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61. Lower Limb Prostheses: Measurement Instruments, Comparison of Component Effects by Subgroups, and Long-Term Outcomes | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/prosthesis/research

62. Management of Insomnia Disorder (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/insomnia_consumer.pdf
    August 01, 2017 - Insomnia disorder is a long-term condition in which a person has trouble falling asleep or staying … Insomnia disorder is a long-term condition in which a person has trouble sleeping. … You may: � Lay awake for a long time before falling asleep. � Stay awake for most of the night. … with you about your sleep habits (such as the time you go to bed, the time you wake up, and how long … � How long would I take the medicine? � Which side effects should I watch for?

63. #14 SUBSTANCE ABUSE (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/substanceabuse_hi_impact.pdf
    January 01, 2012 - Overall High Impact Potential: Long-acting pharmacotherapy for opioid dependence ........ 3 … Long-acting formulations of these pharmacotherapies might address the problems of low adherence and … Long-Acting Pharmacotherapy for Opioid Dependency  Key Facts: Two long-acting versions of currently … Long-acting formulations of these pharmacotherapies might address the problems of low adherence and … Two novel, long-acting versions of currently used pharmacotherapies (buprenorphine and naltrexone)

64. Evidence Report on the (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/weight-loss-surgery_research-protocol.pdf
    December 14, 2010 - The benefits/risks ratio in the long term is also a concern: effectiveness and safety data are very … limited to support any long-term benefits/risks claims. … Long-term outcomes: 5 years or best available post surgery intervention. … Long-term outcomes: 5 years or best available post surgery or medical intervention. … Both short- and long-term outcomes are included.

65. Stem-Cell-Children Surveillance (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/stem-cell-children_surveillance.pdf
    October 29, 2012 - is the comparative effectiveness of HSCT and conventional chemotherapy regarding overall survival, long-term … the comparative harms of HSCT and conventional chemotherapy regarding adverse effects of treatment, long-term … harms of HSCT, ERT, and substrate reduction with iminosugars regarding adverse effects of treatment, long-term … is the comparative effectiveness of HSCT and conventional chemotherapy regarding overall survival, long … the comparative harms of HSCT and conventional chemotherapy regarding adverse effects of treatment, long-term

66. Restless-Legs Research-Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs_research-protocol.pdf
    December 16, 2011 -  Long-term benefits and harms of treatment: Substantial uncertainty exists about the long-term … Yet, the disease is chronic, often requiring life-long treatment. … We do not know the impact of long-term use of these drugs in children. … What are the long-term harms from treatment? … interest are long-term, open label trials and followup studies.

67. Disposition of Comments Report for Evaluation and Treatment of Cryptorchidism (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/undescended-testicle_disposition-comments.pdf
    December 11, 2012 - I would note that in this review that authors have elected to largely omit the topics of long-term … Peer Reviewer #6 Executive Summary Page 22, Line 14-57: Finally, the long-term fertility following … term follow-up and possible long term injury. … Is a testis biopsy helpful in predicting abnormal histology and long-term fertility?2. … Does the use of adjuvant hormonal therapy improve long-term fertility?

68. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0404_01-14-2011.pdf
    January 01, 2011 - What are the long-term (> 90-day) mortality, morbidity, and functional outcomes associated with various … biomarker) for guiding the diagnosis and management of PAH as well as for use in evaluating short- and long-term … medications for PAH over the past 3 decades; however, there continues to be a lack of data supporting the long-term

69. Treatment for Restless Legs Syndrome: Future Research Needs (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs-future_research.pdf
    February 01, 2013 - Cohort studies and long-term extension of randomized trials would be of value in assessing long- term … What are the long-term harms from treatment? KQ 3. … Severe RLS, however, is a chronic progressive disorder that may require long-term treatment. … What are the long-term consequences of RLS beyond currently understood sensory problems? 4. … • What are the long-term consequences of RLS beyond currently understood sensory problems?

70. Stem-Cell-Children Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/stem-cell-children_executive.pdf
    February 01, 2012 - As improvements in survival have been achieved, there is greater concern about long- term effects and … is the comparative effectiveness of HSCT and conventional chemotherapy regarding overall survival, long-term … In contrast, type I autoimmune juvenile diabetes can be managed long term satisfactorily, at relatively … Practitioner review: long-term consequences of childhood cancer. … Long-term cause- specific mortality among survivors of childhood cancer.

71. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_executive.pdf
    June 01, 2011 - This review summarizes the evidence on the comparative long-term benefits and harms of ACEIs, ARBs, and … ACEIs and ARBs appear to have similar long-term effects on ARB); blood pressure among individuals with … Relatively few studies assessed Moderate (ACEI these outcomes over the long term. vs. … Given the importance of these issues, it is notable how few large, long-term, head-to-head studies have … ) • Long-term comparisons of direct renin inhibitors with ACEIs and ARBs.

