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421. Antiplatelet-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
     September 01, 2013 - Clinical Outcomes Several clinical outcomes of interest were reported: all-cause mortality, cardiac … mortality, acute coronary syndromes, stent thrombosis, stroke, major adverse cardiovascular events … All-Cause Mortality (13 Studies; 12 ADP, 1 ADP + AA) Studies did not suggest an association between … increased platelet reactivity as measured by LTA and increased all-cause mortality in patients with … platelet reactivity as measured by LTA and cardiovascular mortality in patients with ischemic heart

422. Misuse of Prescription Stimulants in Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/misuse-prescription-protocol.pdf
     September 13, 2024 - prescription No prior or current stimulant misuse Comparators N/A N/A Outcomes Morbidity and mortality

423. Methods White Paper: Improving the Utility of Evidence Synthesis for Decision Makers in the Face of Insufficient Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/improving-utility-evidence-synthesis-white-paper.pdf
     April 01, 2021 - Does screening for pancreatic adenocarcinoma improve cancer morbidity or mortality or all-cause … mortality? … , all-cause mortality, or quality of life? … At 6 months, 1 year, and 5 years after receipt of an LLP, (accounting for intervening mortality, … No trials reported on micro- and macrovascular complications or on all-cause mortality

424. Weight-Gain-Prevention Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-gain-prevention_executive.pdf
     January 01, 2020 - prevention of breast cancer or cancer recurrence.16 Higher grades of obesity are associated with excess … mortality, primarily from cardiovascular disease, type 2 diabetes, and certain types of cancer.16,17 … Obesity related adverse effects, quality of life, cancer recurrence*, mortality and study adherence were … Very few studies reported on obesity-related clinical outcomes (mortality, quality of life, or cancer … Only one study in the general population reported on mortality.

425. Identification and Treatment of Post-Acute Coronary Syndrome (ACS) Depression: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/acs-depression-research-protocol-amended.pdf
     February 15, 2017 - symptoms using validated continuous or categorical measures § Cardiac-related outcomes • Cardiac mortality … diagnosis Treatments • Pharmacologic • Nonpharmacologic KQ 1 KQ 1 KQ 2 Clinical outcomes • Total mortality … • Depression-related outcomes • Response or remission • Cardiac-related outcomes • Cardiac mortality … symptoms using validated continuous or categorical measures o Cardiac-related outcomes § Cardiac mortality … outcome-specific quality assessment to groups of outcomes that have lower risk of detection bias (e.g., mortality

426. Multiple-Sclerosis Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/multiple-sclerosis_executive.pdf
     April 01, 2015 - use DMT and Author Type of MS at Baseline Median or Mean Years to Final Assessment All-Cause Mortality … Convert to SPMS Strength of Evidence IFNbeta-1b: Goodin, 201218,19 RRMS 21 All-cause mortality … One study with moderate risk of bias examined all- cause mortality over a 21-year period for 366 patients … Participants in the two treatment arms (50 mg and 250 mg) showed lower all-cause mortality compared … As summarized in Table D, low-strength evidence showed increased all-cause mortality for patients who

427. PULMONARY with "Discussions" in Exec Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1412.pdf
     October 01, 2015 - However, patients with IPF have the highest waiting-list mortality rate of any indication for lung … address a significant unmet need in IPF treatment by delaying deterioration in lung function and mortality … However, patients with IPF have the highest waiting-list mortality rate of any indication for lung … address a significant unmet need in IPF treatment by delaying deterioration in lung function and mortality … both drugs have demonstrated the ability to moderately slow the decline of lung function and delay mortality

428. Medical Care for Adults with Down Syndrome (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/care-adults-down-syndrome-protocol-amendment.pdf
     February 05, 2025 - around 60 years today.4, 14 However, significant disparities in access to care, quality of care, and mortality … rates exist between individuals with Down syndrome and those without, as well as among individuals … treatment Health and quality of life outcomes Harms: adverse events related to screening/diagnosis (mortality … values Healthcare utilization Final outcomes: Change in standardized symptom measures Morbidity/mortality … interventions Final Outcomes Change in standardized symptom measures Reduced morbidity Reduced mortality

429. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
     November 22, 2011 - CVD is the leading cause of death in the United States, with cardiovascular mortality accounting for … percent increase in the risk of major adverse cardiovascular outcomes and an 18 percent increase in mortality … There is controversy regarding the value of these tests for predicting clinical outcomes (e.g., mortality … when it is used to assess treatment effects)  Predictive accuracy for clinical events o Overall mortality … reactivity and quality of life (measured during followup), changes in therapeutic decisionmaking, mortality

430. antibiotics-respiratory-infection-protocol-140922 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_research-protocol.pdf
     September 22, 2014 - have been indicated, undesirable outcomes such as medical complications, hospital admissions, and mortality … Key Question 2 • Mortality • Antibiotic resistance • Medical complications • Adverse drug effects … Mortality,!Adverse!drug! effects)! KQ3:# ! Time!to!return!to!work/! school! ! Clinic/ED!visits,! … antibiotic use / overall antibiotic use KQ2: Antibiotic resistance and Medical complications (mortality … antibiotic use / overall antibiotic use KQ2: Antibiotic resistance KQ3: Medical complications (mortality

