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  1. effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-revised-comments.pdf
    December 29, 2020 - Findings regarding opioids are based on published studies evaluating opioids. … contradict the top level key findings of the report with respect to comparative effectiveness of opioidanalgesics versus NSAIDS or other non-opioid treatments. … Studies ask the question “are opioids or non-opioids more effective in a single dose,” but that isn … opioids versus NSAIDs.
  2. effectivehealthcare.ahrq.gov/sites/default/files/dyspnea-advanced-cancer-summary-1.pdf
    November 01, 2020 - • Opioids were not more effective than placebo or anxiolytics for improving breathlessness or exercise … • Opioids had higher rates of constipation compared with steroids. … Although none of the evidence supported the effectiveness of opioids for breathlessness, all but one … Opioids and anxiolytics were not effective, although studies were limited, and few studies evaluated … Well-designed studies are needed to determine when opioids may be effective in various advanced cancer
  3. effectivehealthcare.ahrq.gov/sites/default/files/cer-239-acute-migraine-evidence-summary.pdf
    December 01, 2020 - • Only a small number of studies have evaluated opioids. … Some opioids may reduce pain of episodic migraine. … Some opioids may be less effective than other drugs. … opioid use disorder or overdose, or evaluate risk mitigation strategies to be used when prescribing opioids … When this is viewed in the context of how widely opioids are prescribed for migraine management, it
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/gaps-pain-management.pdf
    January 01, 2023 - • Only a small number of studies have evaluated opioids. … Some opioids may reduce pain of episodic migraine. … Some opioids may be less effective than other drugs. … • Ketamine may provide similar pain relief to opioids. …  Ketamine may provide similar pain relief to opioids.
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-ems-protocol-amendment.pdf
    January 28, 2019 - Non-opioid analgesics, including ketamine, nitrous oxide/oxygen, acetaminophen, and non-steroidal anti-inflammatory … Review This systematic review will assess the comparative effectiveness and harms of opioid and non-opioidanalgesics for the prehospital management of acute pain to support a revision of the current guidelines … Interventions: • KQ 1-4: o Opioids (morphine, fentanyl) or non-opioids (ketamine, nitrous oxide … We will present other comparisons (non-opioids to non-opioids or opioids to opioids) as supplemental
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-4-table-E-5.xlsx
    January 01, 2023 - B Between-cohort differences in discontinuation of strong opioid analgesics: 71.6% vs. 33.8%, p<0.001 … analgesics as an add-on treatment Mean (SD) A: 6.2 (2.4) sprays/day (16.74 mg THC/15.5 mg CBD) B: MME … B Mean number of background pain medications use at 6 months: Mild opioid analgesics: 0.02 (SD 0.14) … vs. 0.07 (SD 0.27) Strong opioid analgesics: 0.22 (SD 0.59) vs. 0.21 (SD 0.60) Mean rescue pain medication … use at 6 months: Mild opioid analgesics: 0.00 (SD 0.06) vs. 0.04 (SD 0.20) Strong opioid analgesics:
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-4-table-F5.xlsx
    January 01, 2022 - B Between-cohort differences in discontinuation of strong opioid analgesics: 71.6% vs. 33.8%, p<0.001 … analgesics as an add-on treatment Mean (SD) A: 6.2 (2.4) sprays/day (16.74 mg THC/15.5 mg CBD) B: MME … B Mean number of background pain medications use at 6 months: Mild opioid analgesics: 0.02 (SD 0.14) … vs. 0.07 (SD 0.27) Strong opioid analgesics: 0.22 (SD 0.59) vs. 0.21 (SD 0.60) Mean rescue pain medication … use at 6 months: Mild opioid analgesics: 0.00 (SD 0.06) vs. 0.04 (SD 0.20) Strong opioid analgesics:
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-220-disposition-comments-analgesics-prehospital-setting.pdf
    September 03, 2019 - Prioritized comparisons were opioids vs. ketamine, opioids plus ketamine vs. opioids, opioids vs. … APAP, opioids vs. nitrous oxide and opioids vs. … RCT and 12 observational studies to assess the comparative effectiveness and harms of opioid vs non-opioidanalgesics administered in emergency department settings. … Perhaps oral opioid analgesics vs oral acetaminophen or oral NSAIDs may have a different comparative
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-opioid-stewardship-protocol.pdf
    July 01, 2023 - What patient safety measures or indicators have been used to examine the harms associated with opioids … practices that have been used to prevent or mitigate the harms associated with prescribed or ordered opioids … However, opioids also carry well known risks, including for overdose, misuse, and opioid use disorder … The updated CDC Clinical Practice Guideline for Prescribing Opioids for Pain provides guidelines for … CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022.
