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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/insomnia_consumer.pdf
    August 01, 2017 - It is an older type of medicine that is no longer used often. 5 What have researchers found about … , total sleep time, and how well you sleep in the short term (4 weeks to 3 months) and long term (longer … There is not enough research to know if the medicines work or are safe in the long term (longer than
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cognitive-decline_executive.pdf
    March 01, 2017 - is some suggestion that processing speed training is associated with improved IADL performance, but longer … More work on cognitive training with longer followup is needed. … Trials that address dementia incidence must be even longer. … Longer, larger, and better studies are needed. … For longer studies, attrition is a major problem.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/cognitive-decline_executive.pdf
    March 01, 2017 - is some suggestion that processing speed training is associated with improved IADL performance, but longer … More work on cognitive training with longer followup is needed. … Trials that address dementia incidence must be even longer. … Longer, larger, and better studies are needed. … For longer studies, attrition is a major problem.
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/multiple-sclerosis_executive.pdf
    April 01, 2015 - Risk for PML increases with natalizumab use longer than 2 years, anti-JC virus antibody status, and … Determining when DMT is no longer helpful is challenging. … for treatment-naïve patients who did not delay starting IFNbeta-1b by 2 years and used DMT for a longer … No study directly asked why people are reluctant to discontinue when treatment seems no longer effective … Some efforts to improve longer term research are underway—for example, the prospective 5-year OPT- Up
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_clinician.pdf
    February 01, 2016 - edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), these categories are no longer … These medications were approved before publication of the DSM-5, which no longer has a separate category … Alcohol is taken in larger amounts or over a longer period than intended. 2.
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/acs-pci-adjunctive-devices_surveillance.pdf
    April 01, 2013 - • If we found new evidence that rendered the CER conclusion out of date or no longer applicable, … conclusions involve refinement of original estimates or do the potential changes mean some therapies are no longer … When we evaluated mortality and MACE in studies of 365 days or longer, we saw no significant difference … When we evaluated mortality and MACE in studies of 365 days or longer, we saw no significant difference
  7. effectivehealthcare.ahrq.gov/sites/default/files/cer-229-opioid-treatments-chronic-pain-evidence-summary.pdf
    April 01, 2020 - though differences were not statistically significant in all studies and estimates decreased with longer … of benzodiazepines and opioids vs. opioids alone; in one study the risk of overdose decreased with longer … One cohort study found higher dose of opioids associated with increased risk of all-cause mortality; longer … • One cohort study found an association between longer duration of therapy and increased risk of new-onset … opioids versus opioids alone and increased risk of overdose; in one study, the risk decreased with longer
  8. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/high-cholestorol-medications_executive.pdf
    September 01, 2009 - treatment is usually required for life, both trial treatment and observation duration should be of longer … Short-duration trials are unlikely to accrue sufficient adverse events, particularly those with longer … • Measures of adherence and persistence are affected by the duration of the study period, and thus longer … We restricted our focus to studies of 24 weeks or longer that reported clinical efficacy outcomes, the … Overall, the update of this review did not add significant evidence on longer term clinical outcomes,
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-265-radiation-bone-disease-summary.pdf
    August 01, 2023 - Both probably provide similar likelihood of overall pain response at longer followup. … response (pain improvement) within 4 weeks of treatment versus SF EBRT but there was no difference at longer
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/search-strategy-white-paper.pdf
    February 01, 2025 - AlvisIR Food Semantic Search Engine exclusion reason: no longer available. 4. … Article-based PubMed Search Engine (APSE) exclusion reason: no longer available. 5. … Qinsight exclusion reason: no longer available. 60. … Quetzal exclusion reason: no longer available. 61. … Sample Size Search (SSS) Tool for PubMed exclusion reason: no longer available. 67.
