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121. Evidence Summary: Management of Colonic Diverticulitis (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-233-diverticulitis-evidence-summary.pdf
     October 01, 2020 - there is insufficient evidence regarding important clinical outcomes, including treatment failure, mortality … With low to moderate SoE, serious surgical complications included 30-day mortality (0.7%), 30-day readmission … management of patients with uncomplicated diverticulitis leads to higher rates of treatment failure, mortality … Adverse outcomes, such as mortality and emergency surgery are uncommon (3% of patients or fewer), regardless … Postoperative mortality is uncommon, but patients not uncommonly require readmission or reoperation.

122. Pain Management Interventions for Elderly Patients With Hip Fracture | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/hip-fracture-pain/clinician
     December 01, 2019 - Background Information Among elderly patients with hip fracture from low-impact injury, mortality rates … insufficient] Continuous versus single-dose modes of spinal anesthesia do not differ for either 30-day mortality … rates or changes in mental status . … [evidence low] Reduce the incidence of delirium (NNT = 9). * [evidence medium] Do not affect mortality … rates (pre- and postoperative use) .

123. Telehealth for Acute and Chronic Care Consultations | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/telehealth-acute-chronic/research
     August 01, 2019 - Remote intensive care unit consultations likely reduce mortality. … Telehealth consultations in emergency services likely reduce heart attack mortality. … Remote intensive care unit (ICU) consultations likely reduce ICU and total hospital mortality with no … patients spend in the emergency department; telehealth for emergency medical services likely reduces mortality … difference in clinical outcomes with inpatient telehealth specialty consultations, no difference in mortality

124. For the disabled and elderly with multiple comorbidities, what is the comparative effectiveness of physician housecalls on outcomes and total cost? | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-the-disabled-and-elderly-with-multiple-comorbidities-what-is-the-comparative-effectiveness-of-physician-housecalls-on-outcomes-and-total-cost
     November 01, 2017 - I am interested in mortality rates, since homebound patients are usually more interested in comfort care … There is little known about comparative mortality rates in this high-cost, complex, multi-morbid patients … Patients exhibit a high degree of therapeutic nihilism which may translate to higher mortality rates

125. Vitamin D and Calcium: A Systematic Review of Health Outcomes | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/vitamin-d-calcium/research-protocol
     December 01, 2019 - Pregnancy-related outcomes Preterm birth or low birth weight Infant mortality Mortality … Cancer and cancer-specific mortality Renal outcomes Soft tissue calcification (Other) adverse … ) Pregnancy-related clinical and intermediate outcomes (preterm birth, infant mortality or low birth … weight, high blood pressure with or without proteinuria, pre-eclampsia) All-cause mortality Bone … ; cancer and cancer-specific mortality, renal outcomes, and soft tissue calcification) Study Design

126. Renal Artery Stenosis Management Strategies: An Updated Comparative Effectiveness Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/renal-update/research
     January 01, 2020 - Outcomes included all-cause and cardiovascular mortality, cardiovascular events, renal replacement therapy … For the primary comparison of PTRAS versus medical therapy, seven RCTs found no difference in mortality … The nonrandomized studies were more variable than the RCTs and found no significant difference in mortality … pulmonary edema or both rapidly declining kidney function and refractory hypertension had decreased mortality

127. Maternal and Childhood Outcomes Associated With the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/outcomes-nutrition/protocol
     June 01, 2022 - , infant mortality, child development/school performance   Publications with no original data (e.g., … , infant mortality, and child development/school performance, we will include studies before or after … ; Maternal mortality;      Child development/school performance.  … data collected before 2009 for all the outcomes except maternal mortality, infant mortality, child development … Infant mortality Child mortality Dietary outcomes Dietary practices of infants and children Infants:

128. Comparative Effectiveness and Safety of Oral Diabetes Medications for Adults With Type 2 Diabetes: An Update of the 2007 Report | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/type-2-diabetes-medications-update/research-protocol
     December 01, 2019 - Review Type 2 diabetes is increasing in the United States and has a high burden of morbidity and mortality … All-cause mortality Cardiovascular mortality Cardiovascular and cerebrovascular morbidity (e.g., … Cardiovascular mortality Cardiovascular and cerebrovascular morbidity (e.g., myocardial infarction … Outcomes include intermediate outcomes, long-term outcomes, safety, adverse events, mortality, and quality … For Key Question 2, we included the following outcomes: all-cause mortality, cardiovascular disease mortality

129. Blood-based Tests for Multiple Cancer Screening: A Systematic Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cell-free-dna-protocol.pdf
     June 05, 2024 - and all-cause mortality? … , cancer mortality by type of cancer, all-cause mortality Late-stage cancer detection overall … We consider all-cause mortality an important outcome. … All-cause mortality is less biased than cancer-specific mortality because it is not subject to misclassification … The Impact of Cancer Screening on All-Cause Mortality.

130. Blood-based Tests for Multiple Cancer Screening: A Systematic Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/cell-free-dna/protocol
     July 01, 2024 - and all-cause mortality? … Outcomes KQ 1: Cancer mortality overall and by cancer type, all-cause mortality, quality of life, functional … , cancer mortality by type of cancer, all-cause mortality Late-stage cancer detection overall and by … All-cause mortality is less biased than cancer-specific mortality because it is not subject to misclassification …     All-cause mortality     Quality of life     Functional status Screening group author-reported mortality

131. Making Healthcare Safer IV: Sepsis Prediction, Recognition, and Intervention | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/sepsis/protocol
     September 01, 2023 - hospital stay. 4 The estimated annual cost of sepsis for Medicare beneficiaries is $41.5 billion, with mortality … rates for sepsis ranging from 60% for septic shock diagnoses to 27% for unspecified sepsis diagnoses … (e.g., time to treatment), but only sparse evidence supporting an impact on patient outcomes (e.g., mortality … of diagnosis and treatment, and adherence to clinical best practices), and patient outcomes (e.g., mortality … Time to Treatment and Mortality during Mandated Emergency Care for Sepsis.

