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201. Disposition of Comments for Pulmonary Arterial Hypertension: Screening, Management, and Treatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertension-pulmonary-arterial_disposition-comments.pdf
     April 25, 2013 - We assessed mortality and hospitalization separately; however, outcomes such as transplantation were … Public Reviewer - ACCP 3 Executive Summary “BNP level is a poor predictor of mortality (high SOE … )” I would emphasize BNP “alone” is a poor predictor of mortality; to distinguish from BNP as part … reason to skip the mortality analysis. … They also found that the presence of a pericardial effusion was associated with increased mortality

202. Methods-Guidance-Applicability Methods (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-applicability_methods.pdf
     January 01, 2011 - For example, outcome studies suggest that mortality after carotid surgery is affected by the experience … Variation in carotid endarterectomy mortality in the Medicare population. … For older patients, prostate cancer mortality may represent a small portion of overall mortality and … thus be less relevant than overall mortality. … The benefits of RP on cancer-specific and overall mortality appears to be limited to men under 65 years

203. Methods Guide Atkins (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/methods_guide_atkins.pdf
     January 01, 2011 - For example, outcome studies suggest that mortality after carotid surgery is affected by the experience … Variation in carotid endarterectomy mortality in the Medicare population. … For older patients, prostate cancer mortality may represent a small portion of overall mortality and … thus be less relevant than overall mortality. … The benefits of RP on cancer-specific and overall mortality appears to be limited to men under 65 years

204. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
     May 18, 2011 - Incidence and mortality rates for CRC have declined over the past 2 decades. 1 This decrease has been … DNA testing to screen for colorectal cancer in reducing morbidity (colorectal cancer incidence) or mortality … Outcomes KQ 1: Final Health Outcomes 1) CRC-specific or all-cause mortality 2) CRC incidence … (CRC) Fecal DNA Screening Colorectal Cancer Decreased Colorectal Cancer or All-Cause Mortality … , and CRC-specific mortality.

205. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/weight-loss-surgery_research-protocol.pdf
     December 14, 2010 - routinely performed laparoscopically, and they have demonstrated reduced obesity-related morbidity and mortality … healthcare utilization/economics o quality of life measures • Adverse events: o Short-term: - mortality … o Long-term: - mortality - reoperation after bariatric surgery (i.e. band removal, band- to-RYGB … • Adverse events: o Short-term: - mortality - systemic medical complications (i.e. myocardial … infarction, stroke) o Long-term: - mortality - adverse effects of medications Timing: Minimum

206. Slide 1
     effectivehealthcare.ahrq.gov/sites/default/files/study-design-considerations-chapter-2.pptx
     January 01, 2013 - A typical example would be a study on the effects of beta-agonists on asthma mortality in patients with … Since the bias would be that the untreated cohort has a higher mortality irrespective of the treatment … Furthermore, it precludes the study of mortality as an outcome. … Paradoxical relations of drug treatment with mortality in older persons. … A meta-analysis of the association between adherence to drug therapy and mortality.

207. EHC Protocol: Addressing Social Isolation To Improve Health of Older Adults: A Rapid Evidence Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-risk-drugs-protocol.pdf
     July 27, 2023 - syndrome, genetic or acquired thrombophilia, cancer).2,3 While anticoagulants may reduce morbidity and mortality … have equivalent need for the intervention) Outcome RQ 5 Safety • All-cause and cause-specific mortality … Low-Molecular-Weight Heparin and Mortality in Acutely Ill Medical Patients. … Heparin therapy reduces 28-day mortality in adult severe sepsis patients: a systematic review and meta-analysis … Review and a Meta-Analysis Comparing Prophylactic and Therapeutic Low Molecular Weight Heparins for Mortality

208. Disposition of Comments_Comparative Effectiveness Review No. 262_Pharmacotherapy for Adults With Alcohol Use Disorder in Outpatient Settings: Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-262-pharmacotherapy-alcohol-disposition-comments.pdf
     November 07, 2023 - We did not repeat the assessment for mortality in this section (for baclofen or for other drugs). … The dose response issue we found was in the mortality assessment (not in the assessment for other … For mortality, we routinely list this outcome under potential benefits because we want to look for … , it makes sense to think of reduced mortality under potentially beneficial health outcomes. … In the case of baclofen, we do have a section on Mortality (with its own header) in the harms KQ

209. Ch 3-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_3-user-guide-to-ocer_130129.pdf
     September 21, 2012 - published.8 This study provided evidence indicating that either streptokinase or aspirin reduced mortality … In the aspirin-treated subjects, there was a reduction in mortality (804 deaths among 8,587 people, … When the ATE is clearly positive (both aspirin and streptokinase reduce mortality in patients with … In contrast to GISSI, the ISIS-2 study found a mortality benefit for streptokinase among these subgroups … Three randomized studies showed that TPA neither decreased nor increased mortality substantially in

210. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_executive.pdf
     July 01, 2011 - Based on the considerable mortality and morbidity associated with it and its attendant comorbidities, … In addition, mortality due to cardiovascular disease, diabetes, motor vehicle accidents, and other causes … The two studies of cardiovascular mortality did not have consistent findings, and the two studies of … • There were 2 quality A studies that evaluated cardiovascular mortality. … OSA treatments • There were 2 retrospective studies that evaluated mortality in Surgery vs.

