 1-week washout for all cross-over studies), the inclusion criteria require that outcome … assessor blinding are all unclear (with the recognition that the participant may be the outcome assessor … Grading the Strength of Evidence for Each Outcome
Following AHRQ Methods guidance, 14 the review team
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effectivehealthcare-admin.ahrq.gov/sites/default/files/wysiwyg/pdf/child-growth-development-outcomes-protocol.pdf
August 19, 2024 - Inclusion and Exclusion Criteria by Population, Intervention, Comparator,
Outcome, Timing, Setting/Study … Based on this prioritized list, the SOE for exposure/intervention-outcome pairs
within each KQ will … The aggregate risk of bias
across individual studies reporting an outcome is considered. … • Directness (direct or indirect)
o This is the degree to which the outcome is directly or indirectly … Low Limited confidence that the estimate of effect lies close to the true effect
for this outcome.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_surveillance.pdf
March 14, 2013 - possibly out of date
- The conclusions for KQ4 (DMARDs and various
categories of JIA) and KQ5 (outcome … Evidence Table
Author, year Trial n Subjects Primary Outcome Duration Findings
Key Question 1: In … Author, year Trial n Subjects Primary Outcome Duration Findings
Quartier, 201121 RCT, anakinra vs … Author, year Trial n Subjects Primary Outcome Duration Findings
No new evidence No new evidence No … Author, year Trial n Subjects Primary Outcome Duration Findings
Wallace, 201128 RCT of
etanercept+
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/juvenile-arthritis-dmards_surveillance.pdf
March 14, 2013 - possibly out of date
- The conclusions for KQ4 (DMARDs and various
categories of JIA) and KQ5 (outcome … Evidence Table
Author, year Trial n Subjects Primary Outcome Duration Findings
Key Question 1: In … Author, year Trial n Subjects Primary Outcome Duration Findings
Quartier, 201121 RCT, anakinra vs … Author, year Trial n Subjects Primary Outcome Duration Findings
No new evidence No new evidence No … Author, year Trial n Subjects Primary Outcome Duration Findings
Wallace, 201128 RCT of
etanercept+
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/fecal-incontinence_research-protocol.pdf
November 30, 2014 - assessment, incomplete outcome data, selective
outcome reporting, and other sources of bias (i.e., … Outcome measures for fecal
incontinence: anorectal structure and function. … Were important
variables known to
impact the outcome(s)
assessed at baseline? … Are statistical
methods used to assess
the primary outcome
appropriate to the data? … Is there suggestion
of selective outcome
reporting?
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effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-bias_methods.pdf
February 01, 2013 - The outcome measures included, and inclusion of non-English
language papers account for at least some … Our analysis of these reviews focused on the prevention of stress ulcer bleeding,
as this outcome was … Outcome
Described as
effectiveness
outcomes
Reviewers determine whether
specific outcomes are … Lack of specificity on other aspects of outcome measurement may also bias SR conclusions. … Selective Outcome Reporting as a Source of
Bias in Reviews of Comparative
Effectiveness.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/wysiwyg/missing-data-registries-guide-3rd-ed-addendum-white-paper.pdf
February 01, 2018 - other factors) and therefore the outcome is
inexplicitly linked to the missing data. … (Prepared by the Outcome
DEcIDE Center [Outcome Sciences, Inc., a
Quintiles company] under Contract … (Prepared by the Outcome DEcIDE Center
[Outcome Sciences, Inc., a Quintiles
company] under Contract … (Prepared by the Outcome
DEcIDE Center [Outcome Sciences, Inc., a
Quintiles company] under Contract … Long-term outcome after acute kidney
injury in critically-ill patients.
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/ptsd-6-draft-report-update-2025.pdf
January 01, 2025 - • Studies reporting only individual symptoms
or symptom clusters without overall PTSD
outcome
• … Studies that did not perform formal
statistical test for between-group
comparison of a PTSD outcome … , we
instead assessed RoB for the PTSD dichotomous outcome in these three studies. … Ratings for
additional outcome measures are available in the evidence table. … data or measurement of the outcome (Table 8).
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effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-194-evidence-summary-corticosteroids-asthma.pdf
October 01, 2017 - relief vs. a higher ICS controller dose
• Reduces the risk of exacerbations measured as a composite outcome … relief
vs. a higher ICS controller dose
• Reduces the risk of exacerbations defined as a composite outcome … as controller at the same ICS dose
• Reduces:
– The risk of exacerbations defined as a composite outcome … LABA as controller at a higher ICS dose
• Reduces the risk of exacerbations defined as a composite outcome … with or without
LABA as controller
• Reduces:
– The risk of exacerbations defined as a composite outcome