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  1. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1406.pdf
    January 01, 2020 - that emerged as having high-impact potential address opioid overdose (both prescription and illicit opioids … to relatively inexpensive illicit opioid drugs, such as heroin, and increased use of prescription opioids … Opioid Overdose Prevention Program (Project Lazarus)  Key Facts: Increased reliance on prescription opioids … for pain management and illegal use of prescription opioids have contributed to nationwide increases … patients may be slow to adopt this intervention because it would indirectly broadcast their use of opioids
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-3-acute-pain.xlsx
    September 21, 2022 - B Opioid use (mean [SD] tablets): 6.33 (7.1) vs. 5.69 (5.8), p=0.24 Consumed opioids postoperatively: … (1.90) vs. 1.84 (1.29) day 1, p=0.01; 3.14 (2.12) vs. 3.29 (2.14) day 7, p=0.17 NR NR Escalated to opioids … B Days taking opioids (mean [range]): 3 (1-5) vs. 5 (2-8), p<0.001 Total morphine equivalents (mean [ … thyroid and parathyroid surgery Postoperative opt-in narcotics treatment vs. usual care A: Preoperative opioids … education (postoperative opt-in narcotics treatment, with opioids given only at patient request) B:
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-2-acute-pain.xlsx
    September 20, 2022 - B Opioid use (mean [SD] tablets): 6.33 (7.1) vs. 5.69 (5.8), p=0.24 Consumed opioids postoperatively: … (1.90) vs. 1.84 (1.29) day 1, p=0.01; 3.14 (2.12) vs. 3.29 (2.14) day 7, p=0.17 NR NR Escalated to opioids … B Days taking opioids (mean [range]): 3 (1-5) vs. 5 (2-8), p<0.001 Total morphine equivalents (mean [ … thyroid and parathyroid surgery Postoperative opt-in narcotics treatment vs. usual care A: Preoperative opioids … education (postoperative opt-in narcotics treatment, with opioids given only at patient request) B:
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/living-systematic-reviews-full-text-articles-white-paper.pdf
    January 01, 2024 - In the case of opioids,5 serious potential harms include risk of opioid use disorder and overdose. … CDC guideline for prescribing opioids for chronic pain– United States, 2016. … CDC guideline for prescribing opioids for chronic pain - United States, 2016. … Concomitant cannabis abuse/dependence in patients treated with opioids for non-cancer pain. … Concomitant cannabis abuse/dependence in patients treated with opioids for non-cancer pain.
  5. effectivehealthcare.ahrq.gov/sites/default/files/diabetic-neuropathy-disposition-170707.pdf
    March 24, 2017 - In contrast to Griebeler et al., we synthesized evidence on atypical opioids (tapentadol and tramadol … Otherwise, typical opioids are considered to be equivalent in efficacy for pain and have been treated … HELPFUL PARTCULATRLY AT NIGHT WITH SLEEP PROBLEMS; THERE NEEDS TO BE SLOW TITRATION and atypical opioids … For tramadol and tapentadol, we report in the abstract that “opioids have significant long-term risks … and in the discussion, that “New guidelines and position papers now recommend against the use of opioids
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/diabetic-neuropathy-disposition-170707.pdf
    March 24, 2017 - In contrast to Griebeler et al., we synthesized evidence on atypical opioids (tapentadol and tramadol … Otherwise, typical opioids are considered to be equivalent in efficacy for pain and have been treated … HELPFUL PARTCULATRLY AT NIGHT WITH SLEEP PROBLEMS; THERE NEEDS TO BE SLOW TITRATION and atypical opioids … For tramadol and tapentadol, we report in the abstract that “opioids have significant long-term risks … and in the discussion, that “New guidelines and position papers now recommend against the use of opioids
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0122_06-29-2009.pdf
    January 01, 2009 - Comparator(s): no analgesic/anesthetic intervention, analgesia/anesthesia, systemic medications (such as opioids
  8. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1412.pdf
    December 01, 2014 - Inexpensive and readily available illicit opioid drugs, such as heroin, and increased use of prescription opioids … Opioid Overdose by Nonclinicians  Key Facts: Fatal opioid overdoses of both prescription and illicit opioids … that patients may be slower to adopt this intervention than families or friends of patients taking opioids … , as it could inadvertently expose an individual’s use of opioids.18 Overall, experts commented that
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/mat-retention-strategies-rapid-review-1.pdf
    August 01, 2020 - Participants were still considered retained in MAT if they continued to use illicit opioids or missed … Unlike naltrexone, buprenorphine does not require a period of complete abstinence from opioids to initiate … of XR-naltrexone and other antagonist therapies that require a period of complete abstinence from opioids … Script in a Day intervention for individuals who are injecting opioids: a feasibility randomized control … Effects of medication-assisted treatment on mortality among opioids users: a systematic review and
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharm-treatment-chronic-pain-protocol.pdf
    December 11, 2018 - benzodiazepines) topical agents,(diclofenac, lidocaine capsaicin)  Medical marijuana (any formulation)  Opioidanalgesics o Key Questions 1-4, 6, subquestion “c”: Exercise o Key Question 5, 6, subquestion “c” … and CBD); FDA approved synthetic cannabinoids (Dronabionol [THC], Nabilone [similar to THC]) • Opioidanalgesics KQs 1-4, 6 subquestion c • Exerciseb KQ 5, 6 subquestion c • Biofeedbackc All KQs: … Efficacy of opioids for chronic pain: a review of the evidence.
