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461. #14 SUBSTANCE ABUSE (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1512.pdf
     December 01, 2015 - Naloxone is a long- standing gold standard medication for rapid reversal of acute opioid overdose symptoms … Although experts were encouraged by preliminary data, they questioned the intervention’s long-term … behavior, allowing patients to engage in self-evaluation.12-14 Patients interact by reporting recent or long-term … reductions persisted for 6 months or longer after the intervention; this report is the first published long-term … text-messaging had some efficacy, but failed to demonstrate broad value for multiple patient populations or long-term

462. Cancer Quality-ASSIST Supportive Oncology Quality Indicator Set: Feasibility, Reliability, and Validity Testing (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-quality-indicator-testing_research.pdf
     April 01, 2010 - For example, the ASSIST quality indicator “IF a cancer patient is receiving a long-acting opioid for … acting opioid for breakthrough pain,” is expressed as The number of patients receiving a short and long-acting … opioid The number of cancer patients receiving a long-acting opioid 2 Effective Health Care … At VAGLAHS, following a week-long training and one-week pilot, three experienced nurse abstractors abstracted … should be screening for the presence or absence of pain If a patient with cancer pain is started on a long-acting

463. Ch 4-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_4-user-guide-to-ocer_130129.pdf
     January 01, 2010 - Specifically, the definition of exposure should capture the long-term use of the medication and not … single-use events; however, the exposure measurement should be able to distinguish short-term use from long-term … which is a bisphosphonate indicated for osteoporosis administered once per month and has a very long … surgical procedure and is a situation in which the measurement of exposure is straightforward as long … Long- term use of fluticasone propionate/salmeterol fixed- dose combination and incidence of nonvertebral

464. Interventions Targeting Sensory Challenges in Children With Autism Spectrum Disorders - An Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/asd-interventions-disposition.pdf
     May 26, 2017 - General Comments One point that was unclear to me was what time frame the authors considered to be ”long-term … We have clarified the time frame to reflect ≤ 6 months as short term and greater than 6 months as long … Methods The key issues studied (impact on core autism symptoms and behavior problems, risk of harm, long-term … Methods The key issues studied (impact on core autism symptoms and behavior problems, risk of harm, long-term … think it would be important to insert one additional point in "Research Gaps": Commentators have long

465. Alcohol-misuse-drug-therapy-140326 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/alcohol-misuse-drug-therapy_research-protocol.pdf
     January 27, 2012 - likelihood of increasing intake and problems.12 Twenty to 30 percent of people with AUDs achieve long-term … .12,24,25 Some studies indicate that less than 10 percent of those with AUDs are able to achieve long … Since the 1990s two oral medications—naltrexone and acamprosate—and one long-acting intramuscular formulation … self-help such as 12-step programs [e.g., Alcoholics Anonymous]) will be eligible for inclusion, as long … The long-term course of alcoholism, 5, 10 and 16 years after treatment.

466. Medication-Therapy-Management Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medication-therapy-management_research-protocol.pdf
     January 01, 2014 - settings (e.g., outpatient clinics, physician practices), retail pharmacies in the community, and in long-term … MTM services will help patients and their health care providers achieve important intermediate and long-term … within their plan by selecting one or more of the following provider types: • Local pharmacist • Long-term … must have been seen in ambulatory settings (e.g., outpatient clinics or private physician offices, long-term … Ambulatory (e.g., outpatient clinics, private physician offices, or retail pharmacy settings) and long-term

467. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0094_04-09-2009.pdf
     January 01, 2009 - early behavioral intervention (e.g., 15 versus 25 hours per week; 2 versus 4 years) for improving long-term

468. DEMENTIA INCLUDING ALZHEIMER'S #04 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/dementia_horizon-scan-high_impact-1306-revised.pdf
     July 09, 2013 - that modify the disease or better manage symptoms to keep patients as independent as possible for as long … easily administered therapy, such as this might improve patient health and also realize dramatic long-term … but some experts noted that early detection might reduce costs associated with AD treatment in the long … The potential long-term savings might be realized through a variety of mechanisms, experts commented … They thought that the drug’s well-known safety profile and long history of use (in diabetes) would

469. Disposition of Comments Report for Treatment of Depression During Pregnancy and the Postpartum Period (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-pregnancy-postpartum_disposition-comments.pdf
     July 08, 2014 - Regardless the existing bodies of evidence in nonpregnant populations do not address the long list of … effect of depression on women and their families; however, realize that many women are depressed long … While we do agree that these are potential long-term consequences, we have included these as outcomes … TEP Member #6 General Clarity and Usability: As mentioned before, the report is much too long and … TEP Member #7 General Clarity and Usability: the report is far too long.

