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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/mat-retention-strategies-rapid-review-1.pdf
    August 01, 2020 - Participants were still considered retained in MAT if they continued to use illicit opioids or missed … Unlike naltrexone, buprenorphine does not require a period of complete abstinence from opioids to initiate … of XR-naltrexone and other antagonist therapies that require a period of complete abstinence from opioids … Script in a Day intervention for individuals who are injecting opioids: a feasibility randomized control … Effects of medication-assisted treatment on mortality among opioids users: a systematic review and
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/scope-communicating-evolving-evidence-white-paper_0.pdf
    June 01, 2025 - In the case of opioids,8 serious potential harms include risk of opioid use disorder and overdose. … Opioids Pain Management Objective Testing Comparisons Monochromatic Infrared Photo Energy (MIRE); … of VER-01 to Opioids in Patients With Chronic Non-specific Low Back Pain VER-01; Opioid Therapy … CDC guideline for prescribing opioids for chronic pain– United States, 2016. … CDC guideline for prescribing opioids for chronic pain - United States, 2016.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-fracture-pain_clinician.pdf
    May 01, 2011 - effectiveness, benefits, or adverse events from differing doses, modes of administration, and the addition of opioids … For example, treatment of moderate to severe pain may require opioids, which present complications that
  4. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1312.pdf
    December 01, 2013 - Community-Based Opioid Overdose Prevention Program (Project Lazarus) Unmet need: Increased prescribing of opioids … deaths associated with these pharmacologic agents.1 Illegal use of prescription pain relievers (i.e., opioids … For patients requiring chronic opioids for pain management or help with opioid dependence, treatment
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-193-disposition-comments-naloxone.pdf
    November 27, 2017 - Will that person keep the pt from using more opioids right away (since the pt will be dope-sick, but … This is especially relevant because of the dramatic rise in the abuse of high-potency opioids such … The urgency is further heightened by the rapid emergence of highly potent synthetic opioids, such as … The increased incidence of high potency opioids involved in an overdose will make the determination … We deleted the sentence discussing the proportion of heroin users who report prescription opioids
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0215_01-06-2010.pdf
    January 01, 2010 - Intervention(s): Dopaminergic agents, antiparkinson agents, benzodiazepines and other sedative-hypnotics, opioids
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-2.pdf
    June 01, 2022 - The original 2020 report examined the evidence on the comparative effectiveness and harms of opioids … RCTs evaluated pharmacologic therapies and were included for KQ 2.4-6 There were no new studies on opioids … the original 2020 report and Surveillance Report 1 on the comparative effectiveness and harms of opioidsOpioids have low or insufficient strength of evidence for acute treatment of migraine. … SES]); (2) patient medical comorbidities (previous opioid use, body mass index [BMI]); (3) dose of opioids
  8. effectivehealthcare.ahrq.gov/sites/default/files/cer-225-substance-abuse-adolescents-evidence-summary%20225%20Substance%20Use%20Adolescents.pdf
    May 01, 2020 - Very few studies evaluated users of opioids, methamphetamines, or substances other than alcohol or cannabis
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/diabetic-neuropathy-disposition-170707.pdf
    March 24, 2017 - In contrast to Griebeler et al., we synthesized evidence on atypical opioids (tapentadol and tramadol … Otherwise, typical opioids are considered to be equivalent in efficacy for pain and have been treated … HELPFUL PARTCULATRLY AT NIGHT WITH SLEEP PROBLEMS; THERE NEEDS TO BE SLOW TITRATION and atypical opioids … For tramadol and tapentadol, we report in the abstract that “opioids have significant long-term risks … and in the discussion, that “New guidelines and position papers now recommend against the use of opioids
  10. effectivehealthcare.ahrq.gov/sites/default/files/diabetic-neuropathy-disposition-170707.pdf
    March 24, 2017 - In contrast to Griebeler et al., we synthesized evidence on atypical opioids (tapentadol and tramadol … Otherwise, typical opioids are considered to be equivalent in efficacy for pain and have been treated … HELPFUL PARTCULATRLY AT NIGHT WITH SLEEP PROBLEMS; THERE NEEDS TO BE SLOW TITRATION and atypical opioids … For tramadol and tapentadol, we report in the abstract that “opioids have significant long-term risks … and in the discussion, that “New guidelines and position papers now recommend against the use of opioids
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharm-treatment-chronic-pain-protocol.pdf
    December 11, 2018 - benzodiazepines) topical agents,(diclofenac, lidocaine capsaicin)  Medical marijuana (any formulation)  Opioidanalgesics o Key Questions 1-4, 6, subquestion “c”: Exercise o Key Question 5, 6, subquestion “c” … and CBD); FDA approved synthetic cannabinoids (Dronabionol [THC], Nabilone [similar to THC]) • Opioidanalgesics KQs 1-4, 6 subquestion c • Exerciseb KQ 5, 6 subquestion c • Biofeedbackc All KQs: … Efficacy of opioids for chronic pain: a review of the evidence.
