- 
                                        
psnet.ahrq.gov/sites/default/files/2022-01/final_spotlight_stacked_opioid_administration_01.03.2022.pdf
January 01, 2022 - • Dose stacking can also occur when a patient receives opioids via 
numerous sources or routes. … • When administered, naloxone rapidly displaces opioids from μ-
receptors and consequently reverses … 28
Thinking Beyond Opioids (1)
• Not all discomfort and pain respond to opioids and repeat opioid … Prescribing of opioid analgesics and related mortality before and after the introduction of long-
acting … Thinking Beyond Opioids (1)
	Thinking Beyond Opioids (2)
	Take Home Points
	Take-Home Points (1)
	References
                                     
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psnet.ahrq.gov/issue/overprescribing-opioids-adults-dentists-us-2011-2015
October 07, 2020 - Study 
 
 
 
 
 
 
 
 
 
 Overprescribing of opioids to adults by dentists in the U.S., 2011-2015. … Overprescribing of opioids to adults by dentists in the U.S., 2011-2015. … National guidelines  published in 2016 recommend prescribing low-dose opioids for short durations when … Overprescribing of opioids to adults by dentists in the U.S., 2011-2015. … October 21, 2020 
 
 
 
 
 
 
 
 Potentially inappropriate medication combination with opioids among
                                     
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psnet.ahrq.gov/issue/patient-outcomes-dose-reduction-or-discontinuation-long-term-opioid-therapy-systematic-review
April 08, 2019 - October 19, 2022 
 
 
 
 
 
 
 
 Assessment of potentially inappropriate prescribing of opioid analgesics … 12, 2014 
 
 
 
 
 
 View More 
 
 
 
 
 
 Related Resources 
 
 
 
 
 
 
 Physician prescribing of opioids … December 6, 2017 
 
 
 
 
 
 
 
 Efficacy, tolerability, and dose-dependent effects of opioid analgesics … December 21, 2016 
 
 
 
 
 
 
 
 Are physicians safely prescribing opioids for chronic noncancer pain … June 1, 2016 
 
 
 
 
 
 
 
 How to maximize patient safety when prescribing opioids.
                                     
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psnet.ahrq.gov/issue/reducing-adverse-drug-events-related-opioids-implementation-guide
January 26, 2022 - Toolkit 
 
 
 
 
 
 
 
 
 
 Reducing Adverse Drug Events Related to Opioids Implementation Guide. … Citation Text: 
 Reducing Adverse Drug Events Related to Opioids Implementation Guide. … Opioids are high-risk medications that are increasingly  problematic  for patients and providers. … instructions to help hospitals implement initiatives to improve safe prescribing and administration of opioids … assess  processes , identify best practices, and engage staff to reduce  adverse events  involving opioids
                                     
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psnet.ahrq.gov/issue/strategies-identify-patient-risks-prescription-opioid-addiction-when-initiating-opioids-pain
November 16, 2022 - Strategies to identify patient risks of prescription opioid addiction when initiating opioids … Strategies to Identify Patient Risks of Prescription Opioid Addiction When Initiating Opioids for Pain … Strategies to Identify Patient Risks of Prescription Opioid Addiction When Initiating Opioids for Pain … May 31, 2017 
 
 
 
 
 
 
 
 Are physicians safely prescribing opioids for chronic noncancer pain? … June 1, 2016 
 
 
 
 
 
 
 
 How to maximize patient safety when prescribing opioids.
                                     
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psnet.ahrq.gov/issue/cdc-clinical-practice-guideline-prescribing-opioids-pain-united-states-2022
September 23, 2020 - Organizational Policy/Guidelines 
 
 
 
 
 
 
 
 
 
 CDC Clinical Practice Guideline for Prescribing Opioids … CDC Clinical Practice Guideline for Prescribing Opioids for Pain — United States, 2022. … The twelve recommendations fall into four broad categories: determining whether or not to initiate opioids … CDC Clinical Practice Guideline for Prescribing Opioids for Pain — United States, 2022. … October 7, 2020 
 
 
 
 
 
 
 
 Inappropriate prescribing of opioids for patients undergoing surgery.
                                     