211. Coronary-Artery-Stenting Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/coronary-artery-stenting_executive.pdf
     February 01, 2013 - All three studies reported no significant mortality differences between groups in either the medium … supports a reduction in repeat revascularization and restenosis, but no significant differences in mortality … , cardiac mortality, MI, and MACE. … of nonrandomized studies found a borderline significant 23 percent reduction in mortality with IVUS … by meta-analysis, but three nonrandomized studies found a significant 47 percent reduction in mortality

212. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-disease-ace-inhibitor-arb-disposition.pdf
     March 10, 2010 - Given the known benefits of beta blockers and statins on cardiovascular morbidity and mortality, the … Results Pg 20, line 52- Why didn’t you think it reasonable to pool cardiovascular mortality and cardiac … mortality? … We felt that cardiovascular mortality (which included death from vascular causes such as stroke) was … Tables Table 13: CV mortality. The authors concluded that ACEI did not reduce CV mortality.

213. Hepatitis-C-Treatment-Adherence Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-treatment-adherence_executive.pdf
     September 22, 2011 - mortality, liver complications (cirrhosis, liver failure, and liver cancer), quality of life (QOL), … In terms of health outcomes, no studies reported morbidity, mortality, or HCV transmission. … No studies reported morbidity, all-cause mortality, or HCV- specific mortality. … No evidence exists regarding mortality and morbidity. … Again, no evidence addressed the effects of the intervention on mortality or morbidity.

214. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/kidney-disease-medicine_research-protocol.pdf
     November 01, 2010 - association of reduced estimated GFR and albuminuria or proteinuria with total and cardiovascular mortality … of studies have suggested that a GFR 30-59 mL/min/1.73 m2 is associated with an increased risk of mortality … • Outcomes for each question Benefits - Clinical outcomes:  Reduced mortality  Reduced/delayed … • Outcomes for each question Benefits - Clinical outcomes:  Reduced mortality  Reduced/delayed … Albuminuria, impaired kidney function and cardiovascular outcomes or mortality in the elderly.

215. Bladder-Cancer-Non-Muscle-Invasive Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/bladder-cancer-non-muscle-invasive_research-protocol.pdf
     July 21, 2014 - primarily in men older than 60 and roughly twice as frequently in white compared to black men,2 though mortality … Bladder cancer remains an important health problem, with no improvement in associated mortality since … , Guidelines of the European Association of Urology or based on urinary biomarker tests) decrease mortality … effectiveness of various intravesical chemotherapeutic or immunotherapeutic agents for decreasing mortality … United States Cancer Statistics: 1999– 2009 Incidence and Mortality Web-based Report.

216. hemorrhage-postpartum-protocol-140611 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hemorrhage-postpartum_research-protocol.pdf
     June 11, 2014 - Adverse Outcomes Associated with Postpartum Hemorrhage PPH is one of the leading causes of maternal mortality … • Blood loss • Transfusion • ICU admission • Anemia • Length of stay Final outcomes • Mortality … characteristics • Blood loss • Transfusion • ICU admission • Anemia • Length of stay • Mortality … Reducing maternal deaths through state maternal mortality review. … Maternal mortality from hemorrhage. Semin Perinatol 2012 Feb;36(1):48-55. PMID: 22280866. 32.

217. Physiologic Predictors of the Need for Trauma Center Care: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/predictors-trauma-care_research-protocol.pdf
     May 31, 2017 - Indicators that have been used or proposed include in-hospital mortality, measures of resource use ( … Indicators of serious injury: o In-hospital mortality o Resource use/intervention standards or lists … Relationship between American College of Surgeons trauma center designation and mortality in patients … A national evaluation of the effect of trauma-center care on mortality. … Improving the prediction of mortality and the need for life- saving interventions in trauma patients

218. Er r or Rate Reduction Regarding Lower Limb Prosthesis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prosthesis_research-protocol.pdf
     March 16, 2017 - emotional health (e.g., increased risk for cardiovascular disease,3 anxiety, and depression4) and higher mortality … (estimated 5-year mortality rates for amputees range between 50%5 and 74%6; estimated 1-year mortality … At 6 months, 1 year, and 5 years after receipt of a LLP, (accounting for intervening mortality, subsequent … “Mortality Rates and Diabetic Foot Ulcers.” J. … “Reamputation, Mortality, and Healthcare Costs Among Persons with Dysvascular Lower-Limb Amputations

219. Alcohol-misuse-drug-therapy-140326 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_research-protocol.pdf
     January 27, 2012 - more than $220 billion.6,7 Alcohol misuse is estimated to be the third leading cause of preventable mortality … is, threefold to fourfold increased rates of early mortality.18-20 They are associated with hypertension … The low use of medications for alcohol dependence could contribute to unnecessary morbidity and mortality … Per capita alcohol consumption and all-cause mortality in Canada, 1950-98. … Mortality attributable to harmful drinking in the United States, 2000.

220. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hip-fracture-pain_research-protocol.pdf
     December 09, 2009 - Objectives for the Systematic Review Background Hip fractures are a source of significant morbidity and mortality … Not only are short-term mortality rates high, but a large proportion of those patients who survive never … We will consider post-hospital mortality of women versus men to note if the pattern the same. … Mortality (30 day and up to 1-year postfracture) b. Functional status c. … to prefracture place of residence, health-related quality of life, health service utilization, and mortality