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-rept-1-acute-pain.xlsx
    May 29, 2025 - B Opioid use (mean [SD] tablets): 6.33 (7.1) vs. 5.69 (5.8), p=0.24 Consumed opioids postoperatively: … (1.90) vs. 1.84 (1.29) day 1, p=0.01; 3.14 (2.12) vs. 3.29 (2.14) day 7, p=0.17 NR NR Escalated to opioids
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-app-f5-table-surveillance-report-2_0_0.xlsx
    May 29, 2025 - discontinuation 49.3% (2650/5373) vs. 72.3% (3887/5373) p<0.001 Estimates of the odds ratio to cease opioids
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/Appendix-E-Table-E5_0.xlsx
    May 29, 2025 - discontinuation 49.3% (2650/5373) vs. 72.3% (3887/5373) p<0.001 Estimates of the odds ratio to cease opioids
  15. effectivehealthcare.ahrq.gov/products/mhs4-opioid-stewardship/protocol
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0122_06-29-2009.pdf
    January 01, 2009 - Comparator(s): no analgesic/anesthetic intervention, analgesia/anesthesia, systemic medications (such as opioids
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-surveillance-report-3_0.pdf
    May 01, 2022 - CDC guideline for prescribing opioids for chronic pain– United States, 2016. … CDC guideline for prescribing opioids for chronic pain - United States, 2016. … Efficacy of opioids for chronic pain: a review of the evidence. … Critical issues on opioids in chronic non-cancer pain: an epidemiological study. … Opioids for chronic noncancer pain: a systematic review and meta-analysis.
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/pain-chronic_disposition-comments.pdf
    September 01, 2011 - Here, it would be “opioids”. … (p.16, L 2-3) Peer Reviewer #1 Summary and Implications In addition, the role that opioids … Additionally, the subheading “Role of opioids” could easily fall under Question 3, the subheading “ … Peer Reviewer #5 Summary and Implications The section on opioids does not transition smoothly … Likewise, the immediately following sections on “role of opioids” and “patient-related issues” appear
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-opioid-chronic-pain-surveillance-report-2.xlsx
    January 01, 2021 - Table E-1. RCT QA Table E-1. RCT quality assessment Author, Year Randomization Adequate? Allocation Concealment Adequate? Groups Similar at Baseline? Outcome Assessors Masked? Care Provider Masked? Patient Masked? Intention-To-Treat (ITT) Analysis Acceptable Levels of Overall Attrition and Between-Group Differences…
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-opioid-chronic-pain-surveillance-report-3.xlsx
    January 01, 2021 - Table E-1. RCT QA Table E-1. RCT quality assessment Author, Year Randomization Adequate? Allocation Concealment Adequate? Groups Similar at Baseline? Outcome Assessors Masked? Care Provider Masked? Patient Masked? Intention-To-Treat (ITT) Analysis Acceptable Levels of Overall Attrition and Between-Group Differences…

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