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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-fracture-pain_consumer.pdf
    May 01, 2011 - Opioid analgesics. Some common names for these drugs are morphine, codeine, and oxycodone. … Common side effects of opioid analgesics include: � Nausea, vomiting, and constipation. … doctor might use a nerve block to help ease your pain if you cannot take medicines like NSAIDs or opioids
  2. effectivehealthcare.ahrq.gov/health-topics/opioid-abuse-and-addiction
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonopioid-pharm-chronic-pain-protocol.pdf
    February 01, 2019 - The most common forms of pharmacologic treatment for pain include opioids, nonsteroidal anti- inflammatory … Nationally, a concern regarding appropriate use, misuse, and diversion of opioids for treatment of chronic … The 2016 CDC Guideline for Prescribing Opioids for Chronic Pain recommends that nonopioid therapy is … Concerns regarding the use of opioids for management of chronic pain are outlined in both the IOM report … CDC Guideline for Prescribing Opioids for Chronic Pain--United States, 2016.
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-emergency_disposition-comments.pdf
    November 27, 2012 - Opioids do not ‘cause ‘ relapse; rather they are associated with a higher risk of relapse. … For example, the routes of administration of opioids DHE not always clear in the text. … We summarize the results for opioids in the discussion section. … that opioids were compared with various other agents including other opioids. … The specific opioids are listed in the table.
  5. effectivehealthcare.ahrq.gov/sites/default/files/cer-227-noninvasive-nonpharm-chronic-pain-comments.pdf
    April 16, 2020 - Patients are usually presented with a single copay for a month’s supply of opioids versus a copay for … No RCTs that compared such interventions to opioids were identified. … There are two concurrent reviews, one on opioids and the other on non-opioid pharmacologic treatments … Given that studies did not directly compare the nonpharmacologic interventios to opioids, extensive … Our concurrent reviews on opioids and nonopioid pharmacologic treatments address the effectiveness
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/main-apps-surv-report-2-acute-pain.pdf
    May 01, 2022 - Preoperative education included information on the opioid epidemic, risks of opioids, safe use of opioids … pain, but opioids were less effective than acetaminophen for kidney stone pain. … Transdermal patches, topical opioids f. … Can we eliminate opioids after anterior cruciate ligament reconstruction? … Opioid analgesics and persistent pain after an acute pain emergency department visit: evidence from
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-193-naloxone-executive-summary.pdf
    November 01, 2017 - and Burden of Opioid Overdose Addiction and overdoses associated with prescription and illicit opioids … Health and Human Services as a national crisis.1 Since 2000, the rate of overdose deaths involving opioids … deaths are now the leading cause of injury-related death in the United States.4 Overdoses due to opioids … In 2015, the number of drug overdose deaths involving prescription or illicit opioids exceeded 33,000 … Drug-poisoning deaths involving opioid analgesics: United States, 1999-2011. NCHS Data Brief 166.
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/main-apps-surv-report-3-acute-pain.pdf
    June 01, 2022 - pain, but opioids were less effective than acetaminophen for kidney stone pain. … Transdermal patches, topical opioids f. … An anti- inflammatory bundle may help avoid opioids for low-risk outpatient procedures. … Can we eliminate opioids after anterior cruciate ligament reconstruction? … Opioid analgesics and persistent pain after an acute pain emergency department visit: evidence from
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-use-disorder_disposition-comments.pdf
    December 06, 2016 - to take on the vexing question of what to do with patients on chronically high and unsafe doses of opioidanalgesics, who nonetheless do NOT meet strict criteria for an opioid use disorder, for example because … , reduce the craving for opioids. … /atod/opioids) also refers to abuse and misuse of opioids, so we kept the term abuse here; however, … Kids being treated with opioid analgesics, and their risks for misuse and addiction, especially given
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0651-131114.pdf
    June 20, 2013 - routine imaging, self-care, education, pharmacological therapies (e.g., NSAIDs, acetaminophen, opioids … (Including NSAIDs, acetaminophen, opioids, antiseizure medications, antidepressants, corticosteroids
  11. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1406.pdf
    January 01, 2020 - that emerged as having high-impact potential address opioid overdose (both prescription and illicit opioids … to relatively inexpensive illicit opioid drugs, such as heroin, and increased use of prescription opioids … for reversing opioid overdose, fatal opioid overdoses—especially heroin and illicit prescription opioids … for pain management and illegal use of prescription opioids have contributed to nationwide increases … patients may be slow to adopt this intervention because it would indirectly broadcast their use of opioids
  12. effectivehealthcare.ahrq.gov/sites/default/files/back-pain-treatment_disposition-comments.pdf
    February 29, 2016 - Opioids: insufficient mention of harms related to long-term risks. … The Furlan systematic review was not included since it evaluated opioids for any chronic pain. … The long- term harms of opioids are extremely serious. … Opioid analgesics such as oxycodone hydrocodone and methadone were involved in about 3 of every 4 … pharmaceutical overdose deaths 16651 confirming the predominant role opioid analgesics play in drug
  13. effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/mhs-IV-epc-grand-rounds-slides.pptx
    January 01, 2023 - Practice Center Opioid Stewardship Can be defined as “rational prescribing, use and deprescribing of opioids … Less likely to be treated with opioids in NRCT Clinical Outcomes: NRCT with no change in pain, 1 RCT … RCT with intervention group more likely to be satisfied with pain management Two RCTs with reduced opioids … Improving Opioid Management in Primary Care AHRQ’s Clinical Decision Support (CDC) Connect Artifacts on Opioids … ’ Opioid Taskforce Playbook Society for Hospital Medicine’s Reducing Adverse Drug Events Related to Opioids
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharma-treatment-pain_research-protocol-amended.pdf
    September 20, 2017 - nonsteroidal anti- inflammatory drugs, acetaminophen, antiseizure medications, antidepressants) • Opioidanalgesics o Key Questions 1-4, 6, subquestion “c”: Exercise o Key Question 5, 6, subquestion “c”: … pharmacological therapy (NSAIDS, acetaminophen, anti-seizure medications, antidepressants) • Opioidanalgesics KQs 1-4, 6 subquestion c • Exercise† KQ 5, 6 subquestion c • Biofeedback‡ All KQs: … Efficacy of opioids for chronic pain: a review of the evidence.
