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261. Effective Health Care (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0334_08-04-2010.pdf
     January 01, 2010 - Outcome(s): Recurrent ischemic events, stent thromboses, cardiovascular disease- related morbidity and mortality … )  While clopidogrel may decrease morbidity and mortality associated with several cardiovascular

262. Prostate-Cancer-Risk-Assessment-Genes Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer-risk-assessment-genes_executive.pdf
     July 01, 2012 - , or in combination with digital rectal examination, suggested no evidence of benefit in reducing mortality … Prediction of prostate cancer mortality in affected men was evaluated for the 5-SNP panel, with and … There was no association between risk alleles and prostate cancer mortality for any of the panels,47,55,59 … Clinical utility of five genetic variants for predicting prostate cancer risk and mortality. … Evaluation of 8q24 and 17q risk loci and prostate cancer mortality.

263. FRN 29: Future Research Needs on Procalcitonin-Guided Antibiotic Therapy (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/procalcitonin-future_research.pdf
     August 01, 2014 - Early initiation of appropriate antibiotics and goal- directed therapies reduce mortality. … Availability of data or ability to recruit Given the high mortality rates for sepsis, patient or … Early initiation of appropriate antibiotics and goal- directed therapies reduce mortality. … A meta-analysis was performed on short-term mortality (28-day or in-hospital mortality) in a group of … Availability of data or ability to recruit Given the high mortality rates for sepsis, patient or

264. Management of Postpartum Hypertensive Disorders of Pregnancy | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/hypertensive-disorders-pregnancy/research
     October 01, 2023 - patients with eclampsia (moderate SoE) There is insufficient evidence regarding the risk of maternal mortality … May increase the risk of recurrent seizures among patients with eclampsia (low SoE) May not affect mortality … Systematic Review Dec 21, 2023 Social and Structural Determinants of Maternal Morbidity and Mortality

265. Use of Natriuretic Peptide Measurement in the Management of Heart Failure | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/heart-failure-natriuretic-peptide/research-protocol
     December 01, 2019 - the same reasons, uncertainty surrounds the BNP or NT-pro-BNP test’s ability to predict morbidity and mortality … , the review will investigate whether BNP and NT-proBNP are independent predictors of morbidity and mortality … , or whether they add information to other methods used to predict morbidity and mortality. … KQ3 to KQ6: Mortality including all cause and HF; Morbidity including hospitalization (including HF, … B-type natriuretic peptide-guided therapy for chronic heart failure reduces all-cause mortality compared

266. EPC Systematic Review Protocol: Achieving Health Equity in Preventive Services: Systematic Evidence Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/health-equity-protocol.pdf
     January 01, 2020 - prevalence of disease including earlier onset or more aggressive progression, and premature or excessive mortality … Outcomes: • Include for all KQ’s: o Clinical outcomes: Differences in the incidence, morbidity, mortality … , and all-cause mortality, quality-of-life, harms of screening Cervical cancer screening Women age … ; perinatal morbidity/mortality; and quality of life, harms of interventions Abbreviations: CHD … MMWR: Morbidity & Mortality Weekly Report - Supplement. 2016 Feb 12;65(1):21-8. doi: https://dx.doi.org

267. Achieving Health Equity in Preventive Services: Systematic Evidence Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/health-equity-preventive/protocol
     September 01, 2019 - diabetes; late stage diagnosis; health care utilization related to diabetes Disease specific mortality … followup imaging, and biopsies Breast cancer incidence, advanced breast cancer, breast cancer mortality … , and all-cause mortality, quality-of-life, harms of screening Cervical cancer screening … ; perinatal morbidity/mortality; and quality of life, harms of interventions Abbreviations: … MMWR: Morbidity & Mortality Weekly Report - Supplement. 2016 Feb 12;65(1):21-8. doi: https://dx.doi.org

268. Disposition of Comments for Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer: An Update of a 2008 Systematic Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_disposition-comments.pdf
     December 16, 2014 - After declining incidence, should also note declining mortality. … Pg. 1 We have now added “decline in mortality” Pg. 3 We have included “staging of prostate cancer … SPCG-4 conducted in absence of PSA testing, had much higher CaP mortality rates. … Mortality after radical prostatectomy or external beam radiotherapy for localized prostate cancer. … Given low CaP mortality in men in PIVOT (early PSA era) the likelihood of any greater than a small mortality

269. AHRQ Slide Template 2009 (ppt file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/topic-refinement.ppt
     March 01, 2010 - Questions That Reflect Uncertainty (II) Can aliskerin reduce the risk of mortality, myocardial infarction … The first question is, “Can aliskerin reduce the risk of mortality, myocardial infarction, and stroke … The final health outcomes include mortality, hospitalization, bone fracture, and health-related quality … in health outcomes of quality of life, bone fracture or development of osteoporosis/osteopenia, or mortality … in health outcomes of quality of life, bone fracture or development of osteoporosis/osteopenia, or mortality

270. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/recombinant-factor-viia_disposition-comments.pdf
     June 01, 2010 - rate (page ES-6) for patients who were treated with rFVIIa. … As an illustration, the mortality rate described in the Premier database (36% mortality in 3639 bodily … rates) and non-trauma centers (which have higher rates of mortality).’4 Therefore, the Premier database … rate (31% rFVIIa versus 51% usual care). … , progressive bleeding risk, and mortality rate Most off-label use of RFVIIa for intracranial bleeding

271. - (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_appendixes.pdf
     January 01, 2009 - Prediction of mortality in patients with cystic fibrosis. … Gender gap in cystic fibrosis mortality. … Peak oxygen uptake and mortality in children with cystic fibrosis. … Predictors of mortality in adults with cystic fibrosis. … Morbidity and mortality data of cystic fibrosis patients.

272. Pharmacologic and Mechanical Prophylaxis of Venous Thromboembolism Among Special Populations | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/vte-prophyalaxis/research
     December 01, 2019 - evidence is low that enoxaparin reduces deep vein thrombosis and that unfractionated heparin reduces mortality … Low-grade evidence supports the idea that IVC filters with usual care are associated with increased mortality

273. Pharmacologic Therapies for the Management of Crohn’s Disease: Comparative Effectiveness | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/crohns-disease/research
     December 01, 2019 - The safety outcomes of interest were mortality, occurrence of lymphomas and other cancers, infections … No pediatric study reported on serious adverse events such as mortality, lymphoma, or other cancers.

274. Hepatitis-C Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/hepatitis-c_executive.pdf
     November 01, 2012 - Final outcomes were morbidity and mortality from HCV infection (including hepatic cirrhosis, HCC, and … in risk of short-term mortality, but reported very few (20 total) events. … confounders found an SVR after antiviral therapy associated with lower risk of all-cause mortality … A sustained virologic response reduces risk of all-cause mortality in patients with hepatitis C. … Regression analysis of trends in mortality from hepatocellular carcinoma in Japan, 1972-2001.

275. Strategies for Improving the Lives of Women Aged 40 and Above Living with HIV/AIDS | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/women-hiv/research-protocol
     March 01, 2020 - Assess co-occurring diseases and risk factors as predictor of all-cause mortality and HIV progression … treatments for managing such diseases on person-level outcomes, and predictive models of all-cause mortality … Examples of person-level outcomes include clinical outcomes such as mortality and morbidity, mental health … For predictive models of all cause mortality or HIV progression, eligible are longitudinal epidemiologic … studies that model risk of (or time to) all cause mortality, AIDS defining illnesses, or changes in

276. Alcohol-Misuse Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/alcohol-misuse_executive.pdf
     April 28, 2010 - more than $220 billion.5,6 Alcohol misuse is estimated to be the third leading cause of preventable mortality … Point estimates trended toward favoring behavioral interventions, few studies reported mortality, and … Few studies reported mortality, additional studies would be needed to increase precision, and there … rates).88 Potential Adverse Effects of Behavioral Counseling Interventions Published trials have given … Meta-analysis of alcohol and all-cause mortality: a validation of NHMRC recommendations.

277. Prostate-Cancer-Therapies-Update Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_research-protocol.pdf
     April 01, 2013 - Potential benefits of regular PSA screening include early cancer detection and reduced mortality rates … Both the ERSPC and PLCO trials found little effect on mortality following PSA screening.11 The Göteborg … trial reported a 0.40 percent absolute risk reduction in prostate cancer mortality, a relative risk … Outcomes • The primary outcome is overall mortality or survival. … Mortality results from the Göteborg randomised population-based prostate-cancer screening trial.

278. Effective Health Care (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0496_12-30-2011.pdf
     January 01, 2011 - surrogate outcomes of biochemical evidence of organ function (serum creatinine or creatinine clearance), mortality … , rate of renal recovery, adverse effects of treatment.

279. CER 229 Evidence Summary: Opioid Treatments for Chronic Pain (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/cer-229-opioid-treatments-chronic-pain-evidence-summary.pdf
     April 01, 2020 - • One cohort study found higher dose of opioids associated with increased risk of all-cause mortality … ; longer duration was associated with decreased risk of all-cause mortality (SOE: low) … Prescription of long-acting opioids and mortality in patients with chronic noncancer pain. … Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting … Mortality After Discontinuation of Primary Care-Based Chronic Opioid Therapy for Pain: a Retrospective

280. Treatment of Depression in Children and Adolescents | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/childhood-depression/research
     March 01, 2022 - Specific Outcome and Population Intervention   Comparator Studies N Finding SOE   Mortality from suicide … Specific Outcome and Population Intervention   Comparator Studies N Finding SOE   Mortality Adolescents … with MDD Fluoxetine Pill placebo 1 221 No mortality from completed suicides insufficient Mortality … and children with MDD Desvenlafaxine Pill placebo 1 227 No deaths insufficient Mortality Adolescents … Adolescents with MDD Psychotherapy Pharmacotherapy 1 220 No suicides reported insufficient Mortality