- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-revised-comments.pdf
December 29, 2020 - Findings regarding opioids are 
based on published studies 
evaluating opioids. … contradict the top level key findings of the 
report with respect to comparative 
effectiveness of opioid … analgesics versus 
NSAIDS or other non-opioid treatments. … Studies ask the question “are opioids or 
non-opioids more effective in a single 
dose,” but that isn … opioids 
versus NSAIDs.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/dyspnea-advanced-cancer-summary-1.pdf
November 01, 2020 - • Opioids were not more effective than placebo or anxiolytics for improving 
breathlessness or exercise … • Opioids had higher rates of constipation compared with steroids. … Although none of the evidence supported the effectiveness of opioids for breathlessness, all but 
one … Opioids and 
anxiolytics were not effective, although studies were limited, and few studies evaluated … Well-designed studies are needed to determine when 
opioids may be effective in various advanced cancer
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/cer-239-acute-migraine-evidence-summary.pdf
December 01, 2020 - • Only a small number of studies have evaluated opioids. … Some opioids may reduce 
pain of episodic migraine. … Some opioids may be less effective than other drugs. … opioid use 
disorder or overdose, or evaluate risk mitigation strategies to be used when 
prescribing opioids … When this is viewed in the 
context of how widely opioids are prescribed for migraine management, it
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/gaps-pain-management.pdf
January 01, 2023 - • Only a small number of studies have evaluated 
opioids. … Some opioids may reduce pain of 
episodic migraine. … Some opioids may be less 
effective than other drugs. … • Ketamine may provide similar pain relief to 
opioids. …  Ketamine may provide similar pain relief to opioids.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-opioid-stewardship-protocol.pdf
July 01, 2023 - What patient safety measures or indicators have been used to examine the harms associated 
with opioids … practices that have been used to prevent or 
mitigate the harms associated with prescribed or ordered opioids … However, opioids also carry well known risks, 
including for overdose, misuse, and opioid use disorder … The updated CDC Clinical Practice Guideline for Prescribing Opioids for Pain provides 
guidelines for … CDC Clinical Practice Guideline for Prescribing Opioids for Pain - 
United States, 2022.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-ems-protocol-amendment.pdf
January 28, 2019 - Non-opioid 
analgesics, including ketamine, nitrous oxide/oxygen, acetaminophen, and non-steroidal 
anti-inflammatory … Review   
This systematic review will assess the comparative effectiveness and harms of opioid and 
non-opioid … analgesics for the prehospital management of acute pain to support a revision 
of the current guidelines … Interventions:  
• KQ 1-4:  
o Opioids (morphine, fentanyl) or non-opioids (ketamine, nitrous 
oxide … We will present other 
comparisons (non-opioids to non-opioids or opioids to opioids) as supplemental
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-220-disposition-comments-analgesics-prehospital-setting.pdf
September 03, 2019 - Prioritized comparisons were opioids 
vs. ketamine, opioids plus ketamine vs. opioids, 
opioids vs. … APAP, opioids vs. nitrous oxide and 
opioids vs. … RCT and 12 observational studies to 
assess the comparative effectiveness and harms of 
opioid vs non-opioid … analgesics administered in 
emergency department settings. … Perhaps oral opioid analgesics vs oral 
acetaminophen or oral NSAIDs may have a different 
comparative
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-4-table-F5.xlsx
January 01, 2022 - B
Between-cohort differences in discontinuation of strong opioid analgesics: 71.6% vs. 33.8%, p<0.001 … analgesics as an add-on treatment	Mean (SD)
A: 6.2 (2.4) sprays/day (16.74 mg THC/15.5 mg CBD)
B: MME … B
Mean number of background pain medications use at 6 months:
Mild opioid analgesics: 0.02 (SD 0.14) … vs. 0.07 (SD 0.27)
Strong opioid analgesics: 0.22 (SD 0.59) vs. 0.21 (SD 0.60)
Mean rescue pain medication … use at 6 months:
Mild opioid analgesics: 0.00 (SD 0.06) vs. 0.04 (SD 0.20)
Strong opioid analgesics:
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-4-table-E-5.xlsx
January 01, 2023 - B
Between-cohort differences in discontinuation of strong opioid analgesics: 71.6% vs. 33.8%, p<0.001 … analgesics as an add-on treatment	Mean (SD)
A: 6.2 (2.4) sprays/day (16.74 mg THC/15.5 mg CBD)
B: MME … B
Mean number of background pain medications use at 6 months:
Mild opioid analgesics: 0.02 (SD 0.14) … vs. 0.07 (SD 0.27)
Strong opioid analgesics: 0.22 (SD 0.59) vs. 0.21 (SD 0.60)
Mean rescue pain medication … use at 6 months:
Mild opioid analgesics: 0.00 (SD 0.06) vs. 0.04 (SD 0.20)
Strong opioid analgesics:
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/cer-232-breathlessness-cancer-comments.pdf
November 19, 2020 - Some were using opioids for treatment (e.g. … of opioids on dyspnea. … Opioids are similar 
enough pharmacologically that we have combined the 
different types of opioids together … “high dose and low dose opioids”. … the use of opioids, 
and in particular systemic opioids in the relief of 
dyspnea in cancer patients
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/topic-brief3-SUD.pdf
April 01, 2021 - analgesics.30 In patients on higher 
doses of buprenorphine, continuing the buprenorphine but decreasing … studies40,41 in the review reported that 
patients taking buprenorphine were effectively treated for pain with opioid … analgesics 
while continuing buprenorphine … Use and misuse of opioids in chronic pain. … Opioid analgesics play an essential role in treating pain, and pain management in the context 
of the
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-brief3-SUD.pdf
April 01, 2021 - analgesics.30 In patients on higher 
doses of buprenorphine, continuing the buprenorphine but decreasing … studies40,41 in the review reported that 
patients taking buprenorphine were effectively treated for pain with opioid … analgesics 
while continuing buprenorphine … Use and misuse of opioids in chronic pain. … Opioid analgesics play an essential role in treating pain, and pain management in the context 
of the
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/peripheral-nerve-blocks-final-exec-sum.pdf
August 01, 2025 - in 
Cardiothoracic Surgery 
 
