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Total Results: 1,425 records

Showing results for "long term".

281. Use of Observational Studies in Systematic Reviews of (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/methodsguidenorris_060420101.pdf
     June 01, 2010 - for access to a treatment, problems with recruitment when a drug is already marketed, the need for long-term … head-to-head efficacy trials were available, but they provided insufficient evidence to assess two important long-term … A potential advantage of this type of study is that long- term benefits, tolerability, and harms can … Many data sources for observational studies are suited to long-term followup but are limited in the … Are long-term outcomes similar to short-term outcomes?

282. Use of Observational Studies in Systematic Reviews of (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-observational-studies_methods.pdf
     June 01, 2010 - for access to a treatment, problems with recruitment when a drug is already marketed, the need for long-term … head-to-head efficacy trials were available, but they provided insufficient evidence to assess two important long-term … A potential advantage of this type of study is that long- term benefits, tolerability, and harms can … Many data sources for observational studies are suited to long-term followup but are limited in the … Are long-term outcomes similar to short-term outcomes?

283. #14 SUBSTANCE ABUSE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/14_substance_abuse_potential_high_impact_2012-12-11.pdf
     January 01, 2012 - Overall high-impact potential: long-acting pharmacotherapy for opioid dependence .................. … Long-acting formulations of these pharmacotherapies might address these issues. … not particularly strong, stating that the 14.3% quit rate is not particularly impressive and that long-term … experts thought that if the program were successful in improving smoking-cessation rates, some of the long-term … term. 8 References 1.

284. Dementia-Agitation-Aggression Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/dementia-agitation-aggression_research-protocol.pdf
     November 13, 2014 - includes both informal care (i.e., unpaid care provided by family and friends) and formal care (e.g., long-term … patient), stress, and decreased psychological health.11-13 These symptoms also challenge staff in long-term … frameworks; designed to evaluate behaviors in a wide range of settings (e.g., in-home, hospital, or long-term … functioning; and improve levels of distress among persons with dementia and reduce or delay residential long-term … psychosis); stratified by dementia disease stage, symptom severity, type of dementia and staff of long-term

285. Disposition of comments for CER 169 Low Back Pain (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/back-pain-treatment_disposition-comments.pdf
     February 29, 2016 - and long term, then corresponding harms. … Methods Peer Reviewer #3 Here the authors define short-term as <6 mo. and long-term >1 year. … Opioids: insufficient mention of harms related to long-term risks. … The long- term harms of opioids are extremely serious. … I very much appreciated the need for long term follow up you highlighted.

286. Arthritis and Nontraumatic Joint Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1512.pdf
     December 29, 2015 - The drug’s long-term safety may also affect its adoption. … Two phase III trials on baricitinib for treating RA are ongoing, including one long-term extension … However, the experts thought that long-term efficacy data are needed to determine secukinumab’s true … Of note, long- term safety and efficacy data were released after we solicited expert comments on this … The experts also thought that long-term safety and efficacy data for baricitinib are needed.

287. Untitled (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-update_research-protocol.pdf
     December 04, 2015 - term:!<6!months! Long!term:!≥6!months6<12!months_!12!months+! Setting! Any!setting! Study!Design! … Long-term (≥ 6 month followup) nonspecific or associated symptoms ◦! … Long-term (≥ 6 month followup) global impressions and functioning* •! Growth and maturation •! … Long-term (≥ 6 month followup) school performance and attendance •! … Long-term (≥ 6 month followup) legal or justice system interaction* •!

288. Evidence Summary CER 208 Treatment For Bipolar Disorder In Adults (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-208-bipolar-evidence-summary.pdf
     August 01, 2018 - Lithium improved acute mania in the short-term and prolonged time to relapse in the long-term compared … time to relapse in the long-term versus placebo in adults with BD-I. … Efficacy and safety of long-term fluoxetine versus lithium monotherapy of bipolar II disorder: a randomized … Risperidone in long-term treatment for bipolar disorder. … Olanzapine in long- term treatment for bipolar disorder.

289. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/11_pepticulcer_potential_high_impact_june_2012.pdf
     January 01, 2012 - In the absence of randomized or long-term trials for POEM, some experts are uncertain of POEM’s degree … Long-term PN can lead to serious side effects such as liver damage, the risk of which increases the … Additionally, a long-term extension trial demonstrated some patients treated with teduglutide were … In the absence of randomized or long-term trials for POEM, some experts remain unsure how impactful … What are the long-term outcomes for children with SBS? [internet].

