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  1. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/episodic-migraine-surveillance-report-2.pdf
    June 01, 2022 - Opioid Pharmacologic Therapy No new studies addressed the comparative effectiveness or harms of opioidOpioid Therapy a. … the accuracy of instruments for predicting risk of opioid misuse, opioid use disorder, or overdose? … the effectiveness of instruments for predicting risk of opioid misuse, opioid use disorder, or overdose … Opioid Therapy: KQ1 a-e.
  2. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/dot-plots-methods.pdf
    October 01, 2021 - Dot plot for dichotomous outcomes, opioids versus placebo or no opioid ..................... 3 Figure … For continuous outcomes (opioid review only), the dataset consisted of: outcome, number of trials, baseline … Dot plot for dichotomous outcomes, opioids versus placebo or no opioid Note: Pain response indicates … Dot plot for continuous outcomes, opioids versus placebo or no opioid Abbreviations: CI = confidence … Opioid Treatments for Chronic Pain.
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/pbt-lsr-draft-ets-obs.xlsx
    March 15, 2022 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … Overall absolute effect after medical cannabis authorization: ˗76.5 (˗308.0 to 154.9) Prescription opioid … C (reference) Opioid initiation (adjusted OR [95% CI]): 2.29 (0.86 to 6.16) Opioid discontinuation (adjusted … C (reference) Opioid initiation (adjusted OR [95% CI]): 1.11 (0.36 to 3.49) Opioid discontinuation (adjusted … B Between-cohort differences in discontinuation of strong opioid analgesics: 71.6% vs. 33.8%, p<0.001
  4. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/pbt-lsr-draft-report.pdf
    February 04, 2022 - Opioid treatments for chronic pain. Rockville, MD; 2020. 10. … The four RCTs that allowed opioid use during the study period did not report on changes in opioid used … study medications on opioid use.54,57,58 Adverse events were poorly reported. … Twenty five percent of patients had used an opioid prior to the study, but did not report on opioidOpioid treatments for chronic pain.
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/draft-living-review-plant-chronic-pain-e-cohort-studies.xlsx
    March 25, 2024 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … C (reference) Opioid initiation (adjusted OR): 2.29 (95% CI 0.86 to 6.16) Opioid discontinuation (adjusted … C (reference) Opioid initiation (adjusted OR): 1.11 (95% CI 0.36 to 3.49) Opioid discontinuation (adjusted … B Between-cohort differences in discontinuation of strong opioid analgesics: 71.6% vs. 33.8%, p<0.001 … use at 6 months: Mild opioid analgesics: 0.00 (SD 0.06) vs. 0.04 (SD 0.20) Strong opioid analgesics:
  6. effectivehealthcare.ahrq.gov/sites/default/files/dyspnea-advanced-cancer-summary-1.pdf
    November 01, 2020 - guidelines that recommend opioids for breathlessness are based mainly on results from short-term studies of opioid-naïve
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-app-f5-table-surveillance-report-2.xlsx
    January 22, 2022 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … 2021 Matched cohort Canada NR NR Mean 52 55 NR NR NR NR NR NR NR NR 10,746 A: 5373 B: 5373 A: Chronic opioid … Overall absolute effect after medical cannabis authorization: ˗76.5 (˗308.0 to 154.9) Prescription opioid … C (reference) Opioid initiation (adjusted OR [95% CI]): 2.29 (0.86 to 6.16) Opioid discontinuation (adjusted … C (reference) Opioid initiation (adjusted OR [95% CI]): 1.11 (0.36 to 3.49) Opioid discontinuation (adjusted
  8. Appendix-E-Table-E5 (xls file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/Appendix-E-Table-E5.xlsx
    November 04, 2021 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … 2021 Matched cohort Canada NR NR Mean 52 55 NR NR NR NR NR NR NR NR 10,746 A: 5373 B: 5373 A: Chronic opioid … Overall absolute effect after medical cannabis authorization: ˗76.5 (˗308.0 to 154.9) Prescription opioid … C (reference) Opioid initiation (adjusted OR [95% CI]): 2.29 (0.86 to 6.16) Opioid discontinuation (adjusted … C (reference) Opioid initiation (adjusted OR [95% CI]): 1.11 (0.36 to 3.49) Opioid discontinuation (adjusted
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-app-f5-table-surveillance-report-2_0.xlsx
    February 16, 2022 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … 2021 Matched cohort Canada NR NR Mean 52 55 NR NR NR NR NR NR NR NR 10,746 A: 5373 B: 5373 A: Chronic opioid … Overall absolute effect after medical cannabis authorization: ˗76.5 (˗308.0 to 154.9) Prescription opioid … C (reference) Opioid initiation (adjusted OR [95% CI]): 2.29 (0.86 to 6.16) Opioid discontinuation (adjusted … C (reference) Opioid initiation (adjusted OR [95% CI]): 1.11 (0.36 to 3.49) Opioid discontinuation (adjusted
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-app-f5-table-surveillance-report-2_0_0.xlsx
    February 16, 2022 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … 2021 Matched cohort Canada NR NR Mean 52 55 NR NR NR NR NR NR NR NR 10,746 A: 5373 B: 5373 A: Chronic opioid … Overall absolute effect after medical cannabis authorization: ˗76.5 (˗308.0 to 154.9) Prescription opioid … C (reference) Opioid initiation (adjusted OR [95% CI]): 2.29 (0.86 to 6.16) Opioid discontinuation (adjusted … C (reference) Opioid initiation (adjusted OR [95% CI]): 1.11 (0.36 to 3.49) Opioid discontinuation (adjusted
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/Appendix-E-Table-E5_0.xlsx
    November 04, 2021 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … 2021 Matched cohort Canada NR NR Mean 52 55 NR NR NR NR NR NR NR NR 10,746 A: 5373 B: 5373 A: Chronic opioid … Overall absolute effect after medical cannabis authorization: ˗76.5 (˗308.0 to 154.9) Prescription opioid … C (reference) Opioid initiation (adjusted OR [95% CI]): 2.29 (0.86 to 6.16) Opioid discontinuation (adjusted … C (reference) Opioid initiation (adjusted OR [95% CI]): 1.11 (0.36 to 3.49) Opioid discontinuation (adjusted
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-protocol-amended.pdf
    June 10, 2018 - Background and Objectives for the Technical Brief Addressing the opioid epidemic in the United States … This reemergence primarily results from the sharp rise in opioid-related deaths in the United States … Opioid related deaths have risen from 3 deaths per 100,000 people in 2000 to more than 13 per 100,000 … opioids were involved in over 40 percent of all overdose deaths in 2016.1 The urgency of the growing opioidOpioid Overdose. 2017. https://www.cdc.gov/drugoverdose/index.html. 2. Institute of Medicine.