470. Rapid-Reviews-End-User White-Paper (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/rapid-reviews-end-user_white-paper.pdf
     April 01, 2016 - Components Literature search It is okay to limit the search by database, journal, year, etc. as long … Oftentimes a bridge search is needed even for recent SRs, because they take so long to complete that … acceptable for local, system-based decisions versus national guidelines: “it’s the tradeoff of how long … prolonged process and multiple stakeholders involved, the end product is sometimes considered too long … Ultimately, we would want to know how long it took to produce each product, if these different review

471. Insomnia Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/insomnia_executive.pdf
     December 01, 2015 - physical pain and discomfort, and cognitive deficiencies.3 Insomnia may also be associated with long-term … Data from large long-term observational studies are included to further assess pharmacologic harms. … What are the long-term harms of treatments for insomnia disorder in adults? … Sleep outcomes remain improved long term (low-strength evidence). … All improvements in sleep outcomes were maintained long term.

472. Despite steadily increasing health care expenditures in the United States, improved health outcomes and quality remain elusive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/medical-interventions-comparing_methods.pdf
     November 01, 2008 - estimated cost growth of 2.4 percent above the Gross Domestic Product. 2 Potential solutions for long-term … The Long- Term Outlook for Health Care Spending.

473. Despite steadily increasing health care expenditures in the United States, improved health outcomes and quality remain elusive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_slutsky_comparing_medical_interventions.pdf
     November 01, 2008 - estimated cost growth of 2.4 percent above the Gross Domestic Product. 2 Potential solutions for long-term … The Long- Term Outlook for Health Care Spending.

474. Treating and Preventing C. difficile Infections (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-update_consumer.pdf
     May 01, 2017 - � Have been in the hospital or a long-term care facility. � Are age 65 or older. … There is not much research on the short-term and long-term side effects of FMT.

475. Diagnosis and Management of Gout: Current State of the Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_clinician.pdf
     January 01, 2017 - gout (solid deposits of monosodium urate [MSU] crystals in skin, soft tissue, and joints) in the long … treatment strategies ��The role of ULT in patients with gout and the potential adverse effects of long-term

476. Arthritis and Nontraumatic Joint Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1506.pdf
     June 01, 2015 - However, the experts thought that more clinical studies are needed to determine the long-term efficacy … may also be prescribed the immunosuppressive therapies sulfasalazine or methotrexate to suppress long-term … However, the experts thought that long-term efficacy data are needed to determine secukinumab’s true … Novartis Pharmaceuticals. 16 week efficacy and 2 year long term safety and efficacy of secukinumab … Novartis Pharmaceuticals. 16 week efficacy and 5 year long term efficacy, safety and tolerability

477. Venous-Ulcers-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/venous-ulcers-treatment_executive.pdf
     January 01, 2014 - Effect Modifiers • Study setting • Ulcer area and depth • Duration of ulcer (short vs. long … treatment), interventions (e.g., usual care/ placebo, compression types [two-layer, short stretch, long … Studies of advanced wound dressings were of short duration (4 months or less) and thus, the long-term … We suggest that a long-term solution to this would be the development and implementation of a clinical … Long-term results of venous valve reconstruction: a four- to twenty-one-year follow-up.

478. Future Research Needs for Diagnosis of Obstructive Sleep Apnea (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
     February 01, 2012 - Outcomes 3O: Long-term outcomes were not evaluated. … With long-term followup, the proposed cohort study can also provide natural history data. … Outcomes 3O: Long-term outcomes were not evaluated. … With long-term followup, the proposed cohort study can also provide natural history data to be used … Of note, the stakeholders were principally interested in the prognostic ability of CPRs on long-term

479. Multidisciplinary Postacute Rehabilitation for Moderate to Severe Traumatic Brain Injury in Adults Disposition of Comments (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/traumatic-brain-injury-rehabilitation_disposition-comments.pdf
     October 07, 2012 - While on P2 long-term disability after severe TBI is acknowledged, it is not discussed or incorporated … Bath in this section and ES2-3, the long term perils of severe TBI are noted, but the focus remains … Reviewer #12 Introduction Lastly, selection of the MPAI-4 alone (P6) appears questionable given the long … Generating the evidence base for the national service framework for the long term conditions: a new … care for individuals with a TBI which have long service provision wait lists.

480. Crosscutting-Horizon-Scan-High-Impact-1406 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/crosscutting-horizon-scan-high-impact-1406.pdf
     June 01, 2014 - . 2 Digital Medicines (Proteus Digital Health Feedback System) for Chronic Conditions Requiring Long-Term … 2. * Digital medicines (Proteus Digital Health Feedback System) for chronic conditions requiring long-term … Visits at the clinic are 40 minutes long and consist of “reviewing the hospitalization, medication … Overall, experts did not anticipate that long-term costs would differ from those of the traditional … Adherence to long-term therapies.