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161. Alcohol-Misuse-Drug-Therapy Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/alcohol-misuse-drug-therapy_executive.pdf
     January 27, 2012 - , flushing, and changes in heart rate and blood pressure Oral: 250 to 500 mg per day Naltrexone Opioid … antagonist; competitively binds to opioid receptors and blocks the effects of endogenous opioids such … more or less effective for adults with specific genotypes (e.g., related to polymorphisms of the mu-opioid … Seven eligible studies assessed variation in naltrexone response related to mu-opioid receptor gene … Food and Drug Administration; KQ = Key Question; OPRM1 = mu-opioid receptor gene; QoL = quality of life

162. Research Protocol: Breast Reconstruction After Mastectomy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-reconstruction-mastectomy-protocol.pdf
     April 09, 2020 - complications (e.g., for infection, bleeding)* o Pain, including chronic pain* o Analgesic (e.g., opioid … complications (e.g., for infection, bleeding)* o Pain, including chronic pain* o Analgesic (e.g., opioid … complications (e.g., for infection, bleeding)* o Pain, including chronic pain* o Analgesic (e.g., opioid … complications (e.g., for infection, bleeding)* o Pain, including chronic pain* o Analgesic (e.g., opioid … complications (e.g., for infection, bleeding)* o Pain, including chronic pain* o Analgesic (e.g., opioid

163. Amended Protocol: Interventions for Breathlessness in Patients with Advanced Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/dyspnea-protocol-amended.pdf
     May 19, 2020 - Gastrointestinal (constipation, nausea, vomiting) • Pruritus • Urinary retention, dry mouth • Opioid … Gastrointestinal (constipation, nausea, vomiting) • Pruritus • Urinary retention, dry mouth • Opioid

164. Management of Primary Headache During Pregnancy: Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/headaches-pregnancy.pdf
     March 23, 2019 - naratriptan, rizatriptan, almotriptan, eletriptan, zolmitriptan, combination sumatriptan and naproxen) o Opioid … Central Nervous System Stimulants”[Mesh] OR “Tryptamines”[Mesh] OR “narcotics”[Mesh] OR “Analgesics, Opioid … Central Nervous System Stimulants”[Mesh] OR “Tryptamines”[Mesh] OR “narcotics”[Mesh] OR “Analgesics, Opioid

165. Disposition of Comments Report for Nitrous Oxide for the Management of Labor Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/labor-nitrous-oxide_disposition-comments.pdf
     August 23, 2012 - Or “Nitrous oxide induces release of endogenous opioid peptides in the midbrain, stimulating descending … The data for efficacy of intravenous opioid labor analgesia would suggest this description for “opioids … IV remifentanil is the most popular opioid being used for that purpose currently, but it can cause … p. 47, I think it would be helpful to note that pethidine is known as Demerol in the US and is an opioid

166. Cer-250-Cannabis-2025-Surv-Rep-Update-Tables-E1-4 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2025-surv-rep-update-tables-e1-4.xlsx
     January 01, 2025 - Race, Other % Pain Duration Measure (Mean, Median) Pain Duration, Months Psychiatric Comorbidity % Opioid … Previous treatment with weak opioid: 42 vs. 38 Previous treatment with strong opioid: 19 vs. 11 96 71 … : 4% (7/167) vs. 4% (7/172) Other opioid: 20% (33/167) vs. 18% (31/172) 339 339 THC 2.7 mg/CBD 2.5 mg … : 9 vs. 13 Opioid: 2 vs. 3 Strong opioid: 3 vs. 0 66 66 THC 2.7 mg/CBD 2.5 mg per 100 mcl oromucosal … Use (Mean Daily Dose [MDD]) Opioid Equivalents Assessment Time (Weeks) Variance Type for Opioid Use

167. Lumbar-Fusion-Draft-Report-Appendix-D (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/lumbar-fusion-draft-report-appendix-d.xlsx
     January 01, 2019 - vs non-opioid. … Changes in back pain NRS, leg pain NRS, and RDQ stratified by opioid vs non-opioid treatment at baseline … months, 18 months, 24 months Spinal stenosis severity; employment characteristics; procedure relief; opioid … levels of pain were reported with deteriorating relief below 50% Data NR NR Most patients received opioid … and non-opioid analgesics, adjuvant analgesics, and some were involved in therapeutic exercise programs

168. March 2nd Mitigating Racial Bias in Healthcare Algorithms Public Meeting (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/impact-healthcare-algorithms-racial-ethnic-disparities-March-2.pdf
     May 15, 2023 - 2021] [Han 2020] USPSTF-2013 PLCOm2012 N (Y for comparator) Lung cancer screening eligibility Opioid … ET Supporting Algorithmic Equity in a Public Healthcare System: a Case Study in Opioid Safety 76 … Shah, MBBS, PhD Supporting Algorithmic Equity in a Public Healthcare System: a Case Study in Opioid

169. Pharmacologic and Non-pharmacologic Therapies in Adult Patients with Acute Exacerbation of COPD: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-research-protocol.pdf
     April 11, 2018 - Incident opioid drug use and adverse respiratory outcomes among older adults with COPD. … exp corticosteroid therapy/ or exp Expectorants/ or exp narcotic analgesic agent/ or exp Analgesics, Opioid … Glucocorticoid* or instruct* or "management plan*" or "Mind- Body" or Mindfulnes* or narcotic* or Nutrition* or opioid … Glucocorticoid* or instruct* or "management plan*" or "Mind-Body" or Mindfulnes* or narcotic* or Nutrition* or opioid

170. Nonopioid Pharmacologic Treatments for Chronic Pain: Evidence Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-summary.pdf
     April 01, 2020 - These initiatives, along with the recent publication of the evidence-based guideline on opioid use … the Centers for Disease Control and Prevention in the United States and the Canadian Guideline for Opioid … Opioid Treatments for Chronic Pain: A Systematic Review.

