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241. Methods Guide for Comparative Effectiveness Reviews - Expanded Guidance on Selected Quantitative Synthesis Topics (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/quantitative-synthesis-expanded-methods_methods.pdf
     March 01, 2013 - In reporting the result, it would be hard to avoid the suggestion of a reduction in mortality even if … hazards of using a naïve meta-regression model to assess the relation between the control rate and mortality … prevent one cardiovascular event in 5 years Trials Number of Subjects Baseline Risk of CHD Mortality … per 100 Person-Years Rate Ratios Number Needed To Treat (5 years) Total Mortality CHD Mortality … All CV Events Total Mortality CHD Mortality All CV Events Primary Prevention AFCAPS/

242. Protocol for Quantitative Assessment of Benefit and Harm analysis of Aspirin for primary prevention (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research.pdf
     February 01, 2014 - The Gail/NCI approach first estimates the number of expected events while considering mortality (or … risk MI: Ix = 0.004 per person-year; RRx aspirin vs. placebo: = 0.86; All-cause mortality: M = 0.005 … based on population-based mortality rates stratified for age and gender. … This considers competing risk of mortality. … (approx. 3 million patients)3 All-cause mortality U.S.

243. Draft - Primary Hypofractionated Radiation Therapy for Localized Prostate Cancer: Appendix D3 Tables (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypofractionated-radiation-therapy-draft-appendix-d3.xlsx
     January 01, 2025 - rate NR NR NR NR NR NR NR NR NR NR Categorical Followup 152 Entire population NR 83 85 NR Count NR NR … rate NR NR NR NR NR NR NR NR NR NR NR NR NR Categorical Followup 520 Entire population NR 83 85 NR Count … NR NR NR NR NR 0.42 NR NR NR 0.15 1.30 NR NR NR NR NR NR NR NR Arcangeli, 2010 KQ1 IG1 IG2 Overall mortality … HR NR NR NR 1.45 CI NR 0.95 0.8 2.59 NR NR 168 NR NR NR NR NR Arcangeli, 2010 KQ1 IG1 IG2 Overall mortality … Mortality rate NR NR NR NR NR NR NR NR NR NR NR NR NR Categorical Followup 520 Entire population NR

244. #14 SUBSTANCE ABUSE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1406.pdf
     January 01, 2020 - Pilot program data demonstrated decreased opioid overdose mortality rates in Wilkes County between … : Project Lazarus was established in 2008, in response to high drug overdose and overdose-related mortality … from 2009 and 2010 for Wilkes County, demonstrating a significant reduction in annual drug overdose mortality … rates, from 46.6 per 100,000 in 2009, to 29.0 per 100,000 in 2010.3 Based on unpublished Wilkes County … Health Department data, the annual overdose mortality rates subsequently decreased to 14.4 deaths

245. Microsoft Word - 3-DKE274__ACEI-ARB-DRI__Comments_Disposition_Table-21_Jan_2011 cyk _2_.docx (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_disposition-comments.pdf
     October 07, 2011 - It is nowhere near long enough to assess diabetes, cardiovascular events or mortality. … effects, could be reasonably assessed in a short timeframe, while many others (e.g. persistence, mortality … Results “Morality” on Pg. 44, line 8 should be “mortality. … “morality” should be replaced by “mortality” This error has been corrected Results Pg 49, table 8, … Summary and Discussion I don’t think that the evidence on mortality is better than “insufficient,

246. Breast-Cancer-Medications Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_surveillance.pdf
     July 01, 2012 - , all-cause mortality, and osteoporotic fractures? … Tamoxifen does not reduce breast cancer mortality compared to placebo. … , all-cause mortality, and osteoporotic fractures? … , all-cause mortality, and osteoporotic fractures? … Tamoxifen does not reduce breast cancer mortality compared to placebo.

247. Treatments for Adults with Schizophrenia: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/schizophrenia-adult_research-protocol.pdf
     September 23, 2016 - in trials) § Withdrawals due to adverse events, time to withdrawal due to adverse events § Mortality … Mortality (all-cause and/or specific) 5. … Schizophrenia: a concise overview of incidence, prevalence, and mortality. … Risk of mortality among individual antipsychotics in patients with dementia. … Antipsychotic drug use and mortality in older adults with dementia.

248. Public-Reporting-Quality-Improvement Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/public-reporting-quality-improvement_research-protocol.pdf
     August 17, 2011 - these factors have potentially serious consequences for patients and their families, including higher mortality … Examples of potential outcomes in this category include decline in mortality for cardiac surgery patients … Two of the earliest public reports in the United States were the data on hospital mortality rates issued … by the Health Care Financing Administration in 1986 and the mortality reports issued by the New York … Geographic location (country, State, city, or region) - The topic of the public reporting (e.g., mortality

249. Executive Summary_Comparative Effectiveness Review No. 252: Management of Infantile Epilepsies (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-252-infantile-epilepsies-executive-summary.pdf
     October 01, 2022 - Surgical mortality for functional hemispherectomy/hemispherotomy and non-hemispheric procedures is rare … hemispheric resective procedures (such as multilobar, lobar, or focal resections) we concluded that mortality

250. Hemorrhage-Postpartum Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemorrhage-postpartum_executive.pdf
     April 01, 2015 - Canada, Australia, Ireland, and Norway, since the 1990s.5-9 PPH is a leading cause of maternal mortality … In another Cochrane review, differences in maternal mortality and morbidity, except for fever, did … In another review, differences in maternal mortality and morbidity, except for fever, did not differ … on changes in mortality. … Reducing maternal deaths through state maternal mortality review.

