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21. Effective Health Care (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0332_07-29-2010.pdf
    January 01, 2010 - who may be candidates for prostate biopsy or II. adult men with previous normal biopsy following … Reduction in unnecessary repeat biopsies in men with previous elevated PSA and ≥1 negative biopsy … Does use of the PCA3 assay influence treatment decisions in men with positive biopsies? i. … Avoidance of unnecessary treatment in men with clinically insignificant prostate cancer ii. … Initiation of treatment in men with a high probability of clinically significant prostate cancer c

22. NIH State-of-the-Science Conference: Role of Active Surveillance in the Management of Men With Localized Prostate Cancer | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/prostate-cancer-surveillance/research-protocol
    December 01, 2019 - NIH State-of-the-Science Conference: Role of Active Surveillance in the Management of Men … Currently, most prostate cancer in men in the United States is found by prostate-specific antigen (PSA … It was projected that in 2010 over 217,000 men would be diagnosed with cancer of the prostate and about … Thus, all men who undergo treatment risk suffering the adverse events of the treatment, while only a … Watchful waiting and active surveillance are two followup strategies for men with prostate cancer.

23. Male Breast Cancer | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/health-topics/male-breast-cancer
    Male Breast Cancer Description Although breast cancer is much more common in women, men … It happens most often to men between the ages of 60 and 70. Breast lumps usually aren't cancer. … However, most men with breast cancer have lumps.

24. Urethral Disorders | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/health-topics/urethral-disorders
    September 15, 2014 - In men, it's a long tube that runs through the penis. It also carries semen in men. … They include Urethral cancer - a rare cancer that happens more often in men Urethral stricture

25. Prostate-Cancer-Therapies-Update Executive (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_executive.pdf
    December 01, 2014 - Review Executive Summary Background Prostate cancer is the most common nondermatologic cancer in men … years of age, but not among men 70 years of age or younger. … There was a significant reduction in PCSM among men with PSA >10 ng/mL and men with high-risk tumors … from those of men diagnosed in the past as well as those of men diagnosed today. … Low risk prostate cancer in men >/= 70 years old: to treat or not to treat.

26. Treatment Strategies for Women With Coronary Artery Disease: Future Research Needs | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/cad-women-treatment-future/research
    December 01, 2019 - More than 500,000 women die of cardiovascular disease each year, exceeding the number of deaths in men … However, women have a worse prognosis than men for manifestations of CAD such as acute myocardial infarction … (MI), and some data suggest that women and men do not respond equally to the same treatments. … Further, women are more likely than men to experience bleeding complications.

27. Prostate Diseases | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/health-topics/prostate-diseases
    May 26, 2016 - Health Topics Prostate Diseases Description The prostate is a gland in men … The older men get, the more likely they are to have prostate trouble. … by bacteria Enlarged prostate (BPH) , or benign prostatic hyperplasia - a common problem in older men

28. Disposition of Comments for Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer: An Update of a 2008 Systematic Review (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer-therapies-update_disposition-comments.pdf
    December 16, 2014 - higher than men currently detected). … Any benefit was limited to men age > 65. … Both sections say AS should be offered to men with “low risk” disease. … I am not sure why men with T3 disease were excluded form analysis 5. … Lee et al. 201237 (study compared men with prostate cancer vs. men who did not carry a diagnosis of

29. Brooks_ECCS2012 (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/brooks_eccs2012.pdf
    January 01, 2012 - Detection of Prostate Cancer  (1 of 2) The American Cancer Society recommends that asymptomatic men … Slide 14: Simple Messages  (“Less  Is  More”) • Prostate cancer affects many men. • There are …  find it early. • We don’t  yet  know  if the benefits of testing  outweigh the risks. • Men … Slide 15: Pictographs Two  pictographs  titled: • 17 out of 100 men … (17%) ago 50 will be diagnosed with prostate cancer during  their  life. • 3 out of 100 men (3%

30. Treatment Strategies for Women With Coronary Artery Disease | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/cad-women-treatment/research
    December 01, 2019 - leading cause of death for women in the United States, treatment studies to date have primarily enrolled men … the trend favoring early invasive therapy suggested at earlier time points and across time points in men … events, which is similar to findings in previous meta-analyses combining results for both women and men … of studies comparing early invasive with initial conservative strategies on a combined population of men … In contrast, previous meta-analyses that combined results for men and women found similar outcomes for

31. Therapies for Clinically Localized Prostate Cancer | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/prostate-cancer-therapies/report
    January 01, 2021 - Main Points In men with clinically localized prostate cancer (CLPC) detected clinically rather than … Mortality reductions may be limited to men age 65 and older and those with intermediate risk disease. … EBR plus AD may slightly reduce mortality and metastases versus EBR alone in men with intermediate- and … Effectiveness may be limited to younger men or to those with intermediate-risk disease and requires many

32. Evidence-based Practice Center Systematic Review Protocol: Therapies for Clinically Localized Prostate Cancer (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-protocol_amended110619.pdf
    November 02, 2019 - malignancy (174,650 new cases) and the second leading cause of cancer death (31,620 deaths) among men … However, for some men, disease progression can cause bothersome, and even fatal, results. … CLPC treatment aims to identify men most likely to benefit from early intervention while minimizing … For men with low- risk CLPC, active surveillance (AS) is often recommended. … Treatment naïve men with CLPC (stages T1 to T3a).