Executive Summary 
 
 
Main Points 
 
 
Background and Purpose 
Opioids … We extracted sample/study characteristics 
and outcomes (e.g. pain, total and rescue opioids, adverse … In head-to-head comparisons between 
ESPB and CWBs, no difference was seen in pain scores, opioids, or … Opioids Prescribed After Low-Risk Surgical 
Procedures in the United States, 2004-2012. … In-hospital use of opioids increases rate of coded 
postoperative paralytic ileus.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-table-e5.xlsx
January 01, 2024 - B
Between-cohort differences in discontinuation of strong opioid analgesics: 71.6% vs. 33.8%, p<0.001 … analgesics as an add-on treatment	Mean (SD)
A: 6.2 (2.4) sprays/day (16.74 mg THC/15.5 mg CBD)
B: MME … B
Mean number of background pain medications use at 6 months:
Mild opioid analgesics: 0.02 (SD 0.14) … vs. 0.07 (SD 0.27)
Strong opioid analgesics: 0.22 (SD 0.59) vs. 0.21 (SD 0.60)
Mean rescue pain medication … use at 6 months:
Mild opioid analgesics: 0.00 (SD 0.06) vs. 0.04 (SD 0.20)
Strong opioid analgesics:
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-other-plant-based-treatments-evidence-summary_0.pdf
October 01, 2021 - adverse effects,7 and the 2016 Centers for Disease 
Control and Prevention Guideline for Prescribing Opioids … CDC 
Guideline for Prescribing Opioids for 
Chronic Pain– United States, 2016. … CDC 
Guideline for Prescribing Opioids for 
Chronic Pain - United States, 2016. … Efficacy of opioids 
for chronic pain: a review of the evidence. … Critical 
issues on opioids in chronic non-cancer 
pain: an epidemiological study.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2025-surv-rep-update-table-e5.xlsx
January 01, 2025 - B
Between-cohort differences in discontinuation of strong opioid analgesics: 71.6% vs. 33.8%, p<0.001 … analgesics as an add-on treatment	Mean (SD)
A: 6.2 (2.4) sprays/day (16.74 mg THC/15.5 mg CBD)
B: MME … B
Mean number of background pain medications use at 6 months:
Mild opioid analgesics: 0.02 (SD 0.14) … vs. 0.07 (SD 0.27)
Strong opioid analgesics: 0.22 (SD 0.59) vs. 0.21 (SD 0.60)
Mean rescue pain medication … use at 6 months:
Mild opioid analgesics: 0.00 (SD 0.06) vs. 0.04 (SD 0.20)
Strong opioid analgesics:
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-pain-opioid-treatment_disposition-comments.pdf
September 29, 2014 - As 
noted in the Methods, we excluded 
patients receiving opioids at end of 
life. … and did not 
receive opioids. … Same question for 
opioids and fractures (I assume 
mediated through falls)? … High-risk use by patients prescribed opioids for pain and its role in overdose 
deaths. … But, promoting a culture of fear of opioids 
could result in much more suffering.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-evidence-summary-2022-update_0.pdf
January 01, 2022 - adverse effects,9 and the 2016 Centers for Disease 
Control and Prevention Guideline for Prescribing Opioids … CDC 
guideline for prescribing opioids for chronic 
pain– United States, 2016. … CDC 
guideline for prescribing opioids for chronic 
pain - United States, 2016. … Efficacy of opioids 
for chronic pain: a review of the evidence. … Critical issues on opioids in 
chronic non-cancer pain: an epidemiological 
study.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/emt-naloxon_research-protocol.pdf
November 29, 2016 - Health and Human Services as a national crisis.1 
Since 2000, the rate of overdose deaths involving opioids … In 2014, the 
number of drug overdose deaths involving prescription or illicit opioids exceeded 28,000 … upon re-exposure), use of illicit opioids, higher doses of 
opioids, obtaining opioids from multiple … synthetic opioids]); and study setting (e.g., field versus clinical setting). … Drug-poisoning Deaths Involving Opioid 
Analgesics: United States, 1999–2011. NCHS Data Brief 166.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/back-pain-treatment_consumer.pdf
November 01, 2016 - Opioids
Examples include tramadol, 
hydrocodone, hydromorphone, 
morphine, and oxycodone
��A type of … ��Other opioids help a little to reduce 
pain in the short term (up to 4 
months). … ��Opioids can cause life-threatening breathing problems. … ��Taking opioids while pregnant may cause the unborn baby to have a condition called 
neonatal opioid … ��Some opioids can cause seizures.