251. Type-2-Diabetes-Medications-Update Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_surveillance.pdf
     December 31, 2013 - • For Key Question 2, conclusions regarding cardiovascular morbidity and mortality are considered … , cardiovascular mortality, cardiovascular and cerebrovascular morbidity, retinopathy, nephropathy, and … Increase in overall mortality risk 28 … Cancer mortality reduction and metformin: a retrospective cohort study in type 2 diabetic patients. … Metformin users were at a lower risk of cancer mortality (adjusted HR 0.73, p<0.001 vs. 0.97 p=0.69

252. Stem-Cell-Children Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/stem-cell-children_surveillance.pdf
     October 29, 2012 - Low-strength evidence on overall survival suggests harm due to higher treatment-related mortality with … relative balance of benefits (e.g., increased overall survival) or harms (e.g., treatment related mortality … Thus, if the original review has found RR=0.70 for mortality, this implies RRR of 0.3. … If the updated meta-analytic result for mortality were 0.90, then the updated RRR would be 0.10, which … Low-strength evidence on overall survival suggests harm due to higher treatment-related mortality with

253. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/field-triage-glascow_research-protocol.pdf
     February 25, 2016 - instruments alone Outcomes (specified for each Key Question) •   KQ1: Predictive utility for mortality …   Source: www.effectivehealthcare.ahrq.gov Published online: February 25, 2016   6 o   Mortality … mGCS KQ1   Final  health   outcomes   Mortality   Morbidity   Quality  of  life KQ  3   … The impact of advanced prehospital emergency care on the mortality of severely brain-injured patients … A national evaluation of the effect of trauma-center care on mortality.

254. Liver-Cancer Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer_research-protocol.pdf
     July 24, 2013 - The age-adjusted death rate is estimated at 5.2 per 100,000 people per year in the United States, with …  Clinical and patient-centered outcomes include:  Overall mortality or survival. … Clinical and patient-centered outcomes include: • Overall mortality or survival. … Clinical and patient-centered outcomes include: • Overall mortality or survival. … Clinical and patient-centered outcomes include: • Overall mortality or survival.

255. Data-Points 2 Diabetic-Foot-Ulcers Data 02-2011 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/data-points_2_diabetic-foot-ulcers_data_02-2011.xlsx
     January 01, 2011 - DFU Mortality Mortality Rates in Diabetic Medicare Parts A and B Fee-for-Service Population, Diabetic … continuous enrollment and continuous FFS enrollment throughout the year) Breakdown Category Year Mortality … Rates (number of beneficiaries who died in given year, divided by the total population) In Enrolled … LEA Mortality Mortality Rates in Diabetic Medicare Parts A and B Fee-for-Service Population, Lower … Rates In Enrolled Diabetic Population In LEA Prevalent Population In LEA Incident Population

256. Grades-Predictive-Values White-Paper-2015 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/grades-predictive-values_white-paper-2015.pdf
     January 01, 2015 - For outcomes that can be considered extremely patient-relevant (e.g., mortality, stroke, myocardial … (0.37 to 82) 0.78 Discordanta Discordantb Discordantc Alejandria et al., 201312 All-cause mortality … (0.11 to 0.52) 0.75 Discordanta Discordantb Discordantc Brito et al., 201122 All-cause mortality … 0.90 (0.79 to 1.02) 0.43 Discordanta Discordantb Discordantc Buchleitner et al., 201223 Mortality … Effect of early treatment with anti-hypertensive drugs on short and long- term mortality in patients

257. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-update_research-protocol.pdf
     May 07, 2010 - Despite the high morbidity and mortality attributable to hypertension, control remains suboptimal. … Outcomes o Blood pressure control (we will prefer seated trough blood pressure, where reported) o Mortality … diabetes control •LV mass/function •Creatinine/GFR •Proteinuria Significant Clinical Outcomes •Mortality … creatinine/glomerular filtration rate [GFR], proteinuria) and/or clinically significant outcomes such as mortality … Online: May 07, 2010 o LV mass/function o Creatinine/GFR o Proteinuria • Health outcomes: o Mortality

258. Disposition of Comments_Comparative Effectiveness Review No. 263: Management of Postpartum Hypertensive Disorders of Pregnancy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertensive-disorders-pregnancy-disposition-comments.pdf
     May 31, 2023 - Hypertensive Disorders in Pregnancy and Mortality at Delivery Hospitalization - United States, 2017 … mmwr.mm7117a1 The National Center for Health Research (NCHR) Background The abysmal maternal mortality … rate and its striking racial disparities in the U.S. must be addressed. … Pregnancy-Related Deaths: Data from Maternal Mortality Review Committees in 36 US States, 2017–2019 … is typically seen after discharge from the hospital and is associated with maternal morbidity and mortality

259. Contrast-Induced Nephropathy (CIN): Current State of the Evidence on Contrast Media and Prevention of CIN (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/nephropathy-contrast-induced_clinician.pdf
     August 01, 2016 - Need for renal replacement therapy e 5 1740 ⬌ – NR ��� Cardiovascular outcomes 7 2258 ⬌ – NR ��� Mortality … they prevent CIN, the SOE is often insufficient for other outcomes (e.g., cardiovascular events, mortality … IOCM) 7 1748 ⬌ – 1.02 (0.70 to 1.48) ��� Need for renal replacement therapy 11 1558 ⬌ – NR ��� Mortality

260. Vte-Prophyalaxis Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/vte-prophyalaxis_executive.pdf
     May 01, 2013 - VTE affects an estimated 900,000 Americans every year, resulting in significant morbidity and mortality … $20,000, respectively.3 Thus, VTE is an important patient safety issue with significant morbidity, mortality … • The strength of evidence is insufficient that IVC filter placement is associated with less mortality … We also found low-grade evidence to support the idea that UFH reduces the rates of total mortality … The very high mortality rate in this study (9 out of 20 participants) was likely related to multi-organ