33. Topic Nomination: Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia 1.Questions to Consider 1. What is the comparative efficacy and effectiveness of currently available and emerging treatments for lower urinary tract… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/topic-nomination-lower-urinary-tract-symptoms-secondary-to-benign-prostatic-hyperplasia-1questions-to-consider-1-what-is-the-comparative-efficacy-and-effectiveness-of-currently-available-and-emerging-treatments-for-lower-uri
    November 01, 2017 - This age range is consistent with BPH NIH trials which typically enroll men ? 45 years of age. … The index patient criterion specifically excludes men who are under 45 years of age and present with … and 90% of men by age 90 demonstrating histologic evidence of BPH3. … The prevalence of moderate to severe LUTS ranges from 26% in men aged 40-49 years to 46% in men aged … As a result men may choose to avoid public urinals and restrict their freedom of movement in order to

34. Therapies for Clinically Localized Prostate Cancer: Update of a 2008 Systematic Review | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/prostate-cancer-therapies-update/research
    December 01, 2019 - In the PIVOT, reduced all-cause mortality was identified among men with prostate-specific antigen >10 … ng/mL and among men with intermediate tumor risk. … therapy (ADT) reported an improvement in overall survival and prostate cancer–specific mortality among men … Adverse events such as urinary incontinence and erectile dysfunction were reported mostly among men who … as genitourinary toxicity, gastrointestinal toxicity, and erectile dysfunction were reported among men

35. Enlarged Prostate (BPH) | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/health-topics/enlarged-prostate-bph
    December 16, 2014 - Topics Enlarged Prostate (BPH) Description The prostate is a gland in men … As men age, their prostate grows bigger. If it gets too large, it can cause problems. … Most men will get BPH as they get older. Symptoms often start after age 50.

36. Therapies for Clinically Localized Prostate Cancer (pdf file)
    effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_clinician.pdf
    January 01, 2016 - Prostate cancer is the most common nondermatologic cancer in men. … Approximately 90 percent of men who are diagnosed with prostate cancer have cancer confined to the … The percentage of men diagnosed with clinically localized prostate cancer might change as a result … The treatment for men with clinically localized prostate cancer has been the subject of much debate. … Identifying those men most likely to benefit from aggressive therapy is challenging.

37. • Identify disparities and reasons for disparities and reevaluate the framework for researching disparities The following article was used in answering this question: Davis, L. M., Kilburn, M. R., and Schultz, D. (2009). Reparable Harm:… | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/identify-disparities-and-reasons-for-disparities-and-reevaluate-the-framework-for-researching-disparities-the-following-article-was-used-in-answering-this-question-davis-l-m-kilburn-m-r-and-schultz-d-2009-reparable-harm-asse
    November 01, 2017 - Reparable Harm: Assessing and Addressing Disparities Faced by Boys and Men of Color in California. … Boys and men of color See Davis, L. M., Kilburn, M. R., and Schultz, D. (2009). … Reparable Harm: Assessing and Addressing Disparities Faced by Boys and Men of Color in California. … Reparable Harm: Assessing and Addressing Disparities Faced by Boys and Men of Color in California. … By promoting a greater awareness to the plight of boys and men of color.

38. Therapies for Clinically Localized Prostate Cancer | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/prostate-cancer-therapies/protocol
    March 01, 2020 - for prostate cancer treatment are projected to rise to $16 billion by 2020. 1 About 90 percent of men … However, for some men, disease progression can cause bothersome, and even fatal, results. … For men with low-risk CLPC, active surveillance (AS) is often recommended. … Treatment naïve men with CLPC (stages T1 to T3a). … Studies enrolling 15% or more treatment naïve men with T3b or unspecified T3 will be excluded.

39. Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer: An Update of a 2008 Comparative Effectiveness Review | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/prostate-cancer-therapies-update/research-protocol
    December 01, 2019 - . 1,2 American Cancer Society data show that in 2012, an estimated 241,740 men were expected to receive … Since 2004, the prostate cancer incidence rate has decreased by 2.7 percent annually among men 65 years … of age or older and has remained steady among men younger than age 65. 1 The major risk factors for … The practice of evaluating healthy men with no prostate symptoms for prostate cancer is controversial … They also estimated that there would be 100 to 120 men with false-positive tests and 110 men with true-positive

40. Therapies for Clinically Localized Prostate Cancer | Effective Health Care (EHC) Program
    effectivehealthcare-admin.ahrq.gov/products/prostate-cancer-therapies-update/clinician
    December 01, 2019 - Background Prostate cancer is the most common nondermatologic cancer in men . … The percentage of men diagnosed with clinically localized prostate cancer might change as a result of … The treatment for men with clinically localized prostate cancer has been the subject of much debate. … Identifying those men most likely to benefit from aggressive therapy is challenging. … treatment, while men with aggressive, localized prostate cancer would be offered curative procedures