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effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/episodic-migraine-surveillance-report-2.pdf
June 01, 2022 - Opioid Pharmacologic Therapy
No new studies addressed the comparative effectiveness or harms of opioid … Opioid Therapy
a. … the accuracy of instruments for predicting
risk of opioid misuse, opioid use disorder, or overdose? … the effectiveness of instruments for
predicting risk of opioid misuse, opioid use disorder, or overdose … Opioid Therapy:
KQ1 a-e.
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effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/dot-plots-methods.pdf
October 01, 2021 - Dot plot for dichotomous outcomes, opioids versus placebo or no opioid ..................... 3
Figure … For continuous outcomes (opioid review only), the
dataset consisted of: outcome, number of trials, baseline … Dot plot for dichotomous outcomes, opioids versus placebo or no opioid
Note: Pain response indicates … Dot plot for continuous outcomes, opioids versus placebo or no opioid
Abbreviations: CI = confidence … Opioid Treatments for Chronic Pain.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/pbt-lsr-draft-ets-obs.xlsx
March 15, 2022 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … Overall absolute effect after medical cannabis authorization: ˗76.5 (˗308.0 to 154.9)
Prescription opioid … C (reference)
Opioid initiation (adjusted OR [95% CI]): 2.29 (0.86 to 6.16)
Opioid discontinuation (adjusted … C (reference)
Opioid initiation (adjusted OR [95% CI]): 1.11 (0.36 to 3.49)
Opioid discontinuation (adjusted … B
Between-cohort differences in discontinuation of strong opioid analgesics: 71.6% vs. 33.8%, p<0.001
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effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/pbt-lsr-draft-report.pdf
February 04, 2022 - Opioid
treatments for chronic pain. Rockville, MD;
2020.
10. … The four RCTs that allowed opioid use during the study period did not report on changes in
opioid used … study medications on opioid use.54,57,58
Adverse events were poorly reported. … Twenty five percent of patients had used an opioid prior to the study, but did not report on opioid … Opioid
treatments for chronic pain.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/draft-living-review-plant-chronic-pain-e-cohort-studies.xlsx
March 25, 2024 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … C (reference)
Opioid initiation (adjusted OR): 2.29 (95% CI 0.86 to 6.16)
Opioid discontinuation (adjusted … C (reference)
Opioid initiation (adjusted OR): 1.11 (95% CI 0.36 to 3.49)
Opioid discontinuation (adjusted … B
Between-cohort differences in discontinuation of strong opioid analgesics: 71.6% vs. 33.8%, p<0.001 … use at 6 months:
Mild opioid analgesics: 0.00 (SD 0.06) vs. 0.04 (SD 0.20)
Strong opioid analgesics:
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effectivehealthcare.ahrq.gov/sites/default/files/dyspnea-advanced-cancer-summary-1.pdf
November 01, 2020 - guidelines that recommend opioids for
breathlessness are based mainly on results from short-term studies of opioid-naïve
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-app-f5-table-surveillance-report-2.xlsx
January 22, 2022 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … 2021 Matched cohort Canada NR NR Mean 52 55 NR NR NR NR NR NR NR NR 10,746
A: 5373
B: 5373 A: Chronic opioid … Overall absolute effect after medical cannabis authorization: ˗76.5 (˗308.0 to 154.9)
Prescription opioid … C (reference)
Opioid initiation (adjusted OR [95% CI]): 2.29 (0.86 to 6.16)
Opioid discontinuation (adjusted … C (reference)
Opioid initiation (adjusted OR [95% CI]): 1.11 (0.36 to 3.49)
Opioid discontinuation (adjusted
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/Appendix-E-Table-E5.xlsx
November 04, 2021 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … 2021 Matched cohort Canada NR NR Mean 52 55 NR NR NR NR NR NR NR NR 10,746
A: 5373
B: 5373 A: Chronic opioid … Overall absolute effect after medical cannabis authorization: ˗76.5 (˗308.0 to 154.9)
Prescription opioid … C (reference)
Opioid initiation (adjusted OR [95% CI]): 2.29 (0.86 to 6.16)
Opioid discontinuation (adjusted … C (reference)
Opioid initiation (adjusted OR [95% CI]): 1.11 (0.36 to 3.49)
Opioid discontinuation (adjusted
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-app-f5-table-surveillance-report-2_0.xlsx
February 16, 2022 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … 2021 Matched cohort Canada NR NR Mean 52 55 NR NR NR NR NR NR NR NR 10,746
A: 5373
B: 5373 A: Chronic opioid … Overall absolute effect after medical cannabis authorization: ˗76.5 (˗308.0 to 154.9)
Prescription opioid … C (reference)
Opioid initiation (adjusted OR [95% CI]): 2.29 (0.86 to 6.16)
Opioid discontinuation (adjusted … C (reference)
Opioid initiation (adjusted OR [95% CI]): 1.11 (0.36 to 3.49)
Opioid discontinuation (adjusted
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-app-f5-table-surveillance-report-2_0_0.xlsx
February 16, 2022 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … 2021 Matched cohort Canada NR NR Mean 52 55 NR NR NR NR NR NR NR NR 10,746
A: 5373
B: 5373 A: Chronic opioid … Overall absolute effect after medical cannabis authorization: ˗76.5 (˗308.0 to 154.9)
Prescription opioid … C (reference)
Opioid initiation (adjusted OR [95% CI]): 2.29 (0.86 to 6.16)
Opioid discontinuation (adjusted … C (reference)
Opioid initiation (adjusted OR [95% CI]): 1.11 (0.36 to 3.49)
Opioid discontinuation (adjusted
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/Appendix-E-Table-E5_0.xlsx
November 04, 2021 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … 2021 Matched cohort Canada NR NR Mean 52 55 NR NR NR NR NR NR NR NR 10,746
A: 5373
B: 5373 A: Chronic opioid … Overall absolute effect after medical cannabis authorization: ˗76.5 (˗308.0 to 154.9)
Prescription opioid … C (reference)
Opioid initiation (adjusted OR [95% CI]): 2.29 (0.86 to 6.16)
Opioid discontinuation (adjusted … C (reference)
Opioid initiation (adjusted OR [95% CI]): 1.11 (0.36 to 3.49)
Opioid discontinuation (adjusted
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-protocol-amended.pdf
June 10, 2018 - Background and Objectives for the Technical Brief
Addressing the opioid epidemic in the United States … This reemergence primarily results
from the sharp rise in opioid-related deaths in the United States … Opioid related deaths have risen
from 3 deaths per 100,000 people in 2000 to more than 13 per 100,000 … opioids were involved in over 40 percent of all overdose deaths in 2016.1
The urgency of the growing opioid … Opioid Overdose. 2017.