431. Disposition of Comments for Venous Thromboembolism Prophylaxis in Orthopedic Surgery (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/blood-clots-hip-knee-surgery_disposition-comments.pdf
     March 01, 2012 - Peer Reviewer #1 Methods Clarify if the outcome of "mortality" is "all-cause mortality". … In the analytic framework, we define mortality as “all cause mortality” in the legend. … Peer Reviewer #1 Results 4.For the mortality section, please cite individual trials when reporting their … The objective of the clinical trial is to compare overall effectiveness (all-cause mortality, clinical … As an alternative, the QIC suggested that AHRQ not focus purely on mortality, but Like QIC, we felt

432. Epilepsy-Medicine Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/epilepsy-medicine_surveillance.pdf
     August 01, 2012 - Newer antiepileptic medications did not significantly impact the risk of mortality versus their older … impact on a long-term outcome such as survival. 2 new studies were identified that reported on mortality … versus Newer Alvarez, 20115 Cohort study Phenytoin or valproate versus levetiracetam Mortality … 201219 RCT Lorazepam Versus levetiracetam Status epilepticus management24-hour seizure free, mortality … Newer antiepileptic medications did not significantly impact the risk of mortality versus their older

433. Epilepsy-Medicine Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/epilepsy-medicine_surveillance.pdf
     August 01, 2012 - Newer antiepileptic medications did not significantly impact the risk of mortality versus their older … impact on a long-term outcome such as survival. 2 new studies were identified that reported on mortality … versus Newer Alvarez, 20115 Cohort study Phenytoin or valproate versus levetiracetam Mortality … 201219 RCT Lorazepam Versus levetiracetam Status epilepticus management24-hour seizure free, mortality … Newer antiepileptic medications did not significantly impact the risk of mortality versus their older

434. Prehospital EMS Blood Transfusion and Fluid Interventions for Hemorrhagic Shock (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ems-blood-transfusion-protocol.pdf
     September 24, 2024 - Background and Objectives for the Systematic Review The leading cause of preventable mortality in both … 1.5 million per year globally, and is second only to central nervous system injury as the cause of mortality … PICOTS Inclusion Criteria Exclusion Criteria Outcomes Patient Health Outcomes (highest priority) • Mortality … Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic

435. Disposition of Comments Report for Comparative Effectiveness Review 128 Oral Mechanical Bowel Preparation for Colorectal Surgery (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_disposition-comments.pdf
     April 30, 2014 - For the remaining four comparisons of OMBP versus no preparation (all-cause mortality, leakage, wound … evidence suggesting that OMBP has similar effectiveness with no preparation with respect to all-cause mortality … evidence suggesting that OMBP has similar effectiveness with no preparation with respect to all-cause mortality … be huge, particularly as the authors are proposing the trial be powered to detect a difference in MORTALITY … From my crude calculations, to demonstrate a 40% relative risk reduction in mortality in this group

436. Dietary-Supplements Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/dietary-supplements_executive.pdf
     April 01, 2012 - Clinical cardiovascular effectiveness/ efficacy outcomes (e.g., mortality and specific cardiovascular … A priori outcomes for grading the strength of evidence Key Question Outcomes 1 Mortality (all-cause … trial contributed evidence 9 Ginkgo biloba With no deaths observed, insufficient evidence for mortality … evidence from single efficacy trials did not demonstrate a difference in the outcome of all-cause mortality … Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis

437. Disposition of Comments for CER 151 Management of Postpartum Hemorrhage (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemorrhage-postpartum_disposition-comments.pdf
     April 28, 2015 - Determining the most effective treatment for postpartum hemorrhage (PPH) is critical to reducing maternal mortality … because PPH is one of the leading causes of maternal mortality. … highlighting the many research limitations related to the management of a common cause of maternal mortality … Most cases of PPH mortality are preventable; what are the implications if systems level interventions … could reduce avoided mortality and severe morbidity?

438. Medication-Therapy-Management Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-therapy-management_research-protocol.pdf
     January 01, 2014 - Finally, still other MTM services relate to patient-centered outcomes (e.g., morbidity, mortality, reduced … Patient-centered outcomes, such as disease-specific morbidity, disease-specific or all- cause mortality … Patient-centered Outcomes† ·∙   Disease-specific morbidity ·∙   Disease-specific or all-cause mortality … reduced number of disease- specific acute exacerbations or events)  Disease-specific or all-cause mortality … , including fall-related mortality  Reduced (actual) adverse drug events (frequency and/or severity

439. Disposition of Comments CER 214 Stroke Prevention in Patients With Atrial Fibrillation (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-214-afib-disposition-comments.pdf
     October 30, 2019 - outcomes, but do not report on the other primary endpoints, cardiovascular mortality and systemic … For example, the authors state that “observational studies demonstrated a benefit [in all-cause mortality … Judy Wagner (Public Reviewer #2) Results Page: 156 Para: 3 Mortality section Please note that … Thomas Seck (Public Reviewer #4) Results • Page 156 When discussing mortality outcomes under the … This study is incorporated in to the table and pooled analysis of all-cause mortality. 154.

440. Stroke Prevention in Atr ial Fibr illation Patients: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/stroke-afib-update_research-protocol-amended.pdf
     October 27, 2017 - immediately life-threatening as ventricular arrhythmias, AF is associated with significant morbidity and mortality … embolic stroke, heart failure, and cognitive impairment; reduced quality of life; and higher overall mortality … and location) b o Minor bleed (stratified by type and location)b • Other clinical outcomes: o Mortality … • All-cause mortality • Cardiovascular mortality o Myocardial infarction o Infection o Heart … outcome-specific quality assessment to groups of outcomes that have lower risk of detection bias (e.g., mortality