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41. Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/osteoporosis-fracture-prevention/research

42. Treatment of Osteoarthritis of the Knee: An Update Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/osteoarthritis-knee-update-executive-170505.pdf
    May 01, 2017 - • Weight loss and general exercise programs show medium- and long- term benefits. … • Evidence was insufficient to assess effects on long-term function. … No studies assessed effects of balneotherapy on short- or long-term outcomes. … no benefit for long-term function (low strength of evidence) … term (meaning after a long intervention or after a shorter intervention with a long follow-up time

43. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-2007_executive.pdf
    January 01, 2007 - This review summarizes the evidence on the comparative long-term benefits and harms of ACEIs vs. … Evidence on comparative long-term benefits and harms of ACEIs vs. … Blood pressure control High ACEIs and ARBs appear to have similar long-term effects on blood pressure … Relatively few studies assessed these to Low outcomes over the long term. … Evidence on comparative long-term benefits and harms of ACEIs vs.

44. Disposition of Comments Report for Comparative Effectiveness of Bariatric Surgery and Nonsurgical Therapy in Adults With Metabolic Conditions and a Body Mass Index of 30.0 to 34.9 kg/m2 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/weight-loss-surgery_disposition-comments.pdf
    June 05, 2013 - On page 35 (now 36) we present long-term results published after those reviews. … Would aid the reader to specify long term vs. short term time frames. … SOE is insufficient for long term, low for short term adverse events. … We emphasize the need for long-term studies in our future research section. … We clearly state the need for comparative long-term studies.

45. Disposition of Comments Report for Comparison of Characteristics of Nursing Homes and Other Residential Long-Term Care Settings for People With Dementia (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/dementia-nursing-home-characteristics_disposition-comments.pdf
    October 23, 2012 - Disposition of Comments Report for Comparison of Characteristics of Nursing Homes and Other Residential Long-Term … Report Research Review Title: Comparison of Characteristics of Nursing Homes and Other Residential Long-Term … Comparison of Characteristics of Nursing Homes and Other Residential Long-Term Care Settings for People … This further focuses on how poor the research effort has been in long term care environments. … Our review was of people with dementia residing in nursing homes and other residential long-term care

46. AHRQ Slide Template
    effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-pain-management-grand-rounds-slides.pptx
    March 01, 2022 - after starting treatment; outcomes assessed at short- (1 to <6 m), intermediate- (≥6 to <12 m), and long-term … ES, SOE Pain Short-Term ES, SOE Pain Intermediate ES, SOE Pain Long-Term ES, SOE Exercise slight … ES, SOE Pain Short-Term ES, SOE Pain Intermediate ES, SOE Pain Long-Term ES, SOE Physical Modalities … ES, SOE Pain Short-Term ES, SOE Pain Intermediate ES, SOE Pain Long-Term ES, SOE “Active” Mind-Body … Unable to evaluate harms that may arise with frequent or long-term intermittent use. 41 Acknowledgments

47. AHRQ Evidence-based Practice Center Program Research Gaps Summary: Primary Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/research-gap-primary-care-summary-table.pdf
    March 01, 2022 - • In the long term, evidence was too limited to draw conclusions. … • Explanatory and pragmatic trials with long-term followup to evaluate differential effectiveness … Study Design • Explanatory and pragmatic trials with long-term follow up to evaluate differential … Studies should include a continuous long-term antiresorptive treatment control group. … Outcomes • Long-term, rigorous comparative studies are needed.

48. Evidence Summary for Treatments for Acute Pain: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-240-acute-pain-evidence-summary.pdf
    December 01, 2020 - back pain or postoperative pain might be associated with increased likelihood of use of opioids at long-term … specific types of acute pain, including effects on pain, function, quality of life, adverse events, and long-term … Being prescribed 3 opioids might be associated with increased risk of long-term use versus … prescribed an opioid for elective or minor surgery might be associated with increased likelihood of long-term … low back pain or postoperative pain was associated with increased likelihood of use of opioids at long-term

49. Cannabis-2022-Update-Surv-Rep-1-App-F-5 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-update-surv-rep-1-app-F-5.xlsx
    January 01, 2022 - frequent cannabis use (≥20 days/mo) B: No cannabis use NR Total: 208 (4 years); yearly assessments Long … or weekly use of marijuana B: Monthly or 1-2 times a month use of marijuana C: No use NR 52 (1 year) Long … acting opioids, OR: 3.090 (95% CI 2.417 to 3.950) Nabiximols vs. long acting opioids, RR: 1.421 (95% … acting opioids, OR: 3.777 (95% CI 2.878 to 4.957) Nabiximols vs. long acting opioids, RR: 1.386 (95% … NA 84 (21 months) Long NR None NR NR NR NR NR A vs.

50. Cannabis-2022-Surv-Rep-3-Table-F5 (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-2022-surv-rep-3-table-F5.xlsx
    January 01, 2022 - frequent cannabis use (≥20 days/mo) B: No cannabis use NR Total: 208 (4 years); yearly assessments Long … or weekly use of marijuana B: Monthly or 1-2 times a month use of marijuana C: No use NR 52 (1 year) Long … acting opioids, OR: 3.090 (95% CI 2.417 to 3.950) Nabiximols vs. long acting opioids, RR: 1.421 (95% … acting opioids, OR: 3.777 (95% CI 2.878 to 4.957) Nabiximols vs. long acting opioids, RR: 1.386 (95% … NA 84 (21 months) Long NR None NR NR NR NR NR A vs.