https://www.cdc.gov/drugoverdose/index.html.
2. Institute of Medicine.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-table-e5-2022-update_0.xlsx
January 01, 2022 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … Overall absolute effect after medical cannabis authorization: ˗76.5 (˗308.0 to 154.9)
Prescription opioid … C (reference)
Opioid initiation (adjusted OR [95% CI]): 2.29 (0.86 to 6.16)
Opioid discontinuation (adjusted … C (reference)
Opioid initiation (adjusted OR [95% CI]): 1.11 (0.36 to 3.49)
Opioid discontinuation (adjusted … B
Between-cohort differences in discontinuation of strong opioid analgesics: 71.6% vs. 33.8%, p<0.001
-
effectivehealthcare.ahrq.gov/products/dyspnea-advanced-cancer/report
November 19, 2020 - Current Page Topic Timeline Oct. 16, 2019 Topic Initiated Oct. 22, 2019 Research Protocol Nov. 19, 2020 Systematic Review Interventions for Breathlessness in Patients With Advanced Cancer
Systematic Review November 19, 2020 Download Main Document PDF 5.9 MB
Related Files Download Evidence Summary [P…
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-232-breathlessness-cancer-comments.pdf
November 19, 2020 - Page 45: given the lack of RR change with opioid
dosing, this is proof the opioid was not adequately … dosed (RR
decreases as the CNS dyspnea signal is blunted by
the opioid)
18. … For
example, standard of care would be to include a
stimulant
laxative when starting any dose of opioid … We have reworded the opioid statements as per other
comments, to be clear that the conclusions about … Please reword
to clarify this point as it pertains to opioid use for
dyspnea.
c.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/plant-based-chronic-pain-review-jan-2020.pdf
January 01, 2020 - medications on opioid use.19,26,31
Adverse events were reported in all the trials. … Opioid
Treatments for Chronic Pain. Comparative
Effectiveness Review No. 229. … J Opioid
Manag. 2009 Nov-Dec;5(6):341-57. PMID:
20073408.
12. … Does
Integrative Medicine Reduce Prescribed
Opioid Use for Chronic Pain? … Addictive behaviors related to opioid use for
chronic pain: a population-based study.
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/research-gaps-womens-health-22.pdf
April 01, 2022 - https://effectivehealthcare.ahrq.gov/products/labor-dystocia/research
7
Opioid Treatments for … • Evidence on the effectiveness and harms of
alternative opioid dosing strategies and the effects … • No instrument has been shown to be associated
with high accuracy for predicting opioid overdose … • Develop and validate instruments for accurately
predicting risk of opioid use disorder or misuse … Outcomes
• Comparative effectiveness studies on harms of
opioid therapy for chronic pain, different
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-227-noninvasive-nonpharm-chronic-pain-comments.pdf
April 16, 2020 - treatment, either allowing their pain to worsen or seeking
immediate albeit short-term relief via an opioid … trials where this
actually occurred)
References:
– Richard A Lawhern, PhD, “The CDC’s Fictitious Opioid … , April 15, 2017,
https://www.ncnp.org/journal-of-medicine/1980-the-cdcs-
fictitious-opioid-epidemic-part … There are two concurrent reviews, one on opioids
and the other on non-opioid pharmacologic
treatments … There were no studies meeting our inclusion
criteria that compared acupuncture to opioid use.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/plant-based-chronic-pain-review-q2.pdf
May 01, 2021 - Opioid
Treatments for Chronic Pain. Comparative
Effectiveness Review No. 229. … J Opioid
Manag. 2009 Nov-Dec;5(6):341-57. PMID:
20073408.
12. … Does
Integrative Medicine Reduce Prescribed
Opioid Use for Chronic Pain? … Addictive behaviors related to opioid use for
chronic pain: a population-based study. … Medical Cannabis: Effects on Opioid and
Benzodiazepine Requirements for Pain
Control.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-fracture-pain_consumer.pdf
May 01, 2011 - Opioid analgesics. Some common names for these drugs are
morphine, codeine, and oxycodone. … Common side effects of opioid analgesics include:
� Nausea, vomiting, and constipation. … before, during, or
after an an operation may ease short-term pain more than the
usual treatment of opioid … may help you avoid “delirium,” or confusion and cloudy thinking,
which can be caused by pain or by opioid … will be
improved or relieved by acupressure, relaxation therapy, or TENS
more than by medicines like opioid