  11. effectivehealthcare.ahrq.gov/products/noninvasive-nonpharm-pain-update/protocol
    March 01, 2019 - benzodiazepines) topical agents,(diclofenac, lidocaine capsaicin) Medical marijuana (any formulation) Opioidanalgesics Key Questions 1-4, 6, subquestion "c": Exercise Key Question 5, 6, subquestion "c": … THC and CBD); FDA approved synthetic cannabinoids (Dronabionol [THC], Nabilone [similar to THC]) Opioidanalgesics KQs 1-4, 6 subquestion c Exercise b KQ 5, 6 subquestion c Biofeedback c All KQs … Efficacy of opioids for chronic pain: a review of the evidence.
  12. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1312.pdf
    December 01, 2013 - Community-Based Opioid Overdose Prevention Program (Project Lazarus) Unmet need: Increased prescribing of opioids … deaths associated with these pharmacologic agents.1 Illegal use of prescription pain relievers (i.e., opioids … For patients requiring chronic opioids for pain management or help with opioid dependence, treatment
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-surveillance-report-3.pdf
    May 01, 2022 - CDC guideline for prescribing opioids for chronic pain– United States, 2016. … CDC guideline for prescribing opioids for chronic pain - United States, 2016. … Efficacy of opioids for chronic pain: a review of the evidence. … Critical issues on opioids in chronic non-cancer pain: an epidemiological study. … Opioids for chronic noncancer pain: a systematic review and meta-analysis.
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-surveillance-report-3_0.pdf
    May 01, 2022 - CDC guideline for prescribing opioids for chronic pain– United States, 2016. … CDC guideline for prescribing opioids for chronic pain - United States, 2016. … Efficacy of opioids for chronic pain: a review of the evidence. … Critical issues on opioids in chronic non-cancer pain: an epidemiological study. … Opioids for chronic noncancer pain: a systematic review and meta-analysis.
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/pain-chronic_disposition-comments.pdf
    September 01, 2011 - Here, it would be “opioids”. … (p.16, L 2-3) Peer Reviewer #1 Summary and Implications In addition, the role that opioids … Additionally, the subheading “Role of opioids” could easily fall under Question 3, the subheading “ … Peer Reviewer #5 Summary and Implications The section on opioids does not transition smoothly … Likewise, the immediately following sections on “role of opioids” and “patient-related issues” appear
  16. effectivehealthcare.ahrq.gov/products/migraine-emergency/research-protocol
    July 18, 2011 - ergot derivatives (e.g., dihydroergotamine), intravenous nonsteroidal anti-inflammatory agents, and opioidsOpioids are often used to treat acute migraine despite their recognized ability to cause dependence and … For example, opioids may be associated with drowsiness and impaired ability to function. … agents Meperidine (Demerol) Valproic acid Other agents: propafol (Diprivan), ketamine (Ketalar), opioids … Ergots Dihydroergotamine 6 D.H.E. 45 IV, IM, SQ NSAID Ketorolac Toradol IV, IM Opioids
  17. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/cer-250-cannabis-surveillance-report-3.pdf
    May 01, 2022 - CDC guideline for prescribing opioids for chronic pain– United States, 2016. … CDC guideline for prescribing opioids for chronic pain - United States, 2016. … Efficacy of opioids for chronic pain: a review of the evidence. … Critical issues on opioids in chronic non-cancer pain: an epidemiological study. … Opioids for chronic noncancer pain: a systematic review and meta-analysis.
  18. effectivehealthcare.ahrq.gov/products/retention-strategies-opioid-use-disorder/rapid-protocol
    May 08, 2019 - Effects of medication-assisted treatment on mortality among opioids users: a systematic review and meta-analysis
  19. effectivehealthcare.ahrq.gov/sites/default/files/cer-225-substance-abuse-adolescents-evidence-summary%20225%20Substance%20Use%20Adolescents.pdf
    May 01, 2020 - Very few studies evaluated users of opioids, methamphetamines, or substances other than alcohol or cannabis
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-2.pdf
    June 01, 2022 - The original 2020 report examined the evidence on the comparative effectiveness and harms of opioids … RCTs evaluated pharmacologic therapies and were included for KQ 2.4-6 There were no new studies on opioids … the original 2020 report and Surveillance Report 1 on the comparative effectiveness and harms of opioidsOpioids have low or insufficient strength of evidence for acute treatment of migraine. … SES]); (2) patient medical comorbidities (previous opioid use, body mass index [BMI]); (3) dose of opioids

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