-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/aggression_disposition-comments.pdf
July 14, 2016 - Quality
measures that are not actually actionable based on
evidence-based practices present a problem … , designed to incentivize
higher quality care, when the evidence
base for those measures is unclear … 49 as follows: “Finally,
using seclusion and restraints is closely
monitored as a quality-of-care measure … There were
no outcomes measures identified. Search criteria are fairly
well developed. … Methods TEP #5 Are the definitions or diagnostic criteria for the outcome
measures appropriate?
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/restless-legs_disposition-comments.pdf
November 27, 2012 - Can you tell us which quality of life scales were used in the
report? … Outcome
measures are valid in their limitations. Statistical methods are
appropriate. … used in this report – consider
changing primary outcome measure to standard measures
traditionally … There are no
validated measures indicating “clinically important
differences”. … correlating change in IRLS and
meaningful improvement, almost all of these studies also used
CGI scales
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_disposition-comments.pdf
July 26, 2012 - The definitions and
diagnostic outcome measures are explicitly stated. … Definitions for outcome measures
appear appropriate. … A priori, we judged stone growth to be a
secondary efficacy outcome measure, and one
that deserves … This means that
improvement in this measure may commonly
occur with or without thiazide treatment, … could
argue that symptomatic stone events comprise a more
reproducible, easily countable outcome measure
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/anxiety-children_research-protocol.pdf
September 12, 2016 - Therefore, we will include
studies that reported such patient centered outcomes measured with scales … attention placebo)
o Placebo
o No treatment
• Outcomes:
o Intermediate outcomes:
§ Standardized measures … graduate)
§ Family dysfunction/stressor:
• Parenting Stress Index (PSI)
• Brief Family Assessment Measure … KQ 2:
• Safety outcomes:
Pediatric Adverse Event
Rating Scale and other
scales, incidence of any … appropriate (i.e., more than 2 trials address
the same PICOTS and provide point estimates and dispersion measures
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_disposition-comments.pdf
March 10, 2010 - How do you
obtain a dispersion measure for this case? … Under the surrogate efficacy measures, add the LDL-C lowering results
from Stein (reference 104). … Non-HDL-c and TG outcome measures have now been considered
for the relevant subgroup population of those … Non-HDL-c and TG outcome measures have now been considered
for the relevant subgroup population of those … Derosa did measure SAE – zero rates in both arms.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-evidence-summary.pdf
June 01, 2021 - • Due to the variation in interventions, co-interventions, comparators, and outcome
measures and … Studies varied by intervention, comparator, measures used to assess effects, and
reported detail. … Studies varied by intervention, comparator, measures used to assess effects, and reported
detail. … Standardizing the use of validated scales and
standardizing outcome reporting in studies would allow
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-medical-executive-170505.pdf
May 01, 2017 - Oppositional
behavior
Low SOE for no
effect
Significant improvement with MPH on parent-
rated measure … at medium dose level only in 1
RCT; no differences on teacher-rated measures. … No
differences in teacher-, parent-, or clinician-rated
measures in another RCT
2 RCT (90) Harms … Four studies reported teacher ratings
of outcome measures that provide some information to
address … In addition, much of the medical intervention literature
relies on baseline and outcome measures that
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-failure-rescue-protocol-amendment.pdf
September 19, 2023 - What patient safety measures or indicators have been used to examine the harms associated
with this … conducting a systematic search for all evidence on the
targeted harms and related patient safety measures … For Review Question 2, we will focus on identifying
relevant measures that are included in the Centers … for Medicare & Medicaid Services (CMS)
patient safety measures, AHRQ’s Patient Safety Indicators ( … PSIs), or the National Committee for
Quality Assurance (NCQA) patient safety related measures.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/executive-summary-2017-schizophrenia-adult.pdf
January 01, 2017 - including suicide and suicide attempts
• Improvements in health-related quality of life (using validated
scales … studies also reported no difference in improvement
in core illness symptoms, measured by symptoms scales … • Measure key health outcomes, using agreed-upon direct
measures. … For example, measuring functional outcomes
using not only valid and reliable scales, but also actual … measures of patient functioning.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/healthcare-infections_research-protocol.pdf
January 01, 2014 - been developed as
another alternative that offers direct, rapid feedback and provides a quantitative measure … If so, could they
serve as useful surrogate measures for HAI transmission? … the challenges associated with measuring
patient-centered outcomes and the optimal use of surrogate measures … In addition to measures of infection rates, what patient-centered outcomes are most
important when … pathogen type, infection site, type of cleaning or monitoring
modality, focus and scope of outcome measure
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/diagnostic-error-executive-summary.pdf
August 01, 2023 - include: (1)
standardizing measurement and research results reporting to maximize comparability of
measures
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/aggression_research-protocol.pdf
October 05, 2015 - terms of frequency, severity, or duration (as
measured by direct counts or by validated aggression scales … scales)!
