- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-1-app-F.xlsx
January 01, 2023 - 13	NR	NR	NR	NR	NR	NR	NR	Patients with major psychiatric disorder or past drug/alcohol abuse excluded	Opioids … abdominal pain	Excluded daily cannabis use in past 3 years	Mean	53	50	96	2	NR	2	NR	NR	NR	Excluded	Weak opioids … : 21/50
Strong opioids: 26/50	65	50	THC oral tablet (Dronabinol): days 1 to 5: 3 mg 3 times/d; days 6 … psoriatic arthritis	Previous CBD use: 18%	Median	62	44	NR	NR	NR	NR	NR	NR	NR	NR	Concomitant medicine:
Opioids … with severe
psychiatric diseases (severe depression and schizophrenia) excluded	Concomitant use of opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2023-surv-rep-4-tables-E-1-E-4.xlsx
January 01, 2023 - 13	NR	NR	NR	NR	NR	NR	NR	Patients with major psychiatric disorder or past drug/alcohol abuse excluded	Opioids … abdominal pain	Excluded daily cannabis use in past 3 years	Mean	53	50	96	2	NR	2	NR	NR	NR	Excluded	Weak opioids … : 21/50
Strong opioids: 26/50	65	50	THC oral tablet (Dronabinol): days 1 to 5: 3 mg 3 times/d; days 6 … psoriatic arthritis	Previous CBD use: 18%	Median	62	44	NR	NR	NR	NR	NR	NR	NR	NR	Concomitant medicine:
Opioids … with severe
psychiatric diseases (severe depression and schizophrenia) excluded	Concomitant use of opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-4-tables-F1-4.xlsx
January 01, 2022 - 13	NR	NR	NR	NR	NR	NR	NR	Patients with major psychiatric disorder or past drug/alcohol abuse excluded	Opioids … abdominal pain	Excluded daily cannabis use in past 3 years	Mean	53	50	96	2	NR	2	NR	NR	NR	Excluded	Weak opioids … : 21/50
Strong opioids: 26/50	65	50	THC oral tablet (Dronabinol): days 1 to 5: 3 mg 3 times/d; days 6 … psoriatic arthritis	Previous CBD use: 18%	Median	62	44	NR	NR	NR	NR	NR	NR	NR	NR	Concomitant medicine:
Opioids … with severe
psychiatric diseases (severe depression and schizophrenia) excluded	Concomitant use of opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/products/treatments-acute-pain/research
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/epc-health-care-practice-delivery.pdf
November 01, 2022 - AHRQ’s Evidence-based Practice Center Program: Synthesizing evidence to improve health care practice and delivery
What Is the Agency for Healthcare Research and Quality (AHRQ) Evidence-based 
Practice Center Program?
AHRQ is the lead Federal Agency within the U.S. Department of Health and Human Services that is 
char… 
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1512.pdf
December 01, 2015 - #14 SUBSTANCE ABUSE
 
 
 
AHRQ Healthcare Horizon Scanning System – Potential 
High-Impact Interventions Report 
 
Priority Area 14: Substance Abuse  
 
Prepared for:  
Agency for Healthcare Research and Quality 
U.S. Department of Health and Human Services 
5600 Fishers Lane  
Rockville, MD 20857 
www.ahr… 
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-3-tables-F1-4.xlsx
January 01, 2022 - abdominal pain	Excluded daily cannabis use in past 3 years	Mean	53	50	96	2	NR	2	NR	NR	NR	Excluded	Weak opioids … : 21/50
Strong opioids: 26/50	65	50	THC oral tablet (Dronabinol): days 1 to 5: 3 mg 3 times/d; days 6 … with a personal or family history of schizophrenia or psychotic disorders excluded 	Previous treatment opioids … psoriatic arthritis	Previous CBD use: 18%	Median	62	44	NR	NR	NR	NR	NR	NR	NR	NR	Concomitant medicine:
Opioids … with severe
psychiatric diseases (severe depression and schizophrenia) excluded	Concomitant use of opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-neuropathy_research.pdf
March 01, 2018 - Studies comparing atypical opioids with placebo identified through ClinicalTrials.gov, 
published literature … For another two comparisons (lacosamide versus placebo 
and atypical opioids versus placebo), we found … No effect No effect 
Atypical opioids vs. … CT.gov = ClinicalTrials.gov; RCT = randomized controlled trial 
 
