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effectivehealthcare.ahrq.gov/products/nonopioid-chronic-pain
March 01, 2019 - Nonopioid Pharmacologic Treatments for Chronic Pain
Timeline
February 25, 2019
Topic … Initiated
March 01, 2019
Research Protocol
Nonopioid Pharmacologic … Treatments for Chronic Pain
April 16, 2020
Systematic Review
Nonopioid
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effectivehealthcare.ahrq.gov/products/nonopioid-chronic-pain/research
April 16, 2020 - Timeline Feb. 25, 2019 Topic Initiated Mar. 1, 2019 Research Protocol Apr. 16, 2020 Systematic Review Nonopioid … Purpose of Review
Evaluate the benefits and harms of nonopioid drugs in randomized controlled trials … Randomized controlled trials (RCTs) of nonopioid pharmacologic agents in patients with chronic pain were … Withdrawal from study due to adverse events was significantly increased with nonopioid drugs, with the … Nonopioid Pharmacologic Treatments for Chronic Pain. Comparative Effectiveness Review No. 228.
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effectivehealthcare.ahrq.gov/products/nonopioid-chronic-pain/protocol
March 01, 2019 - Timeline Feb. 25, 2019 Topic Initiated Mar. 1, 2019 Research Protocol Apr. 16, 2020 Systematic Review Nonopioid … The 2016 CDC Guideline for Prescribing Opioids for Chronic Pain recommends that nonopioid therapy is … The purpose of this report is to evaluate the effectiveness and comparative effectiveness of nonopioid … In patients with chronic pain, what is the comparative effectiveness of nonopioid pharmacologic agents … compared to other nonopioid pharmacologic agents for outcomes related to pain, function, and quality
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonopioid-pharm-chronic-pain-protocol.pdf
February 01, 2019 - Nonopioid Pharmacologic Treatments for Chronic Pain
Evidence-based Practice Center Systematic … Review Protocol
Project Title: Nonopioid Pharmacologic Treatments for Chronic Pain
I. … The 2016 CDC Guideline for Prescribing Opioids for Chronic
Pain recommends that nonopioid therapy is … The purpose of this report is to
evaluate the effectiveness and comparative effectiveness of nonopioid … compared to other nonopioid pharmacologic agents for outcomes
related to pain, function, and quality
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effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-summary.pdf
April 01, 2020 - Nonopioid Pharmacologic Treatments for Chronic Pain: Evidence Summary
Purpose of Review
Evaluate the … benefits and harms of nonopioid drugs
in randomized controlled trials of patients with spe-
cific types … Nonopioid Pharmacologic Treatments
for Chronic Pain
Evidence Summary
Comparative Effectiveness Review … The most common
forms of nonopioid pharmacologic
treatment for pain are nonsteroidal anti-
R
2 … versus other nonopioid
pharmacologic agents
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effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-apg.xlsx
January 01, 2019 - Nonopioid Pharmacologic Treatments for Chronic Pain: Appendix G
Appendix G.
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effectivehealthcare.ahrq.gov/sites/default/files/cer-228-nonopioid-pharm-chronic-pain-comments.pdf
April 16, 2020 - Disposition of Comments: CER 228, Nonopioid Pharmacologic Treatments for Chronic Pain
Comparative … Effectiveness Review Disposition of Comments Report
Research Review Title: Nonopioid Pharmacologic … Nonopioid Pharmacologic Treatments for Chronic Pain. Comparative
Effectiveness Review No. 228. … ASRA recognizes that all drugs – opioid and
nonopioid – carry risks. … https://effectivehealthcare.ahrq.gov/products/nonopioid-chronic-pain/research
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effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-apf2_0.xlsx
January 01, 2018 - Nonopioid Pharmacologic Treatments for Chronic Pain: Appendix F2
Appendix F2.