-! KQs!1a!and!1c!only:!Reduced!use!of!
seclusion!or!restraints!(decreased!
rate,! … For
all analyses, we will use fixed- or random-effects models to estimate summary measures
of effect … Methodological issues in
monitoring the use of coercive measures. … Hospital-Based Inpatient Psychiatric Services (HBIPS) Core Measure Set
Selection Form.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-update_research-protocol.pdf
December 04, 2015 - For continuous outcomes measures,
we will extract (by arm) the mean baseline and endpoint or change … scores, standard deviations
(SD) or other measure of variability, and number analyzed. … For quality of life and
other continuous patient/parent/clinician-reported measures, we will use an … clinically important benefit and harm, as suitable to the measure.51 For other outcomes, we will
seek … (e.g.,
aggression scales or subscales) if the scales are considered to measure the same construct;
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-evidence_methods.pdf
November 01, 2013 - GRADE Approaches to Evaluating Evidence
The EPCs’ strength of evidence approach is based in large measure … For example, studies in a review may use a variety
of scales to measure the same outcome, and those … Moreover, some or all of such scales may not have been
subjected to reliability or validity testing. … Thus, EPCs may not be able to determine a meaningful
threshold across scales with different measurement … because of potential problems in their interpretation and lack of
statistical power.45,46 No single measure
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-update_research-protocol.pdf
December 23, 2014 - Do performance measures vary with sample characteristics?
c. … Studies that do not report CDI incidence
rates and tie incidence to the
intermediate process measures … appropriateness of pooling data.38 We will assess
statistical heterogeneity with Cochran’s Q test and measure … Yes Valid measures, groups ~equivalent
No Non-validated measures or
nonequivalent groups
Uncertain … Yes Measures were valid and reliable
(i.e., objective measure, validated
scale/tool); consistent
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nonpharmacologic-treatment_research-protocol.pdf
October 04, 2016 - Another challenge is that research may
be limited by inadequate or inconsistent measures of allergen … o Individual measures
• Exacerbations
o Systemic corticosteroids
o Hospitalizations
o Emergency/urgent … o Individual measures
• Exacerbations
o Systemic corticosteroids
o Hospitalizations
o Emergency/urgent … measures, and asthma-related quality of life, as described in the
PICOTS framework. … House dust mite control measures for asthma. Cochrane Database Syst Rev.
2008;(2):CD001187.
-
effectivehealthcare.ahrq.gov/sites/default/files/cer-243-prehospital-airway-management-evidence-summary_0.pdf
June 01, 2021 - useful that
most studies included outcomes important to patients and were not limited to process
measures
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment-future_research.pdf
January 01, 2014 - Wound healing (reduction in wound area and incidence of
complete closure) is a secondary outcome measure … That would require validation of the weights. … Therefore, it is necessary to develop validated and standardized scales for
evaluating wound pain as … Wound healing (reduction in wound area
and incidence of complete closure) is a secondary outcome measure … the unbiased administration of these
measures should be adopted or developed.
-
effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/cervical-degenerative-protocol.pdf
January 12, 2022 - determining which outcomes to assess and challenges in assessing them (e.g., use of
multiple instruments to measure … (e.g., VAS, NRS,
NDI, SF-36, SF-12, EQ-5Dm, mJOA
score, Nurick score, MDI, PROMIS-29,
dysphagia scales … We will classify the magnitude of effects for continuous measures of pain
and function using a similar … For analysis of continuous measures
11
across the same … for outcomes measures with similar constructs
together with 95% confidence intervals.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy-2010_research-protocol.pdf
January 01, 2010 - Biomarker endpoints (laboratory measures of induced change)
a) Changes in serum antibody levels … standardized mean differences will be calculated if continuous outcomes are measured by using
different scales … tolerogenic conjugates of
common allergens with monomethoxypolyethylene glycols of different molecular weights … to a 100,000 AU product];
Background Information: "FDA would like to add the following unit of measure … (MeSH)
7) Other Terms
a) Efficacy: measure under ideal conditions; e.g.: demonstrated in clinical