-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/epilepsy-medicine_research-protocol.pdf
February 01, 2008 - solubility/high permeability (Class II), high solubility/low permeability (Class
III) and low solubility … High II
Clonazepam Low High II
Ethosuximide High High I
Phenobarbital High High I
Phenytoin Low … Low High II
Gabapentin High Low III
Lamotrigine High High I
Levetiracetam High High I
Oxcarbazepine … Low Low confidence that the evidence reflects the true effect. … Very Low Very low confidence that the evidence reflects the true effect.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/assessing-applicability.ppt
January 01, 2009 - study-related factors alter the perceived balance of benefits to harms by selecting a population at low … Trials of carotid endarterectomy select surgeons with extensive experience and low complication rates … In the first example, a study of a new antidepressant compares its higher dose regimen to a low dose … In clinical practice, the age of patients with this disease is dispersed across a continuum from low … to high with most patients in the low-to-moderate age range.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
January 01, 2015 - grade (indicating low confidence that
the evidence reflects the true effect, and further research is … We also highlight some key areas for which there
was low-strength or insufficient evidence. … When there were
differences in outcomes among comparisons rated as
having low strength of evidence, … The rest of the outcomes were
rated as low strength of evidence or insufficient. … Only
two comparisons had sufficient data to grade the evidence
as more than insufficient or low.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/migraine-emergency_executive.pdf
November 01, 2012 - The overall strength of evidence
was graded as high, moderate, low, or insufficient. … In general,
neuroleptics were more effective than metoclopramide
for pain relief (low SOE). … There was no difference between MgSO4 and
placebo for headache recurrence (low SOE). … Where
there were multiple trials, the strength of the evidence
was low to moderate. … Consequently, the risk of publication bias should
be low.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_executive.pdf
September 01, 2009 - However, use of risk-reducing
medications for breast cancer is believed to be low in
the United States … evidence (3-5 studies) suggests a harmful effect, but results could be altered by future research.
+ Low … • All models have low discriminatory accuracy in
predicting the probability of breast cancer in an … However,
this threshold has low discriminatory accuracy in
predicting breast cancer in an individual. … the trials are those who are younger (<55
years old), have Gail scores <1.66 percent or considered
low
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer-surveillance_executive.pdf
December 01, 2011 - The
cancer is usually localized, and most tumors
have low histological grades and low Gleason
scores. … Indeed, more than half of prostate
cancers detected by PSA screening are
expected to be early-stage, low-risk … appropriate management strategy for early-stage, low-risk
prostate cancer is an important public health … The
strength of evidence was rated on a four-level scale: High,
Moderate, Low, and Insufficient. … In all cohorts, AS was offered to men with
low-risk or clinically localized prostate cancer.
-
effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-women-in-the-postpartum-period-what-is-the-effectiveness-and-safety-of-screening-and-treatment-for-depression-please-use-the-uspstf-framework-which-considers-not-only-screening-but-followup-treatment-and-management-the-t
November 01, 2017 - other mental health disorders Pregnancy, including preterm birth
AHRQ Priority Populations
Low … Focusing on low-income urban mothers, Chaudron et al. compared the EPDS with the BDI II and the PDSS; … While reports of depression in general are low among African-American and Hispanic populations, these … have birth rates higher than Non-Hispanic White women, and other reasons to be at more risk (e.g., low … In addition, they are likely to be low-income and unable to afford out of pocket costs for mental health
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/hypertension-pulmonary-arterial_executive.pdf
April 01, 2013 - a possible
alternative monitoring mechanism because of its
availability, safety, and relatively low … These domains were considered
qualitatively, and a summary rating of high, moderate, or
low strength … strength of evidence), RAP (moderate
strength of evidence), cardiac index (low strength of
evidence … • BNP level shows poor correlation with RHC pulmonary
capillary wedge pressure (PCWP) (low strength … • Serum uric acid level appears to predict mortality (low
strength of evidence).