  10. Topic-Brief3-Sud (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/topic-brief3-SUD.pdf
    April 01, 2021 - analgesics.30 In patients on higher doses of buprenorphine, continuing the buprenorphine but decreasing … studies40,41 in the review reported that patients taking buprenorphine were effectively treated for pain with opioidanalgesics while continuing buprenorphine … Use and misuse of opioids in chronic pain. … Opioid analgesics play an essential role in treating pain, and pain management in the context of the
  11. Topic-Brief3-Sud (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-brief3-SUD.pdf
    April 01, 2021 - analgesics.30 In patients on higher doses of buprenorphine, continuing the buprenorphine but decreasing … studies40,41 in the review reported that patients taking buprenorphine were effectively treated for pain with opioidanalgesics while continuing buprenorphine … Use and misuse of opioids in chronic pain. … Opioid analgesics play an essential role in treating pain, and pain management in the context of the
  12. effectivehealthcare.ahrq.gov/sites/default/files/cer-232-breathlessness-cancer-comments.pdf
    November 19, 2020 - Some were using opioids for treatment (e.g. … of opioids on dyspnea. … Opioids are similar enough pharmacologically that we have combined the different types of opioids together … “high dose and low dose opioids”. … the use of opioids, and in particular systemic opioids in the relief of dyspnea in cancer patients
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-table-e5.xlsx
    January 01, 2024 - B Between-cohort differences in discontinuation of strong opioid analgesics: 71.6% vs. 33.8%, p<0.001 … analgesics as an add-on treatment Mean (SD) A: 6.2 (2.4) sprays/day (16.74 mg THC/15.5 mg CBD) B: MME … B Mean number of background pain medications use at 6 months: Mild opioid analgesics: 0.02 (SD 0.14) … vs. 0.07 (SD 0.27) Strong opioid analgesics: 0.22 (SD 0.59) vs. 0.21 (SD 0.60) Mean rescue pain medication … use at 6 months: Mild opioid analgesics: 0.00 (SD 0.06) vs. 0.04 (SD 0.20) Strong opioid analgesics:
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-other-plant-based-treatments-evidence-summary_0.pdf
    October 01, 2021 - adverse effects,7 and the 2016 Centers for Disease Control and Prevention Guideline for Prescribing Opioids … CDC Guideline for Prescribing Opioids for Chronic Pain– United States, 2016. … CDC Guideline for Prescribing Opioids for Chronic Pain - United States, 2016. … Efficacy of opioids for chronic pain: a review of the evidence. … Critical issues on opioids in chronic non-cancer pain: an epidemiological study.
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2025-surv-rep-update-table-e5.xlsx
    January 01, 2025 - B Between-cohort differences in discontinuation of strong opioid analgesics: 71.6% vs. 33.8%, p<0.001 … analgesics as an add-on treatment Mean (SD) A: 6.2 (2.4) sprays/day (16.74 mg THC/15.5 mg CBD) B: MME … B Mean number of background pain medications use at 6 months: Mild opioid analgesics: 0.02 (SD 0.14) … vs. 0.07 (SD 0.27) Strong opioid analgesics: 0.22 (SD 0.59) vs. 0.21 (SD 0.60) Mean rescue pain medication … use at 6 months: Mild opioid analgesics: 0.00 (SD 0.06) vs. 0.04 (SD 0.20) Strong opioid analgesics:
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-pain-opioid-treatment_disposition-comments.pdf
    September 29, 2014 - As noted in the Methods, we excluded patients receiving opioids at end of life. … and did not receive opioids. … Same question for opioids and fractures (I assume mediated through falls)? … High-risk use by patients prescribed opioids for pain and its role in overdose deaths. … But, promoting a culture of fear of opioids could result in much more suffering.
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/emt-naloxon_research-protocol.pdf
    November 29, 2016 - Health and Human Services as a national crisis.1 Since 2000, the rate of overdose deaths involving opioids … In 2014, the number of drug overdose deaths involving prescription or illicit opioids exceeded 28,000 … upon re-exposure), use of illicit opioids, higher doses of opioids, obtaining opioids from multiple … synthetic opioids]); and study setting (e.g., field versus clinical setting). … Drug-poisoning Deaths Involving Opioid Analgesics: United States, 1999–2011. NCHS Data Brief 166.
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-evidence-summary-2022-update_0.pdf
    January 01, 2022 - adverse effects,9 and the 2016 Centers for Disease Control and Prevention Guideline for Prescribing Opioids … CDC guideline for prescribing opioids for chronic pain– United States, 2016. … CDC guideline for prescribing opioids for chronic pain - United States, 2016. … Efficacy of opioids for chronic pain: a review of the evidence. … Critical issues on opioids in chronic non-cancer pain: an epidemiological study.
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/back-pain-treatment_consumer.pdf
    November 01, 2016 - Opioids Examples include tramadol, hydrocodone, hydromorphone, morphine, and oxycodone ��A type of … ��Other opioids help a little to reduce pain in the short term (up to 4 months). … ��Opioids can cause life-threatening breathing problems. … ��Taking opioids while pregnant may cause the unborn baby to have a condition called neonatal opioid … ��Some opioids can cause seizures.
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-treatments-research-amended-protocol.pdf
    January 09, 2020 - In contrast, the evidence supporting the use of opioids, other nonopioid pharmacologic therapy, and … of use per month of specific medications.8 Triptans, ergots alkaloids, combination analgesics, or opioids … analgesics and triptans.9 For this reason, the American Headache Society has explicitly stated that opioids … has been identified as a risk factor for disease chronification. 11 12 Despite concern with use of opioids … Rates and Predictors of Using Opioids in the Emergency Department to Treat Migraine in Adolescents and

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