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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/aggression_disposition-comments.pdf
    July 14, 2016 - Quality measures that are not actually actionable based on evidence-based practices present a problem … , designed to incentivize higher quality care, when the evidence base for those measures is unclear … 49 as follows: “Finally, using seclusion and restraints is closely monitored as a quality-of-care measure … There were no outcomes measures identified. Search criteria are fairly well developed. … Methods TEP #5 Are the definitions or diagnostic criteria for the outcome measures appropriate?
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/restless-legs_disposition-comments.pdf
    November 27, 2012 - Can you tell us which quality of life scales were used in the report? … Outcome measures are valid in their limitations. Statistical methods are appropriate. … used in this report – consider changing primary outcome measure to standard measures traditionally … There are no validated measures indicating “clinically important differences”. … correlating change in IRLS and meaningful improvement, almost all of these studies also used CGI scales
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_disposition-comments.pdf
    July 26, 2012 - The definitions and diagnostic outcome measures are explicitly stated. … Definitions for outcome measures appear appropriate. … A priori, we judged stone growth to be a secondary efficacy outcome measure, and one that deserves … This means that improvement in this measure may commonly occur with or without thiazide treatment, … could argue that symptomatic stone events comprise a more reproducible, easily countable outcome measure
  4. Anxiety in Children (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/anxiety-children_research-protocol.pdf
    September 12, 2016 - Therefore, we will include studies that reported such patient centered outcomes measured with scales … attention placebo) o Placebo o No treatment • Outcomes: o Intermediate outcomes: § Standardized measures … graduate) § Family dysfunction/stressor: • Parenting Stress Index (PSI) • Brief Family Assessment Measure … KQ 2: • Safety outcomes: Pediatric Adverse Event Rating Scale and other scales, incidence of any … appropriate (i.e., more than 2 trials address the same PICOTS and provide point estimates and dispersion measures
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_disposition-comments.pdf
    March 10, 2010 - How do you obtain a dispersion measure for this case? … Under the surrogate efficacy measures, add the LDL-C lowering results from Stein (reference 104). … Non-HDL-c and TG outcome measures have now been considered for the relevant subgroup population of those … Non-HDL-c and TG outcome measures have now been considered for the relevant subgroup population of those … Derosa did measure SAE – zero rates in both arms.
  6. effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-evidence-summary.pdf
    June 01, 2021 - • Due to the variation in interventions, co-interventions, comparators, and outcome measures and … Studies varied by intervention, comparator, measures used to assess effects, and reported detail. … Studies varied by intervention, comparator, measures used to assess effects, and reported detail. … Standardizing the use of validated scales and standardizing outcome reporting in studies would allow
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-medical-executive-170505.pdf
    May 01, 2017 - Oppositional behavior Low SOE for no effect Significant improvement with MPH on parent- rated measure … at medium dose level only in 1 RCT; no differences on teacher-rated measures. … No differences in teacher-, parent-, or clinician-rated measures in another RCT 2 RCT (90) Harms … Four studies reported teacher ratings of outcome measures that provide some information to address … In addition, much of the medical intervention literature relies on baseline and outcome measures that
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-failure-rescue-protocol-amendment.pdf
    September 19, 2023 - What patient safety measures or indicators have been used to examine the harms associated with this … conducting a systematic search for all evidence on the targeted harms and related patient safety measures … For Review Question 2, we will focus on identifying relevant measures that are included in the Centers … for Medicare & Medicaid Services (CMS) patient safety measures, AHRQ’s Patient Safety Indicators ( … PSIs), or the National Committee for Quality Assurance (NCQA) patient safety related measures.
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/executive-summary-2017-schizophrenia-adult.pdf
    January 01, 2017 - including suicide and suicide attempts • Improvements in health-related quality of life (using validated scales … studies also reported no difference in improvement in core illness symptoms, measured by symptoms scales … • Measure key health outcomes, using agreed-upon direct measures. … For example, measuring functional outcomes using not only valid and reliable scales, but also actual … measures of patient functioning.
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/healthcare-infections_research-protocol.pdf
    January 01, 2014 - been developed as another alternative that offers direct, rapid feedback and provides a quantitative measure … If so, could they serve as useful surrogate measures for HAI transmission? … the challenges associated with measuring patient-centered outcomes and the optimal use of surrogate measures … In addition to measures of infection rates, what patient-centered outcomes are most important when … pathogen type, infection site, type of cleaning or monitoring modality, focus and scope of outcome measure
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/diagnostic-error-executive-summary.pdf
    August 01, 2023 - include: (1) standardizing measurement and research results reporting to maximize comparability of measures
  12. Untitled (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/aggression_research-protocol.pdf
    October 05, 2015 - terms of frequency, severity, or duration (as measured by direct counts or by validated aggression scalesscales)! -! KQs!1a!and!1c!only:!Reduced!use!of! seclusion!or!restraints!(decreased! rate,! … For all analyses, we will use fixed- or random-effects models to estimate summary measures of effect … Methodological issues in monitoring the use of coercive measures. … Hospital-Based Inpatient Psychiatric Services (HBIPS) Core Measure Set Selection Form.
  13. Untitled (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-update_research-protocol.pdf
    December 04, 2015 - For continuous outcomes measures, we will extract (by arm) the mean baseline and endpoint or change … scores, standard deviations (SD) or other measure of variability, and number analyzed. … For quality of life and other continuous patient/parent/clinician-reported measures, we will use an … clinically important benefit and harm, as suitable to the measure.51 For other outcomes, we will seek … (e.g., aggression scales or subscales) if the scales are considered to measure the same construct;
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-grading-evidence_methods.pdf
    November 01, 2013 - GRADE Approaches to Evaluating Evidence The EPCs’ strength of evidence approach is based in large measure … For example, studies in a review may use a variety of scales to measure the same outcome, and those … Moreover, some or all of such scales may not have been subjected to reliability or validity testing. … Thus, EPCs may not be able to determine a meaningful threshold across scales with different measurement … because of potential problems in their interpretation and lack of statistical power.45,46 No single measure
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-update_research-protocol.pdf
    December 23, 2014 - Do performance measures vary with sample characteristics? c. … Studies that do not report CDI incidence rates and tie incidence to the intermediate process measures … appropriateness of pooling data.38 We will assess statistical heterogeneity with Cochran’s Q test and measure … Yes Valid measures, groups ~equivalent No Non-validated measures or nonequivalent groups Uncertain … Yes Measures were valid and reliable (i.e., objective measure, validated scale/tool); consistent
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nonpharmacologic-treatment_research-protocol.pdf
    October 04, 2016 - Another challenge is that research may be limited by inadequate or inconsistent measures of allergen … o Individual measures • Exacerbations o Systemic corticosteroids o Hospitalizations o Emergency/urgent … o Individual measures • Exacerbations o Systemic corticosteroids o Hospitalizations o Emergency/urgent … measures, and asthma-related quality of life, as described in the PICOTS framework. … House dust mite control measures for asthma. Cochrane Database Syst Rev. 2008;(2):CD001187.
  17. effectivehealthcare.ahrq.gov/sites/default/files/cer-243-prehospital-airway-management-evidence-summary_0.pdf
    June 01, 2021 - useful that most studies included outcomes important to patients and were not limited to process measures
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/venous-ulcers-treatment-future_research.pdf
    January 01, 2014 - Wound healing (reduction in wound area and incidence of complete closure) is a secondary outcome measure … That would require validation of the weights. … Therefore, it is necessary to develop validated and standardized scales for evaluating wound pain as … Wound healing (reduction in wound area and incidence of complete closure) is a secondary outcome measure … the unbiased administration of these measures should be adopted or developed.
  19. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/cervical-degenerative-protocol.pdf
    January 12, 2022 - determining which outcomes to assess and challenges in assessing them (e.g., use of multiple instruments to measure … (e.g., VAS, NRS, NDI, SF-36, SF-12, EQ-5Dm, mJOA score, Nurick score, MDI, PROMIS-29, dysphagia scales … We will classify the magnitude of effects for continuous measures of pain and function using a similar … For analysis of continuous measures 11 across the same … for outcomes measures with similar constructs together with 95% confidence intervals.
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy-2010_research-protocol.pdf
    January 01, 2010 - Biomarker endpoints (laboratory measures of induced change) a) Changes in serum antibody levels … standardized mean differences will be calculated if continuous outcomes are measured by using different scales … tolerogenic conjugates of common allergens with monomethoxypolyethylene glycols of different molecular weights … to a 100,000 AU product]; Background Information: "FDA would like to add the following unit of measure … (MeSH) 7) Other Terms a) Efficacy: measure under ideal conditions; e.g.: demonstrated in clinical

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