171. Labor-Nitrous-Oxide Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/labor-nitrous-oxide_executive.pdf
     August 01, 2012 - United States Epidural • Injection of medications (usually a combination of local anesthetic and opioid … A controlled oximetric evaluation of inhalational, opioid and epidural analgesia in labour.

172. App-D-Surv-Report-3-Noninvasive-Nonpharma 0 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-d-surv-report-3-noninvasive-nonpharma_0.xlsx
     January 01, 2022 - Symptoms: 10.7 vs. 8.9 vs. 10.5 years Pain etiology/type or diagnostic classification: LBP Current opioid … medication use: 56% vs. 47% RDQ (0–24) Pain intensity, Brief Pain Inventory (0–10) Opioid medication … to - 0.11) vs. 0.15 (95% CI -0.18 to 0.47); between-group difference -0.59 (95% CI -1.05 to -0.13) Opioid … C 6 months Opioid Days: 1.61 (0.91) vs. 2.93 (0.93), p=0.31 B vs. … in the 4 weeks prior to baseline: 1% (1/100) vs. 1.2% (1/82) Use of a moderate opioid in the 4 weeks

173. Making Healthcare Safer IV_Rapid Response_Deprescribing To Reduce Medication Harms in Older Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-rapid-response-deprescribing.pdf
     February 01, 2024 - • The Eastern Academic Health Science Network disseminated a toolkit on its website to support opioid … Opioid deprescribing toolkit. n.d. … https://easternahsn.org/about-us/our- projects/opioid-deprescribing-toolkit/. … https://easternahsn.org/about-us/our-projects/opioid-deprescribing-toolkit/ https://easternahsn.org/about-us … Opioid deprescribing toolkit. n.d. https://easternahsn.org/about-us/our- projects/opioid-deprescribing-toolkit

174. Treatments for Acute Pain | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/treatments-acute-pain/research

175. Comparative Effectiveness Review No. 234 Evidence Summary: Management of Primary Headaches in Pregnancy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-234-headaches-pregnancy-summary.pdf
     November 01, 2020 - (I) ↑ (+) Antiemetics (Dopamine antagonists), Antihistamines, Opioid-like analgesics Metoclopramide

176. AHRQ's Evidence-based Practice Center Division Annual Report 2019: Solving the Puzzle for Evidence-Based Decision Making (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-year-in-review-2019.pdf
     January 01, 2019 - 2017) Evidence-Based Guidelines for EMS Administration of Naloxone (NHTSA) Management of Suspected Opioid

177. Treatments, Technologies, and Models for Management of Acute and Chronic Pain in People With a History of Substance Use Disorder | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/pain-management-substance-abuse/research

178. Pharmacotherapy for Adults With Alcohol-Use Disorders in Outpatient Settings: Systematic Review Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/alcohol-pharma-final-protocol.pdf
     January 01, 2023 - acetaldehyde levels37 250 to 500 mg per day Naltrexone oral Acts as a competitive antagonist at opioid … 50 to 100 mg per day Naltrexone intramuscular injectable Acts as a competitive antagonist at opioid … Naltrexone may also be used to treat a patient with AUD and a co-occurring opioid use disorder if the … patient wishes to abstain from opioid use or can do so for a clinically appropriate time before starting … Prevalence of DSM-IV and DSM-5 alcohol, cocaine, opioid, and cannabis use disorders in a largely substance

179. AHRQ’s Evidence-based Practice Center Program Annual Report 2023 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-year-in-review-2023.pdf
     January 01, 2023 - Opioid use disorder at delivery hospitalization in the United States: 2012-2016. … Making Healthcare Safer IV: Opioid Stewardship 28. … effectivehealthcare.ahrq.gov/products/mhs4-hcw-training/protocol https://effectivehealthcare.ahrq.gov/products/mhs4-opioid-stewardship … R18 HS027913-03 Addressing Opioid Use Disorder in Older Adults Through Primary Care Innovation (OUD-

180. Chronic-Cough Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-cough_executive.pdf
     March 01, 2014 - wide variety of pharmaceutical agents have been used to treat the symptom of chronic cough, including opioid … • Of the agents reviewed, the opioid and certain nonopioid/nonanesthetic antitussives most frequently … The opioid and certain nonopioid/nonanesthetic antitussives demonstrated the most promise for managing … wide variety of pharmaceutical agents have been used to treat the symptom of chronic cough, including opioid … The opioid and certain nonopioid/ nonanesthetic antitussives most frequently demonstrated efficacy for