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psnet.ahrq.gov/sites/default/files/2021-09/spotlight_lost_in_transitions_of_care_09.22.2021_final.pdf
January 01, 2021 - analgesics daily 
are often presumed to be opioid tolerant, and therefore at lower 
risk of overdose … analgesics among patients with acute severe pain 
due to sickle cell disease or active cancer, it is … Obtain baseline liver function tests.
49
Methadone and Buprenorphine (5)
• Conversion from other opioid … analgesics to methadone is variable 
and not linear (i.e., the higher the total daily dose (TDD) of … Extended-release (ER) and long-acting (LA) opioid analgesics Risk Evaluation and Mitigation Strategy
                                     
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psnet.ahrq.gov/node/849599/psn-pdf
May 31, 2023 - OUD (naltrexone, naloxone, or buprenorphine) and limiting prescriptions of high-risk medications (opioid … analgesics and benzodiazepines). … increasing-naloxone-prescribing-emergency-department-through-education-and-electronic-medical
https://psnet.ahrq.gov/issue/association-between-concurrent-use-prescription-opioids-and-benzodiazepines-and-overdose … https://psnet.ahrq.gov/issue/physician-prescribing-opioids-patients-increased-risk-overdose-benzodiazepine-use-united
                                     
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psnet.ahrq.gov/issue/mandatory-provider-review-and-pain-clinic-laws-reduce-amounts-opioids-prescribed-and-overdose
August 02, 2017 - Study 
 
 
 
 
 
 
 
 
 
 Mandatory provider review and pain clinic laws reduce the amounts of opioids … Mandatory Provider Review And Pain Clinic Laws Reduce The Amounts Of Opioids Prescribed And Overdose … In states with mandated review, opioid prescribers must check whether patients are receiving opioids … Mandatory Provider Review And Pain Clinic Laws Reduce The Amounts Of Opioids Prescribed And Overdose … November 15, 2017 
 
 
 
 
 
 
 
 How to maximize patient safety when prescribing opioids.
                                     
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psnet.ahrq.gov/issue/request-comments-proposed-measures-and-2020-targets-national-action-plan-adverse-drug-event
October 21, 2016 - analgesics. … analgesics. … highlighted how to reduce adverse drug events associated with anticoagulants, diabetes agents, and opioids … analgesics. … June 16, 2019 
 
 
 
 
 
 
 
 Opioids in Medicare Part D: Concerns About Extreme Use and Questionable
                                     
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psnet.ahrq.gov/issue/hhs-guide-clinicians-appropriate-dosage-reduction-or-discontinuation-long-term-opioid
October 15, 2008 - Analgesics. … HHS Guide for Clinicians on the Appropriate Dosage Reduction or Discontinuation of Long-Term Opioid Analgesics … Analgesics. … HHS Guide for Clinicians on the Appropriate Dosage Reduction or Discontinuation of Long-Term Opioid Analgesics … August 23, 2017 
 
 
 
 
 
 
 
 Opioids in Medicare Part D: Concerns About Extreme Use and Questionable
                                     
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psnet.ahrq.gov/issue/how-maximize-patient-safety-when-prescribing-opioids
December 04, 2015 - Review 
 
 
 
 
 
 
 
 
 
 How to maximize patient safety when prescribing opioids. … How to Maximize Patient Safety When Prescribing Opioids. … How to Maximize Patient Safety When Prescribing Opioids. … Strategies to identify patient risks of prescription opioid addiction when initiating opioids … August 22, 2018 
 
 
 
 
 
 
 
 Opioids and Dentistry.
                                     
