- 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-opioid-chronic-pain-surveill-report-1.xlsx
January 01, 2021 - Table E-1. RCT QA
	Table E-1. RCT quality assessment 
	Author,
Year	Randomization Adequate? 	Allocation Concealment Adequate?	Groups Similar at Baseline?	Outcome Assessors Masked?	Care Provider Masked?	Patient Masked?	Intention-to-Treat (ITT) Analysis	Acceptable Levels of Overall Attrition and Between-Group Differences… 
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/substanceabuse_hi_impact.pdf
January 01, 2012 - #14 SUBSTANCE ABUSE
 
 
 
 AHRQ Healthcare Horizon Scanning System – Potential High 
Impact Interventions Report 
 
 
Priority Area 14: Substance Abuse  
Potential High Impact Interventions Report 
 
Prepared for:  
Agency for Healthcare Research and Quality 
U.S. Department of Health and Human Services 
540… 
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-surveillance-report-3_0.pdf
May 01, 2022 - CDC 
guideline for prescribing opioids for chronic 
pain– United States, 2016. … CDC 
guideline for prescribing opioids for chronic 
pain - United States, 2016. … Efficacy of opioids 
for chronic pain: a review of the evidence. … Critical 
issues on opioids in chronic non-cancer 
pain: an epidemiological study. … Opioids for chronic noncancer pain: a 
systematic review and meta-analysis.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/pain-chronic_disposition-comments.pdf
September 01, 2011 - Here, it would be “opioids”. … (p.16, L 2-3)  
 
Peer Reviewer 
#1 
Summary 
and 
Implications 
In addition, the role that opioids … Additionally, the 
subheading “Role of opioids” could easily fall under Question 3, the 
subheading “ … Peer Reviewer 
#5 
Summary 
and 
Implications 
The section on opioids does not transition smoothly … Likewise, the immediately following 
sections on “role of opioids” and “patient-related issues” appear
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-report-testing-machine-learning-tool-chronic-pain.pdf
November 01, 2020 - For the July/August 
searches, the precision ranged from 0.5 percent (opioids) to 8 percent (nonpharmacologic … For the September/October searches, precision was lower across reviews, ranging 
from 0.2 percent (opioids … precision could be due in part to the breadth of the reviews:  
precision was lowest for a review on opioids … utility, observational studies, and a wide range of interventions and comparisons, 
including various opioids … Even though 
the machine learning classifier was least precise for the opioids review, the time savings
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/14_substanceabuse_potential_high_impact_june_2012.pdf
January 01, 2012 - #14 SUBSTANCE ABUSE
 
 
 
AHRQ Healthcare Horizon Scanning System – Potential High 
Impact Interventions Report 
 
 
Priority Area 14: Substance Abuse  
 
 
Prepared for:  
Agency for Healthcare Research and Quality 
U.S. Department of Health and Human Services 
540 Gaither Road 
Rockville, MD 20850 
www.a… 
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-apps-a-e-surveillance-report-2-final_0_0.pdf
March 01, 2022 - CDC 
Guideline for Prescribing Opioids for 
Chronic Pain– United States, 2016. … CDC 
Guideline for Prescribing Opioids for 
Chronic Pain - United States, 2016. … Efficacy of opioids 
for chronic pain: a review of the evidence. … Critical 
issues on opioids in chronic non-cancer 
pain: an epidemiological study. … Opioids for Chronic Noncancer Pain: A 
Systematic Review and Meta-analysis.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1506.pdf
June 01, 2015 - Opioid Overdose by Nonclinicians 
 Key Facts: Fatal opioid overdoses of both prescription and illicit opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2025-surv-rep-update-executive-sum.pdf
January 01, 2025 - event outcomes (psychosis, cannabis use disorder, cognitive 
deficits) and outcomes related to use of opioids … dronabinol 
Long-acting opioids 
(MME 69.4 [SD 38.9] 
mg/day) 
Route of 
Administration, 
Formulation … ) 
Nabiximols sublingual 
oromucosal spray, 2.7 
mg THC/2.5 mg CBD 
per 100 mcl 
Oral long-acting opioids … events (cannabis use disorder [CUD], psychosis, cognitive deficits) and the impact on the 
use of opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-year-in-review-2022.pdf
January 01, 2022 - for	Disease	Control	and	
Prevention’s	(CDC)	update	of	the	Clinical Practice Guideline for Prescribing Opioids … integrated pain management, emphasize joint 
decision making, and remove maximum dosage warnings for opioids … effectivehealthcare.ahrq.gov/products/nonopioid-chronic-pain/research
https://effectivehealthcare.ahrq.gov/products/opioids-chronic-pain … 2022 Associated Systematic Review  
(Year Published)
CDC Clinical Practice Guideline for Prescribing 
Opioids … /research
https://effectivehealthcare.ahrq.gov/products/opioids-chronic-pain/research
https://effectivehealthcare.ahrq.gov
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-pain-management-grand-rounds-slides.pptx
March 01, 2022 - Examine the role of opioids in pain management and the opioid crisis.
4. … 34
Key Questions
Systematic review and meta-analysis:
Of comparative effectiveness and harms of opioids … The evidence base for many other interventions for acute treatment, including opioids, remains limited
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/14_substance_abuse_potential_high_impact_2012-12-11.pdf
January 01, 2012 - #14 SUBSTANCE ABUSE
 
