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  1. effectivehealthcare.ahrq.gov/products/opioids-older-adults/protocol
    August 16, 2019 - older adults is, thus, commonly difficult to manage as many older adults are unable to tolerate non-opioidanalgesics (e.g., non-steroidal anti-inflammatory drugs) due to impaired liver or kidney function, hypertension … Opioid analgesics and the risk of fractures in older adults with arthritis. … Adverse effects of analgesics commonly used by older adults with osteoarthritis: focus on non-opioid and opioidanalgesics.
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/opioids-oa-protocol.pdf
    June 29, 2019 - older adults is, thus, commonly difficult to manage as many older adults are unable to tolerate non-opioidanalgesics (e.g., non-steroidal anti-inflammatory drugs) due to impaired liver or kidney function, … Opioid analgesics and the risk of fractures in older adults with arthritis. … Adverse effects of analgesics commonly used by older adults with osteoarthritis: focus on non-opioid and opioidanalgesics.
  3. effectivehealthcare.ahrq.gov/products/opioids-chronic-pain/protocol
    February 27, 2019 - used (e.g., pure opioid agonists, partial opioid agonists such as buprenorphine or drugs with mixed … between pure opioid agonists and partial opioid agonists such as buprenorphine or drugs with opioid … misuse, opioid use disorder, and overdose; and doses of opioids used? … opioids (including tapentadol, buprenorphine, and tramadol) opioids Exclude: Intravenous or intramuscular … CDC guideline for prescribing opioids for chronic pain--United States, 2016.
  4. effectivehealthcare.ahrq.gov/products/opioids-older-adults/report
    November 03, 2020 - 16, 2019 Research Protocol Nov. 3, 2020 Technical Brief Prevention, Diagnosis, and Management of Opioids … Prior or early postoperative opioid use, or greater amounts of prescribed opioids (high number of opioid … age among older adults, Black race, dementia, rural/nonurban residence, prescription of long-acting opioids … These included factors associated with opioid use disorder, high-risk obtainment of prescription opioids … Prevention, Diagnosis, and Management of Opioids, Opioid Misuse, and Opioid Use Disorder in Older Adults
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-pain-opioid-treatment_research-protocol.pdf
    December 19, 2013 - Revised Protocol - Opioids 12 13 13[1] … related to pain, function, quality of life, and doses of opioids used? … , addiction, abuse, or misuse; and doses of opioids used? … Curtailing diversion and abuse of opioid analgesics without jeopardizing pain treatment. … Extended-Release and Long-Acting (ER/LA) Opioid Analgesics Risk Evaluation and Mitigation Strategy
  6. effectivehealthcare.ahrq.gov/sites/default/files/cer-229-opioid-treatments-chronic-pain-evidence-summary.pdf
    April 01, 2020 - used (e.g., pure opioid agonists, partial opioid agonists such as buprenorphine, or drugs with mixed … , partial opioid agonists such as buprenorphine, or drugs with opioid and nonopioid mechanisms of … versus placebo, opioids versus nonopioids, opioids plus nonopioids versus nonopioids alone, and opioids … Harms of opioids vs. … Opioid analgesics and the risk of fractures in older adults with arthritis.
  7. effectivehealthcare.ahrq.gov/products/opioids-chronic-pain
    February 27, 2019 - Opioid Treatments for Chronic Pain Timeline February 22, 2019 Topic Initiated February 27, 2019 Research Protocol Opioid Treatments for Chronic Pain April 16, 2020 Systematic Review Opioid Treatments for Chronic Pain
  8. effectivehealthcare.ahrq.gov/products/opioids-chronic-pain/research
    April 16, 2020 - Key Messages Opioids are associated with small improvements versus placebo in pain and function, and … Random effects meta-analysis was conducted on short-term trials of opioids versus placebo, opioids versus … nonopioids, and opioids plus nonopioids versus an opioid or nonopioid alone. … No RCT evaluated intermediate- or long-term benefits of opioids versus placebo. … long-acting opioids were associated with increased risk of overdose.
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/opioid-treatments-chronic-pain-protocol.pdf
    December 19, 2018 - used (e.g., pure opioid agonists, partial opioid agonists such as buprenorphine or drugs with mixed … between pure opioid agonists and partial opioid agonists such as buprenorphine or drugs with opioid … misuse, opioid use disorder, and overdose; and doses of opioids used? … or short- acting opioids (including tapentadol, buprenorphine, and tramadol) opioids Exclude … CDC guideline for prescribing opioids for chronic pain-- United States, 2016.
  10. effectivehealthcare.ahrq.gov/webform/products/opioids-older-adults/submit-sead
    August 16, 2019 - Home » Webform » Products » Opioids Older Adults » Prevention, Diagnosis, and Management … of Opioids, Opioid Misuse and Opioid Use Disorder in Older Adults Prevention, Diagnosis … , and Management of Opioids, Opioid Misuse and Opioid Use Disorder in Older Adults Timeline … August 16, 2019 Research Protocol Prevention, Diagnosis, and Management of Opioids … November 03, 2020 Technical Brief Prevention, Diagnosis, and Management of Opioids
  11. effectivehealthcare.ahrq.gov/sites/default/files/tech-brief-37-opiod-use-adults-comments.pdf
    November 03, 2020 - for the shortest duration possible, and co- prescribing opioids with non-opioid analgesics, but not … analgesics are on the order of a maximum of 0.6% (Ref 2). … mortality in patients of any age who are diagnosed and treated for chronic pain with prescription opioidanalgesics, is very low. … “Cohort study of the impact of high-dose opioid analgesics on overdose mortality”.