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psnet.ahrq.gov/web-mm/lost-transitions-care-managing-opioid-dependent-patient-frequent-hospitalizations
October 27, 2022 - Patients with chronic pain who are taking opioid analgesics daily are often presumed to be opioid tolerant … dose tables, and the lack of evidence supporting use of these tables in converting between different opioid … analgesics among patients with acute severe pain due to sickle cell disease or active cancer, it is … analgesics to methadone is variable and not linear. … Extended-release (ER) and long-acting (LA) opioid analgesics Risk Evaluation and Mitigation Strategy
                                     
                                                                    - 
                                        
psnet.ahrq.gov/issue/assessing-reasons-decreased-primary-care-access-individuals-prescribed-opioids-audit-study
November 17, 2021 - Assessing reasons for decreased primary care access for individuals on prescribed opioids … Assessing reasons for decreased primary care access for individuals on prescribed opioids. … Inappropriate prescribing of  opioids  is a major contributor to the ongoing opioid epidemic. … Findings indicate that primary care providers were generally unwilling to prescribe opioids to patients … Assessing reasons for decreased primary care access for individuals on prescribed opioids.
                                     
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psnet.ahrq.gov/issue/potentially-inappropriate-medication-combination-opioids-among-older-dental-patients
March 18, 2020 - Study 
 
 
 
 
 
 
 
 
 
 Potentially inappropriate medication combination with opioids among older dental … Potentially inappropriate medication combination with opioids among older dental patients: a retrospective … This study analyzed the association between potentially inappropriate prescribing involving  opioids … Results indicated that a significant proportion of older patients prescribed opioids by their dentist … Potentially inappropriate medication combination with opioids among older dental patients: a retrospective
                                     
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psnet.ahrq.gov/node/73899/psn-pdf
September 29, 2021 - Patients with chronic pain who are taking opioid analgesics daily are often presumed to be opioid tolerant … analgesics among patients with acute severe pain due to sickle cell
disease or active cancer, it is … interactions are present, and should obtain baseline liver function tests.19
Conversion from other opioid … analgesics to methadone is variable and not linear. … Extended-release (ER) and long-acting (LA) opioid analgesics
Risk Evaluation and Mitigation Strategy
                                     
                                                                    - 
                                        
psnet.ahrq.gov/perspective/antibiotic-and-opioid-stewardship-dentistry
December 07, 2020 - engage in patient counseling and risk screening prior to prescribing an opioid. 15  Prescribing non-opioid … analgesics with a clear escalation plan in place with patients, should pain continue or worsen may also … Overprescribing of opioids to adults by dentists in the US, 2011-2015. … Summary of State Legislation and Regulations Addressing Prescription Drugs and Opioids. … PDMP before prescribing opioids.
                                     
                                                                    - 
                                        
psnet.ahrq.gov/node/49655/psn-pdf
June 01, 2012 - The opioids prescribed
for this patient are highly inappropriate. … for chronic
pain.(10,12) However, the recent increase in use and abuse of opioids is predominantly … Rather, dialysis patients have a low use of opioids relative to the
extremely high prevalence of pain … Prescribing of opioid analgesics
and related mortality before and after the introduction of long-acting … Misuse of and dependence on opioids: study
of chronic pain patients.
                                     
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psnet.ahrq.gov/issue/opioids-pain-management-older-adults-strategies-safe-prescribing
January 26, 2022 - Commentary 
 
 
 
 
 
 
 
 
 
 Opioids for pain management in older adults: strategies for safe prescribing … Opioids for pain management in older adults. … Use of  opioids  for pain management in  older adults  can contribute to various problems, including … This commentary discusses the role of  nurse practitioners  as prescribers of opioids and offers practice … Opioids for pain management in older adults.
                                     
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psnet.ahrq.gov/issue/misuse-abuse-and-medication-errors-adverse-events-associated-opioids-systematic-review
January 15, 2025 - Review 
 
 
 
 
 
 
 
 
 
 Misuse, abuse and medication errors' adverse events associated with opioids … Misuse, abuse and medication errors' adverse events associated with opioids--a systematic review. … Even when opioids are  appropriately  prescribed, some patients may end up abusing or  misusing  them … The most frequently mentioned opioids were morphine, fentanyl, and oxycodone. … Misuse, abuse and medication errors' adverse events associated with opioids--a systematic review.