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41. Disposition of Comments Report for The Effectiveness and Risks of Long-Term Opioid Treatment of Chronic Pain (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-pain-opioid-treatment_disposition-comments.pdf
    September 29, 2014 - The Effectiveness and Risks of Long-Term Opioid Treatment of Chronic Pain. … Tapentadol was included because it is a much stronger opioid agonist. … formulas in reducing opioid abuse. … Emergency department visits among recipients of chronic opioid therapy. … Association between opioid prescribing patterns and opioid overdose-related deaths.Bohnert AS, Valenstein

42. A Rapid Evidence Review of Retention Strategies for Medications for Addiction Treatment (MAT) in Adults with Opioid Use Disorder | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/retention-strategies-opioid-use-disorder/rapid-protocol

43. Systematic Review on Treatments for Acute Pain: Surveillance Report 3 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/main-apps-surv-report-3-acute-pain.pdf
    June 01, 2022 - (or/1-4) and (5 or 6) 8. exp Analgesics, Opioid/ 9. opioid*.ti,ab,kw. 10. … (or/1-4) and (5 or 6) 8. exp Analgesics, Opioid/ 9. opioid*.ti,ab,kw. 10. … for predicting risk of opioid misuse, opioid use disorder, or overdose? … for predicting risk of opioid misuse, opioid use disorder, or overdose? … The Opioid Analgesic Reduction Study (OARS)-a comparison of opioid vs. non- opioid combination analgesics

44. AHRQ Slide Template 2019-Widescreen
    effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/mhs-IV-epc-grand-rounds-slides.pptx
    January 01, 2023 - Principal – Leavitt Partners 19 Opioid Stewardship Rapid Review Julie M. … The purpose of this review was to determine the effectiveness of opioid stewardship interventions in … Journal of Pain Research 2023;16:383-394 Opioid Stewardship Interventions in Healthcare Facilities … Refills - 4 of 6 RCTs Patient Satisfaction - 3 of 6 RCTs Opioid Prescribing/Ordering - 5 of 6 … Safety for Opioid Prescribing: Handbook for Healthcare Executives U.S.

45. EHC Research Protocol (Amended): Treatments for Acute Episodic Migraine (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-treatments-research-amended-protocol.pdf
    January 09, 2020 - Opioid therapy KQ1a. … What are the effects of prescribing opioid therapy versus not prescribing opioid therapy for acute episodic … of instruments for predicting risk of opioid misuse, opioid use disorder, or overdose? … of instruments for predicting risk of opioid misuse, opioid use disorder, or overdose? … Opioid Therapy: KQ 1a-e.

46. Revised Protocol - Opioids 12 13 13[1] (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-pain-opioid-treatment_research-protocol.pdf
    December 19, 2013 - vs. placebo or non-opioid therapy (including usual care) • For KQ Ic: Opioid vs. non-opioid therapy … plus non-opioid therapy (pharmacological or non- pharmacological) vs. opioid or non-opioid therapy alone … vs. another long-acting opioid • For KQ IIId: Short- plus long-acting opioid vs. long-acting opioid … Association between opioid prescribing patterns and opioid overdose-related deaths. … : 7. exp Analgesics, Opioid/ Opioids 8. opioid*.mp (includes alone 9.

47. Evidence Summary for Treatments for Acute Pain: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-evidence-summary.pdf
    December 01, 2020 - • An opioid might be more effective than gabapentin for acute neuropathic pain. … • Being prescribed an opioid for acute low back pain or postoperative pain might be associated with … and management of postoperative pain following discharge. 2 effectiveness of opioid … Randomized controlled trials (RCTs) of opioid therapy versus nonopioid pharmacologic or nonpharmacologic … might not decrease opioid prescribing.

48. #14 SUBSTANCE ABUSE (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/substanceabuse_hi_impact.pdf
    January 01, 2012 - *Buprenorphine implant for treatment of opioid dependence 2. … *Extended-release naltrexone (Vivitrol) for treatment of opioid dependence 4. … dependence Buprenorphine is a partial opioid agonist that is known to reduce opioid cravings and … play a role in opioid dependence. 2 Blockade of the mu-opioid receptor in particular appears to be … was approved in 1984 for the treatment of opioid dependence.

49. CER 220 Evidence Summary: Comparative Effectiveness of Analgesics To Reduce Acute Pain in the Prehospital Setting (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-220-analgesics-acute-pain-summary.pdf
    September 01, 2019 - PO: 1 4 Characteristic Opioids Versus Ketamine Opioid+Ketamine Versus Opioid Opioids Versus … Combined administration of an opioid and ketamine may reduce acute pain more than an opioid alone but … America’s opioid epidemic: supply and demand considerations. … Opioid prescribing in the cross section of US emergency departments. … J Opioid Manag. 2011 May-Jun;7(3):229-234. PMID: 21823553. 71.

50. #14 SUBSTANCE ABUSE (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1412.pdf
    December 01, 2014 - Evzio for Emergency Treatment of Opioid Overdose by Nonclinicians  Key Facts: Fatal opioid overdoses … years, opioid overdose mortality rates continue to rise. … It can reverse opioid overdose events within 3 minutes of administration. … They also noted Evzio does not address the root causes of opioid overdoses: opioid misuse and dependence … FDA approves new hand-held auto-injector to reverse opioid overdose. [internet].