72. PCA3 Testing in the Diagnosis and Management of Prostate Cancer: Future Research Needs (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-antigen-3-gene_research.pdf
    April 01, 2013 - Does the addition of PCA3 testing change long-term health outcomes in prostate screening? … health outcomes without waiting for completion of a long- term clinical trial. … Does addition of PCA3 testing change long-term health outcomes in prostate screening? … Urology, 2011 79(3):S320 None identified Effect of PCA3 on long-term health outcomes 6. … Uncertainty of impact of PCA3 in biopsy decisionmaking on long term health outcomes. 7.

73. Disposition of Comments for Strategies To Prevent Weight Gain Among Adults (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-gain-prevention_disposition-comments.pdf
    March 25, 2013 - We were open to including studies that examined prevention of weight gain after pregnancy as long as … The question “What is the effectiveness of weight loss interventions for long-term weight stability? … Relationship of a large weight loss to long-term weight change among young and middle-aged US women. … For example, almost explicitly, a perfectly or nearly perfectly performed, unbiased, long- term RCT … , sufficiently powered RCT of long-term weight gain with little cross-over, noncompliance, or loss

74. Restless-Legs Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/restless-legs_executive.pdf
    November 01, 2012 - What are the long-term harms from treatment? Key Question 3. … What are the long-term harms from treatment? … Long-term durability of treatment benefits • Long-term durability of treatment benefits remains unknown … • Long-term studies of augmentation with dopaminergic therapy. … Long-term treatment with pramipexole in restless legs syndrome.

75. App-D-Opioid-Chronic-Pain-Surveill-Report-1 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-d-opioid-chronic-pain-surveill-report-1.xlsx
    September 30, 2015 - DSM-IV =Diagnostic and Statistical Manual of Mental Disorders, 4th edition; f/u = follow-up; LTFU = long-term … National Sample 2012-2016 claims database United States Duration: mean NR, all patients identified as long-term … opioid users had ≥90 days Patients ≥65 years on long-term opioid therapy ≥ with new long-term opioid … , short-acting, and short- and long-acting opioids, Daily MME categorized as <20, 20-50, and ≥120 mg … Mean age: 77 years Race/ethnicity White: 83% Black: 10% Other: 6% Female: 83% Long-term opioid therapy

76. MS Protocol draft_12_12-13 clean[2] (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/multiple-sclerosis_research-protocol.pdf
    December 17, 2013 - Due to the long-term focus, we will concentrate on outcomes relevant to the patient for decisionmaking … To properly answer switching questions, a review will likely need to incorporate both short- and long-term … What is the evidence for long-term harms? c. … Since these drugs are intended for long-term use, possibly for decades, we are looking for studies that … examine long-term use and long-term effects.

77. S116 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/s116.pdf
    October 01, 2007 - However, we did find that the IV was associated with the use of long-acting benzodiazepines. … Long- acting benzodiazepines are not recommended for use in the elderly as they have been associated … Coprescription of a long-acting benzodiazepine was defined as the filling of a prescription within 3 … This is likely to be a result of long-acting benzodiazepines being indicated for certain psychiatric … Benzodiazepines of long and short elimination half-life and the risk of hip fracture.

78. Draft Comparative Effectiveness Review Appendicies (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_appendixes.pdf
    April 01, 2005 - Empirical reconstruction of the renal artery: long-term outcome. … Stents in the treatment of renal artery stenosis: long- term follow-up. … Short- term and long-term outcome following renovascular reconstruction. … Results and long-term follow- up. … Long-term prognosis of surgical treatment of renovascular hypertension.

79. Future Research Needs for First- and Second-Generation Antipsychotics for Children and Young Adults (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-future_research.pdf
    February 01, 2012 - 3 Do FGAs and SGAs differ in the following other short- and long-term outcomes (short-term outcomes … effectiveness outcomes, parent- or care provider–reported outcomes, and long-term effects of acute … Do FGAs and SGAs differ in the following other short- and long-term outcomes (short-term outcomes are … defined as outcomes occurring within 6 months; long-term outcomes are defined as outcomes occurring … A total of 22 studies provided data on a variety of short- and long-term outcomes for patients with

80. App-D-Opioid-Chronic-Pain-Surveillance-Report-2 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-d-opioid-chronic-pain-surveillance-report-2.xlsx
    September 30, 2015 - DSM-IV =Diagnostic and Statistical Manual of Mental Disorders, 4th edition; f/u = follow-up; LTFU = long-term … National Sample 2012-2016 claims database United States Duration: mean NR, all patients identified as long-term … opioid users had ≥90 days Inclusion: Patients ≥65 years on long-term opioid therapy ≥ with new long-term … , short-acting, and short- and long-acting opioids, Daily MME categorized as <20, 20-50, and ≥120 mg … Mean age: 77 years Race/ethnicity White: 83% Black: 10% Other: 6% Female: 83% Long-term opioid therapy