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61. Summary Report Closing the Quality Gap: Revisiting the State of the Science (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/closing-quality-gap-summary_research.pdf
    January 01, 2013 - Comparative effectiveness of medication adherence interventions (Medication Adherence). … Medication Adherence Reducing out-of-pocket medication costs improved adherence. … Medication Adherence There is no single “silver bullet” for improving medication adherence. … Medication Adherence Decreasing out-of-pocket costs can improve medication adherence for patients with … Medication Adherence Medication adherence interventions are a “black box.”

62. Medication-Assisted Treatment Models of Care for Opioid Use Disorder | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/opioid-use-disorder/research-protocol
    February 29, 2016 - 2016 Research Protocol Dec. 6, 2016 Technical Brief Mar. 17, 2017 Disposition of Comments Report Medication-Assisted … Treatment programs that include both the medication and psychosocial components are more effective than … Medication-assisted treatment of opioid use disorder: review of the evidence and future directions. … Medication-Assisted Treatment for Opioid Addiction in Opioid Treatment Programs. … National and state treatment need and capacity for opioid agonist medication-assisted treatment.

63. Executive Summary: ADHD Diagnosis and Treatment in Children and Adolescents (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-267-adhd-executive-summary.pdf
    March 01, 2024 - • We found little evidence that combination therapies of medication plus psychosocial therapies … produce better results than medication alone, but existing research evaluated unique combinations of … Medication studies typically did not include children under six years of age. … Across studies, medication therapy evaluations reported more adverse events than non-medication interventions … Medication therapy remains a central treatment modality, though with a risk of side effects, even as

64. Comparative Effectiveness Review No. 262_Pharmacotherapy for Adults With Alcohol Use Disorder in Outpatient Settings: Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-262-pharmacotherapy-alcohol-summary.pdf
    November 01, 2023 - strength of evidence across multiple outcomes, as well as relative ease of use as a once-daily oral medication … 5 Only 0.9 percent of Americans who reported an alcohol use disorder in the past year received any medication … assisted alcohol use disorder treatment, with 1 percent prescribed an approved medication as part of … We excluded trials that had less than 12 weeks of follow up from the time of medication initiation; … Although medication efficacy does not depend on setting, there may be meaningful differences with regard

65. Research and Surveillance Methods for Improving Medication Safety Using Administrative Claims Databases | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/medicine-safety-databases/abstract
    January 01, 2005 - Research and Surveillance Methods for Improving Medication Safety Using Administrative Claims Databases … but focused literature scan to identify publications that have dealt with the conceptualization of medication

66. Evaluation of Effectiveness and Safety of Antiepileptic Medications in Patients with Epilepsy | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/epilepsy-medicine/research-protocol
    July 01, 2010 - (medication classes, individual medications and medications meeting the definition of having a narrow … (individual drug names, medication formulation, dose, schedule, bioequivalence status (if applicable … will be compared with an individual older epileptic medication. … In the “A” rated generic medication versus another “A” rated generic medication evaluation, only “A” … Assessment: generic substitution for antiepileptic medication. Neurology 1990;40:1641-3.

67. Retention Strategies for Medications for Addiction Treatment in Adults With Opioid Use Disorder: A Rapid Evidence Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/mat-retention-strategies-rapid-review-1.pdf
    August 01, 2020 - Our primary outcome was retention, defined as continued medication engagement for at least 3 months … We defined retention as continued treatment or medication engagement for at least 3 months. … Retention in medication-assisted treatment for opiate dependence: A systematic review. … Rural Expansion of Medication Treatment for Opioid Use Disorder (NIH HEAL Initiative). 2019. … treatment” and mobile or telehealth, “Medication-assisted treatment” and opioid and retention, Medication-assisted

68. Comparative Effectiveness of Strategies to De-escalate Aggressive Behavior in Psychiatric Patients in Acute Care Settings (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/aggression_executive.pdf
    October 01, 2016 - Medication Protocols Versus Other Medication Protocols or Alternative Strategies No studies assessed … medication protocols in patients without active aggression (insufficient SOE). … other medication protocols: Benefits Change in aggressive behavior Aggression response rate … other medication protocols (continued) Adverse effects from medication (continued) Reduction in … Reducing seclusion through involuntary medication: a randomized clinical trial.

69. Crosscutting-Horizon-Scan-High-Impact-1412 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1412.pdf
    December 01, 2014 - The patient ingests the medication along with the sensor, and digestive fluids activate the sensor … Lack of patient adherence to medication regimens tested in clinical trials has been implicated as a … Thus, whether this will add to overall costs or offset costs of nonadherence to medication regimens … Medication adherence was >85%. … Proteus promotes medication adherence using ingestible sensors. Gray Sheet. 2012 Aug 6. 41.

