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121. AHRQ's Evidence-based Practice Center Division Annual Report 2020: Solving the Puzzle for Evidence-Based Decision Making (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-year-in-review-2020.pdf
     January 01, 2020 - Opioid Treatments for Chronic Pain. … Prevention, Diagnosis, and Management of Opioids, Opioid Misuse, and Opioid Use Disorder in Older Adults … Retention Strategies for Medications for Addiction Treatment in Adults With Opioid Use Disorder. … Retention Strategies for Medications for Opioid Use Disorder in Adults: A Rapid Evidence Review. … New Grants Awarded in 2020 Addressing Opioid Use Disorder in Older Adults through Primary Care Innovation

122. Executive summary_Comparative Effectiveness Review No. 250_Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2024 Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2024-surv-rep-update-executive-sum.pdf
     January 01, 2024 - event outcomes (psychosis, cannabis use disorder, cognitive deficits) and outcomes on the impact on opioid … Duration, Weeks (Range) 12 to 208 52 26 24 24 Abbreviations: CBD = cannabidiol; LAO = long-acting opioid … reporting of important outcomes such as dosage, pain response, overall function or disability, effect on opioid … J Opioid Manag. 2009 Nov-Dec;5(6):341-57. doi: 10.5055/jom.2009.0034. PMID: 20073408. 2.

123. Research Protocol for Interventions for Substance Use Disorders in Adolescents: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/suda-final-protocol.pdf
     October 02, 2018 - , among twelfth graders10; with 1 percent of youth between the ages of 12 and 17 reporting current opioid … misused prescription and/or over-the-counter medication before the age of 18.12 National concerns about opioid … misuse, encompassing nonmedical use of prescription opioid-based medications (e.g., morphine, fentanyl … Nonmedical Prescription Opioid Use in Childhood and Early Adolescence Predicts Transitions to Heroin … Medication-Assisted Treatment of Adolescents With Opioid Use Disorders.

124. Management of Suspected Opioid Overdose with Naloxone Guidelines by Emergency Medical Services Personnel | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/emt-naloxon/research-protocol

125. Association Between Outcomes and Dental Services in People With Substance Use Disorder: A Rapid Response Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/outcomes-dental-services-rapid-research.pdf
     May 01, 2025 - examples of FDA-approved medications for SUD include methadone, buprenorphine, and naltrexone for opioid … For instance, oral prescription methadone, a common treatment for opioid use disorder, contains high … no mention of dental care Health Resources and Services Administration Caring for Women with Opioid … American Society of Addiction Medicine ASAM National Practice Guideline for the Treatment of Opioid … dental care Substance Abuse and Mental Health Services Administration Federal Guidelines for Opioid

126. Living Systematic Reviews: Practical Considerations for the Agency for Healthcare Research and Quality Evidence-based Practice Center Program (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/practical-considerations.pdf
     March 01, 2022 - received particular scrutiny due to their addiction and overdose potential,8 especially given the ongoing opioid … Since there was no other evidence on the outcome of interest (effect on opioid use) for the type of … Opioid treatments for chronic pain. Rockville, MD; 2020. 8. U.S. … Reducing the risks of relief--the CDC opioid-prescribing guideline.

127. Executive summary_Comparative Effectiveness Review No. 250_Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2025 Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-2025-surv-rep-update-executive-sum.pdf
     January 01, 2025 - Duration, Weeks (Range) 12 to 208 52 26 24 24 Abbreviations: CBD = cannabidiol; LAO = long acting opioid … reporting of important outcomes such as dosage, pain response, overall function or disability, effect on opioid … J Opioid Manag. 2009 Nov-Dec;5(6):341-57. doi: 10.5055/jom.2009.0034. PMID: 20073408. 8.

128. Migraine-Emergency Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-emergency_executive.pdf
     November 01, 2012 - 1 Comparative Effectiveness Review Number 84 Acute Migraine Treatment in Emergency Settings Executive Summary Introduction Migraine is a chronic neurovascular disorder characterized by dysfunction of the central and peripheral nervous systems and intracranial vasculature.1 Acute exacerbations of episodic …

129. Disposition of comments for CER 169 Low Back Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/back-pain-treatment_disposition-comments.pdf
     February 29, 2016 - Given the harms that are being identified with the use of opioid agents, this seems like a glaring … We cited a recent AHRQ-funded review on long-term opioid therapy that we conducted for an NIH Pathways … Opioid analgesics such as oxycodone hydrocodone and methadone were involved in about 3 of every 4 … pharmaceutical overdose deaths 16651 confirming the predominant role opioid analgesics play in drug … overdose deaths. 6I understand that the CDCs posting of opioid deaths in 2010 an observational study

130. Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review Update - Evidence Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/noninvasive-nonpharm-pain-summary.pdf
     April 01, 2020 - use of nonopioid treatment over opioid therapy. … In our concurrent review on opioid medications for chronic pain management, opioids were associated … Recent guidelines from the CDC7 in the United States and the Canadian Guidelines for Opioid Use in … The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a … The President’s Commission on Combating Drug Addiction and the Opioid Crisis.

131. Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetic-neuropathy-disposition-170707.pdf
     March 24, 2017 - manufacturer itself: Coffey et al, Mortality associated with implantation and management of intrathecal opioid … TEP #2 Results – KQ2 I don’t think a summary statement of opioid efficacy should be made based on … results from a single opioid, i.e., oxycodone.

132. Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/diabetic-neuropathy-disposition-170707.pdf
     March 24, 2017 - manufacturer itself: Coffey et al, Mortality associated with implantation and management of intrathecal opioid … TEP #2 Results – KQ2 I don’t think a summary statement of opioid efficacy should be made based on … results from a single opioid, i.e., oxycodone.

133. Improving Pain Management in the Context of America's Opioid and Substance Use Disorders Crisis | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/collections/improving-pain-management

134. Surveillance Report: CER 30: Comparative Effectiveness of Pain Management for Hip Fracture (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/hip-fracture-pain_surveillance.pdf
     July 08, 2015 - Opioid analgesics and the risk of fractures in older adults with arthritis. … Opioid dose (P > .59) on Postoperative Days 1 and 2 was not predictive of incident delirium. … Opioid analgesia was provided in response to pain at rest to achieve scores of 3 or less. … Opioid dose (P > .59) on Postoperative Days 1 and 2 was not predictive of incident delirium. … Opioid dose (P > .59) on Postoperative Days 1 and 2 was not predictive of incident delirium.

135. AHRQ’s Evidence-based Practice Center Program: Synthesizing evidence to improve health care practice and delivery (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/epc-health-care-practice-delivery.pdf
     November 01, 2022 - health-related topics, including— ◆ Clinical areas (e.g., treatments for depression, management of opioid

136. Topic 0552 Low Back Pain NSD FINAL SJ (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0651-131114.pdf
     June 20, 2013 - Topic 0552 Low Back Pain NSD FINAL SJ Diagnosis and Treatment of Low Back Pain Nomination Summary Document Results of Topic Selection Process & Next Steps  The topic, Dia…

137. Executive Summary_Comparative Effectiveness Review No. 254: Improving Rural Health Through Telehealth-Guided Provider-to-Provider Communication (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-254-rural-telehealth-executive-summary.pdf
     December 01, 2022 - populations experience higher mortality2-5 and morbidity from a wide range of conditions including substance/opioid … Understanding the rural-urban differences in nonmedical prescription opioid use and abuse in the United … Examining rural/urban differences in prescription opioid misuse among US adolescents.

138. Appendix-E-Evidence-Tables-E1-E4 0 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/Appendix-E-Evidence-Tables-E1-E4_0.xlsx
     October 08, 2025 - Race, Other % Pain Duration Measure (Mean, Median) Pain Duration, months Psychiatric Comorbidity % Opioid … Previous treatment with weak opioid: 42 vs. 38 Previous treatment with strong opioid: 19 vs. 11 96 71 … : 4% (7/167) vs. 4% (7/172) Other opioid: 20% (33/167) vs. 18% (31/172) 339 339 THC 2.7 mg/CBD 2.5 mg … : 9 vs. 13 Opioid: 2 vs. 3 Strong opioid: 3 vs. 0 66 66 THC 2.7 mg/CBD 2.5 mg per 100 mcl oromucosal … Use (Mean Daily Dose [MDD]) Opioid Equivalents Assessment Time (Weeks) Variance Type for Opioid Use

139. #14 SUBSTANCE ABUSE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1512.pdf
     December 01, 2015 - Evzio for emergency treatment of opioid overdose by nonclinicians Prior high impact topic; archived due … Healthcare Horizon Scanning System include two intranasal naloxone spray products for treating opioid … high-impact topic from the June 2015 report has been archived:  Evzio for emergency treatment of opioid … overdose by nonclinicians: Opioid overdoses are a potentially fatal consequence of prescription or … illicit opioid abuse.

140. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0477_11-01-2011.pdf
     January 01, 2011 - inhibitors (SSRIs) such as fluoxetine); muscle relaxants (e.g., cyclobenzaprine); simple analgesics; opioid