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effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-ape_0.xlsx
August 08, 2017 - Nonopioid Pharmacologic Treatments for Chronic Pain: Appendix E
Appendix E.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-1-nonopioid-pharmacol-chronic-pain.xlsx
September 20, 2022 - NPP
Table E-1. Neuropathic pain study characteristics
Author, Year
Country
Trial Type
Quality Rating Type(s) of Pain Demographics Other Population Characteristics N Randomized
N Analyzed Intervention Duration (Weeks) Funding Source
Hussain, 2021
Pakistan
Placebo-controlled
Fair NPP (DPN) Age, mean: 45
Female: 0%
R…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f1-surv-report-2-nonopioid-pharmacol-chronic-pain.xlsx
September 20, 2022 - NPP_Pain
Table F-1a. Pain severity for neuropathic pain
Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug 1 Drug 2 Measure Name Measure Scale Assessment Time (Wk) Time Category Grp 1 Baseline N Grp 1 Baseline Mean Pain Score Grp1 Baseline Variance Type Grp1 Baseline Variance Grp1 Baseline Lower Limi…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f2-surv-report-2-nonopioid-pharmacol-chronic-pain.xlsx
September 20, 2022 - TCA_PCT
Table F-2a. Harms of tricyclic antidepressants versus placebo
Author, Year Quality Pain Population Drug Class Drug Assessment Time (Wk) Time Category WAE: n WAE: N SAE: n SAE: N Cardiac Rhythm Abnormalities: Specific AE Cardiac Rhythm Abnormalities: n Cardiac Rhythm Abnormalities: N N Randomized Cognitive Eff…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f1-surv-report-3-nonopioid-pharmacol-chronic-pain.xlsx
September 20, 2022 - NPP_Pain
Table F-1a. Pain severity for neuropathic pain
Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug 1 Drug 2 Measure Name Measure Scale Assessment Time (Wk) Time Category Grp 1 Baseline N Grp 1 Baseline Mean Pain Score Grp1 Baseline Variance Type Grp1 Baseline Variance Grp1 Baseline Lower Limi…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f2-surv-report-1-nonopioid-pharmacol-chronic-pain.xlsx
September 20, 2022 - TCA_PCT
Table F-2a. Harms of tricyclic antidepressants versus placebo
Author, Year Quality Pain Population Drug Class Drug Assessment Time (Wk) Time Category WAE: n WAE: N SAE: n SAE: N Cardiac Rhythm Abnormalities: Specific AE Cardiac Rhythm Abnormalities: n Cardiac Rhythm Abnormalities: N N Randomized Cognitive Eff…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f2-surv-report-3-nonopioid-pharmacol-chronic-pain.xlsx
September 20, 2022 - TCA_PCT
Table F-2a. Harms of tricyclic antidepressants versus placebo
Author, Year Quality Pain Population Drug Class Drug Assessment Time (Wk) Time Category WAE: n WAE: N SAE: n SAE: N Cardiac Rhythm Abnormalities: Specific AE Cardiac Rhythm Abnormalities: n Cardiac Rhythm Abnormalities: N N Randomized Cognitive Eff…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-g-surv-report-1-nonopioid-pharmacol-chronic-pain.xlsx
September 20, 2022 - RCTs
Table G-1. Quality assessments of included randomized controlled trials
Author, Year Randomization Adequate Allocation Concealment Adequate Patients and Personnel Masked Outcome Assessors Masked Groups Similar at Baseline Intent-to-Treat Analysis (at Least 95% Analyzed) Attrition <20%; Difference Between Groups …
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-g-surv-report-2-nonopioid-pharmacol-chronic-pain.xlsx
September 20, 2022 - RCTs
Table G-1. Quality assessments of included randomized controlled trials
Author, Year Randomization Adequate Allocation Concealment Adequate Patients and Personnel Masked Outcome Assessors Masked Groups Similar at Baseline Intent-to-Treat Analysis (at Least 95% Analyzed) Attrition <20%; Difference Between Groups …
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-g-surv-report-3-nonopioid-pharmacol-chronic-pain.xlsx
September 20, 2022 - RCTs
Table G-1. Quality assessments of included randomized controlled trials
Author, Year Randomization Adequate Allocation Concealment Adequate Patients and Personnel Masked Outcome Assessors Masked Groups Similar at Baseline Intent-to-Treat Analysis (at Least 95% Analyzed) Attrition <20%; Difference Between Groups …
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-2-nonopioid-pharmacol-chronic-pain.xlsx
September 20, 2022 - NPP
Table E-1. Neuropathic pain study characteristics
Author, Year
Country
Trial Type
Quality Rating Type(s) of Pain Demographics Other Population Characteristics N Randomized
N Analyzed Intervention Duration (Weeks) Funding Source
Hussain, 2021
Pakistan
Placebo-controlled
Fair NPP (DPN) Age, mean: 45
Female: 0%
R…
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-f1-surv-report-1-nonopioid-pharmacol-chronic-pain.xlsx
September 20, 2022 - NPP_Pain
Table F-1a. Pain severity for neuropathic pain
Author, Year Quality Pain Population Drug Class 1 Drug Class 2 Drug 1 Drug 2 Measure Name Measure Scale Assessment Time (Wk) Time Category Grp 1 Baseline N Grp 1 Baseline Mean Pain Score Grp1 Baseline Variance Type Grp1 Baseline Variance Grp1 Baseline Lower Limi…