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetes-behavior-programs_clinician-2016.pdf
    January 01, 2016 - More evidence is needed to determine if the reduction in HbA1c can be sustained at a 12-month or longer … postintervention followup (���). �– The reduction in HbA1c did not appear to be sustained at a 12-month or longer
  12. effectivehealthcare.ahrq.gov/sites/default/files/tech-brief-35-asthma-self-management-comments.pdf
    April 27, 2020 - The program is no longer available as a training. … Because Asthma 101 is no longer available as a training and the Lung Association uses Asthma Basics … footnote with the first mention of Asthma 101™ as follows: Asthma 101™ What You Need to Know is no longer
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_surveillance.pdf
    April 01, 2016 - which found that CBT was more effective than ECT or antidepressants alone for sustained response and longer … • If we found new evidence that rendered the systematic review conclusion out of date or no longer … For Key Question 5, examining subpopulations, the conclusions related to psychotherapy may no longer … Participants receiving CBT experienced significantly longer relapse-free times as compared to both … Participants receiving CBT experienced significantly longer relapse-free times as compared to both
  14. effectivehealthcare.ahrq.gov/sites/default/files/diabetes-update-2015_executive.pdf
    January 01, 2015 - We separately assessed the strength of evidence for shorter and longer studies (≥2 years); however, … we assessed strength of evidence only for longer studies from which we could draw a conclusion. … After excluding studies that no longer had a comparison or an outcome of interest and cohort studies … The few longer studies were generally consistent with the shorter term results; however, the losses … A newer study with only 52 weeks of followup also corroborated the findings from the longer RCTs.
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/undescended-testicle_disposition-comments.pdf
    December 11, 2012 - In this context, the longer term outcomes associated with cryptorchidism are reasonably omitted from … Many of the longer term studies are epidemiologic in nature and do not present data in such a way that … In this context, the longer term outcomes associated with cryptorchidism are reasonably omitted from … scope of a comparative effectiveness review could potentially synthesize the epidemiologic data on longer … interventions, we sought studies that were clearly effectiveness studies, and in this set of studies, longer
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/ear-infection_executive.pdf
    May 01, 2013 - We were interested primarily in treatment outcomes of 3 months or longer, but we included outcomes … Length of tube retention was higher in the longer term TT. … Evidence was insufficient for longer followup. … Longer acting TT such as Goode T-tubes and Paparella tubes were retained longer than shorter acting … Moderate for harms of longer- term TT TT vs. watchful waiting or myringotomy 5 studies (N=1,129)
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/insomnia_disposition-comments.pdf
    December 30, 2015 - Existing trials used short-term pharmacotherapy and measured longer-term outcomes. Thank you. … This key point has been changed and no longer describes conclusions as ‘more robust’. … Our abstract no longer says that these medications are safe and effective. … Note, page 33, line 8, ‘Eligible drug trials rarely lasted longer than 6 weeks.’ … We no longer refer to the ‘previous fair quality systematic review in the executive summary.
  18. effectivehealthcare.ahrq.gov/sites/default/files/related_files/lysosomal-storage-diseases-therapies_disposition-comments.pdf
    January 01, 2014 - In the age of ERT, however, many of these are no longer used nor recommended (e.g., splenectomy). ” … In the age of ERT, however, many of these are no longer used nor recommended (e.g., splenectomy).” … Life expectancy was 40-50 years before the advent of dialysis, transplant, and ERT, this is no longer … Ceredase is no longer used; hasn’t been used for many ears. … That statement is no longer accurate.
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-brain-injury-surveillance-160902.pdf
    January 30, 2014 - The"second"reviewer"felt"that" conclusions"associated"with"all"key"questions"were"no"longer"current, … $ One$new$study$found$that$female$gender,$ lower$education,$post"injury$unemployment,$ and$longer$ … $believed$the$ conclusion$to$be$current.$ The$second$reviewer$felt$ that$the$conclusion$was$no$ longer … $ One$new$study$found$that$ female$gender,$lower$ education,$post"injury$ unemployment,$and$longer … $believed$the$ conclusion$to$be$current.$ The$second$reviewer$felt$ that$the$conclusion$was$no$ longer
  20. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-radiation_executive.pdf
    November 01, 2009 - Thirty-one studies followed patients longer than 5 years. … Two studies had mean followup longer than 10 years.

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