70. Standardized Library of Asthma Outcome Measures (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/white-paper-library-asthma.pdf
    April 01, 2019 - Of note, several outcome measures focus on change over time, such as change in medication dosage or … Clinical Response Change in asthma controller medication use Measured by patient/caregiver self-report … An additional quick-relief medication includes ipratropium bromide. … Events of Interest Medication adverse events Adverse events related to asthma medications. … medication dispensed during the measurement year divided by the number of canisters of total asthma

71. Standardized Library of Asthma Outcome Measures (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/white-paper-library-asthma.pdf
    April 01, 2019 - Of note, several outcome measures focus on change over time, such as change in medication dosage or … Clinical Response Change in asthma controller medication use Measured by patient/caregiver self-report … An additional quick-relief medication includes ipratropium bromide. … Events of Interest Medication adverse events Adverse events related to asthma medications. … medication dispensed during the measurement year divided by the number of canisters of total asthma

72. Comparative Effectiveness of Antihypertensive Therapies on Cardiovascular Disease Outcomes In End-Stage Renal Disease | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/renal-disease-therapies/abstract
    March 31, 2011 - We will model the association between antihypertensive medication use and outcomes using various longitudinal … Analyses will adjust for potential confounders of the relation between antihypertensive medication and … dependent variables, and we will also account for the interaction between each class of antihypertensive medication

73. S149 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/s149.pdf
    October 01, 2007 - Scores Subclassification to Estimate Effects of Longitudinal Treatments An Example Using a New Diabetes Medication … We estimated a model for the longitudinal propensity score process of receiving a medication of interest … The prescribing physician’s decision to use a new medication and the patient’s decision to fill and to … We combined patients using oral medication with patients using no medication for diabetes because these … We investigated adherence to this medication.

74. Making Healthcare Safer IV: Summary of Findings, 2023-2024 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-1-year-final-report-updated-title_0.pdf
    May 01, 2024 - o Improved medication-related CDSS were associated with reductions of medication errors and adverse … Deprescribing To Reduce Medication Harms in Older Adults 11a. … • Conclusion o Deprescribing reduces medication counts, inappropriate medication use, and pharmacy … involving CDSS to reduce medication errors and adverse drug events. … Deprescribing To Reduce Medication Harms in Older Adults 11a.

75. Evaluation of Effectiveness and Safety of Antiepileptic Medications in Patients With Epilepsy (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/epilepsy-medicine_research-protocol.pdf
    February 01, 2008 - (medication classes, individual medications and medications meeting the definition of having a narrow … (individual drug names, medication formulation, dose, schedule, bioequivalence status (if applicable … will be compared with an individual older epileptic medication. … In the “A” rated generic medication versus another “A” rated generic medication evaluation, only “A” … Assessment: generic substitution for antiepileptic medication. Neurology 1990;40:1641-3. 31.

76. Pharmacotherapy for Adults With Alcohol Use Disorder in Outpatient Settings (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_policymaker.pdf
    August 01, 2016 - Health care utilization studies* report reduced medical costs among patients treated with AUD medication … than those not on the medication.3 Pharmacotherapy for Adults With Alcohol Use Disorder in Outpatient … injectable prescriptions in combination with psychosocial therapy üü Encouraging patients to use medication … Head-to-head trials have not consistently established the superiority of one medication over another … Medication Outcome N Studiesa N Subjects Finding SOE Acamprosate vs. placebo Return to any drinking 16

77. Asthma-Treatment Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/asthma-treatment_executive.pdf
    May 01, 2011 - concerns about asthma medications, and some patients would likely prefer to reduce their use of medication … • Hyperventilation reduction training is no more likely to improve symptoms, controller medication … One trial showed very large reductions in reliever medication use among high medication users: participants … • Evidence is insufficient to determine whether yoga can reduce asthma medication use in adults and … In addition, controller medication use should always be described.

78. A Rapid Evidence Review of Retention Strategies for Medications for Addiction Treatment (MAT) in Adults with Opioid Use Disorder | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/retention-strategies-opioid-use-disorder/rapid-protocol
    May 08, 2019 - impacts the retention of patients receiving MAT, such as: Pharmacologic aspects (e.g., choice of medication … , formulation [extended release], dosage of medication, duration) Psychosocial adjuncts (e.g. counseling … MAT medication/program reimbursement) Social services/logistic support (e.g., housing, transportation … Effects of medication-assisted treatment on mortality among opioids users: a systematic review and meta-analysis … Retention in medication-assisted treatment for opiate dependence: A systematic review .

79. Topic Suggestion Description | Effective Health Care Program
    effectivehealthcare.ahrq.gov/get-involved/nominated-topics/for-adult-patients-with-bipolar-disorder-including-bipolar-i-and-bipolar-ii-disorder-what-is-the-comparative-effectiveness-of-available-treatments-including-psychotherapy-other-psychosocial-treatments-medications-and-other-so
    April 22, 2013 - treatment of a manic episode following inadequate response: Addition of another mood-stabilizing medication … vs. placebo vs. switch to a different mood-stabilizing medication vs. switch to ECT For treatment … ECT Antidepressant monotherapy vs. any mood-stabilizing medication For treatment of a depressive … e.g., motivational enhancement, behavioral, or cognitive behavioral) vs. treatment with maintenance medication … Addition of pharmacotherapy targeting the substance use disorder(s) vs. treatment with maintenance medication

80. Comparative Effectiveness of Hepatitis C Treatment Adherence Interventions | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/hepatitis-c-treatment-adherence/research-protocol
    November 08, 2011 - Usually, treatment adherence includes medication adherence and regimen adherence. … of the prescribed medication. … In our study, we will consider both medication adherence and regimen adherence. … Interventions for enhancing medication adherence. … Medication compliance and persistence: terminology and definitions.