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-nerve-block-protocol.pdf
    November 18, 2023 - and neurovascular responses, cardiac stress, and a longer physiologic surgical stress response.5–8 Opioids … are the mainstay of acute postoperative pain management.9,10 However, opioids are associated not only … Opioids Prescribed After Low-Risk Surgical Procedures in the United States, 2004-2012. … In-hospital use of opioids increases rate of coded postoperative paralytic ileus. … BOPv1U undergoing surgery: unequal burden on younger girls with higher doses of opioids.
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/opioid-use-disorder_research-protocol.pdf
    February 24, 2016 - Department of Health & Human Services as a national crisis.1 OUD involves misuse or abuse of prescription opioids … .15 The purpose of the medication component is to block the euphoric and sedating effects of other opioids … , reduce the craving for other opioids, and/or mitigate the symptoms of opioid withdrawal. … Trends in use of opioids for non-cancer pain conditions 2000-2005 in commercial and Medicaid insurance … America’s Addiction to Opioids: Heroin and Prescription Drug Abuse.
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-3-acute-pain.xlsx
    May 29, 2025 - B Opioid use (mean [SD] tablets): 6.33 (7.1) vs. 5.69 (5.8), p=0.24 Consumed opioids postoperatively: … (1.90) vs. 1.84 (1.29) day 1, p=0.01; 3.14 (2.12) vs. 3.29 (2.14) day 7, p=0.17 NR NR Escalated to opioids … B Days taking opioids (mean [range]): 3 (1-5) vs. 5 (2-8), p<0.001 Total morphine equivalents (mean [ … thyroid and parathyroid surgery Postoperative opt-in narcotics treatment vs. usual care A: Preoperative opioids … education (postoperative opt-in narcotics treatment, with opioids given only at patient request) B:
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-2-acute-pain.xlsx
    May 29, 2025 - B Opioid use (mean [SD] tablets): 6.33 (7.1) vs. 5.69 (5.8), p=0.24 Consumed opioids postoperatively: … (1.90) vs. 1.84 (1.29) day 1, p=0.01; 3.14 (2.12) vs. 3.29 (2.14) day 7, p=0.17 NR NR Escalated to opioids … B Days taking opioids (mean [range]): 3 (1-5) vs. 5 (2-8), p<0.001 Total morphine equivalents (mean [ … thyroid and parathyroid surgery Postoperative opt-in narcotics treatment vs. usual care A: Preoperative opioids … education (postoperative opt-in narcotics treatment, with opioids given only at patient request) B:
  19. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1412.pdf
    December 01, 2014 - Inexpensive and readily available illicit opioid drugs, such as heroin, and increased use of prescription opioids … Opioid Overdose by Nonclinicians  Key Facts: Fatal opioid overdoses of both prescription and illicit opioids … that patients may be slower to adopt this intervention than families or friends of patients taking opioids … , as it could inadvertently expose an individual’s use of opioids.18 Overall, experts commented that
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/living-systematic-reviews-full-text-articles-white-paper.pdf
    January 01, 2024 - In the case of opioids,5 serious potential harms include risk of opioid use disorder and overdose. … CDC guideline for prescribing opioids for chronic pain– United States, 2016. … CDC guideline for prescribing opioids for chronic pain - United States, 2016. … Concomitant cannabis abuse/dependence in patients treated with opioids for non-cancer pain. … Concomitant cannabis abuse/dependence in patients treated with opioids for non-cancer pain.

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