132. Amended Protocol: Maternal and Childhood Outcomes Associated with the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/product/pdf/wic-outcomes-nutrition-protocol-amended.pdf
     October 01, 2020 - , infant mortality, child development/school performance) will studies prior to 2009 be included … , infant mortality, child development/school performance • Publications with no original data ( … Infant mortality; II. Maternal mortality; III. Child development/school performance. … only use data collected before 2009 for all the outcomes except maternal mortality, infant mortality … Infant mortality Child mortality Dietary outcomes Dietary practices of infants and children Infants

133. Therapies for Clinically Localized Prostate Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/prostate-cancer-therapies/protocol
     March 01, 2020 - Objectives for the Systematic Review Prostate cancer is common and results in considerable morbidity, mortality … Prostate cancer specific survival/mortality Metastatic-progression free survival Metastases (lymph … Prostate cancer specific survival/mortality Metastatic free survival/metastases (lymph nodes/distant … general, the figure illustrates how therapies for CPLC may result in final health outcomes such as mortality … /survival; prostate-specific mortality/survival; metastatic progression) and harms (bowel, bladder, and

134. FRN 40 - Screening for Methicillin-Resistant Staphylococcus aureus (MRSA): Future Research Needs (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/mrsa-screening_research.pdf
     June 01, 2013 - Precise estimates of the comparative effectiveness of screening for MRSA-carriage on morbidity and mortality … rate was 6.3 per 100,000 (interval estimate, 3.3–7.5).6 Eighty-five percent of the invasive MRSA … What is the most effective strategy for reducing MRSA infection and associated morbidity, mortality … What is the most effective strategy for reducing MRSA infection rates, morbidity, mortality and resource … 3 13 7 What is the most effective strategy for reducing MRSA infection rates, morbidity, mortality

135. Stroke Prevention in Patients With Atrial Fibrillation: A Systematic Review Update | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/stroke-afib-update/research-2018
     May 01, 2020 - There may also be no evidence for a difference in myocardial infarction or all-cause mortality. … Apixaban also has less risk for major bleeding and may also decrease all-cause mortality compared to … Rivaroxaban is most likely similar to warfarin in the rate of all-cause mortality. … CI 0.66 to 0.95; high SOE), major bleeding (HR 0.69; 95% CI 0.60 to 0.80; high SOE), and all-cause mortality … closure devices showed a trend toward benefit over warfarin for strokes, major bleeding, and all-cause mortality

136. Comparative Effectiveness of First and Second Generation Antipsychotics in the Pediatric and Young Adult Populations | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/antipsychotics-children/research-protocol
     December 01, 2019 - Major adverse events include: Mortality Cerebrovascular disease-related events Development of … Major adverse events: mortality, cerebrovascular disease-related events, development of diabetes mellitus … Safety and effectiveness in pediatric patients <18 years have not been established Increased mortality … Adults Safety and effectiveness in pediatric patients <16 have not been established Increased mortality … Safety and effectiveness in pediatric patients <12 years have not been established Increased mortality

137. Chronic Kidney Disease Stages 1-3: Screening, Monitoring, and Treatment | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/kidney-disease-medicine/research
     December 01, 2019 - had cardiovascular disease or diabetes with other cardiovascular risk factors, ACEI treatment reduced mortality … filtration rate (eGFR) or creatinine clearance, HMG CoA-reductase inhibitors (statins) reduced risk of mortality … In selected CKD patients, ACEI or ARB treatment reduces ESRD risk, ACEI treatment reduces mortality risk … , and statin treatment reduces risk of mortality, MI, and stroke.

138. Oral Mechanical Bowel Preparation for Colorectal Surgery | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/colorectal-surgery-preparation/research
     December 01, 2019 - Eligible comparative studies reported on predetermined clinical outcomes, including overall mortality … in meta-analyses comparing OMBP versus enema or no preparation for the following outcomes: overall mortality … OMBP to no preparation, credible intervals did not exclude modest (e.g., 30-50%) effects on overall mortality … evidence suggesting that OMBP has similar effectiveness as no preparation with respect to all-cause mortality

139. Effective Health Care (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0012_03-21-2008.pdf
     January 01, 2008 - Does screening for sub-clinical thyroid dysfunction reduce morbidity or mortality? 1b. … Does screening high-risk groups for sub-clinical thyroid dysfunction reduce morbidity or mortality? … Does treatment make a difference in morbidity or mortality when sub-clinical hypothyroidism or hyperthyroidism

140. Physiologic Predictors of Severe Injury: Systematic Review, Evidence Summary (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-205-predictors-trauma-care-evidence-summary.pdf
     April 01, 2018 - Utility of the shock index in predicting mortality in traumatically injured patients. … Shock index as a mortality predictor in patients with acute polytrauma. … What do prehospital trauma scores predict besides mortality? … Early prediction of posttraumatic in-hospital mortality in pediatric patients. … A simplified emergency trauma score for predicting mortality in emergency setting.