 
 
AHRQ Healthcare Horizon Scanning System – Potential 
High-Impact Interventions Report 
 
Priority Area 14: Substance Abuse  
 
Prepared for:  
Agency for Healthcare Research and Quality 
U.S. Department of Health and Human Services 
540 Gaither Road 
Rockville, MD 20850 
www.ahrq.… 
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/cer-251-integrated-pain-management-evidence-summary.pdf
October 01, 2021 - and pain in our review were consistent with those 
reported for other therapies for pain, including opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-emergency_research-protocol.pdf
July 18, 2011 - ergot derivatives (e.g., dihydroergotamine), intravenous nonsteroidal anti-inflammatory agents, 
and opioids … Opioids are often used to treat acute migraine despite their recognized ability to cause 
dependence … For example, opioids may be associated with drowsiness 
and impaired ability to function. … – Meperidine (Demerol) 
– Valproic acid 
– Other agents: propafol (Diprivan), ketamine (Ketalar), opioids … ) Meperidine (Demerol) 
h) Valproic acid 
i) Other agents: propafol (Diprivan), ketamine (Ketalar), opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/products/opioid-use-disorder/research-protocol
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/practical-considerations.pdf
March 01, 2022 - , and a series of recent systematic reviews3-7 
have found that commonly used treatments, including opioids … Opioids have received particular 
scrutiny due to their addiction and overdose potential,8 especially … CDC 
guideline for prescribing opioids for chronic 
pain– United States, 2016. … CDC 
guideline for prescribing opioids for chronic 
pain - United States, 2016.
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-1.pdf
June 01, 2022 - The original 2020 report examined the evidence 
on the comparative effectiveness and harms of opioids … , 14-18 and three on 
nonpharmacologic interventions were included for KQ 3.5, 11, 13 No studies of opioids … Opioids have low or insufficient strength of evidence 
for acute treatment of migraine. … SES]); (2) patient medical 
comorbidities (previous opioid use, body mass index [BMI]); (3) dose of opioids … opioid management plans 
Patient education 
Clinician and patient values and preferences related to opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-executive-sum.pdf
January 01, 2024 - dronabinol 
Long-acting opioids 
(MME 69.4 (SD 38.9) 
mg/day) 
Route of 
Administration, 
Formulation … NR) 
Nabiximols sublingual 
oromucosal spray, 2.7 
mg THC/2.5 mg CBD 
per 100 mcl 
Oral long-acting opioids … adverse events 
(cannabis use disorder [CUD], psychosis, cognitive deficits) and the impact on the use of opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/pdf/suda-final-protocol.pdf
October 02, 2018 - 1 percent of 
youth between the ages of 12 and 17 reporting current opioid misuse.11 Youth who use opioids … 1 Substances considered: alcohol, cannabis, opioids, sedatives/hypnotics/anxiolytics, stimulants, 
inhalants … alcohol use in the college setting (we will include existing systematic 
reviews) 
o Cannabis 
o Opioids … Acamprosate 
• Disulfiram 
• Topiramate 
• Ondansetron 
 Cannabis 
• N-acetylcysteine (NAC)  
 Opioids
                                     
                                                                    - 
                                        
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-year-in-review-2020.pdf
January 01, 2020 - Prevention, Diagnosis, and Management of Opioids, Opioid Misuse, and Opioid Use Disorder in Older Adults … effectivehealthcare.ahrq.gov/products/no-touch-disinfection/rapid-research
https://effectivehealthcare.ahrq.gov/products/opioids-chronic-pain … www.ahrq.gov/research/findings/ta/index.html#tacomplete
https://effectivehealthcare.ahrq.gov/products/opioids-older-adults