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421. S29 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s29.pdf
     October 01, 2007 - suggested or volunteered to partic- ipate from a given site, we accepted the additional volunteer as long … it involved 2 short-term drugs instead of 2 long-term drugs? … Study details How many patients would be involved, for how long? … Short-term medications (eg, comparing 2 antibiotics vs. 2 long-term medications such as antidepressants … or antihypertensives) Issues would be the same whether short-term or long-term drugs were involved.

422. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pepticulcer_hi_impact.pdf
     January 01, 2012 - Long-term PN can lead to serious side effects ES-5 AHRQ Healthcare Horizon Scanning System … No effective treatments are available to improve long-term nutritional absorption other than intestinal … -year period was $1.6 million. 23 The estimated mortality rate in infants with SBS is 30%. 24 Long-term … liver damage, the risk of which increases the longer a patient is PN-dependent. 25 No effective long-term … What are the long-term outcomes for children with SBS? [internet].

423. Use of Observational Studies in Systematic Reviews of (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/methodsguidenorris_060420101.pdf
     June 01, 2010 - for access to a treatment, problems with recruitment when a drug is already marketed, the need for long-term … A potential advantage of this type of study is that long- term benefits, tolerability, and harms can … Many data sources for observational studies are suited to long-term followup but are limited in the … Are long-term outcomes similar to short-term outcomes? … outcomes important to patients: the reliability of migraine relief from episode to episode over a long

424. Use of Observational Studies in Systematic Reviews of (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-observational-studies_methods.pdf
     June 01, 2010 - for access to a treatment, problems with recruitment when a drug is already marketed, the need for long-term … A potential advantage of this type of study is that long- term benefits, tolerability, and harms can … Many data sources for observational studies are suited to long-term followup but are limited in the … Are long-term outcomes similar to short-term outcomes? … outcomes important to patients: the reliability of migraine relief from episode to episode over a long

425. home-based-care-protocol-141119 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/home-based-care_research-protocol.pdf
     November 19, 2014 - combines home- based care for medical needs with intense management, care coordination, as well as long-term … Patients in institutions Patients who live in nursing homes, prisons, or long-term care hospitals. … o Home can be any location as long as it is not an institutional setting such as a nursing home or … that serve people in alternative housing arrangements such as assisted living or adult care homes as long … admission • Use of specialty care (either in home or other location) • Hospice care • Other long-term

426. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-adolescents_research-protocol.pdf
     March 29, 2011 - these fundamental core deficits may help children optimize developmental progress in the short and long … • Respondents commented on the need to understand long-term effects (no timeframe specified) of … We will capture data about length of followup and long-term outcomes as reported in studies meeting … and that may also have longer term implications for the ultimate, functional outcomes that are the long-term … o Changes in long-term functional outcome areas, including adaptive independence/self care, http://

427. #05 DEPRESSION (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1512.pdf
     December 01, 2015 - Depressive Disorder  Key Facts: An unmet need exists for effective antidepressants for acute and long-term … Ongoing clinical ES-4 trials are investigating optimal ketamine dosing, long-term effect durability … Ketamine is a racemic, noncompetitive, high-affinity N-methyl-D-aspartate (NMDA) receptor antagonist long … Long-term ketamine self-injections in major depressive disorder: focus on tolerance in ketamine's … Long-term effects of an internet-based treatment for posttraumatic stress.

428. EHC Research Protocol: Management of Colonic Diverticulitis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diverticulitis-research-protocol.pdf
     January 01, 2019 - formation) and mortality  Change in management (treatment decisions) o Medium- (>1 to <12 mo) to long-term … Diverticulitis-related morbidities o Mortality, both diverticulitis-related and all-cause • Medium- to long … Long-term risk of acute diverticulitis among patients with incidental diverticulosis found during colonoscopy … Diverticular Abscess Managed With Long-term Definitive Nonoperative Intent Is Safe. … Long-term follow-up after an initial episode of diverticulitis: what are the predictors of recurrence

429. medication-assisted-treatment-protocol-160224 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/opioid-use-disorder_research-protocol.pdf
     February 24, 2016 - Trends in long-term opioid therapy for chronic non-cancer pain. Pharmacoepidemiol Drug Saf. … The Effectiveness and Risks of Long-Term Opioid Treatment of Chronic Pain. … The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a … Opioid-use disorder among patients on long-term opioid therapy: impact of final DSM-5 diagnostic criteria

430. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_research-protocol.pdf
     November 30, 2011 - interferon alfa-2a or pegylated interferon alfa-2b. 8,9 While the goals of treatment are to prevent the long-term … complications associated with HCV infection such as cirrhosis and liver cancer, clinical trials are never long … Because of this viral kinetics have become important predictors of long-term prognosis in patients … influenza-life syndrome that can have a substantial effect on quality of life due to the usually long

431. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0262_05-11-2007.pdf
     January 01, 2007 - What are the prevalence and incidence of urinary and fecal incontinence in the community and long-term

432. Topic 0484 Treatments for Fecal Incontinence NSD FINAL SJ (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0572-140408.pdf
     January 09, 2014 - What are the prevalence and incidence of urinary and fecal incontinence in the community and long-term

433. Ch 8-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_8-user-guide-to-ocer_130129.pdf
     October 01, 2013 - However, like any long-term study, they can be very expensive to maintain due to the effort required … Data from registries or from clinical care may be ideal for studies requiring long followup. … insurers or Medicaid, however, are so large that reasonable numbers of relevant individuals with long … consider when choosing data (continued) Question To Ask Example Do the data contain a sufficiently long … This makes it much easier to obtain complete, long-term medical records and to follow individuals in

434. Traumatic Brain Injury and Depression (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-brain-injury_executive.pdf
     April 01, 2011 - Injury and Depression Introduction We do not know the extent to which depression contributes to long-term … Relationship of TBI and Depression TBIs are associated with a range of short- and long- term outcomes … What are the outcomes (short and long term, including harm) of treatment for depression among traumatic … Aloia MS, Long CJ and Allen JB. … Traumatic brain injury and long-term quality of life: findings from an Australian study.

435. Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: Final Update of a Rapid, Living Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-3-immunity-after-COVID-19.pdf
     December 31, 2022 - In all three studies, a high proportion of participants had detectable IgG over the long- term.11-13 … Was the follow up time reported and sufficient to be long enough for outcomes to occur? 9. … Up to 13 months Delta Delta analysis: 325,157 Long-term effectiveness analysis: 152,656 … A comprehensive assessment of long-term SARS- CoV-2–specific adaptive immune memory in convalescent … Outcomes of SARS-CoV-2 Omicron infection in residents of Long-Term Care. medRxiv. 2022, January 27;

436. Disposition of Comments for CER 166 Calcineurin Inhibitors (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/calcineurin-inhibitor_disposition-comments.pdf
     March 15, 2016 - Long-term pragmatic clinical studies and large simple trials might be most informative for comparing … Astellas Pharma Global Development Medical Affairs, Americas Results Conventional wisdom has long … Long-term evaluation of analytical methods used in sirolimus therapeutic drug monitoring. … Discussion A summary page would help i.e. no defined range to prevent AR with tac C0 equal to C2 in long … laboratory parameters, even new molecular diagnostic modalities, may be necessary in some cases as long

437. PULMONARY with "Discussions" in Exec Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1312.pdf
     December 01, 2013 - but will require pharmaceutical companies to develop new models and educate investors about the long-term … with a lower proportion of serious adverse events with ivacaftor than with placebo (24% vs. 42%).7 Long-term … in oxygen and chest therapy, hospitalizations, and other complications could offset costs in the long … supply of azithromycin (generic) costs about $39, so the drug would be relatively inexpensive for long-term … Long- term safety and efficacy of Ivacaftor in patients with cystic fibrosis who have the G551D-CFTR

438. Comparative Effectiveness Research Review Disposition of Comments Report (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/disabilities-quality-improvement-outcomes_disposition-comments.pdf
     October 15, 2012 - The executive summary is too long and descriptive and primarily should present the recommendations … The former is long and latter short. We have expanded the discussion. … This is very long sentence and need clarification. Can you explain the limitations of the study. … Peer Reviewer #7 Executive Summary The Executive Summary is far too detailed, too long, and very … We have revised the executive summary but it is still long. See comments above.

439. Disposition of Comments for CER 183 Tonsillectomy for OSDB (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tonsillectomy-disposition-170415.pdf
     January 17, 2017 - Regarding long-term data concerning tonsillectomy for recurrent throat infection, such data would of … See detailed comments above in Introduction re degree of benefit and long- vs short-term. … I disagree that "evidence is inadequate to provide clear evidence for consistent and long-term benefit … Again, see comments above re "long-term" and "modest." Thank you for your comment. … We have revised this language somewhat but note that few studies provided long term data.

440. Systematic Review on Nonopioid Pharmacologic Treatments for Chronic Pain: Surveillance Report 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/surveillance-report-1-nonopioid-pharm-chronic-pain.pdf
     April 01, 2022 - short-term treatment duration (3 to <6 months), intermediate-term treatment duration (6 to <12 months), and long … Evidence on intermediate- and long-term effects on pain, function, and quality of life is limited. … Dronabinol is a safe long-term treatment option for neuropathic pain patients. … treatment duration (3 to <6 months), intermediate-term treatment duration (6 to <12 months), and long-term … Long-term treatment with capsaicin 8% patches: a subgroup analysis in patients with postherpetic neuralgia