51. Disposition of Comments for Comparative Effectiveness Review No. 240: Treatments for Acute Pain: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-revised-comments.pdf
    December 29, 2020 - analgesics versus NSAIDS or other non-opioid treatments. … Baker, Sean Mackey, “Incidence of and Risk Factors for Chronic Opioid Use Among Opioid-Naive Patients … The question isn’t necessarily “I need to give a single dose, should it be opioid or non-opioid?” … use for acute pain and long-term use and predictors of opioid use. … The background section discusses epidemiological data on opioid prescribing, opioid mortality, and

52. AHRQ Evidence-Based Practice Center (EPC) Program Research Gaps Summary: Pain Management (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/gaps-pain-management.pdf
    January 01, 2023 - • An opioid might be more effective than gabapentin for acute neuropathic pain. … and opioid use disorder using standardized methods … • Studies that address how policies aimed at reducing the duration or dose of opioid prescribing … • Longitudinal outcome studies on opioids, including harms (e.g., refractory opioid dependence, … • Combining an opioid with ketamine may be more effective in reducing pain compared with opioids

53. Evidence Summary for CER 239: Acute Treatments for Episodic Migraine (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-239-acute-migraine-evidence-summary.pdf
    December 01, 2020 - • No studies evaluate instruments for predicting risk of opioid misuse, opioid use disorder or overdose … Opioid and butalbital-containing medications have a two-fold higher risk of medication overuse headache … • No studies evaluated instruments for predicting risk of opioid misuse, opioid use disorder or … No included studies evaluated instruments to help in predicting risk of opioid misuse, developing opioid … Excessive opioid use and the development of chronic migraine.

54. App-E-Surv-Report-2-Acute-Pain (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-2-acute-pain.xlsx
    October 08, 2025 - B Opioid medication use: OR 0.48 (99% CI 0.18 to 1.33) day 1; OR 1.50 (99% CI 0.31 to 7.25) day 7; OR … Rhinoplasty Opioid vs. … use education vs. usual care A: Preoperative opioid education B: No preoperative opioid education NA … A: Preoperative opioid education B: No preoperative opioid education A: 3.09 mg B: 6.18 mg 129 A: NR … Third molar extraction Opioid vs.

55. App-E-Surv-Report-3-Acute-Pain (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-3-acute-pain.xlsx
    October 08, 2025 - B Opioid medication use: OR 0.48 (99% CI 0.18 to 1.33) day 1; OR 1.50 (99% CI 0.31 to 7.25) day 7; OR … Rhinoplasty Opioid vs. … use education vs. usual care A: Preoperative opioid education B: No preoperative opioid education NA … A: Preoperative opioid education B: No preoperative opioid education A: 3.09 mg B: 6.18 mg 129 A: NR … Third molar extraction Opioid vs.

56. Opioid Treatments for Chronic Pain | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/opioids-chronic-pain/protocol

57. #14 SUBSTANCE ABUSE (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/14_substanceabuse_potential_high_impact_june_2012.pdf
    January 01, 2012 - *Buprenorphine implant (Probuphine) for treatment of opioid dependence Moderately high 3. …  Key Facts: Opioid abuse is one of the most common forms of prescription drug abuse. … antagonist that was recently approved by FDA for treating opioid dependence. … dependence Buprenorphine is a partial opioid agonist that is known to reduce opioid cravings and is … receptors, each of which is thought to play a role in opioid dependence. 22 Blockade of the mu-opioid

58. #14 SUBSTANCE ABUSE (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1312.pdf
    December 01, 2013 - The toolkit contains pain management guidelines, opioid risk-assessment tools, precautions for opioid … recognizing and responding to an opioid overdose, and different options for opioid abuse treatment. … interventions may include opioid detoxification, opioid replacement therapies (i.e., methadone or … Prescription opioid abuse in chronic pain: a review of opioid abuse predictors and strategies to … curb opioid abuse.

59. medication-assisted-treatment-protocol-160224 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/opioid-use-disorder_research-protocol.pdf
    February 24, 2016 - use disorder related to prescription opioid use for chronic pain versus unprescribed opioid use), and … Opioid-use disorder among patients on long-term opioid therapy: impact of final DSM-5 diagnostic criteria … Medication-Assisted Treatment for Opioid Addiction in Opioid Treatment Programs. … Methadone at tapered doses for the management of opioid withdrawal. … Oral naltrexone maintenance treatment for opioid dependence.

60. Disposition of Comments for Technical Brief 28 MAT Models (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-use-disorder_disposition-comments.pdf
    December 06, 2016 - ) and only about 1 in 5 opioid addicts receive MAT. … Similarly, as opioid medication is the primary active ingredient of treatment for opioid use disorders … Oral naltrexone is approved for prevention of opioid relapse. … Seizing a “reachable moment”- A Transitional Opioid Program (TOP) for hospitalized opioid dependent … The Hubs are opioid treatment programs and can prescribe methadone.