51. Disposition of Comments CER 194 Intermittent Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists for Asthma (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-194-disposition-comments-inhaled-corticosteroids.pdf
    March 19, 2018 - Disposition of Comments CER 194 Intermittent Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists … Disposition of Comments Report Research Review Title: Intermittent Inhaled Corticosteroids and Long-Acting … Intermittent Inhaled Corticosteroids and Long- Acting Muscarinic Antagonists for Asthma. … There are people that will argue that the dose is the same each day as long as their condition does … Long-term controller medications include inhaled corticosteroids, inhaled long-acting bronchodilators

52. Intergrated and Comprehensive Pain Management Programs: Effectiveness and Harms: Evidence Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-251-integrated-pain-management-evidence-summary.pdf
    October 01, 2021 - in function in the short term compared with physical activity alone but not in the intermediate or long … short term (1 to <6 months following treatment completion), intermediate term (≥6 to <12 months), and long … evidence No evidence Intermediate term (≥6 to <12 months) Small + No evidence No evidence Long … ++ None + None + Intermediate term (≥6 to <12 months) None + No evidence No evidence Long … Intermediate term (≥6 to <12 months) None + None + Small + Moderatec + None + Long

53. Template for Draft Reports (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/long-term-care-adults-future_research.pdf
    July 01, 2013 - Template for Draft Reports Future Research Needs Long-Term Care for Older Adults: Future Research … Future Research Needs: Long- Term Care for Older Adults. Future Research Needs Paper No. 44. … Long-term care in the United States: an overview. Health Affairs. 2000;19(3):40-56. … The Heart of Long-Term Care. London: Oxford University Press; 1998. … Minnesota EPC Long-Term Care for OlderAdults Research Needs Stakeholder Meeting Agenda

54. Topic 0559 Disruptive Behavior Disorders in Children NSD FINAL SJ (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0655-131114.pdf
    May 22, 2013 - researcher on behalf of an Organization Nomination The nominator is interested in the short-term and long-term … Intervention(s): Psychological and/or pharmacological interventions or treatments that have short- and long-term … Comparator(s): All other treatment options Outcome(s): Increases in positive short- and long-term outcomes … CD), and disruptive behavior disorder not otherwise specified (DBD NOS), what is the short-term and long-term

55. Systematic Review on Opioid Treatments for Chronic Pain: Surveillance Report 2 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-chronic-pain-surveillance-report-2.pdf
    April 01, 2022 - opioids 3c Different long-acting opioids 3d Short + long-acting opioids vs. long-acting opioids … Long- vs. short- acting opioids Long-acting opioids associated with increased risk of overdose vs … Prescription of Long-Acting Opioids and Mortality in Patients With Chronic Noncancer Pain. … opioid [3b], alternative long-acting opioid [3c], long-acting opioid alone [3d], as-needed dosing … Social cognition impairments in long- term opiate users in treatment.

56. Opioid Treatments for Chronic Pain Research Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/opioid-treatments-chronic-pain-protocol.pdf
    December 19, 2018 - The AHRQ review found insufficient evidence to show benefits of long-term opioid therapy for chronic … The review found that long-term opioid therapy was associated with increased risk of overdose, opioid … In patients with chronic pain, what is the comparative effectiveness of different long-acting opioids … versus long-acting opioids alone on outcomes related to pain, function, and quality of life; risk of … acting opioid Long-acting opioid Pain, function, and quality of life; risk of misuse, opioid

57. Dementia-Nursing-Home-Characteristics Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/dementia-nursing-home-characteristics_executive.pdf
    October 01, 2012 - Effectiveness Review Number 79 Comparison of Characteristics of Nursing Homes and Other Residential Long-Term … It is the most common reason for entry into long-term care settings such as nursing homes (NHs) … Because long- term care settings are highly varied, people with dementia and their families, who … Dying with dementia in long-term care. Gerontologist. 2008 Dec;48(6):741-51. … Trends in the supply of long-term-care facilities and beds in the United States.

58. Noninvasive Treatments for Low Back Pain (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/back-pain-treatment_research_executive.pdf
    February 01, 2016 - long-acting opioid No clear difference 4 RCTs Moderate No clear difference 4 RCTs Moderate Long-acting … term) 5 RCTs (short term) + 4 RCTs (long term) Low Small (short term) and no effect (long term … Small (short and long term) 1 SR (9 RCTs) (short term) + 1 SR (7 RCTs) (long term) Moderate Acupuncture … Long acting opioids vs. … long-acting opioids in pain or function.

59. Systematic Review on Opioid Treatments for Chronic Pain: Surveillance Report 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioids-chronic-pain-surveillance-report-1-final.pdf
    April 01, 2022 - The observational studies evaluated long-term outcomes of opioid therapy,6,7 long-acting versus short-acting … opioids: 6 studies (1 new) 3c Different long-acting opioids: 24 studies 3d Short + long-acting opioids … function vs. non-use), long- versus short-acting opioids (long-acting opioids associated with increased … Long- vs. short- acting opioids Long-acting opioids associated with increased risk of overdose vs … opioid [3b], alternative long-acting opioid [3c], long-acting opioid alone [3d], as-needed dosing

60. Systematic Review on Opioid Treatments for Chronic Pain: Surveillance Report 3 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/opioid-chronic-pain-surveillance-report-3.pdf
    June 01, 2022 - opioids: 6 studies 3c Different long-acting opioids: 24 studies 3d Short + long-acting opioids vs … Long- vs. short- acting opioids Long-acting opioids associated with increased risk of overdose vs … opioid [3b], alternative long-acting opioid [3c], long-acting opioid alone [3d], as-needed dosing … Long-term Opioid Use? … A Risk Prediction Model for Long-term Prescription Opioid Use.