290. Comparing the long-term and real-world effectiveness of initial management strategies for ductal carcinoma in situ (DCIS) | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/dcis-effectiveness/abstract

291. Systematic Review on Nonopioid Pharmacologic Treatments for Chronic Pain: Surveillance Report 3 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-3-nonopioid-pharm-chronic-pain.pdf
     July 01, 2022 - treatment duration (3 to <6 months), intermediate-term treatment duration (6 to <12 months), and long … treatment duration (3 to <6 months), intermediate-term treatment duration (6 to <12 months), and long-term … (1 to <6 months), intermediate term (6 to <12 months), and long-term (≥12 months) followup. … Evidence on intermediate- and long-term effects on pain, function, and quality of life is limited. … treatment duration (3 to <6 months), intermediate-term treatment duration (6 to <12 months), and long-term

292. labor-dystocia-protocol-amended-160728 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/labor-dystocia_research-protocol.pdf
     July 28, 2016 - Neonatal infection/sepsis § Shoulder dystocia § Birth trauma (including brachial plexus injury) § Long-term … spontaneous labor until discharge home (or equivalent for home delivery) for mother and infant o Long-term … Neonatal infection/sepsis • Shoulder dystocia • Birth trauma (including brachial plexus injury) • Long-term … spontaneous labor until discharge home (or equivalent for home delivery) for mother and infant o Long-term … Long-term maternal morbidity associated with repeat cesarean delivery.

293. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gerd-disposition-120104.pdf
     April 01, 2011 - The long term results of open antireflux surgery in a community-based health care center. … However, we did want to point out that the study appears to neglect a discussion of long-term proton … We assessed both long-term and short-term adverse events when reported within the included studies. … As such, it was not designed as a long-term study. … Changes in Gastric Histology – The long-term histological safety of dose-titrated lansoprazole was

294. Comparative Effectiveness Review No. 272_Genitourinary Syndrome of Menopause: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-272-genitourinary-syndrome-executive-summary.pdf
     July 01, 2024 - Of 39 high, serious, or critical RoB publications, we only extracted long-term harms from 15 uncontrolled … endometrial stimulation as measured by transvaginal ultrasound or endometrial biopsy in primarily short-term … studies and 3 year-long studies. 5 Table A. … inconsistently reported but there was not a strong signal for frequent serious adverse effects in short-term … Long-term followup for efficacy, tolerability, and safety represents a critical gap needed to guide

295. Diabetes Mellitus (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1412.pdf
     January 01, 2015 - The delivery system is intended to be used for long-term subcutaneous delivery at a controlled rate … Experts generally agreed that the initial cost of the device would likely be offset by the long-term … Experts generally agreed that the initial cost of the device would likely be offset by the long-term … other long term delivery system available on the market. … Alimera Sciences provides details on FDA approval of ILUVIEN as the first long-term treatment for

296. Antipsychotics-Children Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children_research-protocol.pdf
     June 04, 2010 - Short-term is defined as outcomes occurring within 6 months; long-term is defined as outcomes occurring … and long-term outcomes, including: 1) Response rates with corresponding dose, duration of response … and long- term outcomes (see KQ3) Timing: See KQ1 above Settings: See KQ1 above III. … or attendance, and legal/justice system interaction (i.e., arrests, detention) (KQ1 and KQ4) and/or long-term … outcomes such as long-term symptom response rates (with corresponding dose, duration of response,

297. Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-nomination-apbi-breast-cancer.pdf
     April 01, 2017 - recurrence with IORT compared with whole breast irradiation; the need for prospective monitoring of long-term … Long-term toxicity of an intraoperative radiotherapy boost using low energy X-rays during breast-conserving … Single-center long-term follow-up after intraoperative radiotherapy as a boost during breast-conserving … Long-term cosmesis and toxicity following 3-dimensional conformal radiation therapy in the delivery of … Predictors of long-term toxicity using three-dimensional conformal external beam radiother- apy to deliver

298. Multidisciplinary Rehabilitation Programs for Moderate to Severe Traumatic Brain Injury in Adults: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/traumatic-brain-injury-rehabilitation-future_research.pdf
     January 01, 2013 - assist investigators in designing studies to test the hypothesized relationship of rehabilitation on long-term … Followup: Are benefits received from multidisciplinary rehabilitation programs sustained over the long-term … Followup: Are benefits received from multidisciplinary rehabilitation programs sustained over the long-term … Followup: Are benefits received from multidisciplinary rehabilitation programs sustained over the long-term … The goal of the Executive Plus program is to maximize executive functioning, as well as the long- term

299. #14 SUBSTANCE ABUSE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/14_substanceabuse_potential_high_impact_june_2012.pdf
     January 01, 2012 - Overall High Impact Potential: Long-acting pharmacotherapy for opioid dependence .................. … term efficacy and outcomes data are not yet available. … experts thought that if the program were successful in improving smoking cessation rates, some of the long-term … Two novel, long-acting versions of currently used pharmacotherapies (buprenorphine [Probuphine ™ ] … term.

300. FRN 22: Future Research Needs for Strategies To Reduce Cesarean Birth in Low-Risk Women (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cesarean-birth_research.pdf
     January 01, 2020 - The top-tier methodologic improvements focused on improving the capture of short- and long-term birth … Develop registries that capture both short-term and long-term outcomes. … Develop registries that capture both long-term and short-term outcomes 15. … Develop registries that capture both short-term and long-term outcomes. … Develop registries that capture both long term and short term outcomes. 15.