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-table-e5-2022-update_0.xlsx
    January 01, 2022 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … Overall absolute effect after medical cannabis authorization: ˗76.5 (˗308.0 to 154.9) Prescription opioid … C (reference) Opioid initiation (adjusted OR [95% CI]): 2.29 (0.86 to 6.16) Opioid discontinuation (adjusted … C (reference) Opioid initiation (adjusted OR [95% CI]): 1.11 (0.36 to 3.49) Opioid discontinuation (adjusted … B Between-cohort differences in discontinuation of strong opioid analgesics: 71.6% vs. 33.8%, p<0.001
  14. effectivehealthcare.ahrq.gov/products/dyspnea-advanced-cancer/report
    November 19, 2020 - Current Page Topic Timeline Oct. 16, 2019 Topic Initiated Oct. 22, 2019 Research Protocol Nov. 19, 2020 Systematic Review Interventions for Breathlessness in Patients With Advanced Cancer Systematic Review November 19, 2020 Download Main Document PDF 5.9 MB Related Files Download Evidence Summary [P…
  15. effectivehealthcare.ahrq.gov/sites/default/files/cer-232-breathlessness-cancer-comments.pdf
    November 19, 2020 - Page 45: given the lack of RR change with opioid dosing, this is proof the opioid was not adequately … dosed (RR decreases as the CNS dyspnea signal is blunted by the opioid) 18. … For example, standard of care would be to include a stimulant laxative when starting any dose of opioid … We have reworded the opioid statements as per other comments, to be clear that the conclusions about … Please reword to clarify this point as it pertains to opioid use for dyspnea. c.
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/plant-based-chronic-pain-review-jan-2020.pdf
    January 01, 2020 - medications on opioid use.19,26,31 Adverse events were reported in all the trials. … Opioid Treatments for Chronic Pain. Comparative Effectiveness Review No. 229. … J Opioid Manag. 2009 Nov-Dec;5(6):341-57. PMID: 20073408. 12. … Does Integrative Medicine Reduce Prescribed Opioid Use for Chronic Pain? … Addictive behaviors related to opioid use for chronic pain: a population-based study.
  17. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/research-gaps-womens-health-22.pdf
    April 01, 2022 - https://effectivehealthcare.ahrq.gov/products/labor-dystocia/research 7 Opioid Treatments for … • Evidence on the effectiveness and harms of alternative opioid dosing strategies and the effects … • No instrument has been shown to be associated with high accuracy for predicting opioid overdose … • Develop and validate instruments for accurately predicting risk of opioid use disorder or misuse … Outcomes • Comparative effectiveness studies on harms of opioid therapy for chronic pain, different
  18. effectivehealthcare.ahrq.gov/sites/default/files/cer-227-noninvasive-nonpharm-chronic-pain-comments.pdf
    April 16, 2020 - treatment, either allowing their pain to worsen or seeking immediate albeit short-term relief via an opioid … trials where this actually occurred) References: – Richard A Lawhern, PhD, “The CDC’s Fictitious Opioid … , April 15, 2017, https://www.ncnp.org/journal-of-medicine/1980-the-cdcs- fictitious-opioid-epidemic-part … There are two concurrent reviews, one on opioids and the other on non-opioid pharmacologic treatments … There were no studies meeting our inclusion criteria that compared acupuncture to opioid use.
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/plant-based-chronic-pain-review-q2.pdf
    May 01, 2021 - Opioid Treatments for Chronic Pain. Comparative Effectiveness Review No. 229. … J Opioid Manag. 2009 Nov-Dec;5(6):341-57. PMID: 20073408. 12. … Does Integrative Medicine Reduce Prescribed Opioid Use for Chronic Pain? … Addictive behaviors related to opioid use for chronic pain: a population-based study. … Medical Cannabis: Effects on Opioid and Benzodiazepine Requirements for Pain Control.
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-fracture-pain_consumer.pdf
    May 01, 2011 - Opioid analgesics. Some common names for these drugs are morphine, codeine, and oxycodone. … Common side effects of opioid analgesics include: � Nausea, vomiting, and constipation. … before, during, or after an an operation may ease short-term pain more than the usual treatment of opioid … may help you avoid “delirium,” or confusion and cloudy thinking, which can be caused by pain or by opioid … will be improved or relieved by acupressure, relaxation therapy, or TENS more than by medicines like opioid

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