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-chronic-pain-surveillance-report-3.pdf
    June 01, 2022 - used (e.g., pure opioid agonists, partial opioid agonists such as buprenorphine, or drugs with mixed … , partial opioid agonists such as buprenorphine, or drugs with opioid and nonopioid mechanisms of action … Efficacy and Safety of Opioid Analgesics for the Management of Chronic Low Back Pain: An Evidence from … Does aerobic exercise training alter responses to opioid analgesics in individuals with chronic low … COMET - effectiveness and tolerability of methocarbamol versus oral opioid- analgesics as add-on measure
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-chronic-pain-surveillance-report-2.pdf
    April 01, 2022 - Opioids vs. … used (e.g., pure opioid agonists, partial opioid agonists such as buprenorphine, or drugs with mixed … , partial opioid agonists such as buprenorphine, or drugs with opioid and nonopioid mechanisms of action … Efficacy and Safety of Opioid Analgesics for the Management of Chronic Low Back Pain: An Evidence from … Does aerobic exercise training alter responses to opioid analgesics in individuals with chronic low
  14. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/opioid-chronic-pain-surveillance-report-3.pdf
    June 01, 2022 - used (e.g., pure opioid agonists, partial opioid agonists such as buprenorphine, or drugs with mixed … , partial opioid agonists such as buprenorphine, or drugs with opioid and nonopioid mechanisms of action … Efficacy and Safety of Opioid Analgesics for the Management of Chronic Low Back Pain: An Evidence from … Does aerobic exercise training alter responses to opioid analgesics in individuals with chronic low … COMET - effectiveness and tolerability of methocarbamol versus oral opioid- analgesics as add-on measure
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioids-chronic-pain-surveillance-report-1-final.pdf
    April 01, 2022 - studies (2 new) 2c Opioids vs. non-opioids harms: 13 studies 2d Opioids + non-opioid vs. … used (e.g., pure opioid agonists, partial opioid agonists such as buprenorphine, or drugs with mixed … , partial opioid agonists such as buprenorphine, or drugs with opioid and nonopioid mechanisms of action … Efficacy and Safety of Opioid Analgesics for the Management of Chronic Low Back Pain: An Evidence from … Does aerobic exercise training alter responses to opioid analgesics in individuals with chronic low
  16. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/opioid-chronic-pain-surveillance-report-2.pdf
    April 01, 2022 - Opioids vs. … used (e.g., pure opioid agonists, partial opioid agonists such as buprenorphine, or drugs with mixed … , partial opioid agonists such as buprenorphine, or drugs with opioid and nonopioid mechanisms of action … Efficacy and Safety of Opioid Analgesics for the Management of Chronic Low Back Pain: An Evidence from … Does aerobic exercise training alter responses to opioid analgesics in individuals with chronic low
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-pain-opioid-treatment_executive.pdf
    September 19, 2014 - Analgesics List.32 We received five SIP submissions. … Curtailing diversion and abuse of opioid analgesics without jeopardizing pain treatment. … Extended-Release and Long-Acting (ER/LA) Opioid Analgesics Risk Evaluation and Mitigation Strategy … A survey of chronic noncancer pain patients prescribed opioid analgesics. … Drug Class Review: Long-Acting Opioid Analgesics: Final Update 6 Report.
  18. Appendixes (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendixes-surveillance-report-1.pdf
    September 30, 2021 - used (e.g., pure opioid agonists, partial opioid agonists such as buprenorphine, or drugs with mixed … , partial opioid agonists such as buprenorphine, or drugs with opioid and nonopioid mechanisms of action … Efficacy and Safety of Opioid Analgesics for the Management of Chronic Low Back Pain: An Evidence from … Does aerobic exercise training alter responses to opioid analgesics in individuals with chronic low … Individual opioids, and long- versus short- acting opioids, for chronic noncancer pain: Protocol for
  19. effectivehealthcare.ahrq.gov/products/chronic-pain-opioid-treatment/research-protocol
    December 19, 2013 - related to pain, function, quality of life, and doses of opioids used? … , addiction, abuse, or misuse; and doses of opioids used? … Curtailing diversion and abuse of opioid analgesics without jeopardizing pain treatment. … American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel. … Extended-Release and Long-Acting (ER/LA) Opioid Analgesics Risk Evaluation and Mitigation Strategy (REMS
  20. effectivehealthcare.ahrq.gov/products/acute-pain-ems/research
    September 03, 2019 - Purpose of Review To evaluate effectiveness and harms of opioids compared to nonopioid analgesics as … Acetaminophen may provide similar pain relief to opioids, and may cause fewer side effects overall and … Ketamine may provide similar pain relief to opioids. … Combining an opioid with ketamine may be more effective in reducing pain compared with opioids alone. … Opioids may cause fewer total side effects than ketamine, but more than APAP or NSAIDs.

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