 
34 
Atypical Opioids Versus … Studies comparing atypical opioids with placebo identified through ClinicalTrials.gov, published literature
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/products/retention-strategies-opioid-use-disorder/rapid-protocol
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-254-rural-telehealth-executive-summary.pdf
December 01, 2022 - Executive Summary_Comparative Effectiveness Review No. 254: Improving Rural Health Through Telehealth-Guided Provider-to-Provider Communication
Comparative Effectiveness Review 
Number 254 
Improving Rural Health Through 
Telehealth-Guided Provider-to-Provider 
Communication 
Executive Summary
Main Points 
• Use … 
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_research-protocol.pdf
January 27, 2012 - Opioid antagonist; competitively binds to opioid 
receptors and may block the effects of endogenous 
opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-tables-e1-4.xlsx
January 01, 2024 - 13	NR	NR	NR	NR	NR	NR	NR	Patients with major psychiatric disorder or past drug/alcohol abuse excluded	Opioids … abdominal pain	Excluded daily cannabis use in past 3 years	Mean	53	50	96	2	NR	2	NR	NR	NR	Excluded	Weak opioids … : 21/50
Strong opioids: 26/50	65	50	THC oral tablet (Dronabinol): days 1 to 5: 3 mg 3 times/d; days 6 … psoriatic arthritis	Previous CBD use: 18%	Median	62	44	NR	NR	NR	NR	NR	NR	NR	NR	Concomitant medicine:
Opioids … with severe
psychiatric diseases (severe depression and schizophrenia) excluded	Concomitant use of opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-d-surv-report-2-noninvasive-nonpharma.xlsx
January 01, 2021 - duration of insomnia: 143 vs. 141 vs. 136 months
Mean duration of FM: 115 vs. 95 vs. 110 months
% taking Opioids … Primary outcomes were yes/no use of sleep medication or opioids.	6 months	Mean (SE)
A vs. … medication (including NSAIDS, analgesics, selective serotonin releasing agents, anticonvulsants, and
opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-d-surv-report-1-noninvasive-nonpharma_0.xlsx
January 01, 2021 - duration of insomnia: 143 vs. 141 vs. 136 months
Mean duration of FM: 115 vs. 95 vs. 110 months
% taking Opioids … Primary outcomes were yes/no use of sleep medication or opioids.	6 months	Mean (SE)
A vs. … medication (including NSAIDS, analgesics, selective serotonin releasing agents, anticonvulsants, and
opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs-future_research.pdf
February 01, 2013 - No eligible studies assessed opioids, sedative hypnotics, or tramadol, though these are used 
for RLS … No eligible studies assessed opioids, sedative hypnotics, or tramadol, though these are used 
clinically … What is the effectiveness of other drugs that are not dopamine agonists or alpha 2 ligands 
(e.g., opioids … What is the effectiveness of other drugs that are not dopamine agonists or alpha 2 ligands (e.g., 
opioids … What is the effectiveness of other drugs that are not dopamine agonists or alpha 2 ligands 
(e.g. opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-rapid-response-deprescribing.pdf
February 01, 2024 - clinics, acute 
care hospitals, 
long-term care 
Age ≥65 
years and 
taking 
benzodiazepi
nes and/or 
opioids … • decreased 
benzodiazepines 
and/or 
opioids, with 
variable effect for 
different 
interventions … Pharmacist interventions to deprescribe 
opioids and benzodiazepines in older adults: A 
rapid review
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/labor-nitrous-oxide_research-protocol.pdf
August 24, 2011 - Alternatives/comparators to nitrous oxide include: epidural analgesia/anesthesia; systemic drugs 
such as opioids … include, but are not limited to, epidural analgesia, 
paracervical block, pudendal block, and parenteral opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2025-surv-rep-update-tables-e1-4.xlsx
January 01, 2025 - 13	NR	NR	NR	NR	NR	NR	NR	Patients with major psychiatric disorder or past drug/alcohol abuse excluded	Opioids … abdominal pain	Excluded daily cannabis use in past 3 years	Mean	53	50	96	2	NR	2	NR	NR	NR	Excluded	Weak opioids … : 21/50
Strong opioids: 26/50	65	50	THC oral tablet (Dronabinol): days 1 to 5: 3 mg 3 times/d; days 6 … psoriatic arthritis	Previous CBD use: 18%	Median	62	44	NR	NR	NR	NR	NR	NR	NR	NR	Concomitant medicine:
Opioids … with severe
psychiatric diseases (severe depression and schizophrenia) excluded	Concomitant use of opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/suicide-prevention_research-protocol.pdf
December 23, 2015 - Untitled
 
Source: www.effectivehealthcare.ahrq.gov 
Published online: December 23, 2015 
Evidence-based Practice Center Systematic Review Protocol 
Project Title: Suicide Prevention 
 
I. Background and Objectives for the Systematic Review 
 
 Despite advances in the diagnosis and treatment of major mental disord… 
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/products/arthritis-analgesics-safety/research