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/mass-casualty-events-scarce-resources_executive.pdf
June 01, 2012 - There is also low to medium
evidence that better management of POD operations can
speed throughput … There is low strength
of evidence that public distribution of nonbiological
countermeasures, such as … The
strength of evidence for the set of triage studies is low. … Thus the strength of evidence for the
nontriage studies is also low. … Because we judged the likelihood of bias to be
low, and the 14 studies were generally consistent in
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0122_06-29-2009.pdf
January 01, 2009 - nominator is interested in the safety and effectiveness of nitrous oxide for labor pain
management in low-risk … For low-risk women delivering a full-term baby vaginally, what is the comparative
effectiveness of the
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_executive.pdf
July 01, 2014 - have been reported
with untreated prenatal depression, including
preeclampsia, preterm delivery, low … birth
weight, miscarriage, small-for-gestational-
age babies, low Apgar scores, and neonatal
complications … Studies that had serious flaws were rated high risk of bias,
studies that met all criteria were low … Low-strength evidence from two small
observational studies (N = 266 total) suggested that SSRIs
have … Our overall findings were based on insufficient or low-
strength evidence.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/hibbard-presentation.pdf
November 11, 2015 - They had
very
poor or low competence and
many had
poor problem-‐solving skills. … Wehave just four cells -‐-‐ disease burden, high
and
low, and
PAM level. … Wedichotomize, “high” and
“low” to think about how do you useyour resources more
effectively. … So, people with
high
disease burden
and
low PAM scores: if they’renot
already in
trouble … They have low confidence and
poor problem solving skills.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/insulin-blood-sugar_research.pdf
August 01, 2015 - One stakeholder identified the reactive low glucose suspend pump as the
highest priority for future … glucose suspend pump (automatically suspends insulin delivery when glucose
reaches low threshold) 1 … glucose suspend pump (automatically suspends insulin delivery when glucose
reaches low threshold) 0 … glucose suspend pump (automatically suspends insulin delivery when glucose
reaches low threshold) 1 … glucose suspend pump (automatically suspends insulin delivery when glucose
reaches low threshold) 4
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/preterm-birth-terbutaline-pump_surveillance.pdf
January 30, 2013 - still valid
• No new saftey alerts
Summary Decision:
This CER’s priority for updating is LOW … was categorized into one of the three updating
priority groups: high priority, medium priority, or low … birth weight (< 2500
g) and very low birth weight (< 1500
g) were reported
in cohort studies. … All studies that reported
low birth weight found statistically
significant differences in favor of … birth weight (< 2500 g) and very low birth
weight (< 1500 g) were reported in cohort studies.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/preterm-birth-terbutaline-pump_surveillance.pdf
January 30, 2013 - still valid
• No new saftey alerts
Summary Decision:
This CER’s priority for updating is LOW … was categorized into one of the three updating
priority groups: high priority, medium priority, or low … birth weight (< 2500
g) and very low birth weight (< 1500
g) were reported
in cohort studies. … All studies that reported
low birth weight found statistically
significant differences in favor of … birth weight (< 2500 g) and very low birth
weight (< 1500 g) were reported in cohort studies.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_executive.pdf
April 01, 2012 - We graded the
strength of evidence as high, moderate, low, or insufficient
based on methods guidance … LOW
No head-to-head studies met inclusion criteria;
unable to draw conclusions on the comparative … LOW
No head-to-head studies met inclusion criteria;
unable to draw conclusions on the comparative … greater improvement in
disease activity, functional capacitya and health-related
quality of life.b
LOW … lower rate of withdrawals
because of adverse events than infliximab in a
prospective cohort study
LOW
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/smoking-pregnancy-infants_executive.pdf
February 01, 2014 - , preterm birth, chronic hypertension,
and placenta previa.7-10 Health risks to the
fetus include low … Two reviewers independently assessed
risk of bias as low, high, or unclear for each domain. … Only studies of good quality were considered to be low
risk of bias. … numbers of participants and low adherence rates
in NRT trials that assessed harms. … There is low strength
of evidence for no significant effect on preterm birth and
NICU admission.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/long-term-care-adults_executive.pdf
November 01, 2012 - Therefore, we took a liberal
stance on grading evidence as low-strength rather than
insufficient. … We graded evidence as low if the studies
within a set were high risk of bias but consistent in their … KQ 1c: Harms in HCBS and NHs
Two studies provided low-strength evidence that harms
differed between … Changes in cognitive
function
• Two studies provided low-strength evidence (high risk of bias) that … KQ 1c
Harms • Two studies provided low-strength evidence (high risk of bias) that harms differed.
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/12_pregnancy_potential_high_impact_june_2012.pdf
January 01, 2012 - Overall High Impact Potential: Donor human milk program for
very-low-birth-weight infants ......... … *Donor human milk program for very-low-birth-weight infants High
4. … Very low birth weight. In: Child Health USA
2008-2009 [internet]. Bethesda (MD): U.S. … HS399 - Donor human milk for very low birth
weight infants. 2011 Aug 16 [review date].
37. … HS399 - Donor human milk for
very low birth weight infants. 2011 Aug 16
[review date].
-
effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/insomnia_executive.pdf
December 01, 2015 - Sleep
outcomes remain improved long term (low-strength
evidence). … There was
low- to moderate-strength evidence that doxepin
improved sleep outcomes. … There was low- to moderate-strength evidence
that doxepin improved sleep parameters. … Strength of evidence for all adverse effects was considered
insufficient to low. … We found low-strength evidence that low doses of
